Excess glutamate secreted from astrocytes drives upregulation of P-glycoprotein in endothelial cells in amyotrophic lateral sclerosis
Mohamed, Loqman A., Markandaiah, Shashirekha S., Bonanno, Silvia, Pasinelli, Piera, Trotti, Davide
Published in Experimental neurology (01.06.2019)
Published in Experimental neurology (01.06.2019)
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Journal Article
Antisense Proline-Arginine RAN Dipeptides Linked to C9ORF72-ALS/FTD Form Toxic Nuclear Aggregates that Initiate In Vitro and In Vivo Neuronal Death
Wen, Xinmei, Tan, Wenzhi, Westergard, Thomas, Krishnamurthy, Karthik, Markandaiah, Shashirekha S., Shi, Yingxiao, Lin, Shaoyu, Shneider, Neil A., Monaghan, John, Pandey, Udai B., Pasinelli, Piera, Ichida, Justin K., Trotti, Davide
Published in Neuron (Cambridge, Mass.) (17.12.2014)
Published in Neuron (Cambridge, Mass.) (17.12.2014)
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Journal Article
A mouse model with widespread expression of the C9orf72-linked glycine–arginine dipeptide displays non-lethal ALS/FTD-like phenotypes
Verdone, Brandie Morris, Cicardi, Maria Elena, Wen, Xinmei, Sriramoji, Sindhu, Russell, Katelyn, Markandaiah, Shashirekha S., Jensen, Brigid K., Krishnamurthy, Karthik, Haeusler, Aaron R., Pasinelli, Piera, Trotti, Davide
Published in Scientific reports (04.04.2022)
Published in Scientific reports (04.04.2022)
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Journal Article
Astrocytes drive upregulation of the multidrug resistance transporter ABCB1 (P-Glycoprotein) in endothelial cells of the blood-brain barrier in mutant superoxide dismutase 1-linked amyotrophic lateral sclerosis
Qosa, Hisham, Lichter, Jessica, Sarlo, Mark, Markandaiah, Shashirekha S., McAvoy, Kevin, Richard, Jean-Philippe, Jablonski, Michael R., Maragakis, Nicholas J., Pasinelli, Piera, Trotti, Davide
Published in Glia (01.08.2016)
Published in Glia (01.08.2016)
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Journal Article
Glucose hypometabolism prompts RAN translation and exacerbates C9orf72-related ALS/FTD phenotypes
Nelson, Andrew T, Cicardi, Maria Elena, Markandaiah, Shashirekha S, Han, John YS, Philp, Nancy J, Welebob, Emily, Haeusler, Aaron R, Pasinelli, Piera, Manfredi, Giovanni, Kawamata, Hibiki, Trotti, Davide
Published in EMBO reports (14.05.2024)
Published in EMBO reports (14.05.2024)
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Journal Article
EphrinB2 knockdown in cervical spinal cord preserves diaphragm innervation in a mutant SOD1 mouse model of ALS
Urban, Mark W, Charsar, Brittany A, Heinsinger, Nicolette M, Markandaiah, Shashirekha S, Sprimont, Lindsay, Zhou, Wei, Brown, Eric V, Henderson, Nathan T, Thomas, Samantha J, Ghosh, Biswarup, Cain, Rachel E, Trotti, Davide, Pasinelli, Piera, Wright, Megan C, Dalva, Matthew B, Lepore, Angelo C
Published in eLife (15.01.2024)
Published in eLife (15.01.2024)
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Journal Article
Inhibiting drug efflux transporters improves efficacy of ALS therapeutics
Jablonski, Michael R., Markandaiah, Shashirekha S., Jacob, Dena, Meng, Ni J., Li, Ke, Gennaro, Victoria, Lepore, Angelo C., Trotti, Davide, Pasinelli, Piera
Published in Annals of clinical and translational neurology (01.12.2014)
Published in Annals of clinical and translational neurology (01.12.2014)
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Journal Article
Mutation of the caspase-3 cleavage site in the astroglial glutamate transporter EAAT2 delays disease progression and extends lifespan in the SOD1-G93A mouse model of ALS
Rosenblum, Lauren Taylor, Shamamandri-Markandaiah, Shashirekha, Ghosh, Biswarup, Foran, Emily, Lepore, Angelo C., Pasinelli, Piera, Trotti, Davide
Published in Experimental neurology (01.06.2017)
Published in Experimental neurology (01.06.2017)
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Journal Article
EphrinB2 knockdown in cervical spinal cord preserves diaphragm innervation in a mutant SOD1 mouse model of ALS
Urban, Mark W, Charsar, Brittany A, Heinsinger, Nicolette M, Markandaiah, Shashirekha S, Sprimont, Lindsay, Zhou, Wei, Brown, Eric V, Henderson, Nathan T, Thomas, Samantha J, Ghosh, Biswarup, Cain, Rachel E, Trotti, Davide, Pasinelli, Piera, Wright, Megan C, Dalva, Matthew B, Lepore, Angelo C
Published in eLife (15.01.2024)
Published in eLife (15.01.2024)
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Journal Article
Antisense Proline-Arginine RAN Dipeptides Linked toC9ORF72-ALS/FTD Form Toxic Nuclear Aggregates that Initiate In Vitro and In Vivo Neuronal Death
Wen, Xinmei, Tan, Wenzhi, Westergard, Thomas, Krishnamurthy, Karthik, Markandaiah, Shashirekha S, Shi, Yingxiao, Lin, Shaoyu, Shneider, Neil A, Monaghan, John, Pandey, Udai B, Pasinelli, Piera, Ichida, Justin K, Trotti, Davide
Published in Neuron (Cambridge, Mass.) (17.12.2014)
Published in Neuron (Cambridge, Mass.) (17.12.2014)
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Journal Article
EphrinB2 knockdown in cervical spinal cord preserves diaphragm innervation in a mutant SOD1 mouse model of ALS
Urban, Mark W, Charsar, Brittany A, Heinsinger, Nicolette M, Markandaiah, Shashirekha S, Sprimont, Lindsay, Zhou, Wei, Brown, Eric V, Henderson, Nathan T, Thomas, Samantha J, Ghosh, Biswarup, Cain, Rachel E, Trotti, Davide, Pasinelli, Piera, Wright, Megan C, Dalva, Matthew B, Lepore, Angelo C
Published in bioRxiv : the preprint server for biology (30.10.2023)
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Published in bioRxiv : the preprint server for biology (30.10.2023)
Journal Article
A mouse model with widespread expression of the C9orf72-linked glycine-arginine dipeptide displays non-lethal ALS/FTD-like phenotypes
Verdone, Brandie, Cicardi, Maria, Wen, Xinmei, Sriramoji, Sindhu, Russell, Katelyn, Shashirekha Markandaiah, Jensen, Brigid, Krishnamurthy, Karthik, Haeusler, Aaron, Pasinelli, Piera, Trotti, Davide
Published in Scientific Reports (28.02.2022)
Published in Scientific Reports (28.02.2022)
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C9orf72 poly(PR) mediated neurodegeneration is associated with nucleolar stress
Cicardi, Maria Elena, Hallgren, Justin, Darilang, Mawrie, Krishnamurthy, Karthik, Shashirekha Shamamandri Markandaiah, Nelson, Andrew T, Kankate, Vaishnavi, Anderson, Eric, Pasinelli, Piera, Udai Bhan Pandey, Eischen, Christine M, Trotti, Davide
Published in bioRxiv (16.02.2023)
Published in bioRxiv (16.02.2023)
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