De Novo Design of Nurr1 Agonists via Fragment-Augmented Generative Deep Learning in Low-Data Regime
Ballarotto, Marco, Willems, Sabine, Stiller, Tanja, Nawa, Felix, Marschner, Julian A., Grisoni, Francesca, Merk, Daniel
Published in Journal of medicinal chemistry (22.06.2023)
Published in Journal of medicinal chemistry (22.06.2023)
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Journal Article
Extracellular traps in kidney disease
Nakazawa, Daigo, Marschner, Julian A., Platen, Louise, Anders, Hans-Joachim
Published in Kidney international (01.12.2018)
Published in Kidney international (01.12.2018)
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Journal Article
The macrophage phenotype and inflammasome component NLRP3 contributes to nephrocalcinosis-related chronic kidney disease independent from IL-1–mediated tissue injury
Anders, Hans-Joachim, Suarez-Alvarez, Beatriz, Grigorescu, Melissa, Foresto-Neto, Orestes, Steiger, Stefanie, Desai, Jyaysi, Marschner, Julian A., Honarpisheh, Mohsen, Shi, Chongxu, Jordan, Jutta, Müller, Lisa, Burzlaff, Nicolai, Bäuerle, Tobias, Mulay, Shrikant R.
Published in Kidney international (01.03.2018)
Published in Kidney international (01.03.2018)
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Journal Article
Endocycle-related tubular cell hypertrophy and progenitor proliferation recover renal function after acute kidney injury
Lazzeri, Elena, Angelotti, Maria Lucia, Peired, Anna, Conte, Carolina, Marschner, Julian A., Maggi, Laura, Mazzinghi, Benedetta, Lombardi, Duccio, Melica, Maria Elena, Nardi, Sara, Ronconi, Elisa, Sisti, Alessandro, Antonelli, Giulia, Becherucci, Francesca, De Chiara, Letizia, Guevara, Ricardo Romero, Burger, Alexa, Schaefer, Beat, Annunziato, Francesco, Anders, Hans-Joachim, Lasagni, Laura, Romagnani, Paola
Published in Nature communications (09.04.2018)
Published in Nature communications (09.04.2018)
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Journal Article
Development of Tailless Homologue Receptor (TLX) Agonist Chemical Tools
Hank, Emily C., Sai, Minh, Kasch, Till, Meijer, Isabelle, Marschner, Julian A., Merk, Daniel
Published in Journal of medicinal chemistry (26.09.2024)
Published in Journal of medicinal chemistry (26.09.2024)
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Journal Article
Histones and Neutrophil Extracellular Traps Enhance Tubular Necrosis and Remote Organ Injury in Ischemic AKI
Nakazawa, Daigo, Kumar, Santhosh V, Marschner, Julian, Desai, Jyaysi, Holderied, Alexander, Rath, Lukas, Kraft, Franziska, Lei, Yutian, Fukasawa, Yuichiro, Moeckel, Gilbert W, Angelotti, Maria Lucia, Liapis, Helen, Anders, Hans-Joachim
Published in Journal of the American Society of Nephrology (01.06.2017)
Published in Journal of the American Society of Nephrology (01.06.2017)
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Journal Article
Dipeptidyl peptidase-4 inhibitor teneligliptin accelerates recovery from cisplatin-induced acute kidney injury by attenuating inflammation and promoting tubular regeneration
Iwakura, Takamasa, Zhao, Zhibo, Marschner, Julian A, Devarapu, Satish Kumar, Yasuda, Hideo, Anders, Hans Joachim
Published in Nephrology, dialysis, transplantation (01.10.2019)
Published in Nephrology, dialysis, transplantation (01.10.2019)
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Journal Article
Mitochondria Permeability Transition versus Necroptosis in Oxalate-Induced AKI
Mulay, Shrikant Ramesh, Honarpisheh, Mohsen M, Foresto-Neto, Orestes, Shi, Chongxu, Desai, Jyaysi, Zhao, Zhi Bo, Marschner, Julian A, Popper, Bastian, Buhl, Ewa Miriam, Boor, Peter, Linkermann, Andreas, Liapis, Helen, Bilyy, Rostyslav, Herrmann, Martin, Romagnani, Paola, Belevich, Ilya, Jokitalo, Eija, Becker, Jan U, Anders, Hans-Joachim
Published in Journal of the American Society of Nephrology (01.10.2019)
Published in Journal of the American Society of Nephrology (01.10.2019)
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Journal Article
Intestinal Dysbiosis, Barrier Dysfunction, and Bacterial Translocation Account for CKD-Related Systemic Inflammation
Andersen, Kirstin, Kesper, Marie Sophie, Marschner, Julian A, Konrad, Lukas, Ryu, Mi, Kumar Vr, Santhosh, Kulkarni, Onkar P, Mulay, Shrikant R, Romoli, Simone, Demleitner, Jana, Schiller, Patrick, Dietrich, Alexander, Müller, Susanna, Gross, Oliver, Ruscheweyh, Hans-Joachim, Huson, Daniel H, Stecher, Bärbel, Anders, Hans-Joachim
Published in Journal of the American Society of Nephrology (01.01.2017)
Published in Journal of the American Society of Nephrology (01.01.2017)
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Journal Article
