Search Results - "Marina Tintelnot-Blomley" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

The BACE‐1 inhibitor CNP520 for prevention trials in Alzheimer's disease

The BACE‐1 inhibitor CNP520 for prevention trials in Alzheimer's disease

by Neumann, Ulf, Ufer, Mike, Jacobson, Laura H, Rouzade‐Dominguez, Marie‐Laure, Huledal, Gunilla, Kolly, Carine, Lüönd, Rainer M, Machauer, Rainer, Veenstra, Siem J, Hurth, Konstanze, Rueeger, Heinrich, Tintelnot‐Blomley, Marina, Staufenbiel, Matthias, Shimshek, Derya R, Perrot, Ludovic, Frieauff, Wilfried, Dubost, Valerie, Schiller, Hilmar, Vogg, Barbara, Beltz, Karen, Avrameas, Alexandre, Kretz, Sandrine, Pezous, Nicole, Rondeau, Jean‐Michel, Beckmann, Nicolau, Hartmann, Andreas, Vormfelde, Stefan, David, Olivier J, Galli, Bruno, Ramos, Rita, Graf, Ana, Lopez Lopez, Cristina
Published in EMBO molecular medicine (01.11.2018)

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Structure based design, synthesis and SAR of cyclic hydroxyethylamine (HEA) BACE-1 inhibitors

Structure based design, synthesis and SAR of cyclic hydroxyethylamine (HEA) BACE-1 inhibitors

by Rueeger, Heinrich, Rondeau, Jean-Michel, McCarthy, Clive, Möbitz, Henrik, Tintelnot-Blomley, Marina, Neumann, Ulf, Desrayaud, Sandrine
Published in Bioorganic & medicinal chemistry letters (01.04.2011)

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Cyclophilin D as a Drug Target

Cyclophilin D as a Drug Target

by Waldmeier, Peter C, Zimmermann, Kaspar, Qian, Ting, Tintelnot-Blomley, Marina, Lemasters, John J
Published in Current medicinal chemistry (01.08.2003)

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Substrate-Controlled and Organocatalytic Asymmetric Synthesis of Carbocyclic Amino Acid Dipeptide Mimetics

Substrate-Controlled and Organocatalytic Asymmetric Synthesis of Carbocyclic Amino Acid Dipeptide Mimetics

by Hanessian, Stephen, Maji, Dilip K, Govindan, Subramaniyan, Matera, Riccardo, Tintelnot-Blomley, Marina
Published in Journal of organic chemistry (07.05.2010)

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The BACE ‐1 inhibitor CNP 520 for prevention trials in Alzheimer's disease

The BACE ‐1 inhibitor CNP 520 for prevention trials in Alzheimer's disease

by Neumann, Ulf, Ufer, Mike, Jacobson, Laura H, Rouzade‐Dominguez, Marie‐Laure, Huledal, Gunilla, Kolly, Carine, Lüönd, Rainer M, Machauer, Rainer, Veenstra, Siem J, Hurth, Konstanze, Rueeger, Heinrich, Tintelnot‐Blomley, Marina, Staufenbiel, Matthias, Shimshek, Derya R, Perrot, Ludovic, Frieauff, Wilfried, Dubost, Valerie, Schiller, Hilmar, Vogg, Barbara, Beltz, Karen, Avrameas, Alexandre, Kretz, Sandrine, Pezous, Nicole, Rondeau, Jean‐Michel, Beckmann, Nicolau, Hartmann, Andreas, Vormfelde, Stefan, David, Olivier J, Galli, Bruno, Ramos, Rita, Graf, Ana, Lopez Lopez, Cristina
Published in EMBO molecular medicine (01.11.2018)

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Stereoselective Synthesis of Constrained Oxacyclic Hydroxyethylene Isosteres of Aspartic Protease Inhibitors: Aldol and Mukaiyama Aldol Methodologies for Branched Tetrahydrofuran 2-Carboxylic Acids

Stereoselective Synthesis of Constrained Oxacyclic Hydroxyethylene Isosteres of Aspartic Protease Inhibitors: Aldol and Mukaiyama Aldol Methodologies for Branched Tetrahydrofuran 2-Carboxylic Acids

by Hanessian, Stephen, Hou, Yihua, Bayrakdarian, Malken, Tintelnot-Blomley, Marina
Published in Journal of organic chemistry (19.08.2005)

