The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes
Kasper, Lydia, König, Annika, Koenig, Paul-Albert, Gresnigt, Mark S., Westman, Johannes, Drummond, Rebecca A., Lionakis, Michail S., Groß, Olaf, Ruland, Jürgen, Naglik, Julian R., Hube, Bernhard
Published in Nature communications (15.10.2018)
Published in Nature communications (15.10.2018)
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Journal Article
In vitro infection models to study fungal–host interactions
Last, Antonia, Maurer, Michelle, S. Mosig, Alexander, S. Gresnigt, Mark, Hube, Bernhard
Published in FEMS microbiology reviews (01.09.2021)
Published in FEMS microbiology reviews (01.09.2021)
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Journal Article
Candida albicans colonization of the gastrointestinal tract: A double-edged sword
Alonso-Monge, Rebeca, Gresnigt, Mark S, Román, Elvira, Hube, Bernhard, Pla, Jesús
Published in PLoS pathogens (22.07.2021)
Published in PLoS pathogens (22.07.2021)
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Journal Article
IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans
de Luca, Antonella, Smeekens, Sanne P., Casagrande, Andrea, Iannitti, Rossana, Conway, Kara L., Gresnigt, Mark. S., Begun, Jakob, Plantinga, Theo S., Joosten, Leo A. B., van der Meer, Jos W. M., Chamilos, Georgios, Netea, Mihai G., Xavier, Ramnik J., Dinarello, Charles A., Romani, Luigina, van de Veerdonk, Frank L.
Published in Proceedings of the National Academy of Sciences - PNAS (04.03.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (04.03.2014)
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Journal Article
Aspergillus Cell Wall Melanin Blocks LC3-Associated Phagocytosis to Promote Pathogenicity
Akoumianaki, Tonia, Kyrmizi, Irene, Valsecchi, Isabel, Gresnigt, Mark S., Samonis, George, Drakos, Elias, Boumpas, Dimitrios, Muszkieta, Laetitia, Prevost, Marie-Christine, Kontoyiannis, Dimitrios P., Chavakis, Triantafyllos, Netea, Mihai G., van de Veerdonk, Frank L., Brakhage, Axel A., El-Benna, Jamel, Beauvais, Anne, Latge, Jean-Paul, Chamilos, Georgios
Published in Cell host & microbe (13.01.2016)
Published in Cell host & microbe (13.01.2016)
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Journal Article
Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis
Cheng, Shih-Chin, Scicluna, Brendon P, Arts, Rob J W, Gresnigt, Mark S, Lachmandas, Ekta, Giamarellos-Bourboulis, Evangelos J, Kox, Matthijs, Manjeri, Ganesh R, Wagenaars, Jori A L, Cremer, Olaf L, Leentjens, Jenneke, van der Meer, Anne J, van de Veerdonk, Frank L, Bonten, Marc J, Schultz, Marcus J, Willems, Peter H G M, Pickkers, Peter, Joosten, Leo A B, van der Poll, Tom, Netea, Mihai G
Published in Nature immunology (01.04.2016)
Published in Nature immunology (01.04.2016)
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Journal Article
Lactobacillus rhamnosus colonisation antagonizes Candida albicans by forcing metabolic adaptations that compromise pathogenicity
Alonso-Roman, Raquel, Last, Antonia, Mirhakkak, Mohammad H., Sprague, Jakob L., Möller, Lars, Großmann, Peter, Graf, Katja, Gratz, Rena, Mogavero, Selene, Vylkova, Slavena, Panagiotou, Gianni, Schäuble, Sascha, Hube, Bernhard, Gresnigt, Mark S.
Published in Nature communications (09.06.2022)
Published in Nature communications (09.06.2022)
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Journal Article
Cellular metabolism of myeloid cells in sepsis
Arts, Rob J. W., Gresnigt, Mark S., Joosten, Leo A. B., Netea, Mihai G.
