Tu1068 Effects of Linaclotide Treatment on Patient-Reported Ratings of Change for Symptoms of Irritable Bowel Syndrome With Constipation (IBS-C): Pooled 12-Week Findings From Two Phase 3 Trials
Locke, Giles R, Chey, William D, Kurtz, Caroline B, Carson, Robyn, Baird, Mollie J, MacDougall, James E, Jia, Xinwei D, Currie, Mark G, Schneier, Harvey, Johnston, Jeffrey M
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2012)
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2012)
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Mo1856 Linaclotide Significantly Improved Abdominal Pain Compared With Placebo in Patients With Irritable Bowel Syndrome Regardless of Baseline Pain Severity in Two Phase 3 Trials
Schoenfeld, Philip S, Chey, William D, Lavins, Bernard J, Shiff, Steven J, Kurtz, Caroline B, MacDougall, James E, Jia, Xinwei D, Schneier, Harvey, Currie, Mark G, Johnston, Jeffrey M
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2012)
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2012)
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Tu1423 Effects of Linaclotide on Straining Associated With Bowel Movements in Patients With Irritable Bowel Syndrome With Constipation (IBS-C): A Post Hoc Analysis of Pooled Data From Two Phase 3 Trials
Lembo, Anthony, Rao, Satish S, Shiff, Steven J, Lavins, Bernard J, MacDougall, James E, Shi, Kelvin, Schneier, Harvey, Currie, Mark G, Johnston, Jeffrey M
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2012)
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2012)
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Tu1069 Do Baseline Factors Contribute to Treatment Satisfaction in Patients With Chronic Constipation Treated With Linaclotide vs Placebo?
Schoenfeld, Philip S, Chang, Lin, Carson, Robyn, Shiff, Steven J, Lavins, Bernard J, MacDougall, James E, Jia, Xinwei D, Schneier, Harvey, Currie, Mark G, Johnston, Jeffrey M
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2012)
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2012)
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848 Efficacy of Linaclotide in Improving Abdominal Symptoms Rated as Most Severe by Patients With Irritable Bowel Syndrome With Constipation (IBS-C)
Rao, Satish S, Quigley, Eamonn M, Shiff, Steven J, Lavins, Bernard J, Kurtz, Caroline B, MacDougall, James E, Shi, Kelvin, Schneier, Harvey, Currie, Mark G, Johnston, Jeffrey M
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2012)
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2012)
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Tu1381 Effects of 26 Weeks of Linaclotide Treatment on Adequate Relief and IBS Severity in Patients With Irritable Bowel Syndrome With Constipation
Chey, William D, Quigley, Eamonn M, Lavins, Bernard J, Baird, Mollie J, Fitch, Donald A, Hao, Xinming, Shi, Kelvin, Currie, Mark G, Schneier, Harvey, Johnston, Jeffrey M
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2012)
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2012)
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Sa1094 Developing Benchmarks for Clinically Meaningful Change for IBS-C Symptoms Using Data From Two Phase 3 Trials of Linaclotide
Spiegel, Brennan M, Locke, Giles R, Kurtz, Caroline B, Williams, Valerie, Nelson, Lauren M, Carson, Robyn, Jia, Xinwei D, Currie, Mark G, MacDougall, James E, Schneier, Harvey, Johnston, Jeffrey M
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2012)
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2012)
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Atriopeptin-Immunoreactive Neurons in the Brain: Presence in Cardiovascular Regulatory Areas
Saper, Clifford B., Standaert, David G., Currie, Mark G., Schwartz, David, Geller, David M., Needleman, Philip
Published in Science (American Association for the Advancement of Science) (01.03.1985)
Published in Science (American Association for the Advancement of Science) (01.03.1985)
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Purification and Sequence Analysis of Bioactive Atrial Peptides (Atriopeptins)
Currie, Mark G., Geller, David M., Cole, Barbara R., Siegel, Ned R., Fok, Kam F., Adams, Steven P., Eubanks, Shad R., Galluppi, Gerald R., Needleman, Philip
Published in Science (American Association for the Advancement of Science) (06.01.1984)
Published in Science (American Association for the Advancement of Science) (06.01.1984)
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Characterization of the Cytoprotective Action of Peroxynitrite Decomposition Catalysts
Misko, T P, Highkin, M K, Veenhuizen, A W, Manning, P T, Stern, M K, Currie, M G, Salvemini, D
Published in The Journal of biological chemistry (19.06.1998)
Published in The Journal of biological chemistry (19.06.1998)
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Cyclooxygenase 2‐dependent prostaglandin E2 modulates cartilage proteoglycan degradation in human osteoarthritis explants
Hardy, Medora M., Seibert, Karen, Manning, Pamela T., Currie, Mark G., Woerner, B. Mark, Edwards, Dorothy, Koki, Alane, Tripp, Catherine S.
