Therapeutic potential of novel Cell Division Cycle Kinase 7 inhibitors on TDP‐43‐related pathogenesis such as Frontotemporal Lobar Degeneration (FTLD) and amyotrophic lateral sclerosis (ALS)
Vaca, Gabriela, Martinez‐Gonzalez, Loreto, Fernandez, Ana, Rojas‐Prats, Elisa, Porras, Gracia, Cuevas, Eva P., Gil, Carmen, Martinez, Ana, Martin‐Requero, Ángeles
Published in Journal of neurochemistry (01.02.2021)
Published in Journal of neurochemistry (01.02.2021)
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TDP-43 Modulation by Tau‑Tubulin Kinase 1 Inhibitors: A New Avenue for Future Amyotrophic Lateral Sclerosis Therapy
Nozal, Vanesa, Martínez-González, Loreto, Gomez-Almeria, Marta, Gonzalo-Consuegra, Claudia, Santana, Paula, Chaikuad, Apirat, Pérez-Cuevas, Eva, Knapp, Stefan, Lietha, Daniel, Ramírez, David, Petralla, Sabrina, Monti, Barbara, Gil, Carmen, Martín-Requero, Angeles, Palomo, Valle, de Lago, Eva, Martinez, Ana
Published in Journal of medicinal chemistry (27.01.2022)
Published in Journal of medicinal chemistry (27.01.2022)
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Role of Resveratrol and Selenium on Oxidative Stress and Expression of Antioxidant and Anti-Aging Genes in Immortalized Lymphocytes from Alzheimer's Disease Patients
Cosín-Tomàs, Marta, Senserrich, Júlia, Arumí-Planas, Marta, Alquézar, Carolina, Pallàs, Mercè, Martín-Requero, Ángeles, Suñol, Cristina, Kaliman, Perla, Sanfeliu, Coral
Published in Nutrients (31.07.2019)
Published in Nutrients (31.07.2019)
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Motor neuron preservation and decrease of in vivo TDP-43 phosphorylation by protein CK-1δ kinase inhibitor treatment
Martínez-González, Loreto, Rodríguez-Cueto, Carmen, Cabezudo, Diego, Bartolomé, Fernando, Andrés-Benito, Pol, Ferrer, Isidro, Gil, Carmen, Martín-Requero, Ángeles, Fernández-Ruiz, Javier, Martínez, Ana, de Lago, Eva
Published in Scientific reports (10.03.2020)
Published in Scientific reports (10.03.2020)
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Multitarget Hybrid Fasudil Derivatives as a New Approach to the Potential Treatment of Amyotrophic Lateral Sclerosis
Martín-Cámara, Olmo, Arribas, Marina, Wells, Geoffrey, Morales-Tenorio, Marcos, Martín-Requero, Ángeles, Porras, Gracia, Martínez, Ana, Giorgi, Giorgio, López-Alvarado, Pilar, Lastres-Becker, Isabel, Menéndez, J. Carlos
Published in Journal of medicinal chemistry (10.02.2022)
Published in Journal of medicinal chemistry (10.02.2022)
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Tideglusib, a Non-ATP Competitive Inhibitor of GSK-3β as a Drug Candidate for the Treatment of Amyotrophic Lateral Sclerosis
Martínez-González, Loreto, Gonzalo-Consuegra, Claudia, Gómez-Almería, Marta, Porras, Gracia, de Lago, Eva, Martín-Requero, Ángeles, Martínez, Ana
Published in International journal of molecular sciences (20.08.2021)
Published in International journal of molecular sciences (20.08.2021)
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Casein kinase 1 inhibitor avoids TDP-43 pathology propagation in a patient-derived cellular model of amyotrophic lateral sclerosis
Cuevas, Eva P., Martinez-Gonzalez, Loreto, Gordillo, Clara, Tosat-Bitrián, Carlota, Pérez de la Lastra, Carmen, Sáenz, Amets, Gil, Carmen, Palomo, Valle, Martin-Requero, Ángeles, Martinez, Ana
Published in Neurobiology of disease (01.03.2024)
Published in Neurobiology of disease (01.03.2024)
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Functional Characterization of a Familial ALS-Associated Missense TBK1 (p-Arg573Gly) Mutation in Patient-Derived Lymphoblasts
Porras, Gracia, Ruiz, Silvana, Maestro, Inés, Borrego-Hernández, Daniel, Redondo, Alberto G, Martínez, Ana, Martín-Requero, Ángeles
Published in International journal of molecular sciences (02.02.2023)
Published in International journal of molecular sciences (02.02.2023)
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Molecular Alterations in Sporadic and SOD1 -ALS Immortalized Lymphocytes: Towards a Personalized Therapy
Lastres-Becker, Isabel, Porras, Gracia, Arribas-Blázquez, Marina, Maestro, Inés, Borrego-Hernández, Daniel, Boya, Patricia, Cerdán, Sebastián, García-Redondo, Alberto, Martínez, Ana, Martin-Requero, Ángeles
