Combined genetic analysis of juvenile idiopathic arthritis clinical subtypes identifies novel risk loci, target genes and key regulatory mechanisms
López-Isac, Elena, Smith, Samantha L, Marion, Miranda C, Wood, Abigail, Sudman, Marc, Yarwood, Annie, Shi, Chenfu, Gaddi, Vasanthi Priyadarshini, Martin, Paul, Prahalad, Sampath, Eyre, Stephen, Orozco, Gisela, Morris, Andrew P, Langefeld, Carl D, Thompson, Susan D, Thomson, Wendy, Bowes, John
Published in Annals of the rheumatic diseases (01.03.2021)
Published in Annals of the rheumatic diseases (01.03.2021)
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Journal Article
High-throughput identification of functional regulatory SNPs in systemic lupus erythematosus
Wang, Qiang, Kim, Taehyeung, Martínez-Bonet, Marta, Aguiar, Vitor R. C., Sim, Sangwan, Cui, Jing, Sparks, Jeffrey A., Chen, Xiaoting, Todd, Marc, Wauford, Brian, Marion, Miranda C., Langefeld, Carl D., Weirauch, Matthew T., Gutierrez-Arcelus, Maria, Nigrovic, Peter A.
Published in Nature communications (09.08.2024)
Published in Nature communications (09.08.2024)
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Journal Article
Analysis of Trans-Ancestral SLE Risk Loci Identifies Unique Biologic Networks and Drug Targets in African and European Ancestries
Owen, Katherine A., Price, Andrew, Ainsworth, Hannah, Aidukaitis, Bryce N., Bachali, Prathyusha, Catalina, Michelle D., Dittman, James M., Howard, Timothy D., Kingsmore, Kathryn M., Labonte, Adam C., Marion, Miranda C., Robl, Robert D., Zimmerman, Kip D., Langefeld, Carl D., Grammer, Amrie C., Lipsky, Peter E.
Published in American journal of human genetics (05.11.2020)
Published in American journal of human genetics (05.11.2020)
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Journal Article
Genome‐Wide Association Meta‐Analysis Reveals Novel Juvenile Idiopathic Arthritis Susceptibility Loci
McIntosh, Laura A., Marion, Miranda C., Sudman, Marc, Comeau, Mary E., Becker, Mara L., Bohnsack, John F., Fingerlin, Tasha E., Griffin, Thomas A., Haas, J. Peter, Lovell, Daniel J., Maier, Lisa A., Nigrovic, Peter A., Prahalad, Sampath, Punaro, Marilynn, Rosé, Carlos D., Wallace, Carol A., Wise, Carol A., Moncrieffe, Halima, Howard, Timothy D., Langefeld, Carl D., Thompson, Susan D.
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.11.2017)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.11.2017)
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Journal Article
Molecular pathways identified from single nucleotide polymorphisms demonstrate mechanistic differences in systemic lupus erythematosus patients of Asian and European ancestry
Owen, Katherine A., Bell, Kristy A., Price, Andrew, Bachali, Prathyusha, Ainsworth, Hannah, Marion, Miranda C., Howard, Timothy D., Langefeld, Carl D., Shen, Nan, Yazdany, Jinoos, Dall’era, Maria, Grammer, Amrie C., Lipsky, Peter E.
