Inhibition of major drug metabolizing CYPs by common herbal medicines used by HIV/AIDS patients in Africa-- implications for herb-drug interactions
Awortwe, Charles, Bouic, Patrick J, Masimirembwa, Collen M, Rosenkranz, Bernd
Published in Drug metabolism letters (01.07.2014)
Published in Drug metabolism letters (01.07.2014)
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In Vitro and in Silico Identification and Characterization of Thiabendazole as a Mechanism-Based Inhibitor of CYP1A2 and Simulation of Possible Pharmacokinetic Drug-Drug Interactions
THELINGWANI, Roslyn S, ZVADA, Simbarashe P, DOLGOS, Hugues, UNGELL, Anna-Lena B, MASIMIREMBWA, Collen M
Published in Drug metabolism and disposition (01.06.2009)
Published in Drug metabolism and disposition (01.06.2009)
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Application of Higher Throughput Screening (HTS) Inhibition Assays to Evaluate the Interaction of Antiparasitic Drugs with Cytochrome P450s
BAPIRO, Tashinga E, EGNELL, Ann-Charlotte, HASLER, Julia A, MASIMIREMBWA, Collen M
Published in Drug metabolism and disposition (01.01.2001)
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Published in Drug metabolism and disposition (01.01.2001)
Journal Article
Warfarin Pharmacogenomics for Precision Medicine in Real-Life Clinical Practice in Southern Africa: Harnessing 73 Variants in 29 Pharmacogenes
Muyambo, Sarudzai, Ndadza, Arinao, Soko, Nyarai D, Kruger, Bianca, Kadzirange, Gerard, Chimusa, Emile, Masimirembwa, Collen M, Ntsekhe, Mpiko, Nhachi, Charles F B, Dandara, Collet
Published in Omics (Larchmont, N.Y.) (01.01.2022)
Published in Omics (Larchmont, N.Y.) (01.01.2022)
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Journal Article
Discriminant and quantitative PLS analysis of competitive CYP2C9 inhibitors versus non-inhibitors using alignment independent GRIND descriptors
Afzelius, Lovisa, Masimirembwa, Collen M, Karlén, Anders, Andersson, Tommy B, Zamora, Ismael
Published in Journal of computer-aided molecular design (01.07.2002)
Published in Journal of computer-aided molecular design (01.07.2002)
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Antimalarial benzoheterocyclic 4-aminoquinolines: Structure–activity relationship, in vivo evaluation, mechanistic and bioactivation studies
Ongarora, Dennis S.B., Strydom, Natasha, Wicht, Kathryn, Njoroge, Mathew, Wiesner, Lubbe, Egan, Timothy J., Wittlin, Sergio, Jurva, Ulrik, Masimirembwa, Collen M., Chibale, Kelly
Published in Bioorganic & medicinal chemistry (01.09.2015)
Published in Bioorganic & medicinal chemistry (01.09.2015)
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STRUCTURAL ANALYSIS OF CYP2C9 AND CYP2C5 AND AN EVALUATION OF COMMONLY USED MOLECULAR MODELING TECHNIQUES
AFZELIUS, Lovisa, RAUBACHER, Florian, KARLEN, Anders, JØRGENSEN, Flemming Steen, ANDERSSON, Tommy B, MASIMIREMBWA, Collen M, ZAMORA, Ismael
Published in Drug metabolism and disposition (01.11.2004)
Published in Drug metabolism and disposition (01.11.2004)
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Journal Article
Genetic Polymorphism of Cytochrome P450 1A1 (CYP1A1) and Glutathione Transferases (M1, T1 and P1) among Africans
Dandara, Collet, Sayi, Jane, M. Masimirembwa, Collen, Magimba, Ayoub, Kaaya, Sylvia, Sommers, Klerk De, Snyman, Jacques R., Hasler, Julia A.
Published in Clinical chemistry and laboratory medicine (24.09.2002)
Published in Clinical chemistry and laboratory medicine (24.09.2002)
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Conference Proceeding
Benzoheterocyclic amodiaquine analogues with potent antiplasmodial activity: Synthesis and pharmacological evaluation
Ongarora, Dennis S.B., Gut, Jiri, Rosenthal, Philip J., Masimirembwa, Collen M., Chibale, Kelly
Published in Bioorganic & medicinal chemistry letters (01.08.2012)
Published in Bioorganic & medicinal chemistry letters (01.08.2012)
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Journal Article
Amodiaquine clearance and its metabolism to N-desethylamodiaquine is mediated by CYP2C8: a new high affinity and turnover enzyme-specific probe substrate
Li, Xue-Qing, Björkman, Anders, Andersson, Tommy B, Ridderström, Marianne, Masimirembwa, Collen M
Published in The Journal of pharmacology and experimental therapeutics (01.02.2002)
Published in The Journal of pharmacology and experimental therapeutics (01.02.2002)
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Identification of human cytochrome P450s that metabolise anti-parasitic drugs and predictions of in vivo drug hepatic clearance from in vitro data
LI, Xue-Qing, BJÖRKMAN, Anders, ANDERSSON, Tommy B, GUSTAFSSON, Lars L, MASIMIREMBWA, Collen M
Published in European journal of clinical pharmacology (01.09.2003)
Published in European journal of clinical pharmacology (01.09.2003)
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Establishment of a biobank and pharmacogenetics database of African populations
Matimba, Alice, Oluka, Margaret N, Ebeshi, Benjamin U, Sayi, Jane, Bolaji, Oluseye O, Guantai, Anastasia N, Masimirembwa, Collen M
Published in European journal of human genetics : EJHG (01.07.2008)
Published in European journal of human genetics : EJHG (01.07.2008)
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Evaluation of human liver slices and reporter gene assays as systems for predicting the cytochrome P450 induction potential of drugs in vivo in humans
PERSSON, Kajsa P, EKEHED, Susanne, OTTER, Charlotta, MAREIKE LUTZ, E. S, MCPHEAT, Jane, MASIMIREMBWA, Collen M, ANDERSSON, Tommy B
Published in Pharmaceutical research (2006)
Published in Pharmaceutical research (2006)
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Journal Article
Conformer- and Alignment-Independent Model for Predicting Structurally Diverse Competitive CYP2C9 Inhibitors
Afzelius, Lovisa, Zamora, Ismael, Masimirembwa, Collen M, Karlén, Anders, Andersson, Tommy B, Mecucci, Silvio, Baroni, Massimo, Cruciani, Gabriele
Published in Journal of medicinal chemistry (12.02.2004)
Published in Journal of medicinal chemistry (12.02.2004)
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Competitive CYP2C9 Inhibitors: Enzyme Inhibition Studies, Protein Homology Modeling, and Three-Dimensional Quantitative Structure-Activity Relationship Analysis
Afzelius, Lovisa, Zamora, Ismael, Ridderström, Marianne, Andersson, Tommy B., Karlén, Anders, Masimirembwa, Collen M.
Published in Molecular pharmacology (01.04.2001)
Published in Molecular pharmacology (01.04.2001)
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Artemisinin and thiabendazole are potent inhibitors of cytochrome P450 1A2 (CYP1A2) activity in humans
BAPIRO, Tashinga E, SAYI, Jane, HASLER, Julia A, JANDE, Mary, RIMOY, Gerald, MASSELLE, Amos, MASIMIREMBWA, Collen M
Published in European journal of clinical pharmacology (01.11.2005)
Published in European journal of clinical pharmacology (01.11.2005)
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