A Novel Glucagon Receptor Antagonist Inhibits Glucagon-Mediated Biological Effects
QURESHI, Sajjad A, CANDELORE, Mari Rios, GUOQIANG JIANG, BRADY, Ed, SAPERSTEIN, Richard, DUFFY, Joseph L, TATA, James R, CHAPMAN, Kevin T, MOLLER, David E, ZHANG, Bei B, DAN XIE, XIAODONG YANG, TOTA, Laurie M, DING, Victor D.-H, ZHIHUA LI, BANSAL, Alka, MILLER, Corin, COHEN, Sheila M
Published in Diabetes (New York, N.Y.) (01.12.2004)
Published in Diabetes (New York, N.Y.) (01.12.2004)
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Hepatic glucagon receptor binding and glucose-lowering in vivo by peptidyl and non-peptidyl glucagon receptor antagonists
Dallas-Yang, Qing, Shen, Xiaolan, Strowski, Mathias, Brady, Edward, Saperstein, Richard, Gibson, Raymond E., Szalkowski, Deborah, Qureshi, Sajjad A., Candelore, Mari Rios, Fenyk-Melody, Judith E., Parmee, Emma R., Zhang, Bei B., Jiang, Guoqiang
Published in European journal of pharmacology (06.10.2004)
Published in European journal of pharmacology (06.10.2004)
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Anti-diabetic efficacy and impact on amino acid metabolism of GRA1, a novel small-molecule glucagon receptor antagonist
Mu, James, Qureshi, Sajjad A, Brady, Edward J, Muise, Eric S, Candelore, Mari Rios, Jiang, Guoqiang, Li, Zhihua, Wu, Margaret S, Yang, Xiaodong, Dallas-Yang, Qing, Miller, Corey, Xiong, Yusheng, Langdon, Ronald B, Parmee, Emma R, Zhang, Bei B
Published in PloS one (19.11.2012)
Published in PloS one (19.11.2012)
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Design and synthesis of conformationally constrained tri-substituted ureas as potent antagonists of the human glucagon receptor
Liang, Rui, Abrardo, Lauren, Brady, Edward J., Candelore, Mari Rios, Ding, Victor, Saperstein, Richard, Tota, Laurie M., Wright, Michael, Mock, Steve, Tamvakopolous, Constantin, Tong, Sharon, Zheng, Song, Zhang, Bei B., Tata, James R., Parmee, Emma R.
Published in Bioorganic & medicinal chemistry letters (01.02.2007)
Published in Bioorganic & medicinal chemistry letters (01.02.2007)
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Discovery and investigation of a novel class of thiophene-derived antagonists of the human glucagon receptor
Duffy, Joseph L., Kirk, Brian A., Konteatis, Zenon, Campbell, Elizabeth L., Liang, Rui, Brady, Edward J., Candelore, Mari Rios, Ding, Victor D.H., Jiang, Guoqiang, Liu, Frank, Qureshi, Sajjad A., Saperstein, Richard, Szalkowski, Deborah, Tong, Sharon, Tota, Lauri M., Xie, Dan, Yang, Xiaodong, Zafian, Peter, Zheng, Song, Chapman, Kevin T., Zhang, Bei B., Tata, James R.
Published in Bioorganic & medicinal chemistry letters (01.03.2005)
Published in Bioorganic & medicinal chemistry letters (01.03.2005)
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Phytosphingosine 1-phosphate: a high affinity ligand for the S1P4/Edg-6 receptor
Rios Candelore, Mari, Wright, Michael J, Tota, Laurie M, Milligan, James, Shei, Gan-ju, Bergstrom, James D, Mandala, Suzanne M
Published in Biochemical and biophysical research communications (01.09.2002)
Published in Biochemical and biophysical research communications (01.09.2002)
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Discovery of novel, potent, and orally active spiro-urea human glucagon receptor antagonists
Shen, Dong-Ming, Zhang, Fengqi, Brady, Edward J., Candelore, Mari Rios, Dallas-Yang, Qing, Ding, Victor D.-H., Dragovic, Jasminka, Feeney, William P., Jiang, Guoquiang, McCann, Peggy E., Mock, Steve, Qureshi, Sajjad A., Saperstein, Richard, Shen, Xiaolan, Tamvakopoulos, Constantin, Tong, Xinchun, Tota, Laurie M., Wright, Michael J., Yang, Xiaodong, Zheng, Song, Chapman, Kevin T., Zhang, Bei B., Tata, James R., Parmee, Emma R.
