Identification and Characterization of a Novel Class of Interleukin-1 Post-Translational Processing Inhibitors
Perregaux, D G, McNiff, P, Laliberte, R, Hawryluk, N, Peurano, H, Stam, E, Eggler, J, Griffiths, R, Dombroski, M A, Gabel, C A
Published in The Journal of pharmacology and experimental therapeutics (01.10.2001)
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Published in The Journal of pharmacology and experimental therapeutics (01.10.2001)
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Manganese(III)-based oxidative free-radical tandem and triple cyclizations
Dombroski, Mark A, Kates, Steven A, Snider, Barry B
Published in Journal of the American Chemical Society (01.03.1990)
Published in Journal of the American Chemical Society (01.03.1990)
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Theoretical and Experimental Design of Atypical Kinase Inhibitors: Application to p38 MAP Kinase
McClure, Kim F, Abramov, Yuriy A, Laird, Ellen R, Barberia, John T, Cai, Weiling, Carty, Thomas J, Cortina, Santo R, Danley, Dennis E, Dipesa, Alan J, Donahue, Kathleen M, Dombroski, Mark A, Elliott, Nancy C, Gabel, Christopher A, Han, Seungil, Hynes, Thomas R, LeMotte, Peter K, Mansour, Mahmoud N, Marr, Eric S, Letavic, Michael A, Pandit, Jayvardhan, Ripin, David B, Sweeney, Francis J, Tan, Douglas, Tao, Yong
Published in Journal of medicinal chemistry (08.09.2005)
Published in Journal of medicinal chemistry (08.09.2005)
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Discovery, synthesis and SAR of azinyl- and azolylbenzamides antagonists of the P2X7 receptor
Subramanyam, Chakrapani, Duplantier, Allen J., Dombroski, Mark A., Chang, Shang-Poa, Gabel, Christopher A., Whitney-Pickett, Carrie, Perregaux, David G., Labasi, Jeff M., Yoon, Kwansik, Shepard, Richard M., Fisher, Michael
Published in Bioorganic & medicinal chemistry letters (15.09.2011)
Published in Bioorganic & medicinal chemistry letters (15.09.2011)
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Optimization of the physicochemical and pharmacokinetic attributes in a 6-azauracil series of P2X₇ receptor antagonists leading to the discovery of the clinical candidate CE-224,535
Duplantier, Allen J, Dombroski, Mark A, Subramanyam, Chakrapani, Beaulieu, Aimee M, Chang, Shang-Poa, Gabel, Christopher A, Jordan, Crystal, Kalgutkar, Amit S, Kraus, Kenneth G, Labasi, Jeff M, Mussari, Christopher, Perregaux, David G, Shepard, Rick, Taylor, Timothy J, Trevena, Kristen A, Whitney-Pickett, Carrie, Yoon, Kwansik
Published in Bioorganic & medicinal chemistry letters (15.06.2011)
Published in Bioorganic & medicinal chemistry letters (15.06.2011)
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Orally active and brain permeable proline amides as highly selective 5HT2c agonists for the treatment of obesity
Liu, Kevin K.-C., Lefker, Bruce A., Dombroski, Mark A., Chiang, Phoebe, Cornelius, Peter, Patterson, Terrell A., Zeng, Yuan, Santucci, Stephanie, Tomlinson, Elizabeth, Gibbons, Colleen P., Marala, Ravi, Brown, Janice A., Kong, Jimmy X., Lee, Eunsun, Werner, Wendy, Wenzel, Zane, Giragossian, Craig, Chen, Hou, Coffey, Steven B.
