The role of drug efflux and uptake transporters in the plasma pharmacokinetics and tissue disposition of morphine and its main metabolites
F. Martins, Margarida L., Heydari, Paniz, Li, Wenlong, Martínez-Chávez, Alejandra, el Yattouti, Malika, Lebre, Maria C., Beijnen, Jos H., Schinkel, Alfred H.
Published in Toxicology and applied pharmacology (01.09.2024)
Published in Toxicology and applied pharmacology (01.09.2024)
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Journal Article
The suitability of oral diacetylmorphine in treatment-refractory patients with heroin dependence: A scoping review
F. Martins, Margarida L., Wilthagen, Erica A., Oviedo-Joekes, Eugenia, Beijnen, Jos H., de Grave, Nelda, Uchtenhagen, Ambros, Beck, Thilo, Van den Brink, Wim, Schinkel, Alfred H.
Published in Drug and alcohol dependence (01.10.2021)
Published in Drug and alcohol dependence (01.10.2021)
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Journal Article
P-glycoprotein (MDR1/ABCB1) Restricts Brain Penetration of the Main Active Heroin Metabolites 6-monoacetylmorphine (6-MAM) and Morphine in Mice
F. Martins, Margarida L., Loos, Nancy H. C., el Yattouti, Malika, Offeringa, Lianda, Heydari, Paniz, Hillebrand, Michel J. X., Lebre, Maria C., Beijnen, Jos H., Schinkel, Alfred H.
Published in Pharmaceutical research (01.08.2023)
Published in Pharmaceutical research (01.08.2023)
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Journal Article
P‑Glycoprotein (ABCB1/MDR1) Controls Brain Penetration and Intestinal Disposition of the PARP1/2 Inhibitor Niraparib
F. Martins, Margarida L, Loos, Nancy H. C, Mucuk, Sümeyra, de Jong, Danielle, Lebre, Maria C, Rosing, Hilde, Tibben, Matthijs, Beijnen, Jos H, Schinkel, Alfred H
Published in Molecular pharmaceutics (06.12.2021)
Published in Molecular pharmaceutics (06.12.2021)
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Journal Article
Drug Transporters ABCB1 (P-gp) and OATP, but not Drug-Metabolizing Enzyme CYP3A4, Affect the Pharmacokinetics of the Psychoactive Alkaloid Ibogaine and its Metabolites
F Martins, Margarida L, Heydari, Paniz, Li, Wenlong, Martínez-Chávez, Alejandra, Venekamp, Nikkie, Lebre, Maria C, Lucas, Luc, Beijnen, Jos H, Schinkel, Alfred H
Published in Frontiers in pharmacology (04.03.2022)
Published in Frontiers in pharmacology (04.03.2022)
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Journal Article
The Neuroprotective Action of Amidated-Kyotorphin on Amyloid β Peptide-Induced Alzheimer’s Disease Pathophysiology
Belo, Rita F., Martins, Margarida L. F., Shvachiy, Liana, Costa-Coelho, Tiago, de Almeida-Borlido, Carolina, Fonseca-Gomes, João, Neves, Vera, Vicente Miranda, Hugo, Outeiro, Tiago F., Coelho, Joana E., Xapelli, Sara, Valente, Cláudia A., Heras, Montserrat, Bardaji, Eduard, Castanho, Miguel A. R. B., Diógenes, Maria José, Sebastião, Ana M.
Published in Frontiers in pharmacology (09.07.2020)
Published in Frontiers in pharmacology (09.07.2020)
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Journal Article
Coadministration of ABCB1/P-glycoprotein inhibitor elacridar improves tissue distribution of ritonavir-boosted oral cabazitaxel in mice
Loos, Nancy H C, Martins, Margarida L F, de Jong, Daniëlle, Lebre, Maria C, Tibben, Matthijs, Beijnen, Jos H, Schinkel, Alfred H
Published in International journal of pharmaceutics (25.01.2024)
Published in International journal of pharmaceutics (25.01.2024)
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Journal Article
Enhancement of the Oral Availability of Cabazitaxel Using the Cytochrome P450 3A (CYP3A) Inhibitor Ritonavir in Mice
Loos, Nancy H. C., Martins, Margarida L. F., de Jong, Daniëlle, Lebre, Maria C., Tibben, Matthijs, Beijnen, Jos H., Schinkel, Alfred H.
Published in Molecular pharmaceutics (01.05.2023)
Published in Molecular pharmaceutics (01.05.2023)
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Journal Article
Organic anion-transporting polypeptide 2B1 knockout and humanized mice; insights into the handling of bilirubin and drugs
Li, Wenlong, Iusuf, Dilek, Sparidans, Rolf W., Wagenaar, Els, Wang, Yaogeng, de Waart, Dirk R., Martins, Margarida L.F., van Hoppe, Stéphanie, Lebre, Maria C., van Tellingen, Olaf, Beijnen, Jos H., Schinkel, Alfred H.
Published in Pharmacological research (01.04.2023)
Published in Pharmacological research (01.04.2023)
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Journal Article
Interplay of OATP1A/1B/2B1 uptake transporters and ABCB1 and ABCG2 efflux transporters in the handling of bilirubin and drugs
Li, Wenlong, Sparidans, Rolf W., Wang, Yaogeng, Martins, Margarida L.F., de Waart, Dirk R., van Tellingen, Olaf, Song, Ji-Ying, Lebre, Maria C., van Hoppe, Stéphanie, Wagenaar, Els, Beijnen, Jos H., Schinkel, Alfred H.
Published in Biomedicine & pharmacotherapy (01.06.2024)
Published in Biomedicine & pharmacotherapy (01.06.2024)
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Journal Article
P-glycoprotein and Morphine in Mice
F. Ma, Loos, Nancy H. C, el Yattouti, Malika, Offeringa, Lianda, Heydari, Paniz, Hillebrand, Michel J. X, Lebre, Maria C
Published in Pharmaceutical research (01.08.2023)
Published in Pharmaceutical research (01.08.2023)
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Journal Article
ABCB1 and ABCG2 Restrict Brain and Testis Accumulation and, Alongside CYP3A, Limit Oral Availability of the Novel TRK Inhibitor Selitrectinib
Li, Wenlong, Sparidans, Rolf W, Martins, Margarida L F, El-Lari, Mujtaba, Lebre, Maria C, van Tellingen, Olaf, Beijnen, Jos H, Schinkel, Alfred H
Published in Molecular cancer therapeutics (01.06.2021)
Published in Molecular cancer therapeutics (01.06.2021)
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Journal Article
ABCB1 limits brain exposure of the KRASG12C inhibitor sotorasib, whereas ABCB1, CYP3A, and possibly OATP1a/1b restrict its oral availability
Loos, Nancy H.C., Retmana, Irene A., Li, Wenlong, Martins, Margarida L.F., Lebre, Maria C., Sparidans, Rolf W., Beijnen, Jos H., Schinkel, Alfred H.
Published in Pharmacological research (01.04.2022)
Published in Pharmacological research (01.04.2022)
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Journal Article
ABCB1 limits brain exposure of the KRAS G12C inhibitor sotorasib, whereas ABCB1, CYP3A, and possibly OATP1a/1b restrict its oral availability
Loos, Nancy H C, Retmana, Irene A, Li, Wenlong, Martins, Margarida L F, Lebre, Maria C, Sparidans, Rolf W, Beijnen, Jos H, Schinkel, Alfred H
Published in Pharmacological research (01.04.2022)
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Published in Pharmacological research (01.04.2022)
Journal Article