Discovery of Novel Blood-Brain Barrier Targets to Enhance Brain Uptake of Therapeutic Antibodies
Zuchero, Y. Joy Yu, Chen, Xiaocheng, Bien-Ly, Nga, Bumbaca, Daniela, Tong, Raymond K., Gao, Xiaoying, Zhang, Shuo, Hoyte, Kwame, Luk, Wilman, Huntley, Melanie A., Phu, Lilian, Tan, Christine, Kallop, Dara, Weimer, Robby M., Lu, Yanmei, Kirkpatrick, Donald S., Ernst, James A., Chih, Ben, Dennis, Mark S., Watts, Ryan J.
Published in Neuron (Cambridge, Mass.) (06.01.2016)
Published in Neuron (Cambridge, Mass.) (06.01.2016)
Get full text
Journal Article
Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target
Yu, Y Joy, Zhang, Yin, Kenrick, Margaret, Hoyte, Kwame, Luk, Wilman, Lu, Yanmei, Atwal, Jasvinder, Elliott, J Michael, Prabhu, Saileta, Watts, Ryan J, Dennis, Mark S
Published in Science translational medicine (25.05.2011)
Published in Science translational medicine (25.05.2011)
Get more information
Journal Article
Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants
Bien-Ly, Nga, Yu, Y Joy, Bumbaca, Daniela, Elstrott, Justin, Boswell, C Andrew, Zhang, Yin, Luk, Wilman, Lu, Yanmei, Dennis, Mark S, Weimer, Robby M, Chung, Inhee, Watts, Ryan J
Published in The Journal of experimental medicine (10.02.2014)
Published in The Journal of experimental medicine (10.02.2014)
Get full text
Journal Article
Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates
Yu, Y Joy, Atwal, Jasvinder K, Zhang, Yin, Tong, Raymond K, Wildsmith, Kristin R, Tan, Christine, Bien-Ly, Nga, Hersom, Maria, Maloney, Janice A, Meilandt, William J, Bumbaca, Daniela, Gadkar, Kapil, Hoyte, Kwame, Luk, Wilman, Lu, Yanmei, Ernst, James A, Scearce-Levie, Kimberly, Couch, Jessica A, Dennis, Mark S, Watts, Ryan J
Published in Science translational medicine (05.11.2014)
Published in Science translational medicine (05.11.2014)
Get more information
Journal Article
An anti-CD3/anti–CLL-1 bispecific antibody for the treatment of acute myeloid leukemia
Leong, Steven R., Sukumaran, Siddharth, Hristopoulos, Maria, Totpal, Klara, Stainton, Shannon, Lu, Elizabeth, Wong, Alfred, Tam, Lucinda, Newman, Robert, Vuillemenot, Brian R., Ellerman, Diego, Gu, Chen, Mathieu, Mary, Dennis, Mark S., Nguyen, Allen, Zheng, Bing, Zhang, Crystal, Lee, Genee, Chu, Yu-Waye, Prell, Rodney A., Lin, Kedan, Laing, Steven T., Polson, Andrew G.
Published in Blood (02.02.2017)
Published in Blood (02.02.2017)
Get full text
Journal Article
Monovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agent
Merchant, Mark, Ma, Xiaolei, Maun, Henry R, Zheng, Zhong, Peng, Jing, Romero, Mally, Huang, Arthur, Yang, Nai-ying, Nishimura, Merry, Greve, Joan, Santell, Lydia, Zhang, Yu-Wen, Su, Yanli, Kaufman, Dafna W, Billeci, Karen L, Mai, Elaine, Moffat, Barbara, Lim, Amy, Duenas, Eileen T, Phillips, Heidi S, Xiang, Hong, Young, Judy C, Vande Woude, George F, Dennis, Mark S, Reilly, Dorothea E, Schwall, Ralph H, Starovasnik, Melissa A, Lazarus, Robert A, Yansura, Daniel G
Published in Proceedings of the National Academy of Sciences - PNAS (06.08.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (06.08.2013)
Get full text
Journal Article
Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index
Junutula, Jagath R, Mallet, William, Raab, Helga, Clark, Suzanna, Bhakta, Sunil, Leipold, Douglas D, Weir, Sylvia, Chen, Yvonne, Simpson, Michelle, Tsai, Siao Ping, Dennis, Mark S, Lu, Yanmei, Meng, Y Gloria, Ng, Carl, Yang, Jihong, Lee, Chien C, Duenas, Eileen, Gorrell, Jeffrey, Katta, Viswanatham, Kim, Amy, McDorman, Kevin, Flagella, Kelly, Venook, Rayna, Ross, Sarajane, Spencer, Susan D, Lee Wong, Wai, Lowman, Henry B, Vandlen, Richard, Sliwkowski, Mark X, Scheller, Richard H, Polakis, Paul
Published in Nature biotechnology (01.08.2008)
Published in Nature biotechnology (01.08.2008)
Get full text
Journal Article
Bivalent antibody pliers inhibit β-tryptase by an allosteric mechanism dependent on the IgG hinge
Maun, Henry R., Vij, Rajesh, Walters, Benjamin T., Morando, Ashley, Jackman, Janet K., Wu, Ping, Estevez, Alberto, Chen, Xiaocheng, Franke, Yvonne, Lipari, Michael T., Dennis, Mark S., Kirchhofer, Daniel, Ciferri, Claudio, Loyet, Kelly M., Yi, Tangsheng, Eigenbrot, Charles, Lazarus, Robert A., Koerber, James T.
