Enzymes metabolizing aristolochic acid and their contribution to the development of aristolochic acid nephropathy and urothelial cancer
Stiborová, Marie, Martínek, Václav, Frei, Eva, Arlt, Volker M, Schmeiser, Heinz H
Published in Current drug metabolism (01.07.2013)
Published in Current drug metabolism (01.07.2013)
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In Vivo Metabolism of Aristolochic Acid I and II in Rats Is Influenced by Their Coexposure
Dedı́ková, Alena, Bárta, František, Martínek, Václav, Kotalík, Kevin, Dušková, Šárka, Mráz, Jaroslav, Arlt, Volker Manfred, Stiborová, Marie, Hodek, Petr
Published in Chemical research in toxicology (16.11.2020)
Published in Chemical research in toxicology (16.11.2020)
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Structural characterization of the heme-based oxygen sensor, AfGcHK, its interactions with the cognate response regulator, and their combined mechanism of action in a bacterial two-component signaling system
Stranava, Martin, Martínek, Václav, Man, Petr, Fojtikova, Veronika, Kavan, Daniel, Vaněk, Ondřej, Shimizu, Toru, Martinkova, Marketa
Published in Proteins, structure, function, and bioinformatics (01.10.2016)
Published in Proteins, structure, function, and bioinformatics (01.10.2016)
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Lipid molecules can induce an opening of membrane-facing tunnels in cytochrome P450 1A2
Jerabek, Petr, Florian, Jan, Martinek, Vaclav
Published in Physical chemistry chemical physics : PCCP (09.11.2016)
Published in Physical chemistry chemical physics : PCCP (09.11.2016)
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A Mechanism of O-Demethylation of Aristolochic Acid I by Cytochromes P450 and Their Contributions to This Reaction in Human and Rat Livers: Experimental and Theoretical Approaches
Stiborová, Marie, Bárta, František, Levová, Kateřina, Hodek, Petr, Schmeiser, Heinz H, Arlt, Volker M, Martínek, Václav
Published in International journal of molecular sciences (18.11.2015)
Published in International journal of molecular sciences (18.11.2015)
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Kinetic analysis of a globin-coupled diguanylate cyclase, YddV: Effects of heme iron redox state, axial ligands, and heme distal mutations on catalysis
Lengalova, Alzbeta, Fojtikova-Proskova, Veronika, Vavra, Jakub, Martínek, Václav, Stranava, Martin, Shimizu, Toru, Martinkova, Marketa
Published in Journal of inorganic biochemistry (01.12.2019)
Published in Journal of inorganic biochemistry (01.12.2019)
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Identification of Human Enzymes Oxidizing the Anti-Thyroid-Cancer Drug Vandetanib and Explanation of the High Efficiency of Cytochrome P450 3A4 in its Oxidation
Indra, Radek, Pompach, Petr, Martínek, Václav, Takácsová, Paulína, Vavrová, Katarína, Heger, Zbyněk, Adam, Vojtěch, Eckschlager, Tomáš, Kopečková, Kateřina, Arlt, Volker Manfred, Stiborová, Marie
Published in International journal of molecular sciences (10.07.2019)
Published in International journal of molecular sciences (10.07.2019)
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Coordination and redox state–dependent structural changes of the heme-based oxygen sensor AfGcHK associated with intraprotein signal transduction
Stranava, Martin, Man, Petr, Skálová, Tereza, Kolenko, Petr, Blaha, Jan, Fojtikova, Veronika, Martínek, Václav, Dohnálek, Jan, Lengalova, Alzbeta, Rosůlek, Michal, Shimizu, Toru, Martínková, Markéta
Published in The Journal of biological chemistry (22.12.2017)
Published in The Journal of biological chemistry (22.12.2017)
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Active Site Mutations as a Suitable Tool Contributing to Explain a Mechanism of Aristolochic Acid I Nitroreduction by Cytochromes P450 1A1, 1A2 and 1B1
Milichovský, Jan, Bárta, František, Schmeiser, Heinz H, Arlt, Volker M, Frei, Eva, Stiborová, Marie, Martínek, Václav
Published in International journal of molecular sciences (05.02.2016)
Published in International journal of molecular sciences (05.02.2016)
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Journal Article
Highly conserved nucleotide phosphatase essential for membrane lipid homeostasis in Streptococcus pneumoniae
Kuipers, Kirsten, Gallay, Clement, Martínek, Václav, Rohde, Manfred, Martínková, Markéta, van der Beek, Samantha L., Jong, Wouter S. P., Venselaar, Hanka, Zomer, Aldert, Bootsma, Hester, Veening, Jan‐Willem, de Jonge, Marien I.
