Synthesis and in Vitro and in Vivo Structure−Activity Relationships of Novel Antifungal Triazoles for Dermatology
Meerpoel, Lieven, Backx, Leo J. J, Van der Veken, Louis J. E, Heeres, Jan, Corens, David, De Groot, Alex, Odds, Frank C, Van Gerven, Frans, Woestenborghs, Filip A. A, Van Breda, Andre, Oris, Michel, van Dorsselaer, Pascal, Willemsens, Gustaaf H. M, Vermuyten, Karen J. P, Marichal, Patrick J. M. G, Vanden Bossche, Hugo F, Ausma, Jannie, Borgers, Marcel
Published in Journal of medicinal chemistry (24.03.2005)
Published in Journal of medicinal chemistry (24.03.2005)
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Synthesis and in vitro and in vivo Antifungal Activity of the Hydroxy Metabolites of Saperconazole
Meerpoel, Lieven, Heeres, Jan, Backx, Leo J. J., Van der Veken, Louis J. E., Hendrickx, Rob, Corens, David, De Groot, Alex, Leurs, Stef, Van der Eycken, Luc, Weerts, Johan, Luyts, Paul, Van Gerven, Frans, Woestenborghs, Filip A. A., Van Breda, Andre, Oris, Michel, van Dorsselaer, Pascal, Willemsens, Gustaaf H. M., Bellens, Danny, Marichal, Patrick J. M. G., Vanden Bossche, Hugo F., Odds, Frank C.
Published in ChemMedChem (03.05.2010)
Published in ChemMedChem (03.05.2010)
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The Novel Azole R126638 Is a Selective Inhibitor of Ergosterol Synthesis in Candida albicans, Trichophyton spp., and Microsporum canis
VANDEN BOSSCHE, Hugo, AUSMA, Jannie, BOHETS, Hilde, VERMUYTEN, Karen, WILLEMSENS, Gustaaf, MARICHAL, Patrick, MEERPOEL, Lieven, ODDS, Frank, BORGERS, Marcel
Published in Antimicrobial Agents and Chemotherapy (01.09.2004)
Published in Antimicrobial Agents and Chemotherapy (01.09.2004)
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Accumulation of 3-Ketosteroids Induced by Itraconazole in Azole-Resistant Clinical Candida albicans Isolates
MARICHAL, P, GORRENS, J, ODDS, F, VANDEN BOSSCHE, H, LAURIJSSENS, L, VERMUYTEN, K, VAN HOVE, C, LE JEUNE, L, VERHASSELT, P, SANGLARD, D, BORGERS, M, RAMAEKERS, F. C. S
Published in Antimicrobial Agents and Chemotherapy (01.11.1999)
Published in Antimicrobial Agents and Chemotherapy (01.11.1999)
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Mode of action studies. Basis for the search of new antifungal drugs
Vanden Bossche, H, Marichal, P, Gorrens, J, Geerts, H, Janssen, P A
Published in Annals of the New York Academy of Sciences (01.12.1988)
Published in Annals of the New York Academy of Sciences (01.12.1988)
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Advanced Biological and Chemical Discovery (ABCD): Centralizing Discovery Knowledge in an Inherently Decentralized World
Agrafiotis, Dimitris K, Alex, Simson, Dai, Heng, Derkinderen, An, Farnum, Michael, Gates, Peter, Izrailev, Sergei, Jaeger, Edward P, Konstant, Paul, Leung, Albert, Lobanov, Victor S, Marichal, Patrick, Martin, Douglas, Rassokhin, Dmitrii N, Shemanarev, Maxim, Skalkin, Andrew, Stong, John, Tabruyn, Tom, Vermeiren, Marleen, Wan, Jackson, Xu, Xiang Yang, Yao, Xiang
Published in Journal of chemical information and modeling (01.11.2007)
Published in Journal of chemical information and modeling (01.11.2007)
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Contribution of mutations in the cytochrome P450 14α-demethylase (Erg11p, Cyp51p) to azole resistance in Candida albicans
MARICHAL, P, KOYMANS, L, WILLEMSENS, S, BELLENS, D, VERHASSELT, P, LUYTEN, W, BORGERS, M, RAMAEKERS, F. C. S, ODDS, F. C, BOSSCHE, H. V
Published in Microbiology (Society for General Microbiology) (01.10.1999)
Published in Microbiology (Society for General Microbiology) (01.10.1999)
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Molecular mechanisms of drug resistance in fungi
Vanden Bossche, Hugo, Marichal, Patrick, Odds, Frank C.