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Discovery of Umibecestat (CNP520): A Potent, Selective, and Efficacious beta-Secretase (BACE1) Inhibitor for the Prevention of Alzheimer's Disease

Discovery of Umibecestat (CNP520): A Potent, Selective, and Efficacious beta-Secretase (BACE1) Inhibitor for the Prevention of Alzheimer's Disease

by Machauer, Rainer, Lueoend, Rainer, Hurth, Konstanze, Veenstra, Siem J., Rueeger, Heinrich, Voegtle, Markus, Tintelnot-Blomley, Marina, Rondeau, Jean-Michel, Jacobson, Laura H., Laue, Grit, Beltz, Karen, Neumann, Ulf
Published in Journal of medicinal chemistry (28.10.2021)

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Synthesis of the Potent, Selective, and Efficacious β‑Secretase (BACE1) Inhibitor NB-360

Synthesis of the Potent, Selective, and Efficacious β‑Secretase (BACE1) Inhibitor NB-360

by Rueeger, Heinrich, Lueoend, Rainer, Machauer, Rainer, Veenstra, Siem J, Holzer, Philipp, Hurth, Konstanze, Voegtle, Markus, Frederiksen, Mathias, Rondeau, Jean-Michel, Tintelnot-Blomley, Marina, Jacobson, Laura H, Staufenbiel, Matthias, Laue, Grit, Neumann, Ulf
Published in Journal of medicinal chemistry (22.04.2021)

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Computational Chemistry at Novartis

Computational Chemistry at Novartis

by Richard Lewis, Peter Ertl, Edgar Jacoby, Marina Tintelnot-Blomley, Peter Gedeck, Romain M. Wolf, Manuel C. Peitsch
Published in Chimia (01.07.2005)

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A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice

by Neumann, Ulf, Rueeger, Heinrich, Machauer, Rainer, Veenstra, Siem Jacob, Lueoend, Rainer M, Tintelnot-Blomley, Marina, Laue, Grit, Beltz, Karen, Vogg, Barbara, Schmid, Peter, Frieauff, Wilfried, Shimshek, Derya R, Staufenbiel, Matthias, Jacobson, Laura H
Published in Molecular neurodegeneration (03.09.2015)

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Discovery of amino-1,4-oxazines as potent BACE-1 inhibitors

Discovery of amino-1,4-oxazines as potent BACE-1 inhibitors

by Veenstra, Siem Jakob, Rueeger, Heinrich, Voegtle, Markus, Lueoend, Rainer, Holzer, Philipp, Hurth, Konstanze, Tintelnot-Blomley, Marina, Frederiksen, Mathias, Rondeau, Jean-Michel, Jacobson, Laura, Staufenbiel, Matthias, Neumann, Ulf, Machauer, Rainer
Published in Bioorganic & medicinal chemistry letters (01.07.2018)

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Semicochliodinol A and B: Inhibitors of HIV-1 Protease and EGF-R Protein Tyrosine Kinase Related to Asterriquinones Produced by the Fungus Chrysosporium merdarium

Semicochliodinol A and B: Inhibitors of HIV-1 Protease and EGF-R Protein Tyrosine Kinase Related to Asterriquinones Produced by the Fungus Chrysosporium merdarium

by FREDENHAGEN, ANDREAS, PETERSEN, FRANK, TINTELNOT-BLOMLEY, MARINA, RÖSEL, JOHANNES, METT, HELMUT, HUG, PAUL
Published in Journal of antibiotics (1997)

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Structure-Based Design and Synthesis of Macroheterocyclic Peptidomimetic Inhibitors of the Aspartic Protease β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE)

Structure-Based Design and Synthesis of Macroheterocyclic Peptidomimetic Inhibitors of the Aspartic Protease β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE)

by Hanessian, Stephen, Yang, Gaoqiang, Rondeau, Jean-Michel, Neumann, Ulf, Betschart, Claudia, Tintelnot-Blomley, Marina
Published in Journal of medicinal chemistry (27.07.2006)