Published in Journal of leukocyte biology (01.01.2017)
Published in Journal of leukocyte biology (01.01.2017)
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Journal Article
Human albumin enhances the pathogenic potential of Candida glabrata on vaginal epithelial cells
Pekmezovic, Marina, Kaune, Ann-Kristin, Austermeier, Sophie, Hitzler, Sophia U. J, Mogavero, Selene, Hovhannisyan, Hrant, Gabaldón, Toni, Gresnigt, Mark S, Hube, Bernhard
Published in PLoS pathogens (28.10.2021)
Published in PLoS pathogens (28.10.2021)
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Journal Article
A polysaccharide virulence factor from Aspergillus fumigatus elicits anti-inflammatory effects through induction of Interleukin-1 receptor antagonist
Gresnigt, Mark S, Bozza, Silvia, Becker, Katharina L, Joosten, Leo A B, Abdollahi-Roodsaz, Shahla, van der Berg, Wim B, Dinarello, Charles A, Netea, Mihai G, Fontaine, Thierry, De Luca, Antonella, Moretti, Silvia, Romani, Luigina, Latge, Jean-Paul, van de Veerdonk, Frank L
Published in PLoS pathogens (01.03.2014)
Published in PLoS pathogens (01.03.2014)
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Journal Article
Corticosteroids block autophagy protein recruitment in Aspergillus fumigatus phagosomes via targeting dectin-1/Syk kinase signaling
Kyrmizi, Irene, Gresnigt, Mark S, Akoumianaki, Tonia, Samonis, George, Sidiropoulos, Prodromos, Boumpas, Dimitrios, Netea, Mihai G, van de Veerdonk, Frank L, Kontoyiannis, Dimitrios P, Chamilos, Georgios
Published in The Journal of immunology (1950) (01.08.2013)
Published in The Journal of immunology (1950) (01.08.2013)
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Journal Article
Interferon-gamma as adjunctive immunotherapy for invasive fungal infections: a case series
Delsing, Corine E, Gresnigt, Mark S, Leentjens, Jenneke, Preijers, Frank, Frager, Florence Allantaz, Kox, Matthijs, Monneret, Guillaume, Venet, Fabienne, Bleeker-Rovers, Chantal P, van de Veerdonk, Frank L, Pickkers, Peter, Pachot, Alexandre, Kullberg, Bart Jan, Netea, Mihai G
Published in BMC infectious diseases (26.03.2014)
Published in BMC infectious diseases (26.03.2014)
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Journal Article
Keeping Candida commensal: how lactobacilli antagonize pathogenicity of Candida albicans in an in vitro gut model
Graf, Katja, Last, Antonia, Gratz, Rena, Allert, Stefanie, Linde, Susanne, Westermann, Martin, Gröger, Marko, Mosig, Alexander S, Gresnigt, Mark S, Hube, Bernhard
Published in Disease models & mechanisms (01.09.2019)
Published in Disease models & mechanisms (01.09.2019)
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Journal Article
Rewiring monocyte glucose metabolism via C-type lectin signaling protects against disseminated candidiasis
Domínguez-Andrés, Jorge, Arts, Rob J W, Ter Horst, Rob, Gresnigt, Mark S, Smeekens, Sanne P, Ratter, Jacqueline M, Lachmandas, Ekta, Boutens, Lily, van de Veerdonk, Frank L, Joosten, Leo A B, Notebaart, Richard A, Ardavín, Carlos, Netea, Mihai G
Published in PLoS pathogens (01.09.2017)
Published in PLoS pathogens (01.09.2017)
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Journal Article
A synthetic peptide mimic kills Candida albicans and synergistically prevents infection
Schaefer, Sebastian, Vij, Raghav, Sprague, Jakob L., Austermeier, Sophie, Dinh, Hue, Judzewitsch, Peter R., Müller-Loennies, Sven, Lopes Silva, Taynara, Seemann, Eric, Qualmann, Britta, Hertweck, Christian, Scherlach, Kirstin, Gutsmann, Thomas, Cain, Amy K., Corrigan, Nathaniel, Gresnigt, Mark S., Boyer, Cyrille, Lenardon, Megan D., Brunke, Sascha
Published in Nature communications (09.08.2024)
Published in Nature communications (09.08.2024)
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Journal Article
Albumin Neutralizes Hydrophobic Toxins and Modulates Candida albicans Pathogenicity
Austermeier, Sophie, Pekmezović, Marina, Porschitz, Pauline, Lee, Sejeong, Kichik, Nessim, Moyes, David L, Ho, Jemima, Kotowicz, Natalia K, Naglik, Julian R, Hube, Bernhard, Gresnigt, Mark S
Published in mBio (29.06.2021)
Published in mBio (29.06.2021)
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Journal Article
Genetic deficiency of NOD2 confers resistance to invasive aspergillosis
Gresnigt, Mark S., Cunha, Cristina, Jaeger, Martin, Gonçalves, Samuel M., Malireddi, R. K. Subbarao, Ammerdorffer, Anne, Lubbers, Rosalie, Oosting, Marije, Rasid, Orhan, Jouvion, Grégory, Fitting, Catherine, Jong, Dirk J. de, Lacerda, João, Campos, António, Melchers, Willem J. G., Lagrou, Katrien, Maertens, Johan, Kanneganti, Thirumala-Devi, Carvalho, Agostinho, Ibrahim-Granet, Oumaima, van de Veerdonk, Frank L.
Published in Nature communications (06.07.2018)
Published in Nature communications (06.07.2018)
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Journal Article
Nanobody-mediated neutralization of candidalysin prevents epithelial damage and inflammatory responses that drive vulvovaginal candidiasis pathogenesis
Valentine, Marisa, Rudolph, Paul, Dietschmann, Axel, Tsavou, Antzela, Mogavero, Selene, Lee, Sejeong, Priest, Emily L, Zhurgenbayeva, Gaukhar, Jablonowski, Nadja, Timme, Sandra, Eggeling, Christian, Allert, Stefanie, Dolk, Edward, Naglik, Julian R, Figge, Marc T, Gresnigt, Mark S, Hube, Bernhard
Published in mBio (13.03.2024)
Published in mBio (13.03.2024)
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Journal Article
Editorial: Exploring novel experimental systems to study the mechanistic basis of fungal infections
Gago, Sara, Gresnigt, Mark S., Zelante, Teresa
Published in Frontiers in fungal biology (14.04.2023)
Published in Frontiers in fungal biology (14.04.2023)
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