Published in Trends in microbiology (Regular ed.) (01.10.1994)
Published in Trends in microbiology (Regular ed.) (01.10.1994)
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Journal Article
Data reduction and representation in drug discovery
Howe, Trevor J., Mahieu, Guy, Marichal, Patrick, Tabruyn, Tom, Vugts, Pieter
Published in Drug discovery today (2007)
Published in Drug discovery today (2007)
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Journal Article
Rhodamine 6G efflux for the detection of CDR1-overexpressing azole-resistant Candida albicans strains
MAESAKI, S, MARICHAL, P, VANDEN BOSSCHE, H, SANGLARD, D, KOHNO, S
Published in Journal of antimicrobial chemotherapy (01.07.1999)
Published in Journal of antimicrobial chemotherapy (01.07.1999)
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Molecular biological characterization of an azole-resistant Candida glabrata isolate
MARICHAL, P, VANDEN BOSSCHE, H, ODDS, F. C, NOBELS, G, WARNOCK, D. W, TIMMERMAN, V, VAN BROECKHOVEN, C, FAY, S, MOSE-LARSEN, P
Published in Antimicrobial Agents and Chemotherapy (01.10.1997)
Published in Antimicrobial Agents and Chemotherapy (01.10.1997)
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Journal Article
Pyrrolo[1,2- a][1,4]benzodiazepine: A novel class of non-azole anti-dermatophyte anti-fungal agents
Meerpoel, Lieven, Gestel, Jef Van, Gerven, Frans Van, Woestenborghs, Filip, Marichal, Patrick, Sipido, Vic, Terence, Gilkerson, Nash, Roger, Corens, David, Richards, Ray D.
Published in Bioorganic & medicinal chemistry letters (15.07.2005)
Published in Bioorganic & medicinal chemistry letters (15.07.2005)
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REALISIS: A Medicinal Chemistry-Oriented Reagent Selection, Library Design, and Profiling Platform
Yasri, Aziz, Berthelot, Didier, Gijsen, Harry, Thielemans, Theo, Marichal, Patrick, Engels, Michael, Hoflack, Jan
Published in Journal of Chemical Information and Computer Sciences (01.11.2004)
Published in Journal of Chemical Information and Computer Sciences (01.11.2004)
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Novel antifungals based on 4-substituted imidazole: A combinatorial chemistry approach to lead discovery and optimization
Saha, Ashis K, Liu, Li, Simoneaux, Richard L, Kukla, Michael J, Marichal, Patrick, Odds, Frank
Published in Bioorganic & medicinal chemistry letters (02.10.2000)
Published in Bioorganic & medicinal chemistry letters (02.10.2000)
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Novel antifungals based on 4-substituted imidazole: solid-phase synthesis of substituted aryl sulfonamides towards optimization of in vitro activity
Saha, Ashis K., Liu, Li, Marichal, Patrick, Odds, Frank
Published in Bioorganic & medicinal chemistry letters (18.12.2000)
Published in Bioorganic & medicinal chemistry letters (18.12.2000)
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Hypothesis on the mechanism of resistance to fluconazole in Histoplasma capsulatum
WHEAT, J, MARICHAL, P, VANDEN BOSSCHE, H, LE MONTE, A, CONNOLLY, P
Published in Antimicrobial Agents and Chemotherapy (01.02.1997)
Published in Antimicrobial Agents and Chemotherapy (01.02.1997)
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Contribution of mutations in the cytochrome P450 14{alpha}-demethylase (Erg11p, Cyp51p) to azole resistance in Candida albicans
Marichal, Patrick, Koymans, Luc, Willemsens, Staf, Bellens, Danny, Verhasselt, Peter, Luyten, Walter, Borgers, Marcel, Ramaekers, Frans C. S, Odds, Frank C, Vanden Bossche, Hugo
Published in Microbiology (Society for General Microbiology) (01.10.1999)
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Published in Microbiology (Society for General Microbiology) (01.10.1999)
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