Published in Nature communications (22.12.2020)
Published in Nature communications (22.12.2020)
Get full text
Journal Article
An Anti-GDNF Family Receptor Alpha 1 (GFRA1) Antibody-Drug Conjugate for the Treatment of Hormone Receptor-Positive Breast Cancer
Bhakta, Sunil, Crocker, Lisa M, Chen, Yvonne, Hazen, Meredith, Schutten, Melissa M, Li, Dongwei, Kuijl, Coenraad, Ohri, Rachana, Zhong, Fiona, Poon, Kirsten A, Go, Mary Ann T, Cheng, Eric, Piskol, Robert, Firestein, Ron, Fourie-O'Donohue, Aimee, Kozak, Katherine R, Raab, Helga, Hongo, Jo-Anne, Sampath, Deepak, Dennis, Mark S, Scheller, Richard H, Polakis, Paul, Junutula, Jagath R
Published in Molecular cancer therapeutics (01.03.2018)
Published in Molecular cancer therapeutics (01.03.2018)
Get full text
Journal Article
Antibodies specific for a segment of human membrane IgE deplete IgE-producing B cells in humanized mice
Brightbill, Hans D, Jeet, Surinder, Lin, Zhonghua, Yan, Donghong, Zhou, Meijuan, Tan, Martha, Nguyen, Allen, Yeh, Sherry, Delarosa, Donnie, Leong, Steven R, Wong, Terence, Chen, Yvonne, Ultsch, Mark, Luis, Elizabeth, Ramani, Sree Ranjani, Jackman, Janet, Gonzalez, Lino, Dennis, Mark S, Chuntharapai, Anan, DeForge, Laura, Meng, Y Gloria, Xu, Min, Eigenbrot, Charles, Lee, Wyne P, Refino, Canio J, Balazs, Mercedesz, Wu, Lawren C
Published in The Journal of clinical investigation (01.06.2010)
Published in The Journal of clinical investigation (01.06.2010)
Get full text
Journal Article
Highly specific off-target binding identified and eliminated during the humanization of an antibody against FGF receptor 4
Bumbaca, Daniela, Wong, Anne, Drake, Elizabeth, Reyes II, Arthur E., Lin, Benjamin C., Stephan, Jean-Philippe, Desnoyers, Luc, Shen, Ben-Quan, Dennis, Mark S.
Published in mAbs (01.07.2011)
Published in mAbs (01.07.2011)
Get full text
Journal Article
Function Blocking Antibodies to Neuropilin-1 Generated from a Designed Human Synthetic Antibody Phage Library
Liang, Wei-Ching, Dennis, Mark S., Stawicki, Scott, Chanthery, Yvan, Pan, Qi, Chen, Yongmei, Eigenbrot, Charles, Yin, JianPing, Koch, Alexander W., Wu, Xiumin, Ferrara, Napoleone, Bagri, Anil, Tessier-Lavigne, Marc, Watts, Ryan J., Wu, Yan
Published in Journal of molecular biology (23.02.2007)
Published in Journal of molecular biology (23.02.2007)
Get full text
Journal Article
Effector-attenuating Substitutions That Maintain Antibody Stability and Reduce Toxicity in Mice
Lo, Megan, Kim, Hok Seon, Tong, Raymond K., Bainbridge, Travis W., Vernes, Jean-Michel, Zhang, Yin, Lin, Yuwen Linda, Chung, Shan, Dennis, Mark S., Zuchero, Y. Joy Yu, Watts, Ryan J., Couch, Jessica A., Meng, Y. Gloria, Atwal, Jasvinder K., Brezski, Randall J., Spiess, Christoph, Ernst, James A.