Tubular Epithelial Cell HMGB1 Promotes AKI-CKD Transition by Sensitizing Cycling Tubular Cells to Oxidative Stress: A Rationale for Targeting HMGB1 during AKI Recovery
Zhao, Zhi Bo, Marschner, Julian A, Iwakura, Takamasa, Li, Chenyu, Motrapu, Manga, Kuang, Meisi, Popper, Bastian, Linkermann, Andreas, Klocke, Jan, Enghard, Philipp, Muto, Yoshiharu, Humphreys, Benjamin D, Harris, Helena Erlandsson, Romagnani, Paola, Anders, Hans-Joachim
Published in Journal of the American Society of Nephrology (01.03.2023)
Published in Journal of the American Society of Nephrology (01.03.2023)
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Journal Article
Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury
Tonnus, Wulf, Meyer, Claudia, Steinebach, Christian, Belavgeni, Alexia, von Mässenhausen, Anne, Gonzalez, Nadia Zamora, Maremonti, Francesca, Gembardt, Florian, Himmerkus, Nina, Latk, Markus, Locke, Sophie, Marschner, Julian, Li, Wenjun, Short, Spencer, Doll, Sebastian, Ingold, Irina, Proneth, Bettina, Daniel, Christoph, Kabgani, Nazanin, Kramann, Rafael, Motika, Stephen, Hergenrother, Paul J., Bornstein, Stefan R., Hugo, Christian, Becker, Jan Ulrich, Amann, Kerstin, Anders, Hans-Joachim, Kreisel, Daniel, Pratt, Derek, Gütschow, Michael, Conrad, Marcus, Linkermann, Andreas
Published in Nature communications (20.07.2021)
Published in Nature communications (20.07.2021)
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Journal Article
A High‐Quality Photoswitchable Probe that Selectively and Potently Regulates the Transcription Factor RORγ
Reynders, Martin, Willems, Sabine, Marschner, Julian A., Wein, Thomas, Merk, Daniel, Thorn‐Seshold, Oliver
Published in Angewandte Chemie International Edition (02.12.2024)
Published in Angewandte Chemie International Edition (02.12.2024)
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Journal Article
The Kidney Contains Ontogenetically Distinct Dendritic Cell and Macrophage Subtypes throughout Development That Differ in Their Inflammatory Properties
Salei, Natallia, Rambichler, Stephan, Salvermoser, Johanna, Papaioannou, Nikos E, Schuchert, Ronja, Pakalniškytė, Dalia, Li, Na, Marschner, Julian A, Lichtnekert, Julia, Stremmel, Christopher, Cernilogar, Filippo M, Salvermoser, Melanie, Walzog, Barbara, Straub, Tobias, Schotta, Gunnar, Anders, Hans-Joachim, Schulz, Christian, Schraml, Barbara U
Published in Journal of the American Society of Nephrology (01.02.2020)
Published in Journal of the American Society of Nephrology (01.02.2020)
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Journal Article
Development of a Potent Nurr1 Agonist Tool for In Vivo Applications
Vietor, Jan, Gege, Christian, Stiller, Tanja, Busch, Romy, Schallmayer, Espen, Kohlhof, Hella, Höfner, Georg, Pabel, Jörg, Marschner, Julian A., Merk, Daniel
Published in Journal of medicinal chemistry (11.05.2023)
Published in Journal of medicinal chemistry (11.05.2023)
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Journal Article
Chemogenomics for NR1 nuclear hormone receptors
Isigkeit, Laura, Schallmayer, Espen, Busch, Romy, Brunello, Lorene, Menge, Amelie, Elson, Lewis, Müller, Susanne, Knapp, Stefan, Stolz, Alexandra, Marschner, Julian A., Merk, Daniel
Published in Nature communications (18.06.2024)
Published in Nature communications (18.06.2024)
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Journal Article
Druggability Evaluation of the Neuron Derived Orphan Receptor (NOR‐1) Reveals Inverse NOR‐1 Agonists
Zaienne, Daniel, Arifi, Silvia, Marschner, Julian A., Heering, Jan, Merk, Daniel
Published in ChemMedChem (17.08.2022)
Published in ChemMedChem (17.08.2022)
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Journal Article
Rational Design of a New RXR Agonist Scaffold Enabling Single-Subtype Preference for RXRα, RXRβ, and RXRγ
Adouvi, Gustave, Isigkeit, Laura, López-García, Úrsula, Chaikuad, Apirat, Marschner, Julian A., Schubert-Zsilavecz, Manfred, Merk, Daniel
Published in Journal of medicinal chemistry (12.01.2023)
Published in Journal of medicinal chemistry (12.01.2023)
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Journal Article
Targeting the Alternative Vitamin E Metabolite Binding Site Enables Noncanonical PPARγ Modulation
Arifi, Silvia, Marschner, Julian A., Pollinger, Julius, Isigkeit, Laura, Heitel, Pascal, Kaiser, Astrid, Obeser, Lennart, Höfner, Georg, Proschak, Ewgenij, Knapp, Stefan, Chaikuad, Apirat, Heering, Jan, Merk, Daniel
Published in Journal of the American Chemical Society (12.07.2023)
Published in Journal of the American Chemical Society (12.07.2023)
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Journal Article