Mechanism-Based Personalized Medicine for Cystic Fibrosis by Suppressing Pseudo Exon Inclusion
Shibata, Saiko, Ajiro, Masahiko, Hagiwara, Masatoshi
Published in Cell chemical biology (17.12.2020)
Published in Cell chemical biology (17.12.2020)
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Stress-responsive maturation of Clk1/4 pre-mRNAs promotes phosphorylation of SR splicing factor
Ninomiya, Kensuke, Kataoka, Naoyuki, Hagiwara, Masatoshi
Published in The Journal of cell biology (03.10.2011)
Published in The Journal of cell biology (03.10.2011)
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Journal Article
Chemical induction of splice-neoantigens attenuates tumor growth in a preclinical model of colorectal cancer
Matsushima, Shingo, Ajiro, Masahiko, Iida, Kei, Chamoto, Kenji, Honjo, Tasuku, Hagiwara, Masatoshi
Published in Science translational medicine (30.11.2022)
Published in Science translational medicine (30.11.2022)
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Journal Article
CDC2-like (CLK) protein kinase inhibition as a novel targeted therapeutic strategy in prostate cancer
Uzor, Simon, Porazinski, Sean R., Li, Ling, Clark, Bethany, Ajiro, Masahiko, Iida, Kei, Hagiwara, Masatoshi, Alqasem, Abdullah A., Perks, Claire M., Wilson, Ian D., Oltean, Sebastian, Ladomery, Michael R.
Published in Scientific reports (12.04.2021)
Published in Scientific reports (12.04.2021)
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Journal Article
Therapeutic manipulation of IKBKAP mis-splicing with a small molecule to cure familial dysautonomia
Ajiro, Masahiko, Awaya, Tomonari, Kim, Young Jin, Iida, Kei, Denawa, Masatsugu, Tanaka, Nobuo, Kurosawa, Ryo, Matsushima, Shingo, Shibata, Saiko, Sakamoto, Tetsunori, Studer, Lorenz, Krainer, Adrian R., Hagiwara, Masatoshi
Published in Nature communications (23.07.2021)
Published in Nature communications (23.07.2021)
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Journal Article
In vitro expansion of mouse primordial germ cell‐like cells recapitulates an epigenetic blank slate
Ohta, Hiroshi, Kurimoto, Kazuki, Okamoto, Ikuhiro, Nakamura, Tomonori, Yabuta, Yukihiro, Miyauchi, Hidetaka, Yamamoto, Takuya, Okuno, Yukiko, Hagiwara, Masatoshi, Shirane, Kenjiro, Sasaki, Hiroyuki, Saitou, Mitinori
Published in The EMBO journal (03.07.2017)
Published in The EMBO journal (03.07.2017)
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Journal Article
Convergent synthesis of trifunctional molecules by three sequential azido-type-selective cycloadditions
Yoshida, Suguru, Kanno, Kimiyuki, Kii, Isao, Misawa, Yoshihiro, Hagiwara, Masatoshi, Hosoya, Takamitsu
Published in Chemical communications (Cambridge, England) (2018)
Published in Chemical communications (Cambridge, England) (2018)
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Journal Article
Epigenetic aging in Williams syndrome
Okazaki, Satoshi, Kimura, Ryo, Otsuka, Ikuo, Tomiwa, Kiyotaka, Funabiki, Yasuko, Hagiwara, Masatoshi, Murai, Toshiya, Hishimoto, Akitoyo
Published in Journal of child psychology and psychiatry (01.12.2022)
Published in Journal of child psychology and psychiatry (01.12.2022)
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Journal Article
Prenatal neurogenesis induction therapy normalizes brain structure and function in Down syndrome mice
Nakano-Kobayashi, Akiko, Awaya, Tomonari, Kii, Isao, Sumida, Yuto, Okuno, Yukiko, Yoshida, Suguru, Sumida, Tomoe, Inoue, Haruhisa, Hosoya, Takamitsu, Hagiwara, Masatoshi
Published in Proceedings of the National Academy of Sciences - PNAS (19.09.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (19.09.2017)
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Journal Article
CDK9 Inhibitor FIT-039 Suppresses Viral Oncogenes E6 and E7 and Has a Therapeutic Effect on HPV-Induced Neoplasia
Ajiro, Masahiko, Sakai, Hiroyuki, Onogi, Hiroshi, Yamamoto, Makoto, Sumi, Eriko, Sawada, Teruo, Nomura, Takashi, Kabashima, Kenji, Hosoya, Takamitsu, Hagiwara, Masatoshi
Published in Clinical cancer research (15.09.2018)
Published in Clinical cancer research (15.09.2018)
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Journal Article
