Partitioning of MLX-Family Transcription Factors to Lipid Droplets Regulates Metabolic Gene Expression
Mejhert, Niklas, Kuruvilla, Leena, Gabriel, Katlyn R., Elliott, Shane D., Guie, Marie-Aude, Wang, Huajin, Lai, Zon Weng, Lane, Elizabeth A., Christiano, Romain, Danial, Nika N., Farese, Robert V., Walther, Tobias C.
Published in Molecular cell (19.03.2020)
Published in Molecular cell (19.03.2020)
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Genome-wide siRNA screen identifies the retromer as a cellular entry factor for human papillomavirus
Lipovsky, Alex, Popa, Andreea, Pimienta, Genaro, Wyler, Michael, Bhan, Ashima, Kuruvilla, Leena, Guie, Marie-Aude, Poffenberger, Adrian C., Nelson, Christian D. S., Atwood, Walter J., DiMaio, Daniel
Published in Proceedings of the National Academy of Sciences - PNAS (30.04.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (30.04.2013)
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Machine Learning on DNA-Encoded Libraries: A New Paradigm for Hit Finding
McCloskey, Kevin, Sigel, Eric A, Kearnes, Steven, Xue, Ling, Tian, Xia, Moccia, Dennis, Gikunju, Diana, Bazzaz, Sana, Chan, Betty, Clark, Matthew A, Cuozzo, John W, Guié, Marie-Aude, Guilinger, John P, Huguet, Christelle, Hupp, Christopher D, Keefe, Anthony D, Mulhern, Christopher J, Zhang, Ying, Riley, Patrick
Published in Journal of medicinal chemistry (27.08.2020)
Published in Journal of medicinal chemistry (27.08.2020)
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Discovery of Nanomolar DCAF1 Small Molecule Ligands
Li, Alice Shi Ming, Kimani, Serah, Wilson, Brian, Noureldin, Mahmoud, González-Álvarez, Héctor, Mamai, Ahmed, Hoffer, Laurent, Guilinger, John P., Zhang, Ying, von Rechenberg, Moritz, Disch, Jeremy S., Mulhern, Christopher J., Slakman, Belinda L., Cuozzo, John W., Dong, Aiping, Poda, Gennady, Mohammed, Mohammed, Saraon, Punit, Mittal, Manish, Modh, Pratik, Rathod, Vaibhavi, Patel, Bhashant, Ackloo, Suzanne, Santhakumar, Vijayaratnam, Szewczyk, Magdalena M, Barsyte-Lovejoy, Dalia, Arrowsmith, Cheryl H., Marcellus, Richard, Guié, Marie-Aude, Keefe, Anthony D., Brown, Peter J., Halabelian, Levon, Al-awar, Rima, Vedadi, Masoud
Published in Journal of medicinal chemistry (13.04.2023)
Published in Journal of medicinal chemistry (13.04.2023)
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Encoded Library Synthesis Using Chemical Ligation and the Discovery of sEH Inhibitors from a 334-Million Member Library
Litovchick, Alexander, Dumelin, Christoph E., Habeshian, Sevan, Gikunju, Diana, Guié, Marie-Aude, Centrella, Paolo, Zhang, Ying, Sigel, Eric A., Cuozzo, John W., Keefe, Anthony D., Clark, Matthew A.
