Impact of Apolipoprotein E (ApoE) Polymorphism on Brain ApoE Levels
Riddell, David R, Zhou, Hua, Atchison, Kevin, Warwick, Helen K, Atkinson, Peter J, Jefferson, Julius, Xu, Lin, Aschmies, Suzan, Kirksey, Yolanda, Hu, Yun, Wagner, Erik, Parratt, Adrienne, Xu, Jane, Li, Zhuting, Zaleska, Margaret M, Jacobsen, J. Steve, Pangalos, Menelas N, Reinhart, Peter H
Published in The Journal of neuroscience (05.11.2008)
Published in The Journal of neuroscience (05.11.2008)
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Discovery and Preclinical Characterization of 1‑Methyl‑3-(4‑methylpyridin‑3‑yl)‑6‑(pyridin‑2‑ylmethoxy)‑1H‑pyrazolo-[3,4‑b]pyrazine (PF470): A Highly Potent, Selective, and Efficacious Metabotropic Glutamate Receptor 5 (mGluR5) Negative Allosteric Modulator
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Published in Journal of medicinal chemistry (13.02.2014)
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Enhanced clearance of Aβ in brain by sustaining the plasmin proteolysis cascade
Jacobsen, J. Steven, Comery, Thomas A, Martone, Robert L, Elokdah, Hassan, Crandall, David L, Oganesian, Aram, Aschmies, Suzan, Kirksey, Yolanda, Gonzales, Cathleen, Xu, Jane, Zhou, Hua, Atchison, Kevin, Wagner, Erik, Zaleska, Margaret M, Das, Indranil, Arias, Robert L, Bard, Jonathan, Riddell, David, Gardell, Stephen J, Abou-Gharbia, Magid, Robichaud, Albert, Magolda, Ronald, Vlasuk, George P, Bjornsson, Thorir, Reinhart, Peter H, Pangalos, Menelas N
Published in Proceedings of the National Academy of Sciences - PNAS (24.06.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (24.06.2008)
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Amiloride is neuroprotective in an MPTP model of Parkinson's disease
Arias, Robert L, Sung, Mei-Li A, Vasylyev, Dmytro, Zhang, Mei-Yi, Albinson, Kristin, Kubek, Katie, Kagan, Natasha, Beyer, Chad, Lin, Qian, Dwyer, Jason M, Zaleska, Margaret M, Bowlby, Mark R, Dunlop, John, Monaghan, Michael
Published in Neurobiology of disease (01.09.2008)
Published in Neurobiology of disease (01.09.2008)
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Binding of rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities
Ruan, Benfang, Pong, Kevin, Jow, Flora, Bowlby, Mark, Crozier, Robert A, Liu, Danni, Liang, Shi, Chen, Yi, Mercado, Mary Lynn, Feng, Xidong, Bennett, Frann, von Schack, David, McDonald, Leonard, Zaleska, Margaret M, Wood, Andrew, Reinhart, Peter H, Magolda, Ronald L, Skotnicki, Jerauld, Pangalos, Menelas N, Koehn, Frank E, Carter, Guy T, Abou-Gharbia, Magid, Graziani, Edmund I
Published in Proceedings of the National Academy of Sciences - PNAS (08.01.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (08.01.2008)
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Missing steps in the STAIR case: a Translational Medicine perspective on the development of NXY-059 for treatment of acute ischemic stroke
Feuerstein, Giora Z, Zaleska, Margaret M, Krams, Michael, Wang, Xinkang, Day, Mark, Rutkowski, Julia L, Finklestein, Seth P, Pangalos, Menelas N, Poole, Michael, Stiles, Gary L, Ruffolo, Robert R, Walsh, Frank L
Published in Journal of cerebral blood flow and metabolism (01.01.2008)
Published in Journal of cerebral blood flow and metabolism (01.01.2008)
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Neuroprotective Profile of Novel Src Kinase Inhibitors in Rodent Models of Cerebral Ischemia
Liang, Shi, Pong, Kevin, Gonzales, Cathleen, Chen, Yi, Ling, Huai-Ping, Mark, Robert J, Boschelli, Frank, Boschelli, Diane H, Ye, Fei, Barrios Sosa, Ana Carolina, Mansour, Tarek S, Frost, Philip, Wood, Andrew, Pangalos, Menelas N, Zaleska, Margaret M
Published in The Journal of pharmacology and experimental therapeutics (01.12.2009)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2009)
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Myostatin inhibition slows muscle atrophy in rodent models of amyotrophic lateral sclerosis
Holzbaur, Erika L.F., Howland, David S., Weber, Nicholas, Wallace, Karen, She, Yijin, Kwak, Seung, Tchistiakova, Lioudmilla A., Murphy, Erin, Hinson, Joseph, Karim, Riyez, Tan, Xiang Yang, Kelley, Pamela, McGill, Kevin C., Williams, Gareth, Hobbs, Carl, Doherty, Patrick, Zaleska, Margaret M., Pangalos, Menelas N., Walsh, Frank S.
