Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance
Zhou, Dawang, Zhang, Yongyou, Wu, Hongtan, Barry, Evan, Yin, Yi, Lawrence, Earl, Dawson, Dawn, Willis, Joseph E, Markowitz, Sanford D, Camargo, Fernando D, Avruch, Joseph
Published in Proceedings of the National Academy of Sciences - PNAS (06.12.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (06.12.2011)
Get full text
Journal Article
Downregulation of transcription factor SOX2 in cancer stem cells suppresses growth and metastasis of lung cancer
Xiang, R, Liao, D, Cheng, T, Zhou, H, Shi, Q, Chuang, T S, Markowitz, D, Reisfeld, R A, Luo, Y
Published in British journal of cancer (26.04.2011)
Published in British journal of cancer (26.04.2011)
Get full text
Journal Article
Prostaglandin E2 Activates YAP and a Positive-Signaling Loop to Promote Colon Regeneration After Colitis but Also Carcinogenesis in Mice
Kim, Han-Byul, Kim, Minchul, Park, Young-Soo, Park, Intae, Kim, Tackhoon, Yang, Sung-Yeun, Cho, Charles J, Hwang, DaeHee, Jung, Jin-Hak, Markowitz, Sanford D, Hwang, Sung Wook, Yang, Suk-Kyun, Lim, Dae-Sik, Myung, Seung-Jae
Published in Gastroenterology (New York, N.Y. 1943) (01.02.2017)
Published in Gastroenterology (New York, N.Y. 1943) (01.02.2017)
Get full text
Journal Article
Identifying DNA methylation biomarkers for non-endoscopic detection of Barrett's esophagus
Moinova, Helen R, LaFramboise, Thomas, Lutterbaugh, James D, Chandar, Apoorva Krishna, Dumot, John, Faulx, Ashley, Brock, Wendy, De la Cruz Cabrera, Omar, Guda, Kishore, Barnholtz-Sloan, Jill S, Iyer, Prasad G, Canto, Marcia I, Wang, Jean S, Shaheen, Nicholas J, Thota, Prashanti N, Willis, Joseph E, Chak, Amitabh, Markowitz, Sanford D
Published in Science translational medicine (17.01.2018)
Published in Science translational medicine (17.01.2018)
Get more information
Journal Article
Small molecule inhibitors of 15-PGDH exploit a physiologic induced-fit closing system
Huang, Wei, Li, Hongyun, Kiselar, Janna, Fink, Stephen P., Regmi, Sagar, Day, Alexander, Yuan, Yiyuan, Chance, Mark, Ready, Joseph M., Markowitz, Sanford D., Taylor, Derek J.
Published in Nature communications (11.02.2023)
Published in Nature communications (11.02.2023)
Get full text
Journal Article
5-Fluorouracil Enhances the Antitumor Activity of the Glutaminase Inhibitor CB-839 against PIK3CA -Mutant Colorectal Cancers
Zhao, Yiqing, Feng, Xiujing, Chen, Yicheng, Selfridge, J Eva, Gorityala, Shashank, Du, Zhanwen, Wang, Janet M, Hao, Yujun, Cioffi, Gino, Conlon, Ronald A, Barnholtz-Sloan, Jill S, Saltzman, Joel, Krishnamurthi, Smitha S, Vinayak, Shaveta, Veigl, Martina, Xu, Yan, Bajor, David L, Markowitz, Sanford D, Meropol, Neal J, Eads, Jennifer R, Wang, Zhenghe
Published in Cancer research (Chicago, Ill.) (01.11.2020)
Published in Cancer research (Chicago, Ill.) (01.11.2020)
Get full text
Journal Article
IL-33 activates tumor stroma to promote intestinal polyposis
Maywald, Rebecca L., Doerner, Stephanie K., Pastorelli, Luca, De Salvo, Carlo, Benton, Susan M., Dawson, Emily P., Lanza, Denise G., Berger, Nathan A., Markowitz, Sanford D., Lenz, Heinz-Josef, Nadeau, Joseph H., Pizarro, Theresa T., Heaney, Jason D.
