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Roth Flach, Rachel J, Bollinger, Eliza, Reyes, Allan R, Laforest, Brigitte, Kormos, Bethany L, Liu, Shenping, Reese, Matthew R, Martinez Alsina, Luis A, Buzon, Leanne, Zhang, Yuan, Bechle, Bruce, Rosado, Amy, Sahasrabudhe, Parag V, Knafels, John, Bhattacharya, Samit K, Omoto, Kiyoyuki, Stansfield, John C, Hurley, Liam D, Song, LouJin, Luo, Lina, Breitkopf, Susanne B, Monetti, Mara, Cunio, Teresa, Tierney, Brendan, Geoly, Frank J, Delmore, Jake, Siddall, C Parker, Xue, Liang, Yip, Ka N, Kalgutkar, Amit S, Miller, Russell A, Zhang, Bei B, Filipski, Kevin J
Published in Nature communications (09.08.2023)
Published in Nature communications (09.08.2023)
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Discovery of the Potent and Selective MC4R Antagonist PF-07258669 for the Potential Treatment of Appetite Loss
Garnsey, Michelle R., Smith, Aaron C., Polivkova, Jana, Arons, Autumn L., Bai, Guoyun, Blakemore, Caroline, Boehm, Markus, Buzon, Leanne M., Campion, Sarah N., Cerny, Matthew, Chang, Shiao-Chi, Coffman, Karen, Farley, Kathleen A., Fonseca, Kari R., Ford, Kristen K., Garren, Jeonifer, Kong, Jimmy X., Koos, Martin R. M., Kung, Daniel W., Lian, Yajing, Li, Monica M., Li, Qifang, Martinez-Alsina, Luis A., O’Connor, Rebecca, Ogilvie, Kevin, Omoto, Kiyoyuki, Raymer, Brian, Reese, Matthew R., Ryder, Tim, Samp, Lacey, Stevens, Kimberly A., Widlicka, Daniel W., Yang, Qingyi, Zhu, Kaicheng, Fortin, Jean-Philippe, Sammons, Matthew F.
Published in Journal of medicinal chemistry (09.03.2023)
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Antitumor Activity and Pharmacology of a Selective Focal Adhesion Kinase Inhibitor, PF-562,271
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A Second-Generation Oral SARS-CoV‑2 Main Protease Inhibitor Clinical Candidate for the Treatment of COVID-19
Allerton, Charlotte M. N., Arcari, Joel T., Aschenbrenner, Lisa M., Avery, Melissa, Bechle, Bruce M., Behzadi, Mohammad Amin, Boras, Britton, Buzon, Leanne M., Cardin, Rhonda D., Catlin, Natasha R., Carlo, Anthony A., Coffman, Karen J., Dantonio, Alyssa, Di, Li, Eng, Heather, Farley, Kathleen A., Ferre, Rose Ann, Gernhardt, Steven S., Gibson, Scott A., Greasley, Samantha E., Greenfield, Siennah R., Hurst, Brett L., Kalgutkar, Amit S., Kimoto, Emi, Lanyon, Lorraine F., Lovett, Gabrielle H., Lian, Yajing, Liu, Wei, Martínez Alsina, Luis A., Noell, Stephen, Obach, R. Scott, Owen, Dafydd R., Patel, Nandini C., Rai, Devendra K., Reese, Matthew R., Rothan, Hussin A., Sakata, Sylvie, Sammons, Matthew F., Sathish, Jean G., Sharma, Raman, Steppan, Claire M., Tuttle, Jamison B., Verhoest, Patrick R., Wei, Liuqing, Yang, Qingyi, Yurgelonis, Irina, Zhu, Yuao
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Synthesis of Small 3‑Fluoro- and 3,3-Difluoropyrrolidines Using Azomethine Ylide Chemistry
McAlpine, Indrawan, Tran-Dubé, Michelle, Wang, Fen, Scales, Stephanie, Matthews, Jean, Collins, Michael R, Nair, Sajiv K, Nguyen, Mary, Bian, Jianwei, Alsina, Luis Martinez, Sun, Jianmin, Zhong, Jiaying, Warmus, Joseph S, O’Neill, Brian T
Published in Journal of organic chemistry (17.07.2015)
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Spiropiperidine Sultam and Lactam Templates: Diastereoselective Overman Rearrangement and Metathesis followed by NH Arylation
Martinez-Alsina, Luis A, Murray, John C, Buzon, Leanne M, Bundesmann, Mark W, Young, Joseph M, O’Neill, Brian T
