The Basis for Carbapenem Hydrolysis by Class A β‑Lactamases: A Combined Investigation using Crystallography and Simulations
Fonseca, Fátima, Chudyk, Ewa I, van der Kamp, Marc W, Correia, António, Mulholland, Adrian J, Spencer, James
Published in Journal of the American Chemical Society (07.11.2012)
Published in Journal of the American Chemical Society (07.11.2012)
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Journal Article
Promiscuous recognition of MR1 drives self-reactive mucosal-associated invariant T cell responses
Chancellor, Andrew, Alan Simmons, Robert, Khanolkar, Rahul C, Nosi, Vladimir, Beshirova, Aisha, Berloffa, Giuliano, Colombo, Rodrigo, Karuppiah, Vijaykumar, Pentier, Johanne M, Tubb, Vanessa, Ghadbane, Hemza, Suckling, Richard J, Page, Keith, Crean, Rory M, Vacchini, Alessandro, De Gregorio, Corinne, Schaefer, Verena, Constantin, Daniel, Gligoris, Thomas, Lloyd, Angharad, Hock, Miriam, Srikannathasan, Velupillai, Robinson, Ross A, Besra, Gurdyal S, van der Kamp, Marc W, Mori, Lucia, Calogero, Raffaele, Cole, David K, De Libero, Gennaro, Lepore, Marco
Published in The Journal of experimental medicine (04.09.2023)
Published in The Journal of experimental medicine (04.09.2023)
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Journal Article
Molecular basis of hyper-thermostability in the thermophilic archaeal aldolase MfnB
Maddock, Rosie M. A., Marsh, Carl O., Johns, Samuel T., Rooms, Lynden D., Duke, Phillip W., van der Kamp, Marc W., Stach, James E. M., Race, Paul R.
Published in Extremophiles : life under extreme conditions (01.12.2024)
Published in Extremophiles : life under extreme conditions (01.12.2024)
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Journal Article
Multiscale Simulations of Clavulanate Inhibition Identify the Reactive Complex in Class A β‑Lactamases and Predict the Efficiency of Inhibition
Fritz, Rubén A, Alzate-Morales, Jans H, Spencer, James, Mulholland, Adrian J, van der Kamp, Marc W
Published in Biochemistry (Easton) (03.07.2018)
Published in Biochemistry (Easton) (03.07.2018)
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Journal Article
Cooperative Conformational Transitions Underpin the Activation Heat Capacity in the Temperature Dependence of Enzyme Catalysis
Walker, Emma J., Hamill, Carlin J., Crean, Rory, Connolly, Michael S., Warrender, Annmaree K., Kraakman, Kirsty L., Prentice, Erica J., Steyn-Ross, Alistair, Steyn-Ross, Moira, Pudney, Christopher R., van der Kamp, Marc W., Schipper, Louis A., Mulholland, Adrian J., Arcus, Vickery L.
Published in ACS catalysis (05.04.2024)
Published in ACS catalysis (05.04.2024)
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Journal Article
Rigidifying a De Novo Enzyme Increases Activity and Induces a Negative Activation Heat Capacity
Hindson, Sarah A, Bunzel, H. Adrian, Frank, Bettina, Svistunenko, Dimitri A, Williams, Christopher, van der Kamp, Marc W, Mulholland, Adrian J, Pudney, Christopher R, Anderson, J. L. Ross
Published in ACS catalysis (17.09.2021)
Published in ACS catalysis (17.09.2021)
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Journal Article
Experiment and Simulation Reveal How Mutations in Functional Plasticity Regions Guide Plant Monoterpene Synthase Product Outcome
Leferink, Nicole G. H, Ranaghan, Kara E, Karuppiah, Vijaykumar, Currin, Andrew, van der Kamp, Marc W, Mulholland, Adrian J, Scrutton, Nigel S
Published in ACS catalysis (04.05.2018)
Published in ACS catalysis (04.05.2018)
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Journal Article
An Efficient Computational Assay for β‑Lactam Antibiotic Breakdown by Class A β‑Lactamases
Hirvonen, Viivi H. A, Hammond, Katharine, Chudyk, Ewa I, Limb, Michael A. L, Spencer, James, Mulholland, Adrian J, van der Kamp, Marc W
Published in Journal of chemical information and modeling (26.08.2019)
Published in Journal of chemical information and modeling (26.08.2019)
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Journal Article
Structurally Informed Mutagenesis of a Stereochemically Promiscuous Aldolase Produces Mutants That Catalyze the Diastereoselective Syntheses of All Four Stereoisomers of 3‑Deoxy-hexulosonic Acid
Royer, Sylvain F., Gao, Xuan, Groleau, Robin R., van der Kamp, Marc W., Bull, Steven D., Danson, Michael J., Crennell, Susan J.
Published in ACS catalysis (16.09.2022)
Published in ACS catalysis (16.09.2022)
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Journal Article
Exposing the Interplay Between Enzyme Turnover, Protein Dynamics, and the Membrane Environment in Monoamine Oxidase B
Jones, Hannah B. L, Crean, Rory M, Mullen, Anna, Kendrick, Emanuele G, Bull, Steven D, Wells, Stephen A, Carbery, David R, MacMillan, Fraser, van der Kamp, Marc W, Pudney, Christopher R
Published in Biochemistry (Easton) (07.05.2019)
Published in Biochemistry (Easton) (07.05.2019)
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Journal Article
Rapid Estimation of Catalytic Efficiency by Cumulative Atomic Multipole Moments: Application to Ketosteroid Isomerase Mutants
Beker, Wiktor, van der Kamp, Marc W, Mulholland, Adrian J, Sokalski, W. Andrzej
Published in Journal of chemical theory and computation (14.02.2017)
Published in Journal of chemical theory and computation (14.02.2017)
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Journal Article
Chemical Mapping Exposes the Importance of Active Site Interactions in Governing the Temperature Dependence of Enzyme Turnover
Winter, Samuel D, Jones, Hannah B. L, Răsădean, Dora M, Crean, Rory M, Danson, Michael J, Pantoş, G. Dan, Katona, Gergely, Prentice, Erica, Arcus, Vickery L, van der Kamp, Marc W, Pudney, Christopher R
Published in ACS catalysis (17.12.2021)
Published in ACS catalysis (17.12.2021)
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Journal Article
Uncovering the Relationship between the Change in Heat Capacity for Enzyme Catalysis and Vibrational Frequency through Isotope Effect Studies
Jones, Hannah B. L, Crean, Rory M, Matthews, Christopher, Troya, Anna B, Danson, Michael J, Bull, Steven D, Arcus, Vickery L, van der Kamp, Marc W, Pudney, Christopher R
Published in ACS catalysis (01.06.2018)
Published in ACS catalysis (01.06.2018)
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Journal Article
Epistasis arises from shifting the rate-limiting step during enzyme evolution of a β-lactamase
Fröhlich, Christopher, Bunzel, H Adrian, Buda, Karol, Mulholland, Adrian J, van der Kamp, Marc W, Johnsen, Pål J, Leiros, Hanna-Kirsti S, Tokuriki, Nobuhiko
Published in Nature catalysis (2024)
Published in Nature catalysis (2024)
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