Lysosomes: multifunctional compartments ruled by a complex regulatory network
Martinez‐Fabregas, Jonathan, Tamargo‐Azpilicueta, Joaquin, Diaz‐Moreno, Irene
Published in FEBS open bio (01.04.2022)
Published in FEBS open bio (01.04.2022)
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Journal Article
Mapping Determinants of Cytokine Signaling via Protein Engineering
Gorby, Claire, Martinez-Fabregas, Jonathan, Wilmes, Stephan, Moraga, Ignacio
Published in Frontiers in immunology (27.09.2018)
Published in Frontiers in immunology (27.09.2018)
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Journal Article
Kinetics of cytokine receptor trafficking determine signaling and functional selectivity
Martinez-Fabregas, Jonathan, Wilmes, Stephan, Wang, Luopin, Hafer, Maximillian, Pohler, Elizabeth, Lokau, Juliane, Garbers, Christoph, Cozzani, Adeline, Fyfe, Paul K, Piehler, Jacob, Kazemian, Majid, Mitra, Suman, Moraga, Ignacio
Published in eLife (27.11.2019)
Published in eLife (27.11.2019)
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Journal Article
Competitive binding of STATs to receptor phospho-Tyr motifs accounts for altered cytokine responses
Wilmes, Stephan, Jeffrey, Polly-Anne, Martinez-Fabregas, Jonathan, Hafer, Maximillian, Fyfe, Paul K, Pohler, Elizabeth, Gaggero, Silvia, López-García, Martín, Lythe, Grant, Taylor, Charles, Guerrier, Thomas, Launay, David, Mitra, Suman, Piehler, Jacob, Molina-París, Carmen, Moraga, Ignacio
Published in eLife (19.04.2021)
Published in eLife (19.04.2021)
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Journal Article
IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein
Gaggero, Silvia, Martinez-Fabregas, Jonathan, Cozzani, Adeline, Fyfe, Paul K, Leprohon, Malo, Yang, Jie, Thomasen, F Emil, Winkelmann, Hauke, Magnez, Romain, Conti, Alberto G, Wilmes, Stephan, Pohler, Elizabeth, van Gijsel Bonnello, Manuel, Thuru, Xavier, Quesnel, Bruno, Soncin, Fabrice, Piehler, Jacob, Lindorff-Larsen, Kresten, Roychoudhuri, Rahul, Moraga, Ignacio, Mitra, Suman
Published in Science immunology (16.12.2022)
Published in Science immunology (16.12.2022)
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Journal Article
Identifying cytokine signaling signatures in primary human Th-1 cells by phospho-proteomics analysis
Martinez-Fabregas, Jonathan, Pohler, Elizabeth, Moraga, Ignacio
Published in STAR protocols (18.06.2021)
Published in STAR protocols (18.06.2021)
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Journal Article
Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis
Martínez-Fábregas, Jonathan, Prescott, Alan, van Kasteren, Sander, Pedrioli, Deena Leslie, McLean, Irwin, Moles, Anna, Reinheckel, Thomas, Poli, Valeria, Watts, Colin
Published in Nature communications (17.12.2018)
Published in Nature communications (17.12.2018)
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Journal Article
Structural and Functional Analysis of Novel Human Cytochrome c Targets in Apoptosis
Martínez-Fábregas, Jonathan, Díaz-Moreno, Irene, González-Arzola, Katiuska, Janocha, Simon, Navarro, José A., Hervás, Manuel, Bernhardt, Rita, Velázquez-Campoy, Adrián, Díaz-Quintana, Antonio, De la Rosa, Miguel A.