High-resolution imaging mass spectrometry combined with transcriptomic analysis identified a link between fatty acid composition of phosphatidylinositols and the immune checkpoint pathway at the primary tumour site of breast cancer
Kawashima, Masahiro, Tokiwa, Mariko, Nishimura, Tomomi, Kawata, Yukiko, Sugimoto, Masahiro, Kataoka, Tatsuki R., Sakurai, Takaki, Iwaisako, Keiko, Suzuki, Eiji, Hagiwara, Masatoshi, Harris, Adrian L., Toi, Masakazu
Published in British journal of cancer (01.01.2020)
Published in British journal of cancer (01.01.2020)
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Journal Article
Author Correction: Therapeutic manipulation of IKBKAP mis-splicing with a small molecule to cure familial dysautonomia
Ajiro, Masahiko, Awaya, Tomonari, Kim, Young Jin, Iida, Kei, Denawa, Masatsugu, Tanaka, Nobuo, Kurosawa, Ryo, Matsushima, Shingo, Shibata, Saiko, Sakamoto, Tetsunori, Studer, Lorenz, Krainer, Adrian R., Hagiwara, Masatoshi
Published in Nature communications (12.10.2021)
Published in Nature communications (12.10.2021)
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Journal Article
Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA
Yoshida, Minoru, Kaida, Daisuke, Motoyoshi, Hajime, Tashiro, Etsu, Nojima, Takayuki, Hagiwara, Masatoshi, Ishigami, Ken, Watanabe, Hidenori, Kitahara, Takeshi, Yoshida, Tatsuhiko, Nakajima, Hidenori, Tani, Tokio, Horinouchi, Sueharu
Published in Nature chemical biology (01.09.2007)
Published in Nature chemical biology (01.09.2007)
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Journal Article
Rectifier of aberrant mRNA splicing recovers tRNA modification in familial dysautonomia
Yoshida, Mayumi, Kataoka, Naoyuki, Miyauchi, Kenjyo, Ohe, Kenji, Iida, Kei, Yoshida, Suguru, Nojima, Takayuki, Okuno, Yukiko, Onogi, Hiroshi, Usui, Tomomi, Takeuchi, Akihide, Hosoya, Takamitsu, Suzuki, Tsutomu, Hagiwara, Masatoshi
Published in Proceedings of the National Academy of Sciences - PNAS (03.03.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (03.03.2015)
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Journal Article
Method for Identifying Sequence Motifs in Pre-miRNAs for Small-Molecule Binding
Takashima, Yusuke, Murata, Asako, Iida, Kei, Sugai, Ayako, Hagiwara, Masatoshi, Nakatani, Kazuhiko
Published in ACS chemical biology (21.10.2022)
Published in ACS chemical biology (21.10.2022)
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Journal Article
Selective inhibition of the kinase DYRK1A by targeting its folding process
Kii, Isao, Sumida, Yuto, Goto, Toshiyasu, Sonamoto, Rie, Okuno, Yukiko, Yoshida, Suguru, Kato-Sumida, Tomoe, Koike, Yuka, Abe, Minako, Nonaka, Yosuke, Ikura, Teikichi, Ito, Nobutoshi, Shibuya, Hiroshi, Hosoya, Takamitsu, Hagiwara, Masatoshi
Published in Nature communications (22.04.2016)
Published in Nature communications (22.04.2016)
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Journal Article
Na, K-ATPase α3 is a death target of Alzheimer patient amyloid-β assembly
Ohnishi, Takayuki, Yanazawa, Masako, Sasahara, Tomoya, Kitamura, Yasuki, Hiroaki, Hidekazu, Fukazawa, Yugo, Kii, Isao, Nishiyama, Takashi, Kakita, Akiyoshi, Takeda, Hiroyuki, Takeuchi, Akihide, Arai, Yoshie, Ito, Akane, Komura, Hitomi, Hirao, Hajime, Satomura, Kaori, Inoue, Masafumi, Muramatsu, Shin-ichi, Matsui, Ko, Tada, Mari, Sato, Michio, Saijo, Eri, Shigemitsu, Yoshiki, Sakai, Satoko, Umetsu, Yoshitaka, Goda, Natsuko, Takino, Naomi, Takahashi, Hitoshi, Hagiwara, Masatoshi, Sawasaki, Tatsuya, Iwasaki, Genji, Nakamura, Yu, Nabeshima, Yo-ichi, Teplow, David B., Hoshi, Minako
Published in Proceedings of the National Academy of Sciences - PNAS (11.08.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (11.08.2015)
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Journal Article
PDIVAS: Pathogenicity predictor for Deep-Intronic Variants causing Aberrant Splicing
Kurosawa, Ryo, Iida, Kei, Ajiro, Masahiko, Awaya, Tomonari, Yamada, Mamiko, Kosaki, Kenjiro, Hagiwara, Masatoshi
Published in BMC genomics (10.10.2023)
Published in BMC genomics (10.10.2023)
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