GEF-H1 Signaling upon Microtubule Destabilization Is Required for Dendritic Cell Activation and Specific Anti-tumor Responses
Kashyap, Abhishek S., Fernandez-Rodriguez, Laura, Zhao, Yun, Monaco, Gianni, Trefny, Marcel P., Yoshida, Naohiro, Martin, Kea, Sharma, Ashwani, Olieric, Natacha, Shah, Pankaj, Stanczak, Michal, Kirchhammer, Nicole, Park, Sung-Moo, Wieckowski, Sebastien, Laubli, Heinz, Zagani, Rachid, Kasenda, Benjamin, Steinmetz, Michel O., Reinecker, Hans-Christian, Zippelius, Alfred
Published in Cell reports (Cambridge) (24.09.2019)
Published in Cell reports (Cambridge) (24.09.2019)
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Journal Article
Microtubule-depolymerizing agents used in antibody-drug conjugates induce antitumor immunity by stimulation of dendritic cells
Müller, Philipp, Martin, Kea, Theurich, Sebastian, Schreiner, Jens, Savic, Spasenija, Terszowski, Grzegorz, Lardinois, Didier, Heinzelmann-Schwarz, Viola A, Schlaak, Max, Kvasnicka, Hans-Michael, Spagnoli, Giulio, Dirnhofer, Stephan, Speiser, Daniel E, von Bergwelt-Baildon, Michael, Zippelius, Alfred
Published in Cancer immunology research (01.08.2014)
Published in Cancer immunology research (01.08.2014)
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Journal Article
Pharmacological Inhibition of MALT1 Protease Leads to a Progressive IPEX-Like Pathology
Martin, Kea, Junker, Ursula, Tritto, Elaine, Sutter, Esther, Rubic-Schneider, Tina, Morgan, Hannah, Niwa, Satoru, Li, Jianping, Schlapbach, Achim, Walker, Dana, Bigaud, Marc, Beerli, Christian, Littlewood-Evans, Amanda, Rudolph, Bettina, Laisney, Marc, Ledieu, David, Beltz, Karen, Quancard, Jean, Bornancin, Frédéric, Zamurovic Ribrioux, Natasa, Calzascia, Thomas
Published in Frontiers in immunology (30.04.2020)
Published in Frontiers in immunology (30.04.2020)
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Journal Article
Requirement of Mucosa‐Associated Lymphoid Tissue Lymphoma Translocation Protein 1 Protease Activity for Fcγ Receptor–Induced Arthritis, but Not Fcγ Receptor–Mediated Platelet Elimination, in Mice
Martin, Kea, Touil, Ratiba, Cvijetic, Grozdan, Israel, Laura, Kolb, Yeter, Sarret, Sophie, Valeaux, Stéphanie, Degl'Innocenti, Elena, Le Meur, Thomas, Caesar, Nadja, Bardet, Maureen, Beerli, Christian, Zerwes, Hans‐Guenter, Kovarik, Jiri, Beltz, Karen, Schlapbach, Achim, Quancard, Jean, Régnier, Catherine H., Bigaud, Marc, Junt, Tobias, Wieczorek, Grazyna, Isnardi, Isabelle, Littlewood‐Evans, Amanda, Bornancin, Frédéric, Calzascia, Thomas
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.06.2020)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.06.2020)
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CARD10 cleavage by MALT1 restricts lung carcinoma growth in vivo
Israël, Laura, Glück, Anton, Berger, Marjorie, Coral, Marine, Ceci, Melanie, Unterreiner, Adeline, Rubert, Joëlle, Bardet, Maureen, Ginster, Stefanie, Golding-Ochsenbein, Alexandra M., Martin, Kea, Hoyler, Thomas, Calzascia, Thomas, Wieczorek, Grazyna, Hillenbrand, Rainer, Ferretti, Stéphane, Ferrero, Enrico, Bornancin, Frédéric
Published in Oncogenesis (New York, NY) (06.04.2021)
Published in Oncogenesis (New York, NY) (06.04.2021)
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Trastuzumab emtansine (T-DM1) renders HER2+ breast cancer highly susceptible to CTLA-4/PD-1 blockade
Müller, Philipp, Kreuzaler, Matthias, Khan, Tarik, Thommen, Daniela S, Martin, Kea, Glatz, Katharina, Savic, Spasenija, Harbeck, Nadia, Nitz, Ulrike, Gluz, Oleg, von Bergwelt-Baildon, Michael, Kreipe, Hans, Reddy, Sai, Christgen, Matthias, Zippelius, Alfred
Published in Science translational medicine (25.11.2015)
Published in Science translational medicine (25.11.2015)
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Journal Article
Decrease in Serum Anti-MAG Autoantibodies Is Associated With Therapy Response in Patients With Anti-MAG Neuropathy: Retrospective Study
Hänggi, Pascal, Aliu, Butrint, Martin, Kea, Herrendorff, Ruben, Steck, Andreas Johann
