A study on the trastuzumab conjugation at tyrosine using diazonium salts
Griebenow, Nils, Greven, Simone, Lobell, Mario, Dilmaç, Alicia M, Bräse, Stefan
Published in RSC advances (01.01.2015)
Published in RSC advances (01.01.2015)
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Journal Article
Molecular Characterization of the Principal Substrate Binding Site of the Ubiquitous Folding Catalyst Protein Disulfide Isomerase
Pirneskoski, Annamari, Klappa, Peter, Lobell, Mario, Williamson, Richard A., Byrne, Lee, Alanen, Heli I., Salo, Kirsi E.H., Kivirikko, Kari I., Freedman, Robert B., Ruddock, Lloyd W.
Published in The Journal of biological chemistry (12.03.2004)
Published in The Journal of biological chemistry (12.03.2004)
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Journal Article
Recent Advances in the Prediction of Blood–Brain Partitioning from Molecular Structure
Lobell, Mario, Molnár, László, Keserü, György M.
Published in Journal of pharmaceutical sciences (01.02.2003)
Published in Journal of pharmaceutical sciences (01.02.2003)
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Journal Article
Antibiotic Activity and Characterization of BB-3497, a Novel Peptide Deformylase Inhibitor
CLEMENTS, John M, BECKETT, R. Paul, BAKER, Patrick J, RODGERS, H. Fiona, BARYNIN, Vladimir, RICE, David W, HUNTER, Michael G, BROWN, Anthony, CATLIN, Graham, LOBELL, Mario, PALAN, Shilpa, THOMAS, Wayne, WHITTAKER, Mark, WOOD, Stephen, SALAMA, Sameeh
Published in Antimicrobial Agents and Chemotherapy (01.02.2001)
Published in Antimicrobial Agents and Chemotherapy (01.02.2001)
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Journal Article
Bayer’s in silico ADMET platform: a journey of machine learning over the past two decades
Göller, Andreas H., Kuhnke, Lara, Montanari, Floriane, Bonin, Anne, Schneckener, Sebastian, ter Laak, Antonius, Wichard, Jörg, Lobell, Mario, Hillisch, Alexander
Published in Drug discovery today (01.09.2020)
Published in Drug discovery today (01.09.2020)
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Journal Article
Best of Both Worlds: Combining Pharma Data and State of the Art Modeling Technology To Improve in Silico p K a Prediction
Fraczkiewicz, Robert, Lobell, Mario, Göller, Andreas H., Krenz, Ursula, Schoenneis, Rolf, Clark, Robert D., Hillisch, Alexander
Published in Journal of chemical information and modeling (23.02.2015)
Published in Journal of chemical information and modeling (23.02.2015)
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Journal Article
Best of Both Worlds: Combining Pharma Data and State of the Art Modeling Technology To Improve in Silico pK a Prediction
Fraczkiewicz, Robert, Lobell, Mario, Göller, Andreas H, Krenz, Ursula, Schoenneis, Rolf, Clark, Robert D, Hillisch, Alexander
Published in Journal of chemical information and modeling (23.02.2015)
Published in Journal of chemical information and modeling (23.02.2015)
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Journal Article
Discovery of Rogaratinib (BAY 1163877): a pan‐FGFR Inhibitor
Collin, Marie‐Pierre, Lobell, Mario, Hübsch, Walter, Brohm, Dirk, Schirok, Hartmut, Jautelat, Rolf, Lustig, Klemens, Bömer, Ulf, Vöhringer, Verena, Héroult, Mélanie, Grünewald, Sylvia, Hess‐Stumpp, Holger
Published in ChemMedChem (06.03.2018)
Published in ChemMedChem (06.03.2018)
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Journal Article
Novel TIE‐2 inhibitor BAY‐826 displays in vivo efficacy in experimental syngeneic murine glioma models
Schneider, Hannah, Szabo, Emese, Machado, Raquel A. C., Broggini‐Tenzer, Angela, Walter, Alexander, Lobell, Mario, Heldmann, Dieter, Süssmeier, Frank, Grünewald, Sylvia, Weller, Michael
