Tetrahydro-2-naphthyl and 2‑Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity
Kokkonda, Sreekanth, Deng, Xiaoyi, White, Karen L, Coteron, Jose M, Marco, Maria, de las Heras, Laura, White, John, El Mazouni, Farah, Tomchick, Diana R, Manjalanagara, Krishne, Rudra, Kakali Rani, Chen, Gong, Morizzi, Julia, Ryan, Eileen, Kaminsky, Werner, Leroy, Didier, Martínez-Martínez, María Santos, Jimenez-Diaz, Maria Belen, Bazaga, Santiago Ferrer, Angulo-Barturen, Iñigo, Waterson, David, Burrows, Jeremy N, Matthews, Dave, Charman, Susan A, Phillips, Margaret A, Rathod, Pradipsinh K
Published in Journal of medicinal chemistry (09.06.2016)
Published in Journal of medicinal chemistry (09.06.2016)
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(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium
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Published in Proceedings of the National Academy of Sciences - PNAS (16.12.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (16.12.2014)
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A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance
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Published in Nature communications (24.05.2017)
Published in Nature communications (24.05.2017)
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Abrahams, Katherine A., Chung, Chun-wa, Ghidelli-Disse, Sonja, Rullas, Joaquín, Rebollo-López, María José, Gurcha, Sudagar S., Cox, Jonathan A. G., Mendoza, Alfonso, Jiménez-Navarro, Elena, Martínez-Martínez, María Santos, Neu, Margarete, Shillings, Anthony, Homes, Paul, Argyrou, Argyrides, Casanueva, Ruth, Loman, Nicholas J., Moynihan, Patrick J., Lelièvre, Joël, Selenski, Carolyn, Axtman, Matthew, Kremer, Laurent, Bantscheff, Marcus, Angulo-Barturen, Iñigo, Izquierdo, Mónica Cacho, Cammack, Nicholas C., Drewes, Gerard, Ballell, Lluis, Barros, David, Besra, Gurdyal S., Bates, Robert H.
Published in Nature communications (01.09.2016)
Published in Nature communications (01.09.2016)
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Le Manach, Claire, Nchinda, Aloysius T, Paquet, Tanya, Gonzàlez Cabrera, Diego, Younis, Yassir, Han, Ze, Bashyam, Sridevi, Zabiulla, Mohammed, Taylor, Dale, Lawrence, Nina, White, Karen L, Charman, Susan A, Waterson, David, Witty, Michael J, Wittlin, Sergio, Botha, Mariëtte E, Nondaba, Sindisiswe H, Reader, Janette, Birkholtz, Lyn-Marie, Jiménez-Díaz, María Belén, Martínez, María Santos, Ferrer, Santiago, Angulo-Barturen, Iñigo, Meister, Stephan, Antonova-Koch, Yevgeniya, Winzeler, Elizabeth A, Street, Leslie J, Chibale, Kelly
Published in Journal of medicinal chemistry (10.11.2016)
Published in Journal of medicinal chemistry (10.11.2016)
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A Novel Pyrazolopyridine with in Vivo Activity in Plasmodium berghei- and Plasmodium falciparum -Infected Mouse Models from Structure–Activity Relationship Studies around the Core of Recently Identified Antimalarial Imidazopyridazines
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Published in Journal of medicinal chemistry (12.11.2015)
Published in Journal of medicinal chemistry (12.11.2015)
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Ramachandran, Sreekanth, Hameed P, Shahul, Srivastava, Abhishek, Shanbhag, Gajanan, Morayya, Sapna, Rautela, Nikhil, Awasthy, Disha, Kavanagh, Stefan, Bharath, Sowmya, Reddy, Jitendar, Panduga, Vijender, Prabhakar, K. R, Saralaya, Ramanatha, Nanduri, Robert, Raichurkar, Anandkumar, Menasinakai, Sreenivasaiah, Achar, Vijayashree, Jiménez-Díaz, María Belén, Martínez, María Santos, Angulo-Barturen, Iñigo, Ferrer, Santiago, Sanz, Laura María, Gamo, Francisco Javier, Duffy, Sandra, Avery, Vicky M, Waterson, David, Lee, Marcus C. S, Coburn-Flynn, Olivia, Fidock, David A, Iyer, Pravin S, Narayanan, Shridhar, Hosagrahara, Vinayak, Sambandamurthy, Vasan K
