Discovery and Optimization of a Novel Series of N-Arylamide Oxadiazoles as Potent, Highly Selective and Orally Bioavailable Cannabinoid Receptor 2 (CB2) Agonists
Cheng, Yuan, Albrecht, Brian K, Brown, James, Buchanan, John L, Buckner, William H, DiMauro, Erin F, Emkey, Renee, Fremeau, Robert T, Harmange, Jean-Christophe, Hoffman, Beth J, Huang, Liyue, Huang, Ming, Lee, Josie Han, Lin, Fen-Fen, Martin, Matthew W, Nguyen, Hung Q, Patel, Vinod F, Tomlinson, Susan A, White, Ryan D, Xia, Xiaoyang, Hitchcock, Stephen A
Published in Journal of medicinal chemistry (28.08.2008)
Published in Journal of medicinal chemistry (28.08.2008)
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Journal Article
Discovery of Aminoquinazolines as Potent, Orally Bioavailable Inhibitors of Lck: Synthesis, SAR, and in Vivo Anti-Inflammatory Activity
DiMauro, Erin F, Newcomb, John, Nunes, Joseph J, Bemis, Jean E, Boucher, Christina, Buchanan, John L, Buckner, William H, Cee, Victor J, Chai, Lilly, Deak, Holly L, Epstein, Linda F, Faust, Ted, Gallant, Paul, Geuns-Meyer, Stephanie D, Gore, Anu, Gu, Yan, Henkle, Brad, Hodous, Brian L, Hsieh, Faye, Huang, Xin, Kim, Joseph L, Lee, Josie H, Martin, Matthew W, Masse, Craig E, McGowan, David C, Metz, Daniela, Mohn, Deanna, Morgenstern, Kurt A, Oliveira-dos-Santos, Antonio, Patel, Vinod F, Powers, David, Rose, Paul E, Schneider, Stephen, Tomlinson, Susan A, Tudor, Yan-Yan, Turci, Susan M, Welcher, Andrew A, White, Ryan D, Zhao, Huilin, Zhu, Li, Zhu, Xiaotian
Published in Journal of medicinal chemistry (21.09.2006)
Published in Journal of medicinal chemistry (21.09.2006)
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Journal Article
Novel HDAC11 inhibitors suppress lung adenocarcinoma stem cell self-renewal and overcome drug resistance by suppressing Sox2
Bora-Singhal, Namrata, Mohankumar, Durairaj, Saha, Biswarup, Colin, Christelle M, Lee, Jennifer Y, Martin, Matthew W, Zheng, Xiaozhang, Coppola, Domenico, Chellappan, Srikumar
Published in Scientific reports (13.03.2020)
Published in Scientific reports (13.03.2020)
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Journal Article
Discovery of novel N-hydroxy-2-arylisoindoline-4-carboxamides as potent and selective inhibitors of HDAC11
Martin, Matthew W., Lee, Jennifer Y., Lancia, David R., Ng, Pui Yee, Han, Bingsong, Thomason, Jennifer R., Lynes, Maureen S., Marshall, C. Gary, Conti, Chiara, Collis, Alan, Morales, Monica Alvarez, Doshi, Kshama, Rudnitskaya, Aleksandra, Yao, Lili, Zheng, Xiaozhang
Published in Bioorganic & medicinal chemistry letters (01.07.2018)
Published in Bioorganic & medicinal chemistry letters (01.07.2018)
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Journal Article
Discovery and optimization of novel piperazines as potent inhibitors of fatty acid synthase (FASN)
Martin, Matthew W., Lancia, David R., Li, Hongbin, Schiller, Shawn E.R., Toms, Angela V., Wang, Zhongguo, Bair, Kenneth W., Castro, Jennifer, Fessler, Shawn, Gotur, Deepali, Hubbs, Stephen E., Kauffman, Goss S., Kershaw, Mark, Luke, George P., McKinnon, Crystal, Yao, Lili, Lu, Wei, Millan, David S.