Published in Neurobiology of disease (01.09.2006)
Published in Neurobiology of disease (01.09.2006)
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Sensitive and selective liquid chromatography/tandem mass spectrometry methods for quantitative analysis of 1-methyl-4-phenyl pyridinium (MPP +) in mouse striatal tissue
Zhang, Mei-Yi, Kagan, Natasha, Sung, Mei-Li A, Zaleska, Margaret M., Monaghan, Michael
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (15.10.2008)
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (15.10.2008)
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Phosphodiesterase 10A Inhibition Improves Cortico-Basal Ganglia Function in Huntington’s Disease Models
Beaumont, Vahri, Zhong, Sheng, Lin, Hai, Xu, WenJin, Bradaia, Amyaouch, Steidl, Esther, Gleyzes, Melanie, Wadel, Kristian, Buisson, Bruno, Padovan-Neto, Fernando E., Chakroborty, Shreaya, Ward, Karen M., Harms, John F., Beltran, Jose, Kwan, Mei, Ghavami, Afshin, Häggkvist, Jenny, Tóth, Miklós, Halldin, Christer, Varrone, Andrea, Schaab, Christoph, Dybowski, J. Nikolaj, Elschenbroich, Sarah, Lehtimäki, Kimmo, Heikkinen, Taneli, Park, Larry, Rosinski, James, Mrzljak, Ladislav, Lavery, Daniel, West, Anthony R., Schmidt, Christopher J., Zaleska, Margaret M., Munoz-Sanjuan, Ignacio
Published in Neuron (Cambridge, Mass.) (21.12.2016)
Published in Neuron (Cambridge, Mass.) (21.12.2016)
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Temporal assessment of caspase activation in experimental models of focal and global ischemia
Cho, Seongeun, Liu, Danni, Gonzales, Cathleen, Zaleska, Margaret M, Wood, Andrew
Published in Brain research (29.08.2003)
Published in Brain research (29.08.2003)
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Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease
Martone, Robert L, Zhou, Hua, Atchison, Kevin, Comery, Thomas, Xu, Jane Z, Huang, Xinyi, Gong, Xioahai, Jin, Mei, Kreft, Anthony, Harrison, Boyd, Mayer, Scott C, Aschmies, Suzan, Gonzales, Cathleen, Zaleska, Margaret M, Riddell, David R, Wagner, Erik, Lu, Peimin, Sun, Shaiu-Ching, Sonnenberg-Reines, June, Oganesian, Aram, Adkins, Karissa, Leach, Michael W, Clarke, David W, Huryn, Donna, Abou-Gharbia, Magid, Magolda, Ronald, Bard, Jonathan, Frick, Glen, Raje, Sangeeta, Forlow, S Bradley, Balliet, Carrie, Burczynski, Michael E, Reinhart, Peter H, Wan, Hong I, Pangalos, Menelas N, Jacobsen, J Steven
Published in The Journal of pharmacology and experimental therapeutics (01.11.2009)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2009)
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In vitro phosphodiesterase 10A (PDE10A) binding in whole hemisphere human brain using the PET radioligand [18F]MNI-659
Svedberg, Marie M., Varnäs, Katarina, Varrone, Andrea, Mitsios, Nicholas, Mulder, Jan, Gulyás, Balázs, Beaumont, Vahri, Munoz-Sanjuan, Ignacio, Zaleska, Margaret M., Schmidt, Christopher J., Halldin, Christer, Mrzljak, Ladislav
Published in Brain research (15.05.2019)
Published in Brain research (15.05.2019)
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DPP-4 inhibitors sitagliptin and PF-00734,200 mitigate dopaminergic neurodegeneration, neuroinflammation and behavioral impairment in the rat 6-OHDA model of Parkinson’s disease
Yu, Seong-Jin, Wang, Yun, Shen, Hui, Bae, Eun-Kyung, Li, Yazhou, Sambamurti, Kumar, Tones, Michael A., Zaleska, Margaret M., Hoffer, Barry J., Greig, Nigel H.
