Development of a Highly Selective Plasmodium falciparum Proteasome Inhibitor with Anti‐malaria Activity in Humanized Mice
Zhan, Wenhu, Zhang, Hao, Ginn, John, Leung, Annie, Liu, Yi J., Michino, Mayako, Toita, Akinori, Okamoto, Rei, Wong, Tzu‐Tshin, Imaeda, Toshihiro, Hara, Ryoma, Yukawa, Takafumi, Chelebieva, Sevil, Tumwebaze, Patrick K., Lafuente‐Monasterio, Maria Jose, Martinez‐Martinez, Maria Santos, Vendome, Jeremie, Beuming, Thijs, Sato, Kenjiro, Aso, Kazuyoshi, Rosenthal, Philip J., Cooper, Roland A., Meinke, Peter T., Nathan, Carl F., Kirkman, Laura A., Lin, Gang
Published in Angewandte Chemie International Edition (19.04.2021)
Published in Angewandte Chemie International Edition (19.04.2021)
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Tetrahydro-2-naphthyl and 2‑Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity
Kokkonda, Sreekanth, Deng, Xiaoyi, White, Karen L, Coteron, Jose M, Marco, Maria, de las Heras, Laura, White, John, El Mazouni, Farah, Tomchick, Diana R, Manjalanagara, Krishne, Rudra, Kakali Rani, Chen, Gong, Morizzi, Julia, Ryan, Eileen, Kaminsky, Werner, Leroy, Didier, Martínez-Martínez, María Santos, Jimenez-Diaz, Maria Belen, Bazaga, Santiago Ferrer, Angulo-Barturen, Iñigo, Waterson, David, Burrows, Jeremy N, Matthews, Dave, Charman, Susan A, Phillips, Margaret A, Rathod, Pradipsinh K
Published in Journal of medicinal chemistry (09.06.2016)
Published in Journal of medicinal chemistry (09.06.2016)
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(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium
Jiménez-Díaz, María Belén, Ebert, Daniel, Salinas, Yandira, Pradhan, Anupam, Lehane, Adele M, Myrand-Lapierre, Marie-Eve, O'Loughlin, Kathleen G, Shackleford, David M, Justino de Almeida, Mariana, Carrillo, Angela K, Clark, Julie A, Dennis, Adelaide S M, Diep, Jonathon, Deng, Xiaoyan, Duffy, Sandra, Endsley, Aaron N, Fedewa, Greg, Guiguemde, W Armand, Gómez, María G, Holbrook, Gloria, Horst, Jeremy, Kim, Charles C, Liu, Jian, Lee, Marcus C S, Matheny, Amy, Martínez, María Santos, Miller, Gregory, Rodríguez-Alejandre, Ane, Sanz, Laura, Sigal, Martina, Spillman, Natalie J, Stein, Philip D, Wang, Zheng, Zhu, Fangyi, Waterson, David, Knapp, Spencer, Shelat, Anang, Avery, Vicky M, Fidock, David A, Gamo, Francisco-Javier, Charman, Susan A, Mirsalis, Jon C, Ma, Hongshen, Ferrer, Santiago, Kirk, Kiaran, Angulo-Barturen, Iñigo, Kyle, Dennis E, DeRisi, Joseph L, Floyd, David M, Guy, R Kiplin
Published in Proceedings of the National Academy of Sciences - PNAS (16.12.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (16.12.2014)
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GSK2556286 Is a Novel Antitubercular Drug Candidate Effective In Vivo with the Potential To Shorten Tuberculosis Treatment
Nuermberger, Eric L, Martínez-Martínez, Maria Santos, Sanz, Olalla, Urones, Beatriz, Esquivias, Jorge, Soni, Heena, Tasneen, Rokeya, Tyagi, Sandeep, Li, Si-Yang, Converse, Paul J, Boshoff, Helena I, Robertson, Gregory T, Besra, Gurdyal S, Abrahams, Katherine A, Upton, Anna M, Mdluli, Khisimuzi, Boyle, Gary W, Turner, Sam, Fotouhi, Nader, Cammack, Nicholas C, Siles, Juan Miguel, Alonso, Marta, Escribano, Jaime, Lelievre, Joel, Rullas-Trincado, Joaquin, Pérez-Herrán, Esther, Bates, Robert H, Maher-Edwards, Gareth, Barros, David, Ballell, Lluís, Jiménez, Elena
Published in Antimicrobial agents and chemotherapy (21.06.2022)
Published in Antimicrobial agents and chemotherapy (21.06.2022)
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An efficient synthetic route for preparation of antimycobacterial wollamides and evaluation of their in vitro and in vivo efficacy
