IW-3718 Reduces Heartburn Severity in Patients With Refractory Gastroesophageal Reflux Disease in a Randomized Trial
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Published in Gastroenterology (New York, N.Y. 1943) (01.06.2020)
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Efficacy of linaclotide for patients with chronic constipation
Lembo, Anthony J, Kurtz, Caroline B, Macdougall, James E, Lavins, B J, Currie, Mark G, Fitch, Donald A, Jeglinski, Brenda I, Johnston, Jeffrey M
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Effects of the Soluble Guanylate Cyclase Stimulator Praliciguat in Diabetic Kidney Disease: A Randomized Placebo-Controlled Clinical Trial
Hanrahan, John P, de Boer, Ian H, Bakris, George L, Wilson, Phebe J, Wakefield, James D, Seferovic, Jelena P, Chickering, Jennifer G, Chien, Yueh-Tyng, Carlson, Kenneth, Cressman, Michael D, Currie, Mark G, Milne, G Todd, Profy, Albert T
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Pharmacologic properties, metabolism, and disposition of linaclotide, a novel therapeutic peptide approved for the treatment of irritable bowel syndrome with constipation and chronic idiopathic constipation
Busby, Robert W, Kessler, Marco M, Bartolini, Wilmin P, Bryant, Alexander P, Hannig, Gerhard, Higgins, Carolyn S, Solinga, Robert M, Tobin, Jenny V, Wakefield, James D, Kurtz, Caroline B, Currie, Mark G
Published in The Journal of pharmacology and experimental therapeutics (01.01.2013)
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Linaclotide in irritable bowel syndrome with constipation: A Phase 3 randomized trial in China and other regions
Yang, Yunsheng, Fang, Jingyuan, Guo, Xiaozhong, Dai, Ning, Shen, Xizhong, Yang, Youlin, Sun, Jing, Bhandari, Bal Raj, Reasner, David S, Cronin, Jacquelyn A, Currie, Mark G, Johnston, Jeffrey M, Zeng, Peter, Montreewasuwat, Niwat, Chen, George Zhijian, Lim, Sam
Published in Journal of gastroenterology and hepatology (01.05.2018)
Published in Journal of gastroenterology and hepatology (01.05.2018)
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Pharmacological Characterization of IW-1973, a Novel Soluble Guanylate Cyclase Stimulator with Extensive Tissue Distribution, Antihypertensive, Anti-Inflammatory, and Antifibrotic Effects in Preclinical Models of Disease
Tobin, Jenny V, Zimmer, Daniel P, Shea, Courtney, Germano, Peter, Bernier, Sylvie G, Liu, Guang, Long, Kim, Miyashiro, Joy, Ranganath, Sheila, Jacobson, Sarah, Tang, Kim, Im, G-Yoon Jamie, Sheppeck, 2nd, James, Moore, Joel D, Sykes, Kristine, Wakefield, James, Sarno, Renee, Banijamali, Ali R, Profy, Albert T, Milne, G Todd, Currie, Mark G, Masferrer, Jaime L
Published in The Journal of pharmacology and experimental therapeutics (01.06.2018)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2018)
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Effects of a Gastric-Retentive Extended-Release Bile Acid Sequestrant on Esophageal Erosions in Patients With Persistent GERD: Exploratory Analysis From a Phase 2B Study of IW-3718: 393
Kahrilas, Peter, Shao, James, Chen, Yan, Shea, Elizabeth P., Currie, Mark G., Mittleman, Robert
Published in The American journal of gastroenterology (01.10.2018)
Published in The American journal of gastroenterology (01.10.2018)
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Praliciguat inhibits progression of diabetic nephropathy in ZSF1 rats and suppresses inflammation and apoptosis in human renal proximal tubular cells
Liu, Guang, Shea, Courtney M., Jones, Juli E., Price, Gavrielle M., Warren, William, Lonie, Elisabeth, Yan, Shu, Currie, Mark G., Profy, Albert T., Masferrer, Jaime L., Zimmer, Daniel P.
Published in American journal of physiology. Renal physiology (01.10.2020)
Published in American journal of physiology. Renal physiology (01.10.2020)
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An exploratory, randomised, placebo-controlled, 14 day trial of the soluble guanylate cyclase stimulator praliciguat in participants with type 2 diabetes and hypertension
Hanrahan, John P., Seferovic, Jelena P., Wakefield, James D., Wilson, Phebe J., Chickering, Jennifer G., Jung, Joon, Carlson, Kenneth E., Zimmer, Daniel P., Frelinger, Andrew L., Michelson, Alan D., Morrow, Linda, Hall, Michael, Currie, Mark G., Milne, G. Todd, Profy, Albert T.