Published in Scientific reports (01.04.2023)
Published in Scientific reports (01.04.2023)
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Journal Article
Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM , PXK , KIAA1542 and other loci
Criswell, Lindsey A, Vyse, Timothy J, Langefeld, Carl D, Jacob, Chaim O, Harley, John B, Alarcón-Riquelme, Marta E, Kimberly, Robert P, Moser, Kathy L, Tsao, Betty P
Published in Nature genetics (01.02.2008)
Published in Nature genetics (01.02.2008)
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Journal Article
Platelet Glycoprotein Ib α‐Chain as a Putative Therapeutic Target for Juvenile Idiopathic Arthritis: A Mendelian Randomization Study
Luo, Shan, Clarke, Sarah L. N., Ramanan, Athimalaipet V., Thompson, Susan D., Langefeld, Carl D., Marion, Miranda C., Grom, Alexei A., Schooling, C. Mary, Gaunt, Tom R., Yeung, Shiu Lun Au, Zheng, Jie
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.04.2021)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.04.2021)
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Journal Article
Brief Report: The Genetic Profile of Rheumatoid Factor–Positive Polyarticular Juvenile Idiopathic Arthritis Resembles That of Adult Rheumatoid Arthritis
Hinks, Anne, Marion, Miranda C., Cobb, Joanna, Comeau, Mary E., Sudman, Marc, Ainsworth, Hannah C., Bowes, John, Becker, Mara L., Bohnsack, John F., Haas, Johannes‐Peter, Lovell, Daniel J., Mellins, Elizabeth D., Nelson, J. Lee, Nordal, Ellen, Punaro, Marilynn, Reed, Ann M., Rose, Carlos D., Rosenberg, Alan M., Rygg, Marite, Smith, Samantha L., Stevens, Anne M., Videm, Vibeke, Wallace, Carol A., Wedderburn, Lucy R., Yarwood, Annie, Yeung, Rae S. M., Langefeld, Carl D., Thompson, Susan D., Thomson, Wendy, Prahalad, Sampath
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.06.2018)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.06.2018)
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Journal Article
Identification of a Systemic Lupus Erythematosus Risk Locus Spanning ATG16L2, FCHSD2, and P2RY2 in Koreans
Lessard, Christopher J., Sajuthi, Satria, Zhao, Jian, Kim, Kwangwoo, Ice, John A., Li, He, Ainsworth, Hannah, Rasmussen, Astrid, Kelly, Jennifer A., Marion, Miranda, Bang, So‐Young, Bin Joo, Young, Choi, Jeongim, Lee, Hye‐Soon, Mo Kang, Young, Suh, Chang‐Hee, Tae Chung, Won, Lee, Soo‐Kon, Choe, Jung‐Yoon, Cheol Shim, Seung, Hee Oh, Ji, Jin Kim, Young, Han, Bok‐Ghee, Shen, Nan, Siew Howe, Hwee, Wakeland, Edward K., Li, Quan‐Zhen, Wook Song, Yeong, Gaffney, Patrick M., Alarcón‐Riquelme, Marta E., Criswell, Lindsey A., Jacob, Chaim O., Kimberly, Robert P., Vyse, Timothy J., Harley, John B., Sivils, Kathy L., Bae, Sang‐Cheol, Langefeld, Carl D., Tsao, Betty P.
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.05.2016)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.05.2016)
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Journal Article
Trans-Ethnic Mapping of BANK1 Identifies Two Independent SLE-Risk Linkage Groups Enriched for Co-Transcriptional Splicing Marks
Martínez-Bueno, Manuel, Oparina, Nina, Dozmorov, Mikhail G, Marion, Miranda C, Comeau, Mary E, Gilkeson, Gary, Kamen, Diane, Weisman, Michael, Salmon, Jane, McCune, Joseph W, Harley, John B, Kimberly, Robert, James, Judith A, Merrill, Joan, Montgomery, Courtney, Langefeld, Carl D, Alarcón-Riquelme, Marta E
Published in International journal of molecular sciences (08.08.2018)
Published in International journal of molecular sciences (08.08.2018)
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Journal Article
Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as Susceptibility Loci for Systemic Lupus Erythematosus in a Large-Scale Multiracial Replication Study
Lessard, Christopher J., Adrianto, Indra, Ice, John A., Wiley, Graham B., Kelly, Jennifer A., Glenn, Stuart B., Adler, Adam J., Li, He, Rasmussen, Astrid, Williams, Adrienne H., Ziegler, Julie, Comeau, Mary E., Marion, Miranda, Wakeland, Benjamin E., Liang, Chaoying, Ramos, Paula S., Grundahl, Kiely M., Gallant, Caroline J., Alarcón, Graciela S., Anaya, Juan-Manuel, Bae, Sang-Cheol, Boackle, Susan A., Brown, Elizabeth E., Chang, Deh-Ming, Cho, Soo-Kyung, Criswell, Lindsey A., Edberg, Jeffrey C., Freedman, Barry I., Gilkeson, Gary S., Jacob, Chaim O., James, Judith A., Kamen, Diane L., Kimberly, Robert P., Kim, Jae-Hoon, Martin, Javier, Merrill, Joan T., Niewold, Timothy B., Park, So-Yeon, Petri, Michelle A., Pons-Estel, Bernardo A., Ramsey-Goldman, Rosalind, Reveille, John D., Scofield, R. Hal, Song, Yeong Wook, Stevens, Anne M., Tsao, Betty P., Vila, Luis M., Vyse, Timothy J., Yu, Chack-Yung, Guthridge, Joel M., Kaufman, Kenneth M., Harley, John B., Wakeland, Edward K., Langefeld, Carl D., Gaffney, Patrick M., Montgomery, Courtney G., Moser, Kathy L.
