Serine is a natural ligand and allosteric activator of pyruvate kinase M2
Chaneton, Barbara, Hillmann, Petra, Zheng, Liang, Martin, Agnès C. L., Maddocks, Oliver D. K., Chokkathukalam, Achuthanunni, Coyle, Joseph E., Jankevics, Andris, Holding, Finn P., Vousden, Karen H., Frezza, Christian, O’Reilly, Marc, Gottlieb, Eyal
Published in Nature (London) (15.11.2012)
Published in Nature (London) (15.11.2012)
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Molecular basis of USP7 inhibition by selective small-molecule inhibitors
Turnbull, Andrew P., Ioannidis, Stephanos, Krajewski, Wojciech W., Pinto-Fernandez, Adan, Heride, Claire, Martin, Agnes C. L., Tonkin, Louise M., Townsend, Elizabeth C., Buker, Shane M., Lancia, David R., Caravella, Justin A., Toms, Angela V., Charlton, Thomas M., Lahdenranta, Johanna, Wilker, Erik, Follows, Bruce C., Evans, Nicola J., Stead, Lucy, Alli, Cristina, Zarayskiy, Vladislav V., Talbot, Adam C., Buckmelter, Alexandre J., Wang, Minghua, McKinnon, Crystal L., Saab, Fabienne, McGouran, Joanna F., Century, Hannah, Gersch, Malte, Pittman, Marc S., Marshall, C. Gary, Raynham, Tony M., Simcox, Mary, Stewart, Lorna M. D., McLoughlin, Sheila B., Escobedo, Jaime A., Bair, Kenneth W., Dinsmore, Christopher J., Hammonds, Tim R., Kim, Sunkyu, Urbé, Sylvie, Clague, Michael J., Kessler, Benedikt M., Komander, David
Published in Nature (London) (26.10.2017)
Published in Nature (London) (26.10.2017)
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Structure of the Epigenetic Oncogene MMSET and Inhibition by N‑Alkyl Sinefungin Derivatives
Tisi, Dominic, Chiarparin, Elisabetta, Tamanini, Emiliano, Pathuri, Puja, Coyle, Joseph E, Hold, Adam, Holding, Finn P, Amin, Nader, Martin, Agnes C. L, Rich, Sharna J, Berdini, Valerio, Yon, Jeff, Acklam, Paul, Burke, Rosemary, Drouin, Ludovic, Harmer, Jenny E, Jeganathan, Fiona, van Montfort, Rob L. M, Newbatt, Yvette, Tortorici, Marcello, Westlake, Maura, Wood, Amy, Hoelder, Swen, Heightman, Tom D
Published in ACS chemical biology (18.11.2016)
Published in ACS chemical biology (18.11.2016)
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Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X‑ray Fragment Screening
Woolford, Alison J.-A, Pero, Joseph E, Aravapalli, Sridhar, Berdini, Valerio, Coyle, Joseph E, Day, Philip J, Dodson, Andrew M, Grondin, Pascal, Holding, Finn P, Lee, Lydia Y. W, Li, Peng, Manas, Eric S, Marino, Joseph, Martin, Agnes C. L, McCleland, Brent W, McMenamin, Rachel L, Murray, Christopher W, Neipp, Christopher E, Page, Lee W, Patel, Vipulkumar K, Potvain, Florent, Rich, Sharna, Rivero, Ralph A, Smith, Kirsten, Somers, Donald O, Trottet, Lionel, Velagaleti, Ranganadh, Williams, Glyn, Xie, Ren
Published in Journal of medicinal chemistry (09.06.2016)
Published in Journal of medicinal chemistry (09.06.2016)
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Capacitative Ca2+ Entry via Orai1 and Stromal Interacting Molecule 1 (STIM1) Regulates Adenylyl Cyclase Type 8
Martin, Agnes C L, Willoughby, Debbie, Ciruela, Antonio, Ayling, Laura-Jo, Pagano, Mario, Wachten, Sebastian, Tengholm, Anders, Cooper, Dermot M F
Published in Molecular pharmacology (01.04.2009)
Published in Molecular pharmacology (01.04.2009)