Published in Diabetologia (01.04.2020)
Published in Diabetologia (01.04.2020)
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Effect of 5 days linaclotide on transit and bowel function in females with constipation-predominant irritable bowel syndrome
Andresen, Viola, Camilleri, Michael, Busciglio, Irene A, Grudell, April, Burton, Duane, McKinzie, Sanna, Foxx-Orenstein, Amy, Kurtz, Caroline B, Sharma, Vineeta, Johnston, Jeffrey M, Currie, Mark G, Zinsmeister, Alan R
Published in Gastroenterology (New York, N.Y. 1943) (01.09.2007)
Published in Gastroenterology (New York, N.Y. 1943) (01.09.2007)
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Response to Miner et al
Currie, Mark G, Shiff, Steven J, Schneier, Harvey A, Johnston, Jeffrey M
Published in The American journal of gastroenterology (01.11.2017)
Published in The American journal of gastroenterology (01.11.2017)
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Linaclotide is a potent and selective guanylate cyclase C agonist that elicits pharmacological effects locally in the gastrointestinal tract
Bryant, Alexander P., Busby, Robert W., Bartolini, Wilmin P., Cordero, Etchell A., Hannig, Gerhard, Kessler, Marco M., Pierce, Christine M., Solinga, Robert M., Tobin, Jenny V., Mahajan-Miklos, Shalina, Cohen, Mitchell B., Kurtz, Caroline B., Currie, Mark G.
Published in Life sciences (1973) (08.05.2010)
Published in Life sciences (1973) (08.05.2010)
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Effect of Linaclotide on Severe Abdominal Symptoms in Patients With Irritable Bowel Syndrome With Constipation
Rao, Satish S.C, Quigley, Eamonn M.M, Shiff, Steven J, Lavins, Bernard J, Kurtz, Caroline B, MacDougall, James E, Currie, Mark G, Johnston, Jeffrey M
Published in Clinical gastroenterology and hepatology (01.04.2014)
Published in Clinical gastroenterology and hepatology (01.04.2014)
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Prevention of diabetic vascular dysfunction by guanidines. Inhibition of nitric oxide synthase versus advanced glycation end-product formation
Tilton, R G, Chang, K, Hasan, K S, Smith, S R, Petrash, J M, Misko, T P, Moore, W M, Currie, M G, Corbett, J A, McDaniel, M L
Published in Diabetes (New York, N.Y.) (01.02.1993)
Published in Diabetes (New York, N.Y.) (01.02.1993)
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Pilot Study on the Effect of Linaclotide in Patients With Chronic Constipation
JOHNSTON, Jeffrey M, KURTZ, Caroline B, DROSSMAN, Douglas A, LEMBO, Anthony J, JEGLINSKI, Brenda I, MACDOUGALL, James E, ANTONELLI, Stephen M, CURRIE, Mark G
Published in The American journal of gastroenterology (01.01.2009)
Published in The American journal of gastroenterology (01.01.2009)
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MRP4 Modulation of the Guanylate Cyclase-C/cGMP Pathway: Effects on Linaclotide-Induced Electrolyte Secretion and cGMP Efflux
Tchernychev, Boris, Ge, Pei, Kessler, Marco M, Solinga, Robert M, Wachtel, Derek, Tobin, Jenny V, Thomas, Sara R, Lunte, Craig E, Fretzen, Angelika, Hannig, Gerhard, Bryant, Alexander P, Kurtz, Caroline B, Currie, Mark G, Silos-Santiago, Inmaculada
Published in The Journal of pharmacology and experimental therapeutics (01.10.2015)
Published in The Journal of pharmacology and experimental therapeutics (01.10.2015)
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Tu1211 IW-9179, a Phosphopeptide Designed to Target the Upper Gastrointestinal Tract, Is More Potent at Acidic pH and Is Rapidly Metabolized In Vitro in Rodent Intestinal Fluid
Kessler, Marco, Solinga, Robert, Zimmer, Daniel, Forsyth, Sanjeev, Wachtel, Derek, Cali, Brian M, Currie, Mark G
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2015)
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2015)
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FIRST-IN-HUMAN SINGLE-ASCENDING-DOSE STUDY OF IW-1973, A NEW SOLUBLE GUANYLATE CYCLASE STIMULATOR
Hanrahan, John, Profy, Albert T., Lavins, B. Joseph, Ruff, Dennis, Poirier, Gabrielle, Wakefield, James, Wilson, Phebe, Hall, Michael, Currie, Mark G.
Published in Journal of the American College of Cardiology (05.04.2016)
Published in Journal of the American College of Cardiology (05.04.2016)
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Safety and tolerability of linaclotide for the treatment of chronic idiopathic constipation and irritable bowel syndrome with constipation: pooled Phase 3 analysis
Nee, Judy W., Johnston, Jeffrey M., Shea, Elizabeth P., Walls, Courtney E., Tripp, Kenneth, Shiff, Steven, Fox, Susan M., Bochenek, Wieslaw, Weissman, Darren, Currie, Mark G., Lembo, Anthony J.
Published in Expert review of gastroenterology & hepatology (03.04.2019)
Published in Expert review of gastroenterology & hepatology (03.04.2019)
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A Randomized, Placebo‐Controlled, Multiple‐Ascending‐Dose Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Soluble Guanylate Cyclase Stimulator Praliciguat in Healthy Subjects
Hanrahan, John P., Wakefield, James D., Wilson, Phebe J., Mihova, Marina, Chickering, Jennifer G., Ruff, Dennis, Hall, Michael, Milne, G. Todd, Currie, Mark G., Profy, Albert T.
Published in Clinical pharmacology in drug development (01.07.2019)
Published in Clinical pharmacology in drug development (01.07.2019)
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