Published in Journal of medicinal chemistry (14.08.2014)
Published in Journal of medicinal chemistry (14.08.2014)
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Trisubstituted Pyrimidines as Efficacious and Fast-Acting Antimalarials
Norcross, Neil R, Baragaña, Beatriz, Wilson, Caroline, Hallyburton, Irene, Osuna-Cabello, Maria, Norval, Suzanne, Riley, Jennifer, Stojanovski, Laste, Simeons, Frederick R. C, Porzelle, Achim, Grimaldi, Raffaella, Wittlin, Sergio, Duffy, Sandra, Avery, Vicky M, Meister, Stephan, Sanz, Laura, Jiménez-Díaz, Belén, Angulo-Barturen, Iñigo, Ferrer, Santiago, Martínez, María Santos, Gamo, Francisco Javier, Frearson, Julie A, Gray, David W, Fairlamb, Alan H, Winzeler, Elizabeth A, Waterson, David, Campbell, Simon F, Willis, Paul, Read, Kevin D, Gilbert, Ian H
Published in Journal of medicinal chemistry (14.07.2016)
Published in Journal of medicinal chemistry (14.07.2016)
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Hameed P, Shahul, Chinnapattu, Murugan, Shanbag, Gajanan, Manjrekar, Praveena, Koushik, Krishna, Raichurkar, Anandkumar, Patil, Vikas, Jatheendranath, Sandesh, Rudrapatna, Suresh S, Barde, Shubhada P, Rautela, Nikhil, Awasthy, Disha, Morayya, Sapna, Narayan, Chandan, Kavanagh, Stefan, Saralaya, Ramanatha, Bharath, Sowmya, Viswanath, Pavithra, Mukherjee, Kakoli, Bandodkar, Balachandra, Srivastava, Abhishek, Panduga, Vijender, Reddy, Jitender, Prabhakar, K. R, Sinha, Achyut, Jiménez-Díaz, María Belén, Martínez, María Santos, Angulo-Barturen, Iñigo, Ferrer, Santiago, Sanz, Laura María, Gamo, Francisco Javier, Duffy, Sandra, Avery, Vicky M, Magistrado, Pamela A, Lukens, Amanda K, Wirth, Dyann F, Waterson, David, Balasubramanian, V, Iyer, Pravin S, Narayanan, Shridhar, Hosagrahara, Vinayak, Sambandamurthy, Vasan K, Ramachandran, Sreekanth
Published in Journal of medicinal chemistry (10.07.2014)
Published in Journal of medicinal chemistry (10.07.2014)
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Aminoindoles, a Novel Scaffold with Potent Activity against Plasmodium falciparum
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Published in Antimicrobial Agents and Chemotherapy (01.12.2011)
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A novel multiple-stage antimalarial agent that inhibits protein synthesis
Baragaña, Beatriz, Hallyburton, Irene, Lee, Marcus C. S., Norcross, Neil R., Grimaldi, Raffaella, Otto, Thomas D., Proto, William R., Blagborough, Andrew M., Meister, Stephan, Wirjanata, Grennady, Ruecker, Andrea, Upton, Leanna M., Abraham, Tara S., Almeida, Mariana J., Pradhan, Anupam, Porzelle, Achim, Martínez, María Santos, Bolscher, Judith M., Woodland, Andrew, Luksch, Torsten, Norval, Suzanne, Zuccotto, Fabio, Thomas, John, Simeons, Frederick, Stojanovski, Laste, Osuna-Cabello, Maria, Brock, Paddy M., Churcher, Tom S., Sala, Katarzyna A., Zakutansky, Sara E., Jiménez-Díaz, María Belén, Sanz, Laura Maria, Riley, Jennifer, Basak, Rajshekhar, Campbell, Michael, Avery, Vicky M., Sauerwein, Robert W., Dechering, Koen J., Noviyanti, Rintis, Campo, Brice, Frearson, Julie A., Angulo-Barturen, Iñigo, Ferrer-Bazaga, Santiago, Gamo, Francisco Javier, Wyatt, Paul G., Leroy, Didier, Siegl, Peter, Delves, Michael J., Kyle, Dennis E., Wittlin, Sergio, Marfurt, Jutta, Price, Ric N., Sinden, Robert E., Winzeler, Elizabeth A., Charman, Susan A., Bebrevska, Lidiya, Gray, David W., Campbell, Simon, Fairlamb, Alan H., Willis, Paul A., Rayner, Julian C., Fidock, David A., Read, Kevin D., Gilbert, Ian H.
