TAS-119, a novel selective Aurora A and TRK inhibitor, exhibits antitumor efficacy in preclinical models with deregulated activation of the Myc, β-Catenin, and TRK pathways
Miura, Akihiro, Sootome, Hiroshi, Fujita, Naoya, Suzuki, Takamasa, Fukushima, Hiroto, Mizuarai, Shinji, Masuko, Norio, Ito, Kimihiro, Hashimoto, Akihiro, Uto, Yoshihiro, Sugimoto, Tetsuya, Takahashi, Hidekazu, Mitsuya, Morihiro, Hirai, Hiroshi
Published in Investigational new drugs (01.06.2021)
Published in Investigational new drugs (01.06.2021)
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A novel cinnamic acid derivative that inhibits Cdc25 dual‐specificity phosphatase activity
Aoyagi, Yoshimi, Masuko, Norio, Ohkubo, Shuichi, Kitade, Makoto, Nagai, Kentaro, Okazaki, Shinji, Wierzba, Konstanty, Terada, Tadafumi, Sugimoto, Yoshikazu, Yamada, Yuji
Published in Cancer science (01.09.2005)
Published in Cancer science (01.09.2005)
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Contribution of AP-1 Interference Induced by TAC-101 to Tumor Growth Suppression in a Hepatocellular Carcinoma Model
Eshima, Kokoro, Fukaya, Satoshi, Sugimoto, Akiko, Mori, Tomoko, Yokoi, Hiromi, Yamamoto, Yasuji, Sugiura, Shin, Honda, Shizu, Masuko, Norio, Murakami, Koji, Yamasaki, Yasundo, Kagechika, Hiroyuki
Published in Tumor biology (01.01.2009)
Published in Tumor biology (01.01.2009)
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Aurora A Inhibitor TAS-119 Enhances Antitumor Efficacy of Taxanes In Vitro and In Vivo : Preclinical Studies as Guidance for Clinical Development and Trial Design
Sootome, Hiroshi, Miura, Akihiro, Masuko, Norio, Suzuki, Takamasa, Uto, Yoshihiro, Hirai, Hiroshi
Published in Molecular cancer therapeutics (01.10.2020)
Published in Molecular cancer therapeutics (01.10.2020)
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Cloning and characterization of NE-dlg : a novel human homolog of the Drosophila discs large (dlg) tumor suppressor protein interacts with the APC protein
MAKINO, K, KUWAHARA, H, SAYA, H, MASUKO, N, NISHIYAMA, Y, MORISAKI, T, SASAKI, J.-I, NAKAO, M, KUWANO, A, NAKATA, M, USHIO, Y
Published in Oncogene (22.05.1997)
Published in Oncogene (22.05.1997)
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Deubiquitylation of histone H2A activates transcriptional initiation via trans-histone cross-talk with H3K4 di- and trimethylation
Nakagawa, Takeya, Kajitani, Takuya, Togo, Shinji, Masuko, Norio, Ohdan, Hideki, Hishikawa, Yoshitaka, Koji, Takehiko, Matsuyama, Toshifumi, Ikura, Tsuyoshi, Muramatsu, Masami, Ito, Takashi
Published in Genes & development (01.01.2008)
Published in Genes & development (01.01.2008)
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A Novel NE-dlg/SAP102-associated Protein, p51-nedasin, Related to the Amidohydrolase Superfamily, Interferes with the Association between NE-dlg/SAP102 and N-Methyl-d-aspartate Receptor
Kuwahara, Hiroaki, Araki, Norie, Makino, Keishi, Masuko, Norio, Honda, Shinobu, Kaibuchi, Kozo, Fukunaga, Kohji, Miyamoto, Eishichi, Ogawa, Michio, Saya, Hideyuki
Published in The Journal of biological chemistry (05.11.1999)
Published in The Journal of biological chemistry (05.11.1999)
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Interaction of NE-dlg/SAP102, a Neuronal and Endocrine Tissue-specific Membrane-associated Guanylate Kinase Protein, with Calmodulin and PSD-95/SAP90
Masuko, Norio, Makino, Keishi, Kuwahara, Hiroaki, Fukunaga, Kohji, Sudo, Tamotsu, Araki, Norie, Yamamoto, Hideyuki, Yamada, Yuji, Miyamoto, Eishichi, Saya, Hideyuki
Published in The Journal of biological chemistry (26.02.1999)
Published in The Journal of biological chemistry (26.02.1999)
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Abstract A268: TAS-119, a selective Aurora A inhibitor, enhanced the antitumor efficacy of taxanes in multiple human tumor cell lines including paclitaxel-resistant cells
Miura, Akihiro, Sootome, Hiroshi, Ishihara, Keiko, Masuko, Norio, Hirai, Hiroshi, Utsugi, Teruhiro
Published in Molecular cancer therapeutics (01.11.2013)
Published in Molecular cancer therapeutics (01.11.2013)
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TAS3681: New class of androgen receptor antagonist with androgen receptor downregulating activity
Minamiguchi, Kazuhisa, Seki, Masanao, Aoyagi, Hiroki, Kajiwara, Daisuke, Mori, Tomoko, Masuko, Norio, Fujita, Ryouto, Okajima, Shigeo, Hayashi, Yukio, Sasaki, Eiji, Utsugi, Teruhiro
Published in Journal of clinical oncology (01.03.2015)
Published in Journal of clinical oncology (01.03.2015)
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Abstract A269: A selective Aurora A inhibitor, TAS-119, enhanced the antitumor activity of taxanes in an intermittent dosing schedule without affecting neurotoxicity
Ishihara, Keiko, Sootome, Hiroshi, Suzuki, Takamasa, Masuko, Norio, Miura, Akihiro, Okada, Megumu, Oda, Nobuyuki, Hirai, Hiroshi, Utsugi, Teruhiro
Published in Molecular cancer therapeutics (01.11.2013)
Published in Molecular cancer therapeutics (01.11.2013)
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Abstract 2625: MGCD0103, an oral isotype-selective HDAC inhibitor, has antitumor activity via the induction of the expression of Annexin A1 on AML1/ETO AML in vitro and in vivo
Nameki, Daisuke, Masuko, Norio, Fujita, Ryouto, Sugiura, Shin, Yamamoto, Yasuji, Minamiguchi, Kazuhisa, Matsuo, Ken-Ichi
Published in Cancer research (Chicago, Ill.) (15.04.2011)
Published in Cancer research (Chicago, Ill.) (15.04.2011)
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Zyxin, a Regulator of Actin Filament Assembly, Targets the Mitotic Apparatus by Interacting with h-warts/LATS1 Tumor Suppressor
Hirota, Toru, Morisaki, Tetsuro, Nishiyama, Yasuyuki, Marumoto, Tomotoshi, Tada, Kenji, Hara, Toshihiro, Masuko, Norio, Inagaki, Masaki, Hatakeyama, Katsuyoshi, Saya, Hideyuki
Published in The Journal of cell biology (29.05.2000)
Published in The Journal of cell biology (29.05.2000)
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Abstract B1: Antitumor activity of TSU-68 in PDGF-BB overexpressing U-87MG xenograft model: contribution of PDGFR blocking action
Hosoi, Fumihito, Yokoi, Hiromi, Nameki, Daisuke, Hayashi, Hiroaki, Ito, Kenjiro, Masuko, Norio, Minamiguchi, Kazuhisa, Matsuo, Ken-ichi, Utsugi, Teruhiro
Published in Molecular cancer therapeutics (12.11.2011)
Published in Molecular cancer therapeutics (12.11.2011)
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