Published in Bioorganic & medicinal chemistry letters (15.04.2019)
Published in Bioorganic & medicinal chemistry letters (15.04.2019)
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Journal Article
Purinylpyridinylamino-based DFG-in/αC-helix-out B-Raf inhibitors: Applying mutant versus wild-type B-Raf selectivity indices for compound profiling
Liu, Longbin, Lee, Matthew R., Kim, Joseph L., Whittington, Douglas A., Bregman, Howard, Hua, Zihao, Lewis, Richard T., Martin, Matthew W., Nishimura, Nobuko, Potashman, Michele, Yang, Kevin, Yi, Shuyan, Vaida, Karina R., Epstein, Linda F., Babij, Carol, Fernando, Manory, Carnahan, Josette, Norman, Mark H.
Published in Bioorganic & medicinal chemistry (15.05.2016)
Published in Bioorganic & medicinal chemistry (15.05.2016)
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Journal Article
Design and Optimization of Benzopiperazines as Potent Inhibitors of BET Bromodomains
Millan, David S, Kayser-Bricker, Katherine J, Martin, Matthew W, Talbot, Adam C, Schiller, Shawn E. R, Herbertz, Torsten, Williams, Grace L, Luke, George P, Hubbs, Stephen, Alvarez Morales, Monica A, Cardillo, Daniel, Troccolo, Paul, Mendes, Rachel L, McKinnon, Crystal
Published in ACS medicinal chemistry letters (10.08.2017)
Published in ACS medicinal chemistry letters (10.08.2017)
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Journal Article
Corrigendum to “Purinylpyridinylamino-based DFG-in/αC-helix-out B-Raf inhibitors: Applying mutant versus wild-type B-Raf selectivity indices for compound profiling” [Bioorg. Med. Chem. 24 (2016) 2215–2234]
Liu, Longbin, Lee, Matthew R., Kim, Joseph L., Whittington, Douglas A., Bregman, Howard, Hua, Zihao, Lewis, Richard T., Martin, Matthew W., Nishimura, Nobuko, Potashman, Michele, Yang, Kevin, Yi, Shuyan, Vaida, Karina R., Epstein, Linda F., Babij, Carol, Fernando, Manory, Carnahan, Josette, Norman, Mark H.
Published in Bioorganic & medicinal chemistry (01.07.2016)
Published in Bioorganic & medicinal chemistry (01.07.2016)
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Journal Article
2-Phenylamino-6-cyano-1H-benzimidazole-based isoform selective casein kinase 1 gamma (CK1γ) inhibitors
Hua, Zihao, Huang, Xin, Bregman, Howard, Chakka, Nagasree, DiMauro, Erin F., Doherty, Elizabeth M., Goldstein, Jon, Gunaydin, Hakan, Huang, Hongbing, Mercede, Stephanie, Newcomb, John, Patel, Vinod F., Turci, Susan M., Yan, Jie, Wilson, Cindy, Martin, Matthew W.