Published in GeroScience (02.04.2024)
Published in GeroScience (02.04.2024)
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Sitagliptin elevates plasma and CSF incretin levels following oral administration to nonhuman primates: relevance for neurodegenerative disorders
Li, Yazhou, Vaughan, Kelli L., Wang, Yun, Yu, Seong-Jin, Bae, Eun-Kyung, Tamargo, Ian A., Kopp, Katherine O., Tweedie, David, Chiang, Cheng-Chuan, Schmidt, Keith T., Lahiri, Debomoy K., Tones, Michael A., Zaleska, Margaret M., Hoffer, Barry J., Mattison, Julie A., Greig, Nigel H.
Published in GeroScience (27.03.2024)
Published in GeroScience (27.03.2024)
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Discovery of Begacestat, a Notch-1-Sparing γ-Secretase Inhibitor for the Treatment of Alzheimer’s Disease
Mayer, Scott C, Kreft, Anthony F, Harrison, Boyd, Abou-Gharbia, Magid, Antane, Madelene, Aschmies, Suzan, Atchison, Kevin, Chlenov, Michael, Cole, Derek C, Comery, Thomas, Diamantidis, George, Ellingboe, John, Fan, Kristi, Galante, Rocco, Gonzales, Cathleen, Ho, Douglas M, Hoke, Molly E, Hu, Yun, Huryn, Donna, Jain, Uday, Jin, Mei, Kremer, Kenneth, Kubrak, Dennis, Lin, Melissa, Lu, Peimin, Magolda, Ron, Martone, Robert, Moore, William, Oganesian, Aram, Pangalos, Menelas N, Porte, Alex, Reinhart, Peter, Resnick, Lynn, Riddell, David R, Sonnenberg-Reines, June, Stock, Joseph R, Sun, Shaiu-Ching, Wagner, Erik, Wang, Ting, Woller, Kevin, Xu, Zheng, Zaleska, Margaret M, Zeldis, Joseph, Zhang, Minsheng, Zhou, Hua, Jacobsen, J. Steven
Published in Journal of medicinal chemistry (11.12.2008)
Published in Journal of medicinal chemistry (11.12.2008)
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Discovery and Characterization of (R)‑6-Neopentyl-2-(pyridin-2-ylmethoxy)-6,7-dihydropyrimido[2,1‑c][1,4]oxazin-4(9H)‑one (PF-06462894), an Alkyne-Lacking Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator Profiled in both Rat and Nonhuman Primates
Stepan, Antonia F, Claffey, Michelle M, Reese, Matthew R, Balan, Gayatri, Barreiro, Gabriela, Barricklow, Jason, Bohanon, Michael J, Boscoe, Brian P, Cappon, Gregg D, Chenard, Lois K, Cianfrogna, Julie, Chen, Laigao, Coffman, Karen J, Drozda, Susan E, Dunetz, Joshua R, Ghosh, Somraj, Hou, Xinjun, Houle, Christopher, Karki, Kapil, Lazzaro, John T, Mancuso, Jessica Y, Marcek, John M, Miller, Emily L, Moen, Mark A, O’Neil, Steven, Sakurada, Isao, Skaddan, Marc, Parikh, Vinod, Smith, Deborah L, Trapa, Patrick, Tuttle, Jamison B, Verhoest, Patrick R, Walker, Daniel P, Won, Annie, Wright, Ann S, Whritenour, Jessica, Zasadny, Kenneth, Zaleska, Margaret M, Zhang, Lei, Shaffer, Christopher L
Published in Journal of medicinal chemistry (28.09.2017)
Published in Journal of medicinal chemistry (28.09.2017)
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Screening of immunophilin ligands by quantitative analysis of neurofilament expression and neurite outgrowth in cultured neurons and cells
Liu, Danni, McIlvain, H. Beal, Fennell, Myles, Dunlop, John, Wood, Andrew, Zaleska, Margaret M., Graziani, Edmund I., Pong, Kevin
Published in Journal of neuroscience methods (30.07.2007)
Published in Journal of neuroscience methods (30.07.2007)
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The cPLA2α inhibitor efipladib decreases nociceptive responses without affecting PGE2 levels in the cerebral spinal fluid
Nickerson-Nutter, Cheryl L, Goodwin, Debra, Shen, Marina W H, Damphousse, Christy, Duan, Weili, Samad, Tarek A, McKew, John C, Lee, Katherine L, Zaleska, Margaret M, Mollova, Nevena, Clark, James D
Published in Neuropharmacology (01.03.2011)
Published in Neuropharmacology (01.03.2011)
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