Published in Proceedings of the National Academy of Sciences - PNAS (12.05.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (12.05.2015)
Get full text
Journal Article
Differences in DNA Methylation Signatures Reveal Multiple Pathways of Progression From Adenoma to Colorectal Cancer
Luo, Yanxin, Wong, Chao-Jen, Kaz, Andrew M, Dzieciatkowski, Slavomir, Carter, Kelly T, Morris, Shelli M, Wang, Jianping, Willis, Joseph E, Makar, Karen W, Ulrich, Cornelia M, Lutterbaugh, James D, Shrubsole, Martha J, Zheng, Wei, Markowitz, Sanford D, Grady, William M
Published in Gastroenterology (New York, N.Y. 1943) (01.08.2014)
Published in Gastroenterology (New York, N.Y. 1943) (01.08.2014)
Get full text
Journal Article
Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration
Zhang, Yongyou, Desai, Amar, Yang, Sung Yeun, Bae, Ki Beom, Antczak, Monika I., Fink, Stephen P., Tiwari, Shruti, Willis, Joseph E., Williams, Noelle S., Dawson, Dawn M., Wald, David, Chen, Wei-Dong, Wang, Zhenghe, Kasturi, Lakshmi, Larusch, Gretchen A., He, Lucy, Cominelli, Fabio, Di Martino, Luca, Djuric, Zora, Milne, Ginger L., Chance, Mark, Sanabria, Juan, Dealwis, Chris, Mikkola, Debra, Naidoo, Jacinth, Wei, Shuguang, Tai, Hsin-Hsiung, Gerson, Stanton L., Ready, Joseph M., Posner, Bruce, Willson, James K. V., Markowitz, Sanford D.
Published in Science (American Association for the Advancement of Science) (12.06.2015)
Published in Science (American Association for the Advancement of Science) (12.06.2015)
Get full text
Journal Article
Comparative lesion sequencing provides insights into tumor evolution
Jones, Siân, Chen, Wei-dong, Parmigiani, Giovanni, Diehl, Frank, Beerenwinkel, Niko, Antal, Tibor, Traulsen, Arne, Nowak, Martin A, Siegel, Christopher, Velculescu, Victor E, Kinzler, Kenneth W, Vogelstein, Bert, Willis, Joseph, Markowitz, Sanford D
Published in Proceedings of the National Academy of Sciences - PNAS (18.03.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (18.03.2008)
Get full text
Journal Article
DNMT1 stability is regulated by proteins coordinating deubiquitination and acetylation-driven ubiquitination
Du, Zhanwen, Song, Jing, Wang, Yong, Zhao, Yiqing, Guda, Kishore, Yang, Shuming, Kao, Hung-Ying, Xu, Yan, Willis, Joseph, Markowitz, Sanford D, Sedwick, David, Ewing, Robert M, Wang, Zhenghe
Published in Science signaling (02.11.2010)
Published in Science signaling (02.11.2010)
Get more information
Journal Article
Genomic Landscapes of Human Breast and Colorectal Cancers
Wood, Laura D, Parsons, D. Williams, Jones, Siân, Lin, Jimmy, Sjöblom, Tobias, Leary, Rebecca J, Shen, Dong, Boca, Simina M, Barber, Thomas, Ptak, Janine, Silliman, Natalie, Szabo, Steve, Dezso, Zoltan, Ustyanksky, Vadim, Nikolskaya, Tatiana, Nikolsky, Yuri, Karchin, Rachel, Wilson, Paul A, Kaminker, Joshua S, Zhang, Zemin, Croshaw, Randal, Willis, Joseph, Dawson, Dawn, Shipitsin, Michail, Willson, James K.V, Sukumar, Saraswati, Polyak, Kornelia, Park, Ben Ho, Pethiyagoda, Charit L, Pant, P.V. Krishna, Ballinger, Dennis G, Sparks, Andrew B, Hartigan, James, Smith, Douglas R, Suh, Erick, Papadopoulos, Nickolas, Buckhaults, Phillip, Markowitz, Sanford D, Parmigiani, Giovanni, Kinzler, Kenneth W, Velculescu, Victor E, Vogelstein, Bert
Published in Science (American Association for the Advancement of Science) (16.11.2007)
