AI-guided pipeline for protein–protein interaction drug discovery identifies a SARS-CoV-2 inhibitor
Trepte, Philipp, Secker, Christopher, Olivet, Julien, Blavier, Jeremy, Kostova, Simona, Maseko, Sibusiso B, Minia, Igor, Silva Ramos, Eduardo, Cassonnet, Patricia, Golusik, Sabrina, Zenkner, Martina, Beetz, Stephanie, Liebich, Mara J, Scharek, Nadine, Schütz, Anja, Sperling, Marcel, Lisurek, Michael, Wang, Yang, Spirohn, Kerstin, Hao, Tong, Calderwood, Michael A, Hill, David E, Landthaler, Markus, Choi, Soon Gang, Twizere, Jean-Claude, Vidal, Marc, Wanker, Erich E
Published in Molecular systems biology (02.04.2024)
Published in Molecular systems biology (02.04.2024)
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A proteome-scale map of the SARS-CoV-2-human contactome
Kim, Dae-Kyum, Weller, Benjamin, Lin, Chung-Wen, Sheykhkarimli, Dayag, Knapp, Jennifer J, Dugied, Guillaume, Zanzoni, Andreas, Pons, Carles, Tofaute, Marie J, Maseko, Sibusiso B, Spirohn, Kerstin, Laval, Florent, Lambourne, Luke, Kishore, Nishka, Rayhan, Ashyad, Sauer, Mayra, Young, Veronika, Halder, Hridi, la Rosa, Nora Marín-de, Pogoutse, Oxana, Strobel, Alexandra, Schwehn, Patrick, Li, Roujia, Rothballer, Simin T, Altmann, Melina, Cassonnet, Patricia, Coté, Atina G, Vergara, Lena Elorduy, Hazelwood, Isaiah, Liu, Betty B, Nguyen, Maria, Pandiarajan, Ramakrishnan, Dohai, Bushra, Coloma, Patricia A Rodriguez, Poirson, Juline, Giuliana, Paolo, Willems, Luc, Taipale, Mikko, Jacob, Yves, Hao, Tong, Hill, David E, Brun, Christine, Twizere, Jean-Claude, Krappmann, Daniel, Heinig, Matthias, Falter, Claudia, Aloy, Patrick, Demeret, Caroline, Vidal, Marc, Calderwood, Michael A, Roth, Frederick P, Falter-Braun, Pascal
Published in Nature biotechnology (01.01.2023)
Published in Nature biotechnology (01.01.2023)
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A systematic approach to identify host targets and rapidly deliver broad-spectrum antivirals
Olivet, Julien, Maseko, Sibusiso B., Volkov, Alexander N., Salehi-Ashtiani, Kourosh, Das, Kalyan, Calderwood, Michael A., Twizere, Jean-Claude, Gorgulla, Christoph
Published in Molecular therapy (04.05.2022)
Published in Molecular therapy (04.05.2022)
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Identification of small molecule antivirals against HTLV-1 by targeting the hDLG1-Tax-1 protein-protein interaction
Maseko, Sibusiso B., Brammerloo, Yasmine, Van Molle, Inge, Sogues, Adrià, Martin, Charlotte, Gorgulla, Christoph, Plant, Estelle, Olivet, Julien, Blavier, Jeremy, Ntombela, Thandokuhle, Delvigne, Frank, Arthanari, Haribabu, El Hajj, Hiba, Bazarbachi, Ali, Van Lint, Carine, Salehi-Ashtiani, Kourosh, Remaut, Han, Ballet, Steven, Volkov, Alexander N., Twizere, Jean-Claude
Published in Antiviral research (01.09.2023)
Published in Antiviral research (01.09.2023)
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Nanobody against SARS-CoV-2 non-structural protein Nsp9 inhibits viral replication in human airway epithelia
Venit, Tomas, Blavier, Jeremy, Maseko, Sibusiso B., Shu, Sam, Espada, Lilia, Breunig, Christopher, Holthoff, Hans-Peter, Desbordes, Sabrina C., Lohse, Martin, Esposito, Gennaro, Twizere, Jean-Claude, Percipalle, Piergiorgio
Published in Molecular therapy. Nucleic acids (10.09.2024)
Published in Molecular therapy. Nucleic acids (10.09.2024)
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I36T↑T mutation in South African subtype C (C-SA) HIV-1 protease significantly alters protease-drug interactions
Maseko, Sibusiso B., Padayachee, Eden, Govender, Thavendran, Sayed, Yasien, Kruger, Gert, Maguire, Glenn E.M., Lin, Johnson
Published in Biological chemistry (26.09.2017)
Published in Biological chemistry (26.09.2017)
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Identification of potent L,D-transpeptidase 5 inhibitors for Mycobacterium tuberculosis as potential anti-TB leads: virtual screening and molecular dynamics simulations
Sabe, Victor T., Tolufashe, Gideon F., Ibeji, Collins U., Maseko, Sibusiso B., Govender, Thavendran, Maguire, Glenn E. M., Lamichhane, Gyanu, Honarparvar, Bahareh, Kruger, Hendrik G.
Published in Journal of molecular modeling (01.11.2019)
Published in Journal of molecular modeling (01.11.2019)
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Purification and characterization of naturally occurring HIV-1 (South African subtype C) protease mutants from inclusion bodies
Maseko, Sibusiso B., Natarajan, Satheesh, Sharma, Vikas, Bhattacharyya, Neelakshi, Govender, Thavendran, Sayed, Yasien, Maguire, Glenn E.M., Lin, Johnson, Kruger, Hendrik G.
Published in Protein expression and purification (01.06.2016)
Published in Protein expression and purification (01.06.2016)
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An insight to the molecular interactions of the FDA approved HIV PR drugs against L38L↑N↑L PR mutant
Sanusi, Zainab K., Govender, Thavendran, Maguire, Glenn E. M., Maseko, Sibusiso B., Lin, Johnson, Kruger, Hendrik G., Honarparvar, Bahareh
Published in Journal of computer-aided molecular design (01.03.2018)
Published in Journal of computer-aided molecular design (01.03.2018)
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AI-guided pipeline for protein-protein interaction drug discovery identifies a SARS-CoV-2 inhibitor
Trepte, Philipp, Secker, Christopher, Kostova, Simona, Maseko, Sibusiso B, Choi, Soon Gang, Blavier, Jeremy, Minia, Igor, Ramos, Eduardo Silva, Cassonnet, Patricia, Golusik, Sabrina, Zenkner, Martina, Beetz, Stephanie, Liebich, Mara J, Scharek, Nadine, Schütz, Anja, Sperling, Marcel, Lisurek, Michael, Wang, Yang, Spirohn, Kerstin, Hao, Tong, Calderwood, Michael A, Hill, David E, Landthaler, Markus, Olivet, Julien, Twizere, Jean-Claude, Vidal, Marc, Wanker, Erich E
Published in bioRxiv : the preprint server for biology (14.06.2023)
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Published in bioRxiv : the preprint server for biology (14.06.2023)
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