Insertional mutagenesis identifies multiple networks of cooperating genes driving intestinal tumorigenesis
March, H Nikki, Rust, Alistair G, Wright, Nicholas A, ten Hoeve, Jelle, de Ridder, Jeroen, Eldridge, Matthew, van der Weyden, Louise, Berns, Anton, Gadiot, Jules, Uren, Anthony, Kemp, Richard, Arends, Mark J, Wessels, Lodewyk F A, Winton, Douglas J, Adams, David J
Published in Nature genetics (01.12.2011)
Published in Nature genetics (01.12.2011)
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Journal Article
The discovery of 2-substituted phenol quinazolines as potent RET kinase inhibitors with improved KDR selectivity
Newton, Rebecca, Bowler, Katherine A., Burns, Emily M., Chapman, Philip J., Fairweather, Emma E., Fritzl, Samantha J.R., Goldberg, Kristin M., Hamilton, Niall M., Holt, Sarah V., Hopkins, Gemma V., Jones, Stuart D., Jordan, Allan M., Lyons, Amanda J., Nikki March, H., McDonald, Neil Q., Maguire, Laura A., Mould, Daniel P., Purkiss, Andrew G., Small, Helen F., Stowell, Alexandra I.J., Thomson, Graeme J., Waddell, Ian D., Waszkowycz, Bohdan, Watson, Amanda J., Ogilvie, Donald J.
Published in European journal of medicinal chemistry (13.04.2016)
Published in European journal of medicinal chemistry (13.04.2016)
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Journal Article
Identification of selective inhibitors of RET and comparison with current clinical candidates through development and validation of a robust screening cascade [version 1; peer review: 4 approved]
Watson, Amanda J, Hopkins, Gemma V, Hitchin, Samantha, Begum, Habiba, Jones, Stuart, Jordan, Allan, Holt, Sarah, March, H. Nikki, Newton, Rebecca, Small, Helen, Stowell, Alex, Waddell, Ian D, Waszkowycz, Bohdan, Ogilvie, Donald J
Published in F1000 research (2016)
Published in F1000 research (2016)
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Journal Article
Identification of selective inhibitors of RET and comparison with current clinical candidates through development and validation of a robust screening cascade
Watson, Amanda J., Hopkins, Gemma V., Hitchin, Samantha, Begum, Habiba, Jones, Stuart, Jordan, Allan, Holt, Sarah, March, H. Nikki, Newton, Rebecca, Small, Helen, Stowell, Alex, Waddell, Ian D., Waszkowycz, Bohdan, Ogilvie, Donald J.
Published in F1000 research (2016)
Published in F1000 research (2016)
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Journal Article
Nuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formation
Wilson, Catherine H, Crombie, Catriona, van der Weyden, Louise, Poulogiannis, George, Rust, Alistair G, Pardo, Mercedes, Gracia, Tannia, Yu, Lu, Choudhary, Jyoti, Poulin, Gino B, McIntyre, Rebecca E, Winton, Douglas J, March, H Nikki, Arends, Mark J, Fraser, Andrew G, Adams, David J
Published in The EMBO journal (30.05.2012)
Published in The EMBO journal (30.05.2012)
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Journal Article
Anilinoquinazoline inhibitors of the RET kinase domain—Elaboration of the 7-position
Jordan, Allan M., Begum, Habiba, Fairweather, Emma, Fritzl, Samantha, Goldberg, Kristin, Hopkins, Gemma V., Hamilton, Niall M., Lyons, Amanda J., March, H. Nikki, Newton, Rebecca, Small, Helen F., Vishwanath, Swamy, Waddell, Ian D., Waszkowycz, Bohdan, Watson, Amanda J., Ogilvie, Donald J.
Published in Bioorganic & medicinal chemistry letters (01.06.2016)
Published in Bioorganic & medicinal chemistry letters (01.06.2016)
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Journal Article
Abstract B05: Discovery, validation and targeting of novel synthetic lethal interactions in academic drug discovery
March, H. Nikki, Chapman, Phil, Blaikley, Elizabeth, Eberlein, Catherine A., Cockerill, Mark, Hitchin, Samantha, Waddell, Ian D., Ogilvie, Donald
Published in Molecular cancer therapeutics (01.10.2017)
Published in Molecular cancer therapeutics (01.10.2017)
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Abstract 1139: Novel, cellular active inhibitors of G6PD, a key mediator of ROS-induced cellular stress
Jordan, Allan M., Hamilton, Niall M., Hamilton, Nicola S., Hitchin, James R., James, Dominic I., Jones, Stuart D., Lyons, Amanda J., March, H. Nikki, Thomson, Graeme J., Waddell, Ian D., Ogilvie, Donald J.
Published in Cancer research (Chicago, Ill.) (15.04.2012)
Published in Cancer research (Chicago, Ill.) (15.04.2012)
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Journal Article
Nuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formation: Nrbp1 regulates cell fate and tumourigenesis
Wilson, Catherine H, Crombie, Catriona, van der Weyden, Louise, Poulogiannis, George, Rust, Alistair G, Pardo, Mercedes, Gracia, Tannia, Yu, Lu, Choudhary, Jyoti, Poulin, Gino B, McIntyre, Rebecca E, Winton, Douglas J, March, H Nikki, Arends, Mark J, Fraser, Andrew G, Adams, David J
Published in The EMBO journal (30.05.2012)
Published in The EMBO journal (30.05.2012)
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Journal Article
Insertional mutagenesis identifies multiple networks of co-operating genes driving intestinal tumorigenesis
March, H. Nikki, Rust, Alistair G., Wright, Nicholas A., Hoeve, Jelle ten, de Ridder, Jeroen, Eldridge, Matthew, van der Weyden, Louise, Berns, Anton, Gadiot, Jules, Uren, Anthony, Kemp, Richard, Arends, Mark J., Wessels, Lodewyk F. A., Winton, Douglas J., Adams, David J.
Published in Nature genetics (06.11.2011)
Published in Nature genetics (06.11.2011)
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