Published in Neurology : neuroimmunology & neuroinflammation (01.01.2022)
Published in Neurology : neuroimmunology & neuroinflammation (01.01.2022)
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Journal Article
Immune cell landscaping reveals a protective role for regulatory T cells during kidney injury and fibrosis
do Valle Duraes, Fernanda, Lafont, Armelle, Beibel, Martin, Martin, Kea, Darribat, Katy, Cuttat, Rachel, Waldt, Annick, Naumann, Ulrike, Wieczorek, Grazyna, Gaulis, Swann, Pfister, Sabina, Mertz, Kirsten D, Li, Jianping, Roma, Guglielmo, Warncke, Max
Published in JCI insight (13.02.2020)
Published in JCI insight (13.02.2020)
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Optimized synthesis, polymer conjugation, and proof‐of‐concept studies of the gd‐IgA1 epitope for antibody‐scavenging therapies in IgA nephropathy
Bechtler, Clément, Barneoud‐Rousset, Ouliana, Pang, Lijuan, Martin, Kea, König, Katrin F., Hänggi, Pascal, Pearson, Nick, Ricklin, Daniel
Published in Chemical biology & drug design (01.09.2023)
Published in Chemical biology & drug design (01.09.2023)
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Journal Article
Malt1 Protease Deficiency in Mice Disrupts Immune Homeostasis at Environmental Barriers and Drives Systemic T Cell-Mediated Autoimmunity
Martin, Kea, Touil, Ratiba, Kolb, Yeter, Cvijetic, Grozdan, Murakami, Kiichi, Israel, Laura, Duraes, Fernanda, Buffet, David, Glück, Anton, Niwa, Satoru, Bigaud, Marc, Junt, Tobias, Zamurovic, Natasa, Smith, Philip, McCoy, Kathy D, Ohashi, Pamela S, Bornancin, Frédéric, Calzascia, Thomas
Published in The Journal of immunology (1950) (01.12.2019)
Published in The Journal of immunology (1950) (01.12.2019)
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Journal Article
The microtubule-depolymerizing agent ansamitocin P3 programs dendritic cells toward enhanced anti-tumor immunity
Martin, Kea, Müller, Philipp, Schreiner, Jens, Prince, Spasenija Savic, Lardinois, Didier, Heinzelmann-Schwarz, Viola A., Thommen, Daniela S., Zippelius, Alfred
Published in Cancer Immunology, Immunotherapy (01.09.2014)
Published in Cancer Immunology, Immunotherapy (01.09.2014)
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Journal Article
Abstract 4071: The first-in-class PD1-IL18 conjugate BPT567 induces potent anti-tumor immunity by preferentially activating PD1+IL18R+ intratumoral effector T cells in cis
Martin, Kea, Luu, Thuy, Carralot, Jean-Philippe, Gremlich, Lilian, Herzig, Petra, Herr, Caoimhe, Meoded, Roy, Moosmann, Philipp, Goepfert, Arnaud, Zippelius, Alfred, Pattabiraman, Vijaya, Kreft, Bertolt
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Abstract 1850: A first-in-class PD1-IL18 immunocytokine (BPT567) targets PD-1+ IL18R+ CD8+ T effector cells enriched in the tumor microenvironment and exhibits potent antitumor efficacy with excellent tolerability
Carralot, Jean-Philippe, Martin, Kea, Sanchez, Rubén Alvarez, Meoded, Roy, Herr, Caoimhe, Moosman, Philipp, Goepfert, Arnaud, Chi, Andrew, Pattabiraman, Vijaya J., Kreft, Bertolt
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Journal Article
IMMUNE ANTIGEN SPECIFIC IL-18 IMMUNOCYTOKINES AND USES THEREOF
KREFT, Bertolt, PATTABIRAMAN, Vijaya Raghavan, MARTIN, Kea, CARRALOT, Jean-Philippe, GOEPFERT, Arnaud, CHI, Andrew
Year of Publication 29.08.2024
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Year of Publication 29.08.2024
Patent
IMMUNE ANTIGEN SPECIFIC IL-18 IMMUNOCYTOKINES AND USES THEREOF
KREFT, Bertolt, PATTABIRAMAN, Vijaya Raghavan, MARTIN, Kea, CARRALOT, Jean-Philippe, GOEPFERT, Arnaud, CHI, Andrew
Year of Publication 09.11.2023
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Year of Publication 09.11.2023
Patent
IMMUNE ANTIGEN SPECIFIC IL-18 IMMUNOCYTOKINES AND USES THEREOF
KREFT, Bertolt, PATTABIRAMAN, Vijaya Raghavan, MARTIN, Kea, CARRALOT, Jean-Philippe, GOEPFERT, Arnaud, CHI, Andrew
Year of Publication 31.08.2023
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Year of Publication 31.08.2023
Patent