Asfaw, Henok, Wetzlar, Thomas, Martinez-Martinez, Maria Santos, Imming, Peter
Published in Bioorganic & medicinal chemistry letters (15.09.2018)
Published in Bioorganic & medicinal chemistry letters (15.09.2018)
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The Role of Mucin in the Toxicological Impact of Polystyrene Nanoparticles
Inkielewicz-Stepniak, Iwona, Tajber, Lidia, Behan, Gavin, Zhang, Hongzhou, Radomski, Marek W, Medina, Carlos, Santos-Martinez, Maria J
Published in Materials (03.05.2018)
Published in Materials (03.05.2018)
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Nanoparticle Adhesion to the Cell Membrane and Its Effect on Nanoparticle Uptake Efficiency
Lesniak, Anna, Salvati, Anna, Santos-Martinez, Maria J, Radomski, Marek W, Dawson, Kenneth A, Åberg, Christoffer
Published in Journal of the American Chemical Society (30.01.2013)
Published in Journal of the American Chemical Society (30.01.2013)
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A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance
O’Neill, Paul M., Amewu, Richard K., Charman, Susan A., Sabbani, Sunil, Gnädig, Nina F., Straimer, Judith, Fidock, David A., Shore, Emma R., Roberts, Natalie L., Wong, Michael H.-L., Hong, W. David, Pidathala, Chandrakala, Riley, Chris, Murphy, Ben, Aljayyoussi, Ghaith, Gamo, Francisco Javier, Sanz, Laura, Rodrigues, Janneth, Cortes, Carolina Gonzalez, Herreros, Esperanza, Angulo-Barturén, Iñigo, Jiménez-Díaz, María Belén, Bazaga, Santiago Ferrer, Martínez-Martínez, María Santos, Campo, Brice, Sharma, Raman, Ryan, Eileen, Shackleford, David M., Campbell, Simon, Smith, Dennis A., Wirjanata, Grennady, Noviyanti, Rintis, Price, Ric N., Marfurt, Jutta, Palmer, Michael J., Copple, Ian M., Mercer, Amy E., Ruecker, Andrea, Delves, Michael J., Sinden, Robert E., Siegl, Peter, Davies, Jill, Rochford, Rosemary, Kocken, Clemens H. M., Zeeman, Anne-Marie, Nixon, Gemma L., Biagini, Giancarlo A., Ward, Stephen A.
Published in Nature communications (24.05.2017)
Published in Nature communications (24.05.2017)
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Design, synthesis and structure-activity relationship study of wollamide B; a new potential anti TB agent
Asfaw, Henok, Laqua, Katja, Walkowska, Anna Maria, Cunningham, Fraser, Martinez-Martinez, Maria Santos, Cuevas-Zurita, Juan Carlos, Ballell-Pages, Lluís, Imming, Peter
Published in PloS one (19.04.2017)
Published in PloS one (19.04.2017)
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Medicinal Chemistry Optimization of a Diaminopurine Chemotype: Toward a Lead for Trypanosoma brucei Inhibitors
Singh, Baljinder, Diaz-Gonzalez, Rosario, Ceballos-Perez, Gloria, Rojas-Barros, Domingo I, Gunaganti, Naresh, Gillingwater, Kirsten, Martinez-Martinez, Maria Santos, Manzano, Pilar, Navarro, Miguel, Pollastri, Michael P
Published in Journal of medicinal chemistry (10.09.2020)
Published in Journal of medicinal chemistry (10.09.2020)
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Identification of KasA as the cellular target of an anti-tubercular scaffold
Abrahams, Katherine A., Chung, Chun-wa, Ghidelli-Disse, Sonja, Rullas, Joaquín, Rebollo-López, María José, Gurcha, Sudagar S., Cox, Jonathan A. G., Mendoza, Alfonso, Jiménez-Navarro, Elena, Martínez-Martínez, María Santos, Neu, Margarete, Shillings, Anthony, Homes, Paul, Argyrou, Argyrides, Casanueva, Ruth, Loman, Nicholas J., Moynihan, Patrick J., Lelièvre, Joël, Selenski, Carolyn, Axtman, Matthew, Kremer, Laurent, Bantscheff, Marcus, Angulo-Barturen, Iñigo, Izquierdo, Mónica Cacho, Cammack, Nicholas C., Drewes, Gerard, Ballell, Lluis, Barros, David, Besra, Gurdyal S., Bates, Robert H.