Published in American journal of human genetics (06.04.2012)
Published in American journal of human genetics (06.04.2012)
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Journal Article
Mendelian randomization and pathway analysis demonstrate shared genetic associations between lupus and coronary artery disease
Kain, Jessica, Owen, Katherine A., Marion, Miranda C., Langefeld, Carl D., Grammer, Amrie C., Lipsky, Peter E.
Published in Cell reports. Medicine (15.11.2022)
Published in Cell reports. Medicine (15.11.2022)
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Journal Article
Gut dysbiosis and the clinical spectrum in anti-Ro positive mothers of children with neonatal lupus
Clancy, Robert M., Marion, Miranda C., Ainsworth, Hannah C., Chang, Miao, Howard, Timothy D., Izmirly, Peter M., Masson, Mala, Buyon, Jill P., Langefeld, Carl D.
Published in Gut microbes (2022)
Published in Gut microbes (2022)
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Journal Article
Association of Natural Killer Cell Ligand Polymorphism HLA-C Asn80Lys With the Development of Anti-SSA/Ro-Associated Congenital Heart Block
Ainsworth, Hannah C, Marion, Miranda C, Bertero, Tiziana, Brucato, Antonio, Cimaz, Rolando, Costedoat-Chalumeau, Nathalie, Fredi, Micaela, Gaffney, Patrick, Kelly, Jennifer, Levesque, Kateri, Maltret, Alice, Morel, Nathalie, Ramoni, Veronique, Ruffatti, Amelia, Langefeld, Carl D, Buyon, Jill P, Clancy, Robert M
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.11.2017)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.11.2017)
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Journal Article
The modifying influence of HLA class II DQB1∗06:02 on the Streptococcus and clinical phenotype correlation among anti-Ro+ mothers of children with neonatal lupus
Clancy, Robert M., Guthridge, Carla J., Marion, Miranda C., Guthridge, Joel, Howard, Timothy D., Izmirly, Peter M., Masson, Mala, Buyon, Jill P., James, Judith A., Langefeld, Carl D.
Published in Genes & diseases (01.07.2023)
Published in Genes & diseases (01.07.2023)
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Journal Article
Genetic Variation in the Peroxisome Proliferator Activated Receptor-Gamma Gene Is Associated with Histologically Advanced NAFLD
Gawrieh, Samer, Marion, Miranda C., Komorowski, Richard, Wallace, James, Charlton, Michael, Kissebah, Ahmed, Langefeld, Carl D., Olivier, Michael
Published in Digestive diseases and sciences (01.04.2012)
Published in Digestive diseases and sciences (01.04.2012)
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Journal Article
Genome-wide association analysis of juvenile idiopathic arthritis identifies a new susceptibility locus at chromosomal region 3q13
Thompson, Susan D., Marion, Miranda C., Sudman, Marc, Ryan, Mary, Tsoras, Monica, Howard, Timothy D., Barnes, Michael G., Ramos, Paula S., Thomson, Wendy, Hinks, Anne, Haas, Johannes-Peter, Prahalad, Sampath, Bohnsack, John F., Wise, Carol A., Punaro, Marilynn, Rosé, Carlos D., Pajewski, Nicholas M., Spigarelli, Michael, Keddache, Mehdi, Wagner, Michael, Langefeld, Carl D., Glass, David N.
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.08.2012)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.08.2012)
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Journal Article
Nucleic Acid-Sensing and Interferon-Inducible Pathways Show Differential Methylation in MZ Twins Discordant for Lupus and Overexpression in Independent Lupus Samples: Implications for Pathogenic Mechanism and Drug Targeting
Marion, Miranda C, Ramos, Paula S, Bachali, Prathyusha, Labonte, Adam C, Zimmerman, Kip D, Ainsworth, Hannah C, Heuer, Sarah E, Robl, Robert D, Catalina, Michelle D, Kelly, Jennifer A, Howard, Timothy D, Lipsky, Peter E, Grammer, Amrie C, Langefeld, Carl D
Published in Genes (26.11.2021)
Published in Genes (26.11.2021)
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Journal Article
Brief Report: Association of Natural Killer Cell Ligand Polymorphism HLA–C Asn80Lys With the Development of Anti‐SSA/Ro–Associated Congenital Heart Block
Ainsworth, Hannah C., Marion, Miranda C., Bertero, Tiziana, Brucato, Antonio, Cimaz, Rolando, Costedoat‐Chalumeau, Nathalie, Fredi, Micaela, Gaffney, Patrick, Kelly, Jennifer, Levesque, Kateri, Maltret, Alice, Morel, Nathalie, Ramoni, Veronique, Ruffatti, Amelia, Langefeld, Carl D., Buyon, Jill P., Clancy, Robert M.
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.11.2017)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.11.2017)
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Journal Article