Spleen tyrosine kinase inhibition is an effective treatment for established vasculitis in a pre-clinical model
McAdoo, Stephen P., Prendecki, Maria, Tanna, Anisha, Bhatt, Tejal, Bhangal, Gurjeet, McDaid, John, Masuda, Esteban S., Cook, H. Terence, Tam, Frederick W.K., Pusey, Charles D.
Published in Kidney international (01.06.2020)
Published in Kidney international (01.06.2020)
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Discovery and Development of Spleen Tyrosine Kinase (SYK) Inhibitors
Singh, Rajinder, Masuda, Esteban S, Payan, Donald G
Published in Journal of medicinal chemistry (26.04.2012)
Published in Journal of medicinal chemistry (26.04.2012)
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R406, an Orally Available Spleen Tyrosine Kinase Inhibitor Blocks Fc Receptor Signaling and Reduces Immune Complex-Mediated Inflammation
Braselmann, Sylvia, Taylor, Vanessa, Zhao, Haoran, Wang, Su, Sylvain, Catherine, Baluom, Muhammad, Qu, Kunbin, Herlaar, Ellen, Lau, Angela, Young, Chi, Wong, Brian R, Lovell, Scott, Sun, Thomas, Park, Gary, Argade, Ankush, Jurcevic, Stipo, Pine, Polly, Singh, Rajinder, Grossbard, Elliott B, Payan, Donald G, Masuda, Esteban S
Published in The Journal of pharmacology and experimental therapeutics (01.12.2006)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2006)
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Eliminating chronic myeloid leukemia stem cells by IRAK1/4 inhibitors
Tanaka, Yosuke, Takeda, Reina, Fukushima, Tsuyoshi, Mikami, Keiko, Tsuchiya, Shun, Tamura, Moe, Adachi, Keito, Umemoto, Terumasa, Asada, Shuhei, Watanabe, Naoki, Morishita, Soji, Imai, Misa, Nagata, Masayoshi, Araki, Marito, Takizawa, Hitoshi, Fukuyama, Tomofusa, Lamagna, Chrystelle, Masuda, Esteban S, Ito, Ryoji, Goyama, Susumu, Komatsu, Norio, Takaku, Tomoiku, Kitamura, Toshio
Published in Nature communications (12.01.2022)
Published in Nature communications (12.01.2022)
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Bicyclic pyrimidine compounds as potent IRAK4 inhibitors
Chen, Yan, Tso, Kin, Heckrodt, Thilo J., Li, Hui, Yen, Rose, Lin, Nan, Singh, Rajinder, Taylor, Vanessa, Masuda, Esteban S., Park, Gary, Payan, Donald G.
Published in Bioorganic & medicinal chemistry letters (01.10.2022)
Published in Bioorganic & medicinal chemistry letters (01.10.2022)
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Journal Article
Syk Activation in Circulating and Tissue Innate Immune Cells in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis
Prendecki, Maria, Gulati, Kavita, Pisacano, Noelle, Pinheiro, Damilola, Bhatt, Tejal, Mawhin, Marie‐Anne, Toulza, Frederic, Masuda, Esteban S., Cowburn, Andrew, Lodge, Katharine M., Tam, Frederick W. K., Roufosse, Candice, Pusey, Charles D., McAdoo, Stephen P.
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.01.2023)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.01.2023)
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Discovery of 5‑Aryl-2,4-diaminopyrimidine Compounds as Potent and Selective IRAK4 Inhibitors
Chen, Yan, Singh, Rajinder, Lin, Nan, Taylor, Vanessa, Masuda, Esteban S, Payan, Donald G
Published in ACS medicinal chemistry letters (14.04.2022)
Published in ACS medicinal chemistry letters (14.04.2022)
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Regulation of bone homeostasis by MERTK and TYRO3
Engelmann, Janik, Zarrer, Jennifer, Gensch, Victoria, Riecken, Kristoffer, Berenbrok, Nikolaus, Luu, The Vinh, Beitzen-Heineke, Antonia, Vargas-Delgado, Maria Elena, Pantel, Klaus, Bokemeyer, Carsten, Bhamidipati, Somasekhar, Darwish, Ihab S, Masuda, Esteban, Burstyn-Cohen, Tal, Alberto, Emily J, Ghosh, Sourav, Rothlin, Carla, Hesse, Eric, Taipaleenmäki, Hanna, Ben-Batalla, Isabel, Loges, Sonja
Published in Nature communications (12.12.2022)
Published in Nature communications (12.12.2022)
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Inhibition of spleen tyrosine kinase decreases donor specific antibody levels in a rat model of sensitization
Tempest-Roe, Shenzhen, Prendecki, Maria, McAdoo, Stephen P, Clarke, Candice, Tanna, Anisha, Turner-Stokes, Tabitha, Masuda, Esteban S, Willicombe, Michelle, Cook, H Terence, Roufosse, Candice, Taube, David, Pusey, Charles D, Tam, Frederick W K
Published in Scientific reports (28.02.2022)
Published in Scientific reports (28.02.2022)
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Assessment of thrombotic risk during long-term treatment of immune thrombocytopenia with fostamatinib
Cooper, Nichola, Altomare, Ivy, Thomas, Mark R., Nicolson, Phillip L. R., Watson, Steve P., Markovtsov, Vadim, Todd, Leslie K., Masuda, Esteban, Bussel, James B.