Published in The Journal of biological chemistry (03.03.2017)
Published in The Journal of biological chemistry (03.03.2017)
Get full text
Journal Article
Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys
Kariolis, Mihalis S, Wells, Robert C, Getz, Jennifer A, Kwan, Wanda, Mahon, Cathal S, Tong, Raymond, Kim, Do Jin, Srivastava, Ankita, Bedard, Catherine, Henne, Kirk R, Giese, Tina, Assimon, Victoria A, Chen, Xiaocheng, Zhang, Yin, Solanoy, Hilda, Jenkins, Katherine, Sanchez, Pascal E, Kane, Lesley, Miyamoto, Takashi, Chew, Kylie S, Pizzo, Michelle E, Liang, Nicholas, Calvert, Meredith E K, DeVos, Sarah L, Baskaran, Sulochanadevi, Hall, Sejal, Sweeney, Zachary K, Thorne, Robert G, Watts, Ryan J, Dennis, Mark S, Silverman, Adam P, Zuchero, Y Joy Yu
Published in Science translational medicine (27.05.2020)
Published in Science translational medicine (27.05.2020)
Get more information
Journal Article
Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation
Liao, Fan, Li, Aimin, Xiong, Monica, Bien-Ly, Nga, Jiang, Hong, Zhang, Yin, Finn, Mary Beth, Hoyle, Rosa, Keyser, Jennifer, Lefton, Katheryn B, Robinson, Grace O, Serrano, Javier Remolina, Silverman, Adam P, Guo, Jing L, Getz, Jennifer, Henne, Kirk, Leyns, Cheryl Eg, Gallardo, Gilbert, Ulrich, Jason D, Sullivan, Patrick M, Lerner, Eli Paul, Hudry, Eloise, Sweeney, Zachary K, Dennis, Mark S, Hyman, Bradley T, Watts, Ryan J, Holtzman, David M
Published in The Journal of clinical investigation (01.05.2018)
Published in The Journal of clinical investigation (01.05.2018)
Get full text
Journal Article
Brain delivery and activity of a lysosomal enzyme using a blood-brain barrier transport vehicle in mice
Ullman, Julie C, Arguello, Annie, Getz, Jennifer A, Bhalla, Akhil, Mahon, Cathal S, Wang, Junhua, Giese, Tina, Bedard, Catherine, Kim, Do Jin, Blumenfeld, Jessica R, Liang, Nicholas, Ravi, Ritesh, Nugent, Alicia A, Davis, Sonnet S, Ha, Connie, Duque, Joseph, Tran, Hai L, Wells, Robert C, Lianoglou, Steve, Daryani, Vinay M, Kwan, Wanda, Solanoy, Hilda, Nguyen, Hoang, Earr, Timothy, Dugas, Jason C, Tuck, Michael D, Harvey, Jennifer L, Reyzer, Michelle L, Caprioli, Richard M, Hall, Sejal, Poda, Suresh, Sanchez, Pascal E, Dennis, Mark S, Gunasekaran, Kannan, Srivastava, Ankita, Sandmann, Thomas, Henne, Kirk R, Thorne, Robert G, Di Paolo, Gilbert, Astarita, Giuseppe, Diaz, Dolores, Silverman, Adam P, Watts, Ryan J, Sweeney, Zachary K, Kariolis, Mihalis S, Henry, Anastasia G
Published in Science translational medicine (27.05.2020)
Published in Science translational medicine (27.05.2020)
Get more information
Journal Article
Relative Target Affinities of T-Cell-Dependent Bispecific Antibodies Determine Biodistribution in a Solid Tumor Mouse Model
Mandikian, Danielle, Takahashi, Nene, Lo, Amy A, Li, Ji, Eastham-Anderson, Jeffrey, Slaga, Dionysos, Ho, Jason, Hristopoulos, Maria, Clark, Robyn, Totpal, Klara, Lin, Kedan, Joseph, Sean B, Dennis, Mark S, Prabhu, Saileta, Junttila, Teemu T, Boswell, C Andrew
Published in Molecular cancer therapeutics (01.04.2018)
Published in Molecular cancer therapeutics (01.04.2018)
Get full text
Journal Article
Anti-CD20/CD3 T cell-dependent bispecific antibody for the treatment of B cell malignancies
Sun, Liping L, Ellerman, Diego, Mathieu, Mary, Hristopoulos, Maria, Chen, Xiaocheng, Li, Yijin, Yan, Xiaojie, Clark, Robyn, Reyes, Arthur, Stefanich, Eric, Mai, Elaine, Young, Judy, Johnson, Clarissa, Huseni, Mahrukh, Wang, Xinhua, Chen, Yvonne, Wang, Peiyin, Wang, Hong, Dybdal, Noel, Chu, Yu-Waye, Chiorazzi, Nicholas, Scheer, Justin M, Junttila, Teemu, Totpal, Klara, Dennis, Mark S, Ebens, Allen J
Published in Science translational medicine (13.05.2015)
Published in Science translational medicine (13.05.2015)
Get more information
Journal Article