Published in Bioorganic & medicinal chemistry letters (15.10.2005)
Published in Bioorganic & medicinal chemistry letters (15.10.2005)
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Brain-Derived Acidic Fibroblast Growth Factor: Complete Amino Acid Sequence and Homologies
Gimenez-Gallego, Guillermo, Rodkey, John, Bennett, Carl, Rios-Candelore, Mari, DiSalvo, Jerry, Thomas, Kenneth
Published in Science (American Association for the Advancement of Science) (20.12.1985)
Published in Science (American Association for the Advancement of Science) (20.12.1985)
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Beta-3 Adrenergic Receptor Agonists Cause an Increase in Gastrointestinal Transit Time in Wild-type Mice, But Not in Mice Lacking the Beta-3 Adrenergic Receptor
Fletcher, D S, Candelore, M R, Grujic, D, Lowell, B B, Luell, S, Susulic, V S, Macintyre, D E
Published in The Journal of pharmacology and experimental therapeutics (01.11.1998)
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Published in The Journal of pharmacology and experimental therapeutics (01.11.1998)
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Phytosphingosine 1-phosphate: a high affinity ligand for the S1P(4)/Edg-6 receptor
Candelore, Mari Rios, Wright, Michael J, Tota, Laurie M, Milligan, James, Shei, Gan-ju, Bergstrom, James D, Mandala, Suzanne M
Published in Biochemical and biophysical research communications (27.09.2002)
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Published in Biochemical and biophysical research communications (27.09.2002)
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Direct observation (NMR) of the efficacy of glucagon receptor antagonists in murine liver expressing the human glucagon receptor
Cohen, Sheila M., Duffy, Joseph L., Miller, Corin, Kirk, Brian A., Candelore, Mari Rios, Ding, Victor D.H., Kaczorowski, Gregory, Tota, Laurie M., Werrmann, Jeffrey G., Wright, Michael, Parmee, Emma R., Tata, James R., Zhang, Bei B.
Published in Bioorganic & medicinal chemistry (01.03.2006)
Published in Bioorganic & medicinal chemistry (01.03.2006)
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Journal Article
Phytosphingosine 1-phosphate: a high affinity ligand for the S1P 4/Edg-6 receptor
Rios Candelore, Mari, Wright, Michael J, Tota, Laurie M, Milligan, James, Shei, Gan-ju, Bergstrom, James D, Mandala, Suzanne M
Published in Biochemical and biophysical research communications (2002)
Published in Biochemical and biophysical research communications (2002)
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Identification of Residues Required for Ligand Binding to the β -adrenergic Receptor
Strader, Catherine D., Sigal, Irving S., Register, R. Bruce, Candelore, Mari Rios, Rands, Elaine, Richard A. F. Dixon
Published in Proceedings of the National Academy of Sciences - PNAS (01.07.1987)
Published in Proceedings of the National Academy of Sciences - PNAS (01.07.1987)
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Acute effect of ephedrine on 24-h energy balance
Shannon, J. R., Gottesdiener, K., Jordan, J., Chen, K., Flattery, S., Larson, P. J., Candelore, M. R., Gertz, B., Robertson, D., Sun, M.
Published in Clinical science (1979) (01.05.1999)
Published in Clinical science (1979) (01.05.1999)
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Ligand binding to the beta-adrenergic receptor involves its rhodopsin-like core
Dixon, R A, Sigal, I S, Rands, E, Register, R B, Candelore, M R, Blake, A D, Strader, C D
Published in Nature (London) (05.03.1987)
Published in Nature (London) (05.03.1987)
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L-750355, a human ß3-adrenoceptor agonist; in vitro pharmacology and profile of activity in vivo in the rhesus monkey
Forrest, Michael J, Hom, Gary, Bach, Tom, Candelore, Mari Rios, Cascieri, Margaret A, Strader, Catherine, Tota, Laurie, Fisher, Michael H, Szumiloski, John, Ok, Hyun O, Weber, Ann E, Wyvratt, Matthew, Vicario, Pasquale, Marko, Olga, Deng, Liping, Cioffe, Christine, Hegarty-Friscino, Bonnie, MacIntyre, Euan
Published in European journal of pharmacology (27.10.2000)
Published in European journal of pharmacology (27.10.2000)
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Pure Brain-Derived Acidic Fibroblast Growth Factor is a Potent Angiogenic Vascular Endothelial Cell Mitogen with Sequence Homology to Interleukin 1
Thomas, Kenneth A., Rios-Candelore, Mari, Gimenez-Gallego, Guillermo, DiSalvo, Jerry, Bennett, Carl, Rodkey, John, Fitzpatrick, Susan
Published in Proceedings of the National Academy of Sciences - PNAS (01.10.1985)
Published in Proceedings of the National Academy of Sciences - PNAS (01.10.1985)
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Journal Article
Potent and Selective Human β3-Adrenergic Receptor Antagonists
Mari Rios Candelore, Liping Deng, Laurie Tota, Xiao-Ming Guan, Angela Amend, Yong Liu, Ron Newbold, Margaret A. Cascieri, Ann E. Weber
Published in The Journal of pharmacology and experimental therapeutics (01.08.1999)
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Published in The Journal of pharmacology and experimental therapeutics (01.08.1999)
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β3-Adrenoceptor Agonist-Induced Increases in Lipolysis, Metabolic Rate, Facial Flushing, and Reflex Tachycardia in Anesthetized Rhesus Monkeys
Gary J. Hom, Michael J. Forrest, Thomas J. Bach, Edward Brady, Mari Rios Candelore, Margaret A. Cascieri, Donna J. Fletcher, Michael H. Fisher, Susan A. Iliff, Robert Mathvink, Joseph Metzger, Victor Pecore, Richard Saperstein, Thomas Shih, Ann E. Weber, Matthew Wyvratt, Peter Zafian, D. Euan MacIntyre
Published in The Journal of pharmacology and experimental therapeutics (01.04.2001)
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Published in The Journal of pharmacology and experimental therapeutics (01.04.2001)
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