Published in Bioorganic & medicinal chemistry letters (01.09.2012)
Published in Bioorganic & medicinal chemistry letters (01.09.2012)
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Journal Article
Novel 2,3-Dihydro-1,4-Benzoxazines as Potent and Orally Bioavailable Inhibitors of Tumor-Driven Angiogenesis
La, Daniel S, Belzile, Julie, Bready, James V, Coxon, Angela, DeMelfi, Thomas, Doerr, Nicholas, Estrada, Juan, Flynn, Julie C, Flynn, Shaun R, Graceffa, Russell F, Harriman, Shawn P, Larrow, Jay F, Long, Alexander M, Martin, Matthew W, Morrison, Michael J, Patel, Vinod F, Roveto, Philip M, Wang, Ling, Weiss, Matthew M, Whittington, Douglas A, Teffera, Yohannes, Zhao, Zhiyang, Polverino, Anthony J, Harmange, Jean-Christophe
Published in Journal of medicinal chemistry (27.03.2008)
Published in Journal of medicinal chemistry (27.03.2008)
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Journal Article
Structure-Based Design of Novel 2-Amino-6-phenyl-pyrimido[5′,4′:5,6]pyrimido[1,2-a]benzimidazol-5(6H)-ones as Potent and Orally Active Inhibitors of Lymphocyte Specific Kinase (Lck): Synthesis, SAR, and In Vivo Anti-Inflammatory Activity
Martin, Matthew W, Newcomb, John, Nunes, Joseph J, Boucher, Christina, Chai, Lilly, Epstein, Linda F, Faust, Theodore, Flores, Sylvia, Gallant, Paul, Gore, Anu, Gu, Yan, Hsieh, Faye, Huang, Xin, Kim, Joseph L, Middleton, Scot, Morgenstern, Kurt, Oliveira-dos-Santos, Antonio, Patel, Vinod F, Powers, David, Rose, Paul, Tudor, Yanyan, Turci, Susan M, Welcher, Andrew A, Zack, Debra, Zhao, Huilin, Zhu, Li, Zhu, Xiaotian, Ghiron, Chiara, Ermann, Monika, Johnston, David, Saluste, Carl-Gustaf Pierre
Published in Journal of medicinal chemistry (27.03.2008)
Published in Journal of medicinal chemistry (27.03.2008)
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Journal Article
Update on lymphocyte specific kinase inhibitors: a patent survey
Martin, Matthew W, Machacek, Michelle R
Published in Expert opinion on therapeutic patents (01.11.2010)
Published in Expert opinion on therapeutic patents (01.11.2010)
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Journal Article
Naphthamides as Novel and Potent Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitors: Design, Synthesis, and Evaluation
Harmange, Jean-Christophe, Weiss, Matthew M, Germain, Julie, Polverino, Anthony J, Borg, George, Bready, James, Chen, Danlin, Choquette, Deborah, Coxon, Angela, DeMelfi, Tom, DiPietro, Lucian, Doerr, Nicholas, Estrada, Juan, Flynn, Julie, Graceffa, Russell F, Harriman, Shawn P, Kaufman, Stephen, La, Daniel S, Long, Alexander, Martin, Matthew W, Neervannan, Sesha, Patel, Vinod F, Potashman, Michele, Regal, Kelly, Roveto, Phillip M, Schrag, Michael L, Starnes, Charlie, Tasker, Andrew, Teffera, Yohannes, Wang, Ling, White, Ryan D, Whittington, Douglas A, Zanon, Roger
Published in Journal of medicinal chemistry (27.03.2008)
Published in Journal of medicinal chemistry (27.03.2008)
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Journal Article
Novel 2-Aminopyrimidine Carbamates as Potent and Orally Active Inhibitors of Lck: Synthesis, SAR, and in Vivo Antiinflammatory Activity