Published in Molecular microbiology (01.07.2016)
Published in Molecular microbiology (01.07.2016)
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Cytochrome b(5) shifts oxidation of the anticancer drug ellipticine by cytochromes P450 1A1 and 1A2 from its detoxication to activation, thereby modulating its pharmacological efficacy
Kotrbová, Věra, Mrázová, Barbora, Moserová, Michaela, Martínek, Václav, Hodek, Petr, Hudeček, Jiří, Frei, Eva, Stiborová, Marie
Published in Biochemical pharmacology (15.09.2011)
Published in Biochemical pharmacology (15.09.2011)
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Sudan I is a potential carcinogen for humans: Evidence for its metabolic activation and detoxication by human recombinant cytochrome P450 1A1 and liver microsomes
STIBOROVA, Marie, MARTINEK, Vaclav, RYDLOVA, Helena, HODEK, Petr, FREI, Eva
Published in Cancer research (Chicago, Ill.) (15.10.2002)
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Published in Cancer research (Chicago, Ill.) (15.10.2002)
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DNA Duplex Stability: The Role of Preorganized Electrostatics
Bren, Urban, Lah, Jurij, Bren, Matevž, Martínek, Václav, Florián, Jan
Published in The journal of physical chemistry. B (04.03.2010)
Published in The journal of physical chemistry. B (04.03.2010)
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The human carcinogen aristolochic acid i is activated to form DNA adducts by human NAD(P)H:quinone oxidoreductase without the contribution of acetyltransferases or sulfotransferases
Stiborová, Marie, Mareîs, Jaroslav, Frei, Eva, Arlt, Volker M., Martínek, Václav, Schmeiser, Heinz H.
Published in Environmental and molecular mutagenesis (01.07.2011)
Published in Environmental and molecular mutagenesis (01.07.2011)
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Induced Expression of Cytochrome P450 1A and NAD(P)H:Quinone Oxidoreductase Determined at mRNA, Protein, and Enzyme Activity Levels in Rats Exposed to the Carcinogenic Azo Dye 1‑Phenylazo-2-naphthol (Sudan I)
Stiborová, Marie, Dračínská, Helena, Martínek, Václav, Svášková, Dagmar, Hodek, Petr, Milichovský, Jan, Hejduková, Žaneta, Brotánek, Jaroslav, Schmeiser, Heinz H, Frei, Eva
Published in Chemical research in toxicology (18.02.2013)
Published in Chemical research in toxicology (18.02.2013)
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Comparison of the oxidation of carcinogenic aristolochic acid I and II by microsomal cytochromes P450 in vitro: experimental and theoretical approaches
Martínek, Václav, Bárta, František, Hodek, Petr, Frei, Eva, Schmeiser, Heinz H., Arlt, Volker M., Stiborová, Marie
Published in Monatshefte für Chemie (2017)
Published in Monatshefte für Chemie (2017)
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Cytochrome b5 increases cytochrome P450 3A4-mediated activation of anticancer drug ellipticine to 13-hydroxyellipticine whose covalent binding to DNA is elevated by sulfotransferases and N,O-acetyltransferases
Stiborová, Marie, Indra, Radek, Moserová, Michaela, Cerná, Věra, Rupertová, Martina, Martínek, Václav, Eckschlager, Tomáš, Kizek, René, Frei, Eva
Published in Chemical research in toxicology (21.05.2012)
Published in Chemical research in toxicology (21.05.2012)
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Mechanisms of the Different DNA Adduct Forming Potentials of the Urban Air Pollutants 2-Nitrobenzanthrone and Carcinogenic 3-Nitrobenzanthrone
Stiborová, Marie, Martínek, Václav, Svobodová, Martina, Šístková, Jana, Dvořák, Zdeněk, Ulrichová, Jitka, Šimánek, Vilím, Frei, Eva, Schmeiser, Heinz H, Phillips, David H, Arlt, Volker M
Published in Chemical research in toxicology (19.07.2010)
Published in Chemical research in toxicology (19.07.2010)
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