Published in Therapeutic advances in hematology (2021)
Published in Therapeutic advances in hematology (2021)
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Spleen tyrosine kinase inhibition attenuates autoantibody production and reverses experimental autoimmune GN
McAdoo, Stephen P, Reynolds, John, Bhangal, Gurjeet, Smith, Jennifer, McDaid, John P, Tanna, Anisha, Jackson, William D, Masuda, Esteban S, Cook, H Terence, Pusey, Charles D, Tam, Frederick W K
Published in Journal of the American Society of Nephrology (01.10.2014)
Published in Journal of the American Society of Nephrology (01.10.2014)
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Optimization of Pyrimidine Compounds as Potent JAK1 Inhibitors and the Discovery of R507 as a Clinical Candidate
Chen, Yan, Li, Hui, Yen, Rose, Heckrodt, Thilo J., McMurtrie, Darren, Singh, Rajinder, Taylor, Vanessa, Masuda, Esteban S., Park, Gary, Payan, Donald G.
Published in ACS medicinal chemistry letters (10.11.2022)
Published in ACS medicinal chemistry letters (10.11.2022)
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Therapeutic targeting of Syk in autoimmune diabetes
Colonna, Lucrezia, Catalano, Geoffrey, Chew, Claude, D'Agati, Vivette, Thomas, James W, Wong, F Susan, Schmitz, Jochen, Masuda, Esteban S, Reizis, Boris, Tarakhovsky, Alexander, Clynes, Raphael
Published in The Journal of immunology (1950) (01.08.2010)
Published in The Journal of immunology (1950) (01.08.2010)
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Spleen tyrosine kinase is important in the production of proinflammatory cytokines and cell proliferation in human mesangial cells following stimulation with IgA1 isolated from IgA nephropathy patients
Kim, Min Jeong, McDaid, John P, McAdoo, Stephen P, Barratt, Jonathan, Molyneux, Karen, Masuda, Esteban S, Pusey, Charles D, Tam, Frederick W K
Published in The Journal of immunology (1950) (01.10.2012)
Published in The Journal of immunology (1950) (01.10.2012)
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A Spleen Tyrosine Kinase Inhibitor Reduces the Severity of Established Glomerulonephritis
SMITH, Jennifer, MCDAID, John P, BHANGAL, Gurjeet, CHAWANASUNTORAPOJ, Ratana, MASUDA, Esteban S, COOK, H. Terence, PUSEY, Charles D, TAM, Frederick W. K
Published in Journal of the American Society of Nephrology (01.02.2010)
Published in Journal of the American Society of Nephrology (01.02.2010)
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Inhibition of Janus kinase signaling during controlled mechanical ventilation prevents ventilation‐induced diaphragm dysfunction
Smith, Ira J., Godinez, Guillermo L., Singh, Baljit K., McCaughey, Kelly M., Alcantara, Raniel R., Gururaja, Tarikere, Ho, Melissa S., Nguyen, Henry N., Friera, Annabelle M., White, Kathy A., McLaughlin, John R., Hansen, Derek, Romero, Jason M., Baltgalvis, Kristen A., Claypool, Mark D., Li, Wei, Lang, Wayne, Yam, George C., Gelman, Marina S., Ding, Rongxian, Yung, Stephanie L., Creger, Daniel P., Chen, Yan, Singh, Rajinder, Smuder, Ashley J., Wiggs, Michael P., Kwon, Oh‐Sung, Sollanek, Kurt J., Powers, Scott K., Masuda, Esteban S., Taylor, Vanessa C., Payan, Donald G., Kinoshita, Taisei, Kinsella, Todd M.
Published in The FASEB journal (01.07.2014)
Published in The FASEB journal (01.07.2014)
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Design, synthesis of diaminopyrimidine inhibitors targeting IgE- and IgG-mediated activation of Fc receptor signaling
Argade, Ankush, Bhamidipati, Somasekhar, Li, Hui, Sylvain, Catherine, Clough, Jeffrey, Carroll, David, Keim, Holger, Braselmann, Sylvia, Taylor, Vanessa, Zhao, Haoran, Herlaar, Ellen, Issakani, Sarkiz D., Wong, Brian R., Masuda, Esteban S., Payan, Donald G., Singh, Rajinder
Published in Bioorganic & medicinal chemistry letters (15.05.2015)
Published in Bioorganic & medicinal chemistry letters (15.05.2015)
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Syk Activation in Dendritic Cells Is Essential for Airway Hyperresponsiveness and Inflammation
Matsubara, Shigeki, Koya, Toshiyuki, Takeda, Katsuyuki, Joetham, Anthony, Miyahara, Nobuaki, Pine, Polly, Masuda, Esteban S, Swasey, Christina H, Gelfand, Erwin W
Published in American journal of respiratory cell and molecular biology (01.04.2006)
Published in American journal of respiratory cell and molecular biology (01.04.2006)
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