Published in Science (American Association for the Advancement of Science) (16.11.2007)
Get full text
Journal Article
The noncoding RNA, miR-126, suppresses the growth of neoplastic cells by targeting phosphatidylinositol 3-kinase signaling and is frequently lost in colon cancers
Guo, Chunguang, Sah, Jerome F., Beard, Lydia, Willson, James K. V., Markowitz, Sanford D., Guda, Kishore
Published in Genes chromosomes & cancer (01.11.2008)
Published in Genes chromosomes & cancer (01.11.2008)
Get full text
Journal Article
Hotspots of aberrant enhancer activity punctuate the colorectal cancer epigenome
Cohen, Andrea J., Saiakhova, Alina, Corradin, Olivia, Luppino, Jennifer M., Lovrenert, Katreya, Bartels, Cynthia F., Morrow, James J., Mack, Stephen C., Dhillon, Gursimran, Beard, Lydia, Myeroff, Lois, Kalady, Matthew F., Willis, Joseph, Bradner, James E., Keri, Ruth A., Berger, Nathan A., Pruett-Miller, Shondra M., Markowitz, Sanford D., Scacheri, Peter C.
Published in Nature communications (07.02.2017)
Published in Nature communications (07.02.2017)
Get full text
Journal Article
Novel recurrently mutated genes in African American colon cancers
Guda, Kishore, Veigl, Martina L., Varadan, Vinay, Nosrati, Arman, Ravi, Lakshmeswari, Lutterbaugh, James, Beard, Lydia, Willson, James K. V., Sedwick, W. David, Wang, Zhenghe John, Molyneaux, Neil, Miron, Alexander, Adams, Mark D., Elston, Robert C., Markowitz, Sanford D., Willis, Joseph E.
Published in Proceedings of the National Academy of Sciences - PNAS (27.01.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (27.01.2015)
Get full text
Journal Article
Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer
Baylin, Stephen B, Suzuki, Hiromu, Watkins, D Neil, Jair, Kam-Wing, Schuebel, Kornel E, Markowitz, Sanford D, Dong Chen, Wei, Pretlow, Theresa P, Yang, Bin, Akiyama, Yoshimitsu, van Engeland, Manon, Toyota, Minoru, Tokino, Takashi, Hinoda, Yuji, Imai, Kohzoh, Herman, James G
Published in Nature genetics (01.04.2004)
Published in Nature genetics (01.04.2004)
Get full text
Journal Article
Emerging Paradigms for the Initiation of Mucin-type Protein O-Glycosylation by the Polypeptide GalNAc Transferase Family of Glycosyltransferases
Gerken, Thomas A., Jamison, Oliver, Perrine, Cynthia L., Collette, Jeremy C., Moinova, Helen, Ravi, Lakshmeswari, Markowitz, Sanford D., Shen, Wei, Patel, Himatkumar, Tabak, Lawrence A.
Published in The Journal of biological chemistry (22.04.2011)
Published in The Journal of biological chemistry (22.04.2011)
Get full text
Journal Article
Consensus Coding Sequences of Human Breast and Colorectal Cancers
Sjöblom, Tobias, Jones, Siân, Wood, Laura D, Parsons, D. Williams, Lin, Jimmy, Barber, Thomas D, Mandelker, Diana, Leary, Rebecca J, Ptak, Janine, Silliman, Natalie, Szabo, Steve, Buckhaults, Phillip, Farrell, Christopher, Meeh, Paul, Markowitz, Sanford D, Willis, Joseph, Dawson, Dawn, Willson, James K.V, Gazdar, Adi F, Hartigan, James, Wu, Leo, Liu, Changsheng, Parmigiani, Giovanni, Park, Ben Ho, Bachman, Kurtis E, Papadopoulos, Nickolas, Vogelstein, Bert, Kinzler, Kenneth W, Velculescu, Victor E
Published in Science (American Association for the Advancement of Science) (13.10.2006)
Published in Science (American Association for the Advancement of Science) (13.10.2006)
Get full text
Journal Article