Published in Arthritis and rheumatism (01.07.2002)
Published in Arthritis and rheumatism (01.07.2002)
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Synthesis and Biological Characterization of L-N6-(1-Iminoethyl)lysine 5-Tetrazole-amide, a Prodrug of a Selective iNOS Inhibitor
Hallinan, E. Ann, Tsymbalov, Sofya, Dorn, Clifford R, Pitzele, Barnett S, Hansen, Donald W, Moore, William M, Jerome, Gina M, Connor, Jane R, Branson, Linda F, Widomski, Deborah L, Zhang, Yan, Currie, Mark G, Manning, Pamela T
Published in Journal of medicinal chemistry (11.04.2002)
Published in Journal of medicinal chemistry (11.04.2002)
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Comparison of adequate relief with symptom, global, and responder endpoints in linaclotide phase 3 trials in IBS-C
Camilleri, Michael, Lembo, Anthony J, Lavins, Bernard J, MacDougall, James E, Carson, Robyn T, Williams, Valerie SL, Nelson, Lauren M, Shiff, Steven J, Currie, Mark G, Kurtz, Caroline B, Johnston, Jeffrey M
Published in United European gastroenterology journal (01.02.2015)
Published in United European gastroenterology journal (01.02.2015)
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DELAYED RELEASE COMPOSITIONS OF LINACLOTIDE
MATTHEW MILLER, ANDREAS GRILL, MO YUN, MAHENDRA DEDHIYA, ANGELIKA FRETZEN, ANIL CHHETTRY, RITESH SANGHVI, AHMAD HASHASH, MOHAMMAD MAFRUHUL BARI, MARK G CURRIE
Year of Publication 07.09.2023
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Year of Publication 07.09.2023
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Synthesis and biological characterization of L-N(6)-(1-iminoethyl)lysine 5-tetrazole-amide, a prodrug of a selective iNOS inhibitor
Hallinan, E Ann, Tsymbalov, Sofya, Dorn, Clifford R, Pitzele, Barnett S, Hansen, Jr, Donald W, Moore, William M, Jerome, Gina M, Connor, Jane R, Branson, Linda F, Widomski, Deborah L, Zhang, Yan, Currie, Mark G, Manning, Pamela T
Published in Journal of medicinal chemistry (11.04.2002)
Published in Journal of medicinal chemistry (11.04.2002)
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Selective inhibition of the inducible nitric oxide synthase by aminoguanidine
Misko, Thomas P., Moore, William M., Kasten, Thomas P., Nickols, G.Allen, Corbett, John A., Tilton, Ronald G., McDaniel, Michael L., Williamson, Joseph R., Currie, Mark G.
Published in European journal of pharmacology (16.03.1993)
Published in European journal of pharmacology (16.03.1993)
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Protective effects of a superoxide dismutase mimetic and peroxynitrite decomposition catalysts in endotoxin‐induced intestinal damage
Salvemini, Daniela, Riley, Dennis P, Lennon, Patrick J, Wang, Zhi‐Qiang, Currie, Mark G, Macarthur, Heather, Misko, Thomas P
Published in British journal of pharmacology (01.06.1999)
Published in British journal of pharmacology (01.06.1999)
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Role of inducible nitric oxide synthase expression and peroxynitrite formation in guinea pig ileitis
Miller, M J, Thompson, J H, Zhang, X J, Sadowska-Krowicka, H, Kakkis, J L, Munshi, U K, Sandoval, M, Rossi, J L, Eloby-Childress, S, Beckman, J S
Published in Gastroenterology (New York, N.Y. 1943) (01.11.1995)
Published in Gastroenterology (New York, N.Y. 1943) (01.11.1995)
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