Published in Journal of neurochemistry (01.01.2017)
Published in Journal of neurochemistry (01.01.2017)
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Journal Article
Best of both worlds: combining pharma data and state of the art modeling technology to improve in Silico pKa prediction
Fraczkiewicz, Robert, Lobell, Mario, Göller, Andreas H, Krenz, Ursula, Schoenneis, Rolf, Clark, Robert D, Hillisch, Alexander
Published in Journal of chemical information and modeling (23.02.2015)
Published in Journal of chemical information and modeling (23.02.2015)
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Journal Article
Best of Both Worlds: Combining Pharma Data and State of the Art Modeling Technology To Improve in Silico pK^sub a^ Prediction
Fraczkiewicz, Robert, Lobell, Mario, Göller, Andreas H, Krenz, Ursula, Schoenneis, Rolf, Clark, Robert D, Hillisch, Alexander
Published in Journal of chemical information and modeling (23.02.2015)
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Published in Journal of chemical information and modeling (23.02.2015)
Journal Article
Abstract 3234: Development of potent and selective antibody-drug conjugates with pyrrole-based KSP inhibitors as novel payload class
Lerchen, Hans-Georg, Wittrock, Sven, Griebenow, Nils, Lobell, Mario, Rebstock, Anne-Sophie, Cancho-Grande, Yolanda, Stelte-Ludwig, Beatrix, Mahlert, Christoph, Greven, Simone, Sommer, Anette, Berndt, Sandra, Terjung, Carsten, Apeler, Heiner, Kreft, Bertolt, Jautelat, Rolf
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
Improving the hit-to-lead process: data-driven assessment of drug-like and lead-like screening hits
Wunberg, Tobias, Hendrix, Martin, Hillisch, Alexander, Lobell, Mario, Meier, Heinrich, Schmeck, Carsten, Wild, Hanno, Hinzen, Berthold
Published in Drug discovery today (01.02.2006)
Published in Drug discovery today (01.02.2006)
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Journal Article
Abstract 4332: Discovery of BAY 1163877 - A pan-FGFR inhibitor: De novo structure-based design and lead optimization of benzothiophenyl-pyrrolotriazines
Collin, Marie-Pierre L., Lobell, Mario, Huebsch, Walter, Brohm, Dirk, Héroult, Mélanie, Lustig, Klemens, Gruenewald, Sylvia, Boemer, Ulf, Jautelat, Rolf, Hess-Stump, Holger, Jaroch, Stefan, Brands, Michael, Ziegelbauer, Karl
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
In Silico ADMET Traffic Lights as a Tool for the Prioritization of HTS Hits
Lobell, Mario, Hendrix, Martin, Hinzen, Berthold, Keldenich, Jörg, Meier, Heinrich, Schmeck, Carsten, Schohe-Loop, Rudolf, Wunberg, Tobias, Hillisch, Alexander
Published in ChemMedChem (01.11.2006)
Published in ChemMedChem (01.11.2006)
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Journal Article
Abstract 1739: Preclinical profile of BAY 1163877 - a selective pan-FGFR inhibitor in phase 1 clinical trial
Heroult, Melanie, Ellinghaus, Peter, Sieg, Christian, Brohm, Dirk, Gruenewald, Sylvia, Collin, Marie-Pierre, Boemer, Ulf, Lobell, Mario, Huebsch, Walter, Ocker, Matthias, Ince, Stuart, Haegebarth, Andrea, Jautelat, Rolf, Hess-Stumpp, Holger, Brands, Michael, Ziegelbauer, Karl
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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Journal Article
Abstract 1026: Novel Tie2 inhibitor with in vivo efficacy in disseminated hematological tumor models in mice
Gruenewald, Sylvia, Schueler, Julia, Haerter, Michael, Suessmeier, Frank, Klingner, Kerstin, Boemer, Ulf, Kaulfuss, Stefan, Walter, Alexander, Lobell, Mario, Hartung, Ingo V., Buchmann, Bernd, Heldmann, Dieter, Hess-Stumpp, Holger, Ziegelbauer, Karl
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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Journal Article