Published in Molecular & cellular proteomics (01.06.2014)
Published in Molecular & cellular proteomics (01.06.2014)
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Journal Article
CDK8 Fine-Tunes IL-6 Transcriptional Activities by Limiting STAT3 Resident Time at the Gene Loci
Martinez-Fabregas, Jonathan, Wang, Luopin, Pohler, Elizabeth, Cozzani, Adeline, Wilmes, Stephan, Kazemian, Majid, Mitra, Suman, Moraga, Ignacio
Published in Cell reports (Cambridge) (22.12.2020)
Published in Cell reports (Cambridge) (22.12.2020)
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Journal Article
PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T Cells
Stathopoulou, Chaido, Gangaplara, Arunakumar, Mallett, Grace, Flomerfelt, Francis A., Liniany, Lukasz P., Knight, David, Samsel, Leigh A., Berlinguer-Palmini, Rolando, Yim, Joshua J., Felizardo, Tania C., Eckhaus, Michael A., Edgington-Mitchell, Laura, Martinez-Fabregas, Jonathan, Zhu, Jinfang, Fowler, Daniel H., van Kasteren, Sander I., Laurence, Arian, Bogyo, Matthew, Watts, Colin, Shevach, Ethan M., Amarnath, Shoba
Published in Immunity (Cambridge, Mass.) (21.08.2018)
Published in Immunity (Cambridge, Mass.) (21.08.2018)
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Journal Article
Competitive binding of STATs to receptor phospho-Tyr motifs accounts for altered cytokine responses in autoimmune disorders
Wilmes, Stephan, Polly-Anne, Jeffrey, Martinez-Fabregas, Jonathan, Hafer, Maximillian, Fyfe, Paul, Pohler, Elizabeth, Gaggero, Silvia, López-García, Martín, Lythe, Grant, Guerrier, Thomas, Launay, David, Mitra Suman, Piehler, Jacob, Molina-París, Carmen, Moraga, Ignacio
Published in bioRxiv (09.01.2021)
Published in bioRxiv (09.01.2021)
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Paper
PD-1 through Asparaginyl Endopeptidase Regulates Foxp3 Stability in Induced Regulatory T Cells
Mallett, Grace, Gangaplara, Arun, Stathopolou, Chaido, Flomerfelt, Francis, Samsel, Leigh, Felizardo, Tania, Eckhaus, Michael, Edgington, Laura, Yim, Joshua, Martinez-Fabregas, Jonathan, Zhu, Jinfang, Fowler, Daniel H., Bogyo, Matthew, van-Kasteren, Sanders, Watts, Colin, Shevach, Ethan, Laurence, Arian Dominic John, Amarnath, Shoba
Published in Blood (08.12.2017)
Published in Blood (08.12.2017)
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Journal Article
Programmed death-1 receptor signaling downregulates asparaginyl endopeptidase to maintain Foxp3 stability in induced Regulatory T cells
Stathopoulou, Chaido, Gangaplara, Arunakumar, Mallett, Grace, Flomerfelt, Francis A., Liniany, Lukasz P., Knight, David, Samsel, Leigh A., Berlinguer-Palmini, Rolando, Yim, Joshua J., Felizardo, Tania C., Eckhaus, Michael A., Edgington-Mitchell, Laura, Martinez-Fabregas, Jonathan, Zhu, Jinfang, Fowler, Daniel H., van Kasteren, Sanders I., Laurence, Arian, Bogyo, Matthew, Watts, Colin, Shevach, Ethan M., Amarnath, Shoba
Published in Immunity (Cambridge, Mass.) (24.07.2018)
Published in Immunity (Cambridge, Mass.) (24.07.2018)
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Journal Article
Nucleus-translocated mitochondrial cytochrome c liberates nucleophosmin-sequestered ARF tumor suppressor by changing nucleolar liquid–liquid phase separation
González-Arzola, Katiuska, Díaz-Quintana, Antonio, Bernardo-García, Noelia, Martínez-Fábregas, Jonathan, Rivero-Rodríguez, Francisco, Casado-Combreras, Miguel Á, Elena-Real, Carlos A, Velázquez-Cruz, Alejandro, Gil-Caballero, Sergio, Velázquez-Campoy, Adrián, Szulc, Elzbieta, Gavilán, María P, Ayala, Isabel, Arranz, Rocío, Ríos, Rosa M, Salvatella, Xavier, Valpuesta, José M, Hermoso, Juan A, De la Rosa, Miguel A, Díaz-Moreno, Irene
Published in Nature structural & molecular biology (01.10.2022)
Published in Nature structural & molecular biology (01.10.2022)
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Journal Article
New Arabidopsis thaliana Cytochrome c Partners: A Look Into the Elusive Role of Cytochrome c in Programmed Cell Death in Plants
Martínez-Fábregas, Jonathan, Díaz-Moreno, Irene, González-Arzola, Katiuska, Janocha, Simon, Navarro, José A., Hervás, Manuel, Bernhardt, Rita, Díaz-Quintana, Antonio, De la Rosa, Miguel Á.
Published in Molecular & cellular proteomics (01.12.2013)
Published in Molecular & cellular proteomics (01.12.2013)
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Journal Article
Kinetics of cytokine receptor trafficking determine signaling and functional selectivity
Martinez-Fabregas, Jonathan, Wilmes, Stephan, Wang, Luopin, Hafer, Maximillian, Pohler, Elizabeth, Lokau, Juliane, Garbers, Christoph, Cozzani, Adeline, Piehler, Jacob, Kazemian, Majid, Mitra, Suman, Moraga, Ignacio
Published in bioRxiv (16.05.2019)
Published in bioRxiv (16.05.2019)
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Paper
Respiratory Cytochrome c: a Master Pleiotropic Cell Regulator
Díaz-Moreno, Irene, Giner-Arroyo, Rafael, Pérez-Mejías, Gonzalo, Velázquez-Cruz, Alejandro, Baños-Jaime, Blanca, Casado-Combreras, Miguel A., Rivero-Rodríguez, Francisco, Guerra-Castellano, Alejandra, Corrales-Guerrero, Laura, Martínez-Fábregas, Jonathan, De la Rosa, Miguel A.
Published in Biochimica et biophysica acta. Bioenergetics (01.09.2022)
Published in Biochimica et biophysica acta. Bioenergetics (01.09.2022)
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Journal Article