Published in Nature (London) (18.06.2015)
Published in Nature (London) (18.06.2015)
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Pyrazoleamide compounds are potent antimalarials that target Na+ homeostasis in intraerythrocytic Plasmodium falciparum
Vaidya, Akhil B., Morrisey, Joanne M., Zhang, Zhongsheng, Das, Sudipta, Daly, Thomas M., Otto, Thomas D., Spillman, Natalie J., Wyvratt, Matthew, Siegl, Peter, Marfurt, Jutta, Wirjanata, Grennady, Sebayang, Boni F., Price, Ric N., Chatterjee, Arnab, Nagle, Advait, Stasiak, Marcin, Charman, Susan A., Angulo-Barturen, Iñigo, Ferrer, Santiago, Belén Jiménez-Díaz, María, Martínez, María Santos, Gamo, Francisco Javier, Avery, Vicky M., Ruecker, Andrea, Delves, Michael, Kirk, Kiaran, Berriman, Matthew, Kortagere, Sandhya, Burrows, Jeremy, Fan, Erkang, Bergman, Lawrence W.
Published in Nature communications (25.11.2014)
Published in Nature communications (25.11.2014)
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Comparative study of the disposition of levofloxacin, netilmicin and cefepime in the isolated rat lung
Martínez Martínez, María Santos, Gandarillas, Clara Isabel Colino, Martínez Lanao, José, Sánchez Navarro, Amparo
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Published in Journal of pharmacy and pharmacology (01.07.2005)
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Triaminopyrimidine is a fast-killing and long-acting antimalarial clinical candidate
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Published in Nature communications (31.03.2015)
Published in Nature communications (31.03.2015)
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Histone methyltransferase inhibitors are orally bioavailable, fast-acting molecules with activity against different species causing malaria in humans
Malmquist, Nicholas A, Sundriyal, Sandeep, Caron, Joachim, Chen, Patty, Witkowski, Benoit, Menard, Didier, Suwanarusk, Rossarin, Renia, Laurent, Nosten, Francois, Jiménez-Díaz, María Belén, Angulo-Barturen, Iñigo, Santos Martínez, María, Ferrer, Santiago, Sanz, Laura M, Gamo, Francisco-Javier, Wittlin, Sergio, Duffy, Sandra, Avery, Vicky M, Ruecker, Andrea, Delves, Michael J, Sinden, Robert E, Fuchter, Matthew J, Scherf, Artur
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Published in Antimicrobial agents and chemotherapy (01.02.2015)
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Synthesis and profiling of benzylmorpholine 1,2,4,5-tetraoxane analogue N205: Towards tetraoxane scaffolds with potential for single dose cure of malaria
O' Neill, Paul M., Stocks, Paul A., Sabbani, Sunil, Roberts, Natalie L., Amewu, Richard K., Shore, Emma R., Aljayyoussi, Ghaith, Angulo-Barturén, Iñigo, Belén, María, Jiménez-Díaz, Bazaga, Santiago Ferrer, Martínez, María Santos, Campo, Brice, Sharma, Raman, Charman, Susan A., Ryan, Eileen, Chen, Gong, Shackleford, David M., Davies, Jill, Nixon, Gemma L., Biagini, Giancarlo A., Ward, Stephen A.
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Published in Bioorganic & medicinal chemistry (15.07.2018)
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