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Design and Synthesis of Clinical Candidate PF-06751979: A Potent, Brain Penetrant, β‑Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor Lacking Hypopigmentation
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Discovery of a Series of Efficient, Centrally Efficacious BACE1 Inhibitors through Structure-Based Drug Design
Butler, Christopher R, Brodney, Michael A, Beck, Elizabeth M, Barreiro, Gabriela, Nolan, Charles E, Pan, Feng, Vajdos, Felix, Parris, Kevin, Varghese, Alison H, Helal, Christopher J, Lira, Ricardo, Doran, Shawn D, Riddell, David R, Buzon, Leanne M, Dutra, Jason K, Martinez-Alsina, Luis A, Ogilvie, Kevin, Murray, John C, Young, Joseph M, Atchison, Kevin, Robshaw, Ashley, Gonzales, Cathleen, Wang, Jinlong, Zhang, Yong, O’Neill, Brian T
Published in Journal of medicinal chemistry (26.03.2015)
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Published in ACS medicinal chemistry letters (09.02.2012)
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Year of Publication 16.07.2024
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LRRK2 억제제로서의 신규 이미다조[4,5-C]퀴놀린 유도체
BRODNEY MICHAEL AARON, CHAPPIE THOMAS ALLEN, WAGER TRAVIS T, CHEN JINSHAN MICHAEL, GARNSEY MICHELLE RENEE, COFFMAN KAREN JEAN, COE JOTHAM WADSWORTH, REESE MATTHEW RICHARD, VERHOEST PATRICK ROBERT, KURUMBAIL RAVI G, MARTINEZ ALSINA LUIS ANGEL, GALATSIS PAUL, ROSE COLIN RICHARD, WARMUS JOSEPH SCOTT, PETTERSSON MARTIN YOUNGJIN, HELAL CHRISTOPHER JOHN, ZHANG YUAN, KORMOS BETHANY LYN, HENDERSON JACLYN LOUISE, STEPAN ANTONIA FRIEDERIKE
Year of Publication 16.12.2019
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Year of Publication 16.12.2019
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Pinnick Oxidation on Scale: Process Development of a BDK Inhibitor
Arcari, Joel T., Buckley, Catherine, Buzon, Leanne M., Dan, Yongbo, Houck, Timothy, Jin, Zuxi, Li, Chao, Li, Peifang, Liu, Kai, Liu, Yiyang, Magano, Javier, Martinez-Alsina, Luis A., Nguyen, Bao, Pearson, Robert, Piper, Jared L., Ragan, John A., Reese, Matthew R., Tian, Wanli, Van Haitsma, Jared, Vetelino, Michael G., Zhang, Yuan
Published in Organic process research & development (19.07.2024)
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Utilizing Structures of CYP2D6 and BACE1 Complexes To Reduce Risk of Drug–Drug Interactions with a Novel Series of Centrally Efficacious BACE1 Inhibitors
Brodney, Michael A, Beck, Elizabeth M, Butler, Christopher R, Barreiro, Gabriela, Johnson, Eric F, Riddell, David, Parris, Kevin, Nolan, Charles E, Fan, Ying, Atchison, Kevin, Gonzales, Cathleen, Robshaw, Ashley E, Doran, Shawn D, Bundesmann, Mark W, Buzon, Leanne, Dutra, Jason, Henegar, Kevin, LaChapelle, Erik, Hou, Xinjun, Rogers, Bruce N, Pandit, Jayvardhan, Lira, Ricardo, Martinez-Alsina, Luis, Mikochik, Peter, Murray, John C, Ogilvie, Kevin, Price, Loren, Sakya, Subas M, Yu, Aijia, Zhang, Yong, O’Neill, Brian T
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Aminomethyl-Derived Beta Secretase (BACE1) Inhibitors: Engaging Gly230 without an Anilide Functionality
Butler, Christopher R, Ogilvie, Kevin, Martinez-Alsina, Luis, Barreiro, Gabriela, Beck, Elizabeth M, Nolan, Charles E, Atchison, Kevin, Benvenuti, Eric, Buzon, Leanne, Doran, Shawn, Gonzales, Cathleen, Helal, Christopher J, Hou, Xinjun, Hsu, Mei-Hui, Johnson, Eric F, Lapham, Kimberly, Lanyon, Lorraine, Parris, Kevin, O’Neill, Brian T, Riddell, David, Robshaw, Ashley, Vajdos, Felix, Brodney, Michael A
Published in Journal of medicinal chemistry (12.01.2017)