Published in International journal of molecular sciences (16.03.2021)
Published in International journal of molecular sciences (16.03.2021)
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Proteome Aggregation in Cells Derived from Amyotrophic Lateral Sclerosis Patients for Personalized Drug Evaluation
Pérez de la Lastra Aranda, Carmen, Tosat-Bitrián, Carlota, Porras, Gracia, Dafinca, Ruxandra, Muñoz-Torrero, Diego, Talbot, Kevin, Martín-Requero, Ángeles, Martínez, Ana, Palomo, Valle
Published in ACS chemical neuroscience (06.11.2024)
Published in ACS chemical neuroscience (06.11.2024)
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Impact of Multiple Sclerosis Risk Polymorphism rs7665090 on MANBA Activity, Lysosomal Endocytosis, and Lymphocyte Activation
González-Jiménez, Adela, López-Cotarelo, Pilar, Agudo-Jiménez, Teresa, Casanova, Ignacio, Silanes, Carlos López de, Martín-Requero, Ángeles, Matesanz, Fuencisla, Urcelay, Elena, Espino-Paisán, Laura
Published in International journal of molecular sciences (23.07.2022)
Published in International journal of molecular sciences (23.07.2022)
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TTBK1 and CK1 inhibitors restore TDP-43 pathology and avoid disease propagation in lymphoblast from Alzheimer’s disease patients
Martinez-Gonzalez, Loreto, Cuevas, Eva P., Tosat-Bitrián, Carlota, Nozal, Vanesa, Gil, Carmen, Palomo, Valle, Martín-Requero, Ángeles, Martinez, Ana
Published in Frontiers in molecular neuroscience (09.08.2023)
Published in Frontiers in molecular neuroscience (09.08.2023)
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Targeting Cannabinoid Receptor Activation and BACE-1 Activity Counteracts TgAPP Mice Memory Impairment and Alzheimer’s Disease Lymphoblast Alterations
Nuñez-Borque, Emilio, González-Naranjo, Pedro, Bartolomé, Fernando, Alquézar, Carolina, Reinares-Sebastián, Alejandro, Pérez, Concepción, Ceballos, Maria L., Páez, Juan A., Campillo, Nuria E., Martín-Requero, Ángeles
Published in Molecular neurobiology (01.04.2020)
Published in Molecular neurobiology (01.04.2020)
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Lymphocytes in Alzheimer's disease pathology: Altered signaling pathways
Esteras, Noemí, Alquézar, Carolina, de la Encarnación, Ana, Martín-Requero, Ángeles
Published in Current Alzheimer research (01.04.2016)
Published in Current Alzheimer research (01.04.2016)
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Altered cell cycle-related gene expression in brain and lymphocytes from a transgenic mouse model of Alzheimer's disease [amyloid precursor protein/presenilin 1 (PS1)]
Esteras, Noemí, Bartolomé, Fernando, Alquézar, Carolina, Antequera, Desireé, Muñoz, Úrsula, Carro, Eva, Martín-Requero, Ángeles
Published in The European journal of neuroscience (01.09.2012)
Published in The European journal of neuroscience (01.09.2012)
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Progranulin Deficiency Induces Mitochondrial Dysfunction in Frontotemporal Lobar Degeneration with TDP-43 Inclusions
Rodríguez-Periñán, Guiomar, de la Encarnación, Ana, Moreno, Fermín, López de Munain, Adolfo, Martínez, Ana, Martín-Requero, Ángeles, Alquézar, Carolina, Bartolomé, Fernando
Published in Antioxidants (25.02.2023)
Published in Antioxidants (25.02.2023)
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Inactivation of CDK/pRb pathway normalizes survival pattern of lymphoblasts expressing the FTLD-progranulin mutation c.709-1G>A
Alquezar, Carolina, Esteras, Noemí, Alzualde, Ainhoa, Moreno, Fermín, Ayuso, Matilde S, López de Munain, Adolfo, Martín-Requero, Ángeles
Published in PloS one (18.05.2012)
Published in PloS one (18.05.2012)
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Altered calmodulin degradation and signaling in non-neuronal cells from Alzheimer's disease patients
Esteras, Noemí, Muñoz, Úrsula, Alquézar, Carolina, Bartolomé, Fernando, Bermejo-Pareja, Félix, Martín-Requero, Ángeles
Published in Current Alzheimer research (01.03.2012)
Published in Current Alzheimer research (01.03.2012)
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