Published in Bioorganic & medicinal chemistry letters (01.04.2010)
Published in Bioorganic & medicinal chemistry letters (01.04.2010)
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Structure–activity relationships of triazolopyridine oxazole p38 inhibitors: Identification of candidates for clinical development
McClure, Kim F., Letavic, Michael A., Kalgutkar, Amit S., Gabel, Christopher A., Audoly, Laurent, Barberia, John T., Braganza, John F., Carter, Demetrius, Carty, Thomas J., Cortina, Santo R., Dombroski, Mark A., Donahue, Kathleen M., Elliott, Nancy C., Gibbons, Colleen P., Jordan, Crystal K., Kuperman, Alexander V., Labasi, Jeff M., LaLiberte, Ronald E., McCoy, Jennifer M., Naiman, Brian M., Nelson, Kendra L., Nguyen, Hang T., Peese, Kevin M., Sweeney, Francis J., Taylor, Timothy J., Trebino, Catherine E., Abramov, Yuriy A., Laird, Ellen R., Volberg, Walter A., Zhou, Jun, Bach, Justin, Lombardo, Franco
Published in Bioorganic & medicinal chemistry letters (15.08.2006)
Published in Bioorganic & medicinal chemistry letters (15.08.2006)
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Control of the regioselectivity of oxidative free-radical cyclizations by addition to haloalkenes
Snider, Barry B, Zhang, Qingwei, Dombroski, Mark A
Published in Journal of organic chemistry (01.07.1992)
Published in Journal of organic chemistry (01.07.1992)
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Benzimidazolone p38 inhibitors
DOMBROSKI, Mark A, LETAVIC, Michael A, JORDAN, Crystal K, LABASI, Jeff M, MARTIN, William H, PEESE, Kevin M, STOCK, Ingrid A, SVENSSON, Linne, SWEENEY, Francis J, YU, Chul H, MCCLURE, Kim F, BARBERIA, John T, CARTY, Thomas J, CORTINA, Santo R, CSIKI, Csilla, DIPESA, Alan J, ELLIOTT, Nancy C, GABEL, Christopher A
Published in Bioorganic & medicinal chemistry letters (23.02.2004)
Published in Bioorganic & medicinal chemistry letters (23.02.2004)
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Cyclizations of unsaturated .bul.CR(COX)2 radicals. Manganese(III) acetate oxidative cyclizations of unsaturated acetoacetates and atom-transfer cyclizations of unsaturated haloacetoacetates give the same radicals
Curran, Dennis P, Morgan, Tina M, Schwartz, C. Eric, Snider, Barry B, Dombroski, Mark A
Published in Journal of the American Chemical Society (01.08.1991)
Published in Journal of the American Chemical Society (01.08.1991)
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Optimization of the physicochemical and pharmacokinetic attributes in a 6-azauracil series of P2X 7 receptor antagonists leading to the discovery of the clinical candidate CE-224,535
Duplantier, Allen J., Dombroski, Mark A., Subramanyam, Chakrapani, Beaulieu, Aimee M., Chang, Shang-Poa, Gabel, Christopher A., Jordan, Crystal, Kalgutkar, Amit S., Kraus, Kenneth G., Labasi, Jeff M., Mussari, Christopher, Perregaux, David G., Shepard, Rick, Taylor, Timothy J., Trevena, Kristen A., Whitney-Pickett, Carrie, Yoon, Kwansik
Published in Bioorganic & medicinal chemistry letters (15.06.2011)
Published in Bioorganic & medicinal chemistry letters (15.06.2011)
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Glutathione S-Transferase Omega 1-1 Is a Target of Cytokine Release Inhibitory Drugs and May Be Responsible for Their Effect on Interleukin-1 beta Posttranslational Processing
Laliberte, R E, Perregaux, D G, Hoth, L R, Rosner, P J, Jordan, C K, Peese, K M, Eggler, J, Dombroski, MA, Geoghegan, K F, Gabel, CA
Published in The Journal of biological chemistry (09.05.2003)
Published in The Journal of biological chemistry (09.05.2003)
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Discovery, synthesis and SAR of azinyl- and azolylbenzamides antagonists of the P2X sub(7 receptor)
Subramanyam, Chakrapani, Duplantier, Allen J, Dombroski, Mark A, Chang, Shang-Poa, Gabel, Christopher A, Whitney-Pickett, Carrie, Perregaux, David G, Labasi, Jeff M, Yoon, Kwansik, Shepard, Richard M, Fisher, Michael
Published in Bioorganic & medicinal chemistry letters (15.09.2011)
Published in Bioorganic & medicinal chemistry letters (15.09.2011)
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Journal Article
Optimization of the physicochemical and pharmacokinetic attributes in a 6-azauracil series of P2X sub(7 receptor antagonists leading to the discovery of the clinical candidate CE-224,535)
Duplantier, Allen J, Dombroski, Mark A, Subramanyam, Chakrapani, Beaulieu, Aimee M, Chang, Shang-Poa, Gabel, Christopher A, Jordan, Crystal, Kalgutkar, Amit S, Kraus, Kenneth G, Labasi, Jeff M, Mussari, Christopher, Perregaux, David G, Shepard, Rick, Taylor, Timothy J, Trevena, Kristen A, Whitney-Pickett, Carrie, Yoon, Kwansik
Published in Bioorganic & medicinal chemistry letters (15.06.2011)
Published in Bioorganic & medicinal chemistry letters (15.06.2011)
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Proton catalyzed cis-trans stereomutation of cis-1,2-diarylcyclobutanes
Flippin, Lee A, Dombroski, Mark A
Published in Journal of the American Chemical Society (01.07.1986)
Published in Journal of the American Chemical Society (01.07.1986)
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