Published in Scientific reports (10.06.2015)
Published in Scientific reports (10.06.2015)
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Discovery of a First-in-Class Small-Molecule Ligand for WDR91 Using DNA-Encoded Chemical Library Selection Followed by Machine Learning
Ahmad, Shabbir, Xu, Jin, Feng, Jianwen A., Hutchinson, Ashley, Zeng, Hong, Ghiabi, Pegah, Dong, Aiping, Centrella, Paolo A., Clark, Matthew A., Guié, Marie-Aude, Guilinger, John P., Keefe, Anthony D., Zhang, Ying, Cerruti, Thomas, Cuozzo, John W., von Rechenberg, Moritz, Bolotokova, Albina, Li, Yanjun, Loppnau, Peter, Seitova, Alma, Li, Yen-Yen, Santhakumar, Vijayaratnam, Brown, Peter J., Ackloo, Suzanne, Halabelian, Levon
Published in Journal of medicinal chemistry (14.12.2023)
Published in Journal of medicinal chemistry (14.12.2023)
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Development of Potent Mcl‑1 Inhibitors: Structural Investigations on Macrocycles Originating from a DNA-Encoded Chemical Library Screen
Hekking, Koen F. W., Maroto, Sergio, van Kekem, Kees, Haasjes, Frank S., Slootweg, Jack C., Oude Alink, Patrick G. B., Dirks, Ron, Sardana, Malvika, Bolster, Marjon G., Kuijpers, Brian, Smith, Dennis, Doodeman, Robin, Scheepstra, Marcel, Zech, Birgit, Mulvihill, Mark, Renzetti, Louis M., Babiss, Lee, Centrella, Paolo A., Clark, Matthew A., Cuozzo, John W., Guié, Marie-Aude, Sigel, Eric, Habeshian, Sevan, Hupp, Christopher D., Liu, Julie, Thomson, Heather A., Zhang, Ying, Keefe, Anthony D., Müller, Gerhard, Gremmen, Stijn
Published in Journal of medicinal chemistry (22.02.2024)
Published in Journal of medicinal chemistry (22.02.2024)
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Novel Nucleic Acid Binding Small Molecules Discovered Using DNA-Encoded Chemistry
Litovchick, Alexander, Tian, Xia, Monteiro, Michael I, Kennedy, Kaitlyn M, Guié, Marie-Aude, Centrella, Paolo, Zhang, Ying, Clark, Matthew A, Keefe, Anthony D
Published in Molecules (Basel, Switzerland) (27.05.2019)
Published in Molecules (Basel, Switzerland) (27.05.2019)
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Discovery of cofactor-specific, bactericidal Mycobacterium tuberculosis InhA inhibitors using DNA-encoded library technology
Soutter, Holly H., Centrella, Paolo, Clark, Matthew A., Cuozzo, John W., Dumelin, Christoph E., Guie, Marie-Aude, Habeshian, Sevan, Keefe, Anthony D., Kennedy, Kaitlyn M., Sigel, Eric A., Troast, Dawn M., Zhang, Ying, Ferguson, Andrew D., Davies, Gareth, Stead, Eleanor R., Breed, Jason, Madhavapeddi, Prashanti, Read, Jon A.
Published in Proceedings of the National Academy of Sciences - PNAS (06.12.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (06.12.2016)
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Novel irreversible covalent BTK inhibitors discovered using DNA-encoded chemistry
Guilinger, John P., Archna, Archna, Augustin, Martin, Bergmann, Andreas, Centrella, Paolo A., Clark, Matthew A., Cuozzo, John W., Däther, Maike, Guié, Marie-Aude, Habeshian, Sevan, Kiefersauer, Reiner, Krapp, Stephan, Lammens, Alfred, Lercher, Lukas, Liu, Julie, Liu, Yanbin, Maskos, Klaus, Mrosek, Michael, Pflügler, Klaus, Siegert, Markus, Thomson, Heather A., Tian, Xia, Zhang, Ying, Konz Makino, Debora L., Keefe, Anthony D.
Published in Bioorganic & medicinal chemistry (15.07.2021)
Published in Bioorganic & medicinal chemistry (15.07.2021)
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Discovery of Small Molecule Interleukin 17A Inhibitors with Novel Binding Mode and Stoichiometry: Optimization of DNA-Encoded Chemical Library Hits to In Vivo Active Compounds
Ramos, Ashley L., Goedken, Eric R., Frank, Kristine E., Argiriadi, Maria A., Bazzaz, Sana, Bian, Zhiguo, Brown, Jesse T. C., Centrella, Paolo A., Chen, Hui-Ju, Disch, Jeremy S., Donner, Pamela L., Duignan, David B., Gikunju, Diana, Greszler, Stephen N., Guié, Marie-Aude, Habeshian, Sevan, Hartl, Hajnalka E., Hein, Christopher D., Hutchins, Charles W., Jetson, Rachael, Keefe, Anthony D., Khan, Hasan, Li, Huan-Qiu, Olszewski, Allison, Ortiz Cardona, Benjamin J., Osuma, Augustine, Panchal, Sanjay C., Phelan, Ryan, Qiu, Wei, Shotwell, J. Brad, Shrestha, Anurupa, Srikumaran, Myron, Su, Zhi, Sun, Chaohong, Upadhyay, Anup K., Wood, Michael D., Wu, Haihong, Zhang, Ruijie, Zhang, Ying, Zhao, Gang, Zhu, Haizhong, Webster, Matthew P.