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Macrocyclic BACE-1 inhibitors acutely reduce Aβ in brain after po application

Macrocyclic BACE-1 inhibitors acutely reduce Aβ in brain after po application

by Lerchner, Andreas, Machauer, Rainer, Betschart, Claudia, Veenstra, Siem, Rueeger, Heinrich, McCarthy, Clive, Tintelnot-Blomley, Marina, Jaton, Anne-Lise, Rabe, Sabine, Desrayaud, Sandrine, Enz, Albert, Staufenbiel, Matthias, Paganetti, Paolo, Rondeau, Jean-Michel, Neumann, Ulf
Published in Bioorganic & medicinal chemistry letters (15.01.2010)

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Structure-based design and synthesis of novel P2/P3 modified, non-peptidic β-secretase (BACE-1) inhibitors

Structure-based design and synthesis of novel P2/P3 modified, non-peptidic β-secretase (BACE-1) inhibitors

by Hanessian, Stephen, Shao, Zhihui, Betschart, Claudia, Rondeau, Jean-Michel, Neumann, Ulf, Tintelnot-Blomley, Marina
Published in Bioorganic & medicinal chemistry letters (15.03.2010)

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Corrigendum to “Structure-based design and synthesis of novel P2/P3 modified, non-peptidic β-secretase (BACE-1) inhibitors” [Bioorg. Med. Chem. Lett. 20 (2010) 1924–1927]

Corrigendum to “Structure-based design and synthesis of novel P2/P3 modified, non-peptidic β-secretase (BACE-1) inhibitors” [Bioorg. Med. Chem. Lett. 20 (2010) 1924–1927]

by Hanessian, Stephen, Shao, Zhihui, Betschart, Claudia, Rondeau, Jean-Michel, Neumann, Ulf, Tintelnot-Blomley, Marina
Published in Bioorganic & medicinal chemistry letters (15.04.2013)

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Structure-based design and synthesis of macrocyclic peptidomimetic β-secretase (BACE-1) inhibitors

Structure-based design and synthesis of macrocyclic peptidomimetic β-secretase (BACE-1) inhibitors

by Machauer, Rainer, Veenstra, Siem, Rondeau, Jean-Michel, Tintelnot-Blomley, Marina, Betschart, Claudia, Neumann, Ulf, Paganetti, Paolo
Published in Bioorganic & medicinal chemistry letters (01.03.2009)

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Macrocyclic peptidomimetic β-secretase (BACE-1) inhibitors with activity in vivo

Macrocyclic peptidomimetic β-secretase (BACE-1) inhibitors with activity in vivo

by Machauer, Rainer, Laumen, Kurt, Veenstra, Siem, Rondeau, Jean-Michel, Tintelnot-Blomley, Marina, Betschart, Claudia, Jaton, Anne-Lise, Desrayaud, Sandrine, Staufenbiel, Matthias, Rabe, Sabine, Paganetti, Paolo, Neumann, Ulf
Published in Bioorganic & medicinal chemistry letters (01.03.2009)

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2-Cyano-pyrimidines: A New Chemotype for Inhibitors of the Cysteine Protease Cathepsin K

2-Cyano-pyrimidines: A New Chemotype for Inhibitors of the Cysteine Protease Cathepsin K

by Altmann, Eva, Aichholz, Reiner, Betschart, Claudia, Buhl, Thomas, Green, Jonathan, Irie, Osamu, Teno, Naoki, Lattmann, René, Tintelnot-Blomley, Marina, Missbach, Martin
Published in Journal of medicinal chemistry (22.02.2007)

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Exploring subtype selectivity and metabolic stability of a novel series of ligands for the benzodiazepine binding site of the GABA A receptor

Exploring subtype selectivity and metabolic stability of a novel series of ligands for the benzodiazepine binding site of the GABA A receptor

by Hintermann, Samuel, Hurth, Konstanze, Nozulak, Joachim, Tintelnot-Blomley, Marina, Aichholz, Reiner, Blanz, Joachim, Kaupmann, Klemens, Mosbacher, Johannes
Published in Bioorganic & medicinal chemistry letters (01.03.2011)

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