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Fragment-Based Discovery of 6‑Azaindazoles As Inhibitors of Bacterial DNA Ligase
Howard, Steven, Amin, Nader, Benowitz, Andrew B, Chiarparin, Elisabetta, Cui, Haifeng, Deng, Xiaodong, Heightman, Tom D, Holmes, David J, Hopkins, Anna, Huang, Jianzhong, Jin, Qi, Kreatsoulas, Constantine, Martin, Agnes C. L, Massey, Frances, McCloskey, Lynn, Mortenson, Paul N, Pathuri, Puja, Tisi, Dominic, Williams, Pamela A
Published in ACS medicinal chemistry letters (12.12.2013)
Published in ACS medicinal chemistry letters (12.12.2013)
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Selected non-steroidal anti-inflammatory drugs and their derivatives target gamma-secretase at a novel site. Evidence for an allosteric mechanism
Beher, Dirk, Clarke, Earl E, Wrigley, Jonathan D J, Martin, Agnes C L, Nadin, Alan, Churcher, Ian, Shearman, Mark S
Published in The Journal of biological chemistry (15.10.2004)
Published in The Journal of biological chemistry (15.10.2004)
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Functional Overexpression of γ-Secretase Reveals Protease-independent Trafficking Functions and a Critical Role of Lipids for Protease Activity
Wrigley, Jonathan D.J., Schurov, Irina, Nunn, Emma J., Martin, Agnes C.L., Clarke, Earl E., Ellis, Semantha, Bonnert, Timothy P., Shearman, Mark S., Beher, Dirk
Published in The Journal of biological chemistry (01.04.2005)
Published in The Journal of biological chemistry (01.04.2005)
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Correction: Corrigendum: Serine is a natural ligand and allosteric activator of pyruvate kinase M2
Chaneton, Barbara, Hillmann, Petra, Zheng, Liang, Martin, Agnés C. L., Maddocks, Oliver D. K., Chokkathukalam, Achuthanunni, Coyle, Joseph E., Jankevics, Andris, Holding, Finn P., Vousden, Karen H., Frezza, Christian, O’Reilly, Marc, Gottlieb, Eyal
Published in Nature (London) (18.04.2013)
Published in Nature (London) (18.04.2013)
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Journal Article
Capacitative Ca 2+ Entry via Orai1 and Stromal Interacting Molecule 1 (STIM1) Regulates Adenylyl Cyclase Type 8
Martin, Agnes C. L., Willoughby, Debbie, Ciruela, Antonio, Ayling, Laura-Jo, Pagano, Mario, Wachten, Sebastian, Tengholm, Anders, Cooper, Dermot M. F.
Published in Molecular pharmacology (01.04.2009)
Published in Molecular pharmacology (01.04.2009)
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Journal Article
Selected Non-steroidal Anti-inflammatory Drugs and Their Derivatives Target γ-Secretase at a Novel Site
Dirk Beher, Earl E. Clarke, Jonathan D. J. Wrigley, Agnes C. L. Martin, Alan Nadin, Ian Churcher, Mark S. Shearman
Published in The Journal of biological chemistry (15.10.2004)
Published in The Journal of biological chemistry (15.10.2004)
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Journal Article
Functional Overexpression of γ-Secretase Reveals Protease-independent Trafficking Functions and a Critical Role of Lipids for Protease Activity
Jonathan D. J. Wrigley, Irina Schurov, Emma J. Nunn, Agnes C. L. Martin, Earl E. Clarke, Semantha Ellis, Timothy P. Bonnert, Mark S. Shearman, Dirk Beher
Published in The Journal of biological chemistry (01.04.2005)
Published in The Journal of biological chemistry (01.04.2005)
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