Published in Journal of medicinal chemistry (25.04.2024)
Published in Journal of medicinal chemistry (25.04.2024)
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Identification and Evaluation of Reversible Covalent Binders to Cys55 of Bfl‑1 from a DNA-Encoded Chemical Library Screen
Lucas, Simon C. C., Blackwell, J. Henry, Börjesson, Ulf, Hargreaves, David, Milbradt, Alexander G., Ahmed, Samiyah, Bostock, Mark J., Guerot, Carine, Gohlke, Andrea, Kinzel, Olaf, Lamb, Michelle L., Selmi, Nidhal, Stubbs, Christopher J., Su, Nancy, Su, Qibin, Luo, Haiou, Xiong, Ting, Zuo, Xiaoqian, Bazzaz, Sana, Bienstock, Corey, Centrella, Paolo A., Denton, Kyle E., Gikunju, Diana, Guié, Marie-Aude, Guilinger, John P., Hupp, Christopher, Keefe, Anthony D., Satoh, Takashi, Zhang, Ying, Rivers, Emma L.
Published in ACS medicinal chemistry letters (13.06.2024)
Published in ACS medicinal chemistry letters (13.06.2024)
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Synthesis and preliminary in vitro evaluation of antimycobacterial activity of new pyrrolo[1,2-a] quinoxaline-carboxylic acid hydrazide derivatives
Guillon, Jean, Reynolds, Robert C, Leger, Jean-Michel, Guie, Marie-Aude, Massip, Stephane, Dallemagne, Patrick, Jarry, Christian
Published in Journal of enzyme inhibition and medicinal chemistry (01.12.2004)
Published in Journal of enzyme inhibition and medicinal chemistry (01.12.2004)
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Inhibitors of the Thioesterase Activity of Mycobacterium tuberculosis Pks13 Discovered Using DNA-Encoded Chemical Library Screening
Krieger, Inna V., Yalamanchili, Subbarao, Dickson, Paige, Engelhart, Curtis A., Zimmerman, Matthew D, Wood, Jeremy, Clary, Ethan, Nguyen, Jasmine, Thornton, Natalie, Centrella, Paolo A., Chan, Betty, Cuozzo, John W, Gengenbacher, Martin, Guié, Marie-Aude, Guilinger, John P, Bienstock, Corey, Hartl, Hajnalka, Hupp, Christopher D., Jetson, Rachael, Satoh, Takashi, Yeoman, John T. S., Zhang, Ying, Dartois, Veronique, Schnappinger, Dirk, Keefe, Anthony D., Sacchettini, James C.
Published in ACS infectious diseases (10.05.2024)
Published in ACS infectious diseases (10.05.2024)
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Agonists and Antagonists of Protease-Activated Receptor 2 Discovered within a DNA-Encoded Chemical Library Using Mutational Stabilization of the Target
Brown, Dean G., Brown, Giles A., Centrella, Paolo, Certel, Kaan, Cooke, Robert M., Cuozzo, John W., Dekker, Niek, Dumelin, Christoph E., Ferguson, Andrew, Fiez-Vandal, Cédric, Geschwindner, Stefan, Guié, Marie-Aude, Habeshian, Sevan, Keefe, Anthony D., Schlenker, Oliver, Sigel, Eric A., Snijder, Arjan, Soutter, Holly T., Sundström, Linda, Troast, Dawn M., Wiggin, Giselle, Zhang, Jing, Zhang, Ying, Clark, Matthew A.