Published in Nature communications (01.09.2016)
Published in Nature communications (01.09.2016)
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Hit-to-Lead Optimization of Benzoxazepinoindazoles As Human African Trypanosomiasis Therapeutics
Klug, Dana M, Tschiegg, Laura, Diaz, Rosario, Rojas-Barros, Domingo, Perez-Moreno, Guiomar, Ceballos, Gloria, García-Hernández, Raquel, Martinez-Martinez, Maria Santos, Manzano, Pilar, Ruiz, Luis Miguel, Caffrey, Conor R, Gamarro, Francisco, Pacanowska, Dolores Gonzalez, Ferrins, Lori, Navarro, Miguel, Pollastri, Michael P
Published in Journal of medicinal chemistry (12.03.2020)
Published in Journal of medicinal chemistry (12.03.2020)
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Exploring the SAR of the β‑Ketoacyl-ACP Synthase Inhibitor GSK3011724A and Optimization around a Genotoxic Metabolite
Cunningham, Fraser, Esquivias, Jorge, Fernández-Menéndez, Raquel, Pérez, Arancha, Guardia, Ana, Escribano, Jaime, Rivero, Cristina, Vimal, Mythily, Cacho, Mónica, de Dios-Antón, Paco, Martínez-Martínez, María Santos, Jiménez, Elena, Huertas Valentín, Leticia, Rebollo-López, María José, López-Román, Eva María, Sousa-Morcuende, Verónica, Rullas, Joaquín, Neu, Margaret, Chung, Chun-wa, Bates, Robert H
Published in ACS infectious diseases (08.05.2020)
Published in ACS infectious diseases (08.05.2020)
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Bleeding and Thrombosis in Multiple Myeloma: Platelets as Key Players during Cell Interactions and Potential Use as Drug Delivery Systems
Kulkarni, Anushka, Bazou, Despina, Santos-Martinez, Maria José
Published in International journal of molecular sciences (01.11.2023)
Published in International journal of molecular sciences (01.11.2023)
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Selectivity and Physicochemical Optimization of Repurposed Pyrazolo[1,5‑b]pyridazines for the Treatment of Human African Trypanosomiasis
Tear, Westley F, Bag, Seema, Diaz-Gonzalez, Rosario, Ceballos-Pérez, Gloria, Rojas-Barros, Domingo I, Cordon-Obras, Carlos, Pérez-Moreno, Guiomar, García-Hernández, Raquel, Martinez-Martinez, Maria Santos, Ruiz-Perez, Luis Miguel, Gamarro, Francisco, Gonzalez Pacanowska, Dolores, Caffrey, Conor R, Ferrins, Lori, Manzano, Pilar, Navarro, Miguel, Pollastri, Michael P
Published in Journal of medicinal chemistry (23.01.2020)
Published in Journal of medicinal chemistry (23.01.2020)
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Journal Article
Lead Optimization of 3,5-Disubstituted-7-Azaindoles for the Treatment of Human African Trypanosomiasis
Klug, Dana M, Mavrogiannaki, Eftychia M, Forbes, Katherine C, Silva, Lisseth, Diaz-Gonzalez, Rosario, Pérez-Moreno, Guiomar, Ceballos-Pérez, Gloria, Garcia-Hernández, Raquel, Bosch-Navarrete, Cristina, Cordón-Obras, Carlos, Gómez-Liñán, Claudia, Saura, Andreu, Momper, Jeremiah D, Martinez-Martinez, Maria Santos, Manzano, Pilar, Syed, Ali, El-Sakkary, Nelly, Caffrey, Conor R, Gamarro, Francisco, Ruiz-Perez, Luis Miguel, Gonzalez Pacanowska, Dolores, Ferrins, Lori, Navarro, Miguel, Pollastri, Michael P
Published in Journal of medicinal chemistry (08.07.2021)
Published in Journal of medicinal chemistry (08.07.2021)
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Identification of a Potential Antimalarial Drug Candidate from a Series of 2‑Aminopyrazines by Optimization of Aqueous Solubility and Potency across the Parasite Life Cycle
Le Manach, Claire, Nchinda, Aloysius T, Paquet, Tanya, Gonzàlez Cabrera, Diego, Younis, Yassir, Han, Ze, Bashyam, Sridevi, Zabiulla, Mohammed, Taylor, Dale, Lawrence, Nina, White, Karen L, Charman, Susan A, Waterson, David, Witty, Michael J, Wittlin, Sergio, Botha, Mariëtte E, Nondaba, Sindisiswe H, Reader, Janette, Birkholtz, Lyn-Marie, Jiménez-Díaz, María Belén, Martínez, María Santos, Ferrer, Santiago, Angulo-Barturen, Iñigo, Meister, Stephan, Antonova-Koch, Yevgeniya, Winzeler, Elizabeth A, Street, Leslie J, Chibale, Kelly
Published in Journal of medicinal chemistry (10.11.2016)
Published in Journal of medicinal chemistry (10.11.2016)
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Linking Murine and Human Plasmodium falciparum Challenge Models in a Translational Path for Antimalarial Drug Development
McCarthy, James S, Marquart, Louise, Sekuloski, Silvana, Trenholme, Katharine, Elliott, Suzanne, Griffin, Paul, Rockett, Rebecca, O'Rourke, Peter, Sloots, Theo, Angulo-Barturen, Iñigo, Ferrer, Santiago, Jiménez-Díaz, María Belén, Martínez, María-Santos, Hooft van Huijsduijnen, Rob, Duparc, Stephan, Leroy, Didier, Wells, Timothy N C, Baker, Mark, Möhrle, Jörg J
Published in Antimicrobial agents and chemotherapy (01.06.2016)
Published in Antimicrobial agents and chemotherapy (01.06.2016)
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