The novel persistent sodium current inhibitor PRAX‐562 has potent anticonvulsant activity with improved protective index relative to standard of care sodium channel blockers
Kahlig, Kristopher M., Scott, Liam, Hatch, Robert J., Griffin, Andrew, Martinez Botella, Gabriel, Hughes, Zoë A., Wittmann, Marion
Published in Epilepsia (Copenhagen) (01.03.2022)
Published in Epilepsia (Copenhagen) (01.03.2022)
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Journal Article
Antibacterial Inhibitors of Gram-Positive Thymidylate Kinase: Structure–Activity Relationships and Chiral Preference of a New Hydrophobic Binding Region
Kawatkar, Sameer P, Keating, Thomas A, Olivier, Nelson B, Breen, John N, Green, Oluyinka M, Guler, Satenig Y, Hentemann, Martin F, Loch, James T, McKenzie, Andrew R, Newman, Joseph V, Otterson, Linda G, Martínez-Botella, Gabriel
Published in Journal of medicinal chemistry (12.06.2014)
Published in Journal of medicinal chemistry (12.06.2014)
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Journal Article
Discovery of Selective and Potent Inhibitors of Gram-Positive Bacterial Thymidylate Kinase (TMK)
Martínez-Botella, Gabriel, Breen, John N, Duffy, James E. S, Dumas, Jacques, Geng, Bolin, Gowers, Ian K, Green, Oluyinka M, Guler, Satenig, Hentemann, Martin F, Hernandez-Juan, Felix A, Joseph-McCarthy, Diane, Kawatkar, Sameer, Larsen, Nicholas A, Lazari, Ovadia, Loch, James T, Macritchie, Jacqueline A, McKenzie, Andrew R, Newman, Joseph V, Olivier, Nelson B, Otterson, Linda G, Owens, Andrew P, Read, Jon, Sheppard, David W, Keating, Thomas A
Published in Journal of medicinal chemistry (26.11.2012)
Published in Journal of medicinal chemistry (26.11.2012)
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Journal Article
In Vivo Validation of Thymidylate Kinase (TMK) with a Rationally Designed, Selective Antibacterial Compound
Keating, Thomas A, Newman, Joseph V, Olivier, Nelson B, Otterson, Linda G, Andrews, Beth, Boriack-Sjodin, P. Ann, Breen, John N, Doig, Peter, Dumas, Jacques, Gangl, Eric, Green, Oluyinka M, Guler, Satenig Y, Hentemann, Martin F, Joseph-McCarthy, Diane, Kawatkar, Sameer, Kutschke, Amy, Loch, James T, McKenzie, Andrew R, Pradeepan, Selvi, Prasad, Swati, Martínez-Botella, Gabriel
Published in ACS chemical biology (16.11.2012)
Published in ACS chemical biology (16.11.2012)
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Journal Article
Neuroactive Steroid N‑Methyl‑d‑aspartate Receptor Positive Allosteric Modulators: Synthesis, SAR, and Pharmacological Activity
La, Daniel S, Salituro, Francesco G, Martinez Botella, Gabriel, Griffin, Andrew M, Bai, Zhu, Ackley, Michael A, Dai, Jing, Doherty, James J, Harrison, Boyd L, Hoffmann, Ethan C, Kazdoba, Tatiana M, Lewis, Michael C, Quirk, Michael C, Robichaud, Albert J
Published in Journal of medicinal chemistry (22.08.2019)
Published in Journal of medicinal chemistry (22.08.2019)
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Journal Article
Neuroactive Steroids. 1. Positive Allosteric Modulators of the (γ-Aminobutyric Acid)A Receptor: Structure–Activity Relationships of Heterocyclic Substitution at C‑21
Martinez Botella, Gabriel, Salituro, Francesco G, Harrison, Boyd L, Beresis, Richard T, Bai, Zhu, Shen, Kaisheng, Belfort, Gabriel M, Loya, Carlos M, Ackley, Michael A, Grossman, Scott J, Hoffmann, Ethan, Jia, Shiling, Wang, Jiamiao, Doherty, James J, Robichaud, Albert J
Published in Journal of medicinal chemistry (23.04.2015)
Published in Journal of medicinal chemistry (23.04.2015)
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Journal Article
Anticonvulsant profile of the neuroactive steroid, SGE-516, in animal models
Hammond, Rebecca S, Althaus, Alison L, Ackley, Michael A, Maciag, Carla, Martinez Botella, Gabriel, Salituro, Francesco G, Robichaud, Albert J, Doherty, James J
Published in Epilepsy research (01.08.2017)
Published in Epilepsy research (01.08.2017)
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Journal Article
Sulfonylpiperidines as novel, antibacterial inhibitors of Gram-positive thymidylate kinase (TMK)
Martínez-Botella, Gabriel, Loch, James T., Green, Oluyinka M., Kawatkar, Sameer P., Olivier, Nelson B., Boriack-Sjodin, P. Ann, Keating, Thomas A.
Published in Bioorganic & medicinal chemistry letters (01.01.2013)
Published in Bioorganic & medicinal chemistry letters (01.01.2013)
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Journal Article
Rescue of deficient amygdala tonic γ-aminobutyric acidergic currents in the Fmr-/y mouse model of fragile X syndrome by a novel γ-aminobutyric acid type A receptor-positive allosteric modulator
Martin, Brandon S., Martinez-Botella, Gabriel, Loya, Carlos M., Salituro, Francesco G., Robichaud, Albert J., Huntsman, Molly M., Ackley, Mike A., Doherty, James J., Corbin, Joshua G.
Published in Journal of neuroscience research (01.06.2016)
Published in Journal of neuroscience research (01.06.2016)
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CNS COMPOSITIONS AND METHODS FOR TREATING CNS DISORDERS
MARTINEZ BOTELLA GABRIEL, SALITURO FRANCESCO G, ROBICHAUD ALBERT JEAN, HARRISON BOYD L
Year of Publication 19.12.2023
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Year of Publication 19.12.2023
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Year of Publication 10.01.2023
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Year of Publication 10.01.2023
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Year of Publication 11.10.2023
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Year of Publication 11.10.2023
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Year of Publication 30.08.2022
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Year of Publication 30.08.2022
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Year of Publication 18.04.2023
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Year of Publication 18.04.2023
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Year of Publication 17.09.2021
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Year of Publication 17.09.2021
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Year of Publication 09.02.2022
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Year of Publication 09.02.2022
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MARTINEZ BOTELLA GABRIEL, MARRON BRIAN EDWARD, GRIFFIN ANDREW MARK, REDDY KIRAN, CHARIFSON PAUL S, KAHLIG MICHAEL KRISTOPHER MATHIEU
Year of Publication 08.02.2022
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Year of Publication 08.02.2022
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Year of Publication 05.03.2021
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Year of Publication 05.03.2021
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