Published in SLAS discovery (01.06.2018)
Published in SLAS discovery (01.06.2018)
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A Target Class Ligandability Evaluation of WD40 Repeat-Containing Proteins
Ackloo, Suzanne, Li, Fengling, Szewczyk, Magda, Seitova, Almagul, Loppnau, Peter, Zeng, Hong, Xu, Jin, Ahmad, Shabbir, Arnautova, Yelena A, Baghaie, A J, Beldar, Serap, Bolotokova, Albina, Centrella, Paolo A, Chau, Irene, Clark, Matthew A, Cuozzo, John W, Dehghani-Tafti, Saba, Disch, Jeremy S, Dong, Aiping, Dumas, Antoine, Feng, Jianwen A, Ghiabi, Pegah, Gibson, Elisa, Gilmer, Justin, Goldman, Brian, Green, Stuart R, Guié, Marie-Aude, Guilinger, John P, Harms, Nathan, Herasymenko, Oleksandra, Houliston, Scott, Hutchinson, Ashley, Kearnes, Steven, Keefe, Anthony D, Kimani, Serah W, Kramer, Trevor, Kutera, Maria, Kwak, Haejin A, Lento, Cristina, Li, Yanjun, Liu, Jenny, Loup, Joachim, Machado, Raquel A C, Mulhern, Christopher J, Perveen, Sumera, Righetto, Germanna L, Riley, Patrick, Shrestha, Suman, Sigel, Eric A, Silva, Madhushika, Sintchak, Michael D, Slakman, Belinda L, Taylor, Rhys D, Thompson, James, Torng, Wen, Underkoffler, Carl, von Rechenberg, Moritz, Walsh, Ryan T, Watson, Ian, Wilson, Derek J, Wolf, Esther, Yadav, Manisha, Yazdi, Aliakbar K, Zhang, Junyi, Zhang, Ying, Santhakumar, Vijayaratnam, Edwards, Aled M, Barsyte-Lovejoy, Dalia, Schapira, Matthieu, Brown, Peter J, Halabelian, Levon, Arrowsmith, Cheryl H
Published in Journal of medicinal chemistry (04.11.2024)
Published in Journal of medicinal chemistry (04.11.2024)
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Abstract 1826: New inhibitors of oncology targets discovered using the affinity-mediated selection of DNA-encoded chemical libraries followed by machine-learning
Keefe, Anthony D., AbouZleikha, Mohamed, Baghaie, AJ, Clark, Matthew A., Guie, Marie-Aude, Guilinger, John P., Walsh, Ryan, Zhang, Ying
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Targeting the Moesin‐CD44 pathway for therapeutic intervention in Alzheimer’s disease
Katis, Vittorio, Bradshaw, William, Betarbet, Ranjita, Jimenez‐Antunez, Carmen, Seyfried, Nicholas T., Slakman, Belinda, Mulhern, Christopher, Guie, Marie‐Aude, Keefe, Anthony, Guilinger, John, Zhang, Ying, Huguet, Christelle, Levey, Allan I., Brennan, Paul E., Mangravite, Lara M., Gileadi, Opher
Published in Alzheimer's & dementia (01.12.2020)
Published in Alzheimer's & dementia (01.12.2020)
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Targeting the Moesin‐CD44 pathway for therapeutic intervention in Alzheimer’s disease: Molecular and cell biology/protein‐protein interactions
Katis, Vittorio, Bradshaw, William, Betarbet, Ranjita, Jimenez‐Antunez, Carmen, Seyfried, Nicholas T., Slakman, Belinda, Mulhern, Christopher, Guie, Marie‐Aude, Keefe, Anthony, Guilinger, John, Zhang, Ying, Huguet, Christelle, Levey, Allan I., Brennan, Paul E., Mangravite, Lara M., Gileadi, Opher
Published in Alzheimer's & dementia (01.12.2020)
Published in Alzheimer's & dementia (01.12.2020)
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Machine learning on DNA-encoded libraries: A new paradigm for hit-finding
McCloskey, Kevin, Sigel, Eric A, Kearnes, Steven, Xue, Ling, Tian, Xia, Moccia, Dennis, Gikunju, Diana, Bazzaz, Sana, Chan, Betty, Clark, Matthew A, Cuozzo, John W, Marie-Aude Guié, Guilinger, John P, Huguet, Christelle, Hupp, Christopher D, Keefe, Anthony D, Mulhern, Christopher J, Zhang, Ying, Riley, Patrick
Published in arXiv.org (31.01.2020)
Published in arXiv.org (31.01.2020)
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