Martin, Matthew W, Newcomb, John, Nunes, Joseph J, McGowan, David C, Armistead, David M, Boucher, Christina, Buchanan, John L, Buckner, William, Chai, Lilly, Elbaum, Daniel, Epstein, Linda F, Faust, Theodore, Flynn, Shaun, Gallant, Paul, Gore, Anu, Gu, Yan, Hsieh, Faye, Huang, Xin, Lee, Josie H, Metz, Daniela, Middleton, Scot, Mohn, Deanna, Morgenstern, Kurt, Morrison, Michael J, Novak, Perry M, Oliveira-dos-Santos, Antonio, Powers, David, Rose, Paul, Schneider, Stephen, Sell, Stephanie, Tudor, Yanyan, Turci, Susan M, Welcher, Andrew A, White, Ryan D, Zack, Debra, Zhao, Huilin, Zhu, Li, Zhu, Xiaotian, Ghiron, Chiara, Amouzegh, Patricia, Ermann, Monika, Jenkins, James, Johnston, David, Napier, Spencer, Power, Eoin
Published in Journal of medicinal chemistry (10.08.2006)
Published in Journal of medicinal chemistry (10.08.2006)
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Journal Article
Structure-Based Design of Potent and Selective CK1γ Inhibitors
Huang, Hongbing, Acquaviva, Lisa, Berry, Virginia, Bregman, Howard, Chakka, Nagasree, O’Connor, Anne, DiMauro, Erin F, Dovey, Jennifer, Epstein, Oleg, Grubinska, Barbara, Goldstein, Jon, Gunaydin, Hakan, Hua, Zihao, Huang, Xin, Huang, Liyue, Human, Jason, Long, Alex, Newcomb, John, Patel, Vinod F, Saffran, Doug, Serafino, Randy, Schneider, Steve, Strathdee, Craig, Tang, Jin, Turci, Susan, White, Ryan, Yu, Violeta, Zhao, Huilin, Wilson, Cindy, Martin, Matthew W
Published in ACS medicinal chemistry letters (13.12.2012)
Published in ACS medicinal chemistry letters (13.12.2012)
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Journal Article
Discovery of 4-amino-5,6-biaryl-furo[2,3- d]pyrimidines as inhibitors of Lck: Development of an expedient and divergent synthetic route and preliminary SAR
DiMauro, Erin F., Newcomb, John, Nunes, Joseph J., Bemis, Jean E., Boucher, Christina, Buchanan, John L., Buckner, William H., Cheng, Alan, Faust, Theodore, Hsieh, Faye, Huang, Xin, Lee, Josie H., Marshall, Teresa L., Martin, Matthew W., McGowan, David C., Schneider, Stephen, Turci, Susan M., White, Ryan D., Zhu, Xiaotian
Published in Bioorganic & medicinal chemistry letters (15.04.2007)
Published in Bioorganic & medicinal chemistry letters (15.04.2007)
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Journal Article
Discovery of novel 2,3-diarylfuro[2,3- b]pyridin-4-amines as potent and selective inhibitors of Lck: Synthesis, SAR, and pharmacokinetic properties
Martin, Matthew W., Newcomb, John, Nunes, Joseph J., Bemis, Jean E., McGowan, David C., White, Ryan D., Buchanan, John L., DiMauro, Erin F., Boucher, Christina, Faust, Theodore, Hsieh, Faye, Huang, Xin, Lee, Josie H., Schneider, Stephen, Turci, Susan M., Zhu, Xiaotian
Published in Bioorganic & medicinal chemistry letters (15.04.2007)
Published in Bioorganic & medicinal chemistry letters (15.04.2007)
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Journal Article
Structure-Guided Design of Aminopyrimidine Amides as Potent, Selective Inhibitors of Lymphocyte Specific Kinase: Synthesis, Structure–Activity Relationships, and Inhibition of in Vivo T Cell Activation
DiMauro, Erin F, Newcomb, John, Nunes, Joseph J, Bemis, Jean E, Boucher, Christina, Chai, Lilly, Chaffee, Stuart C, Deak, Holly L, Epstein, Linda F, Faust, Ted, Gallant, Paul, Gore, Anu, Gu, Yan, Henkle, Brad, Hsieh, Faye, Huang, Xin, Kim, Joseph L, Lee, Josie H, Martin, Matthew W, McGowan, David C, Metz, Daniela, Mohn, Deanna, Morgenstern, Kurt A, Oliveira-dos-Santos, Antonio, Patel, Vinod F, Powers, David, Rose, Paul E, Schneider, Stephen, Tomlinson, Susan A, Tudor, Yan-Yan, Turci, Susan M, Welcher, Andrew A, Zhao, Huilin, Zhu, Li, Zhu, Xiaotian
Published in Journal of medicinal chemistry (27.03.2008)
Published in Journal of medicinal chemistry (27.03.2008)
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Journal Article