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Abstract A86: Design, synthesis, and SAR of focal adhesion kinase (FAK) inhibitors
Roberts, Walter Gregory, Berliner, Martin, Coleman, Kevin, Emerson, Erling, Griffor, Matt, Hulford, Catherine, Jani, Jitesh, Kath, John, LaGreca, Susan, Lin, Jing, Lorenzen, Marianne J., Marr, Eric, Martinez-Alsina, Luis, Patel, Nandini, Richter, Daniel, Roberts, Erika, Autry, Christopher, Ung, Ethan, Felix, Vajdos, Vetelino, Beth, Wessel, Matthew, Whalen, Pamela, Xu, Huiping, Yao, Lili
Published in Molecular cancer therapeutics (10.12.2009)
Published in Molecular cancer therapeutics (10.12.2009)
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P3‐282: β‐secretase inhibitors for treatment of Alzheimer's disease
O'Neill, Brian T., Brodney, Michael A., Ambroise, Claude, Borzilleri, Kris, Coffman, Karen, Efremov, Ivan, Hajos-Korcsok, Eva, Helal, Christopher, Kauffman, Gregory, Lanyon, Lorraine, Liston, Dane, JianHua Liu, Lu, Yasong, Martinez-Alsina, Luis, Murray, John, Nelson, Frederick R., Noell, Stephen, Nolan, Charles, Oborski, Christine, Ogilvie, Kevin, Tuttle, Jamison, Vajdos, Felix, Withka, Jane
Published in Alzheimer's & dementia (01.07.2010)
Published in Alzheimer's & dementia (01.07.2010)
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β-secretase inhibitors for treatment of Alzheimer's disease
O'Neill, Brian T, Brodney, Michael A, Ambroise, Claude, Borzilleri, Kris, Coffman, Karen, Efremov, Ivan, Hajos-Korcsok, Eva, Helal, Christopher, Kauffman, Gregory, Lanyon, Lorraine, Liston, Dane, JianHua Liu, Lu, Yasong, Martinez-Alsina, Luis, Murray, John, Nelson, Frederick R, Noell, Stephen, Nolan, Charles, Oborski, Christine, Ogilvie, Kevin, Tuttle, Jamison, Vajdos, Felix, Withka, Jane
Published in Alzheimer's & dementia (01.07.2010)
Published in Alzheimer's & dementia (01.07.2010)
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3-phenyl-1-benzothiophene-2-carboxylic acid derivatives as branched-chain alpha keto acid dehydrogenase kinase inhibitors for the treatment of diabetes, kidney diseases, nash and heart failure
CAMERON Kimberly O'Keefe, GRIFFITH David Andrew, REESE Matthew Richard, FILIPSKI Kevin James, BUZON Leanne Marie, DEBOYACE Kevin Francis, KORMOS Bethany Lyn, MARTINEZ ALSINA Luis Angel, LIU Shenping, ROTH FLACH Rachel Jane, ZHANG Yuan
Year of Publication 01.06.2024
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Year of Publication 01.06.2024
Patent
3-PHENYL-1-BENZOTHIOPHENE-2-CARBOXYLIC ACID DERIVATIVES AS BRANCHED-CHAIN ALPHA KETO ACID DEHYDROGENASE KINASE INHIBITORS FOR THE TREATMENT OF DIABETES, KIDNEY DISEASES, NASH AND HEART FAILURE
ZHANG, Yuan, FILIPSKI, Kevin James, LIU, Shenping, BUZON, Leanne Marie, DEBOYACE, Kevin Francis, ROTH FLACH, Rachel Jane, KORMOS, Bethany Lyn, REESE, Matthew Richard, GRIFFITH, David Andrew, CAMERON, Kimberly O'Keefe, MARTINEZ ALSINA, Luis Angel
Year of Publication 02.05.2024
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Year of Publication 02.05.2024
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THIENO[3,2-B]THIOPHENE-2-CARBOXYLIC ACID COMPOUNDS HAVING BCKDK INHIBITING ACTIVITY
GRIFFITH, DAVID ANDREW, REESE, MATTHEW RICHARD, FILIPSKI, KEVIN JAMES, ZHANG, YUAN, KORMOS, BETHANY LYN, MILLER, RUSSELL ALAN, BHATTACHARYA, SAMIT KUMAR, BUZON, LEANNE MARIE, MARTINEZ-ALSINA, LUIS ANGEL, ROTH FLACH, RACHEL JANE
Year of Publication 05.12.2023
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Year of Publication 05.12.2023
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