SARS-CoV-2 Omicron variant: Antibody evasion and cryo-EM structure of spike protein-ACE2 complex
Mannar, Dhiraj, Saville, James W, Zhu, Xing, Srivastava, Shanti S, Berezuk, Alison M, Tuttle, Katharine S, Marquez, Ana Citlali, Sekirov, Inna, Subramaniam, Sriram
Published in Science (American Association for the Advancement of Science) (18.02.2022)
Published in Science (American Association for the Advancement of Science) (18.02.2022)
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Structural and biochemical rationale for enhanced spike protein fitness in delta and kappa SARS-CoV-2 variants
Saville, James W., Mannar, Dhiraj, Zhu, Xing, Srivastava, Shanti S., Berezuk, Alison M., Demers, Jean-Philippe, Zhou, Steven, Tuttle, Katharine S., Sekirov, Inna, Kim, Andrew, Li, Wei, Dimitrov, Dimiter S., Subramaniam, Sriram
Published in Nature communications (08.02.2022)
Published in Nature communications (08.02.2022)
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Structure and activity of human TMPRSS2 protease implicated in SARS-CoV-2 activation
Fraser, Bryan J., Beldar, Serap, Seitova, Almagul, Hutchinson, Ashley, Mannar, Dhiraj, Li, Yanjun, Kwon, Daniel, Tan, Ruiyan, Wilson, Ryan P., Leopold, Karoline, Subramaniam, Sriram, Halabelian, Levon, Arrowsmith, Cheryl H., Bénard, François
Published in Nature chemical biology (01.09.2022)
Published in Nature chemical biology (01.09.2022)
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Cryo-electron microscopy structures of the N501Y SARS-CoV-2 spike protein in complex with ACE2 and 2 potent neutralizing antibodies
Zhu, Xing, Mannar, Dhiraj, Srivastava, Shanti S, Berezuk, Alison M, Demers, Jean-Philippe, Saville, James W, Leopold, Karoline, Li, Wei, Dimitrov, Dimiter S, Tuttle, Katharine S, Zhou, Steven, Chittori, Sagar, Subramaniam, Sriram
Published in PLoS biology (29.04.2021)
Published in PLoS biology (29.04.2021)
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Altered receptor binding, antibody evasion and retention of T cell recognition by the SARS-CoV-2 XBB.1.5 spike protein
Mannar, Dhiraj, Saville, James W., Poloni, Chad, Zhu, Xing, Bezeruk, Alison, Tidey, Keith, Ahmed, Sana, Tuttle, Katharine S., Vahdatihassani, Faezeh, Cholak, Spencer, Cook, Laura, Steiner, Theodore S., Subramaniam, Sriram
Published in Nature communications (29.02.2024)
Published in Nature communications (29.02.2024)
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SARS-CoV-2 variants of concern: spike protein mutational analysis and epitope for broad neutralization
Mannar, Dhiraj, Saville, James W., Sun, Zehua, Zhu, Xing, Marti, Michelle M., Srivastava, Shanti S., Berezuk, Alison M., Zhou, Steven, Tuttle, Katharine S., Sobolewski, Michele D., Kim, Andrew, Treat, Benjamin R., Da Silva Castanha, Priscila Mayrelle, Jacobs, Jana L., Barratt-Boyes, Simon M., Mellors, John W., Dimitrov, Dimiter S., Li, Wei, Subramaniam, Sriram
Published in Nature communications (18.08.2022)
Published in Nature communications (18.08.2022)
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Structural analysis of receptor engagement and antigenic drift within the BA.2 spike protein
Saville, James W., Mannar, Dhiraj, Zhu, Xing, Berezuk, Alison M., Cholak, Spencer, Tuttle, Katharine S., Vahdatihassani, Faezeh, Subramaniam, Sriram
Published in Cell reports (Cambridge) (31.01.2023)
Published in Cell reports (Cambridge) (31.01.2023)
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AAA ATPase protein–protein interactions as therapeutic targets in cancer
Mannar, Dhiraj, Ahmed, Sana, Subramaniam, Sriram
Published in Current opinion in cell biology (01.02.2024)
Published in Current opinion in cell biology (01.02.2024)
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High Potency of a Bivalent Human VH Domain in SARS-CoV-2 Animal Models
Li, Wei, Schäfer, Alexandra, Kulkarni, Swarali S., Liu, Xianglei, Martinez, David R., Chen, Chuan, Sun, Zehua, Leist, Sarah R., Drelich, Aleksandra, Zhang, Liyong, Ura, Marcin L., Berezuk, Alison, Chittori, Sagar, Leopold, Karoline, Mannar, Dhiraj, Srivastava, Shanti S., Zhu, Xing, Peterson, Eric C., Tseng, Chien-Te, Mellors, John W., Falzarano, Darryl, Subramaniam, Sriram, Baric, Ralph S., Dimitrov, Dimiter S.
Published in Cell (15.10.2020)
Published in Cell (15.10.2020)
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Structural analysis of receptor binding domain mutations in SARS-CoV-2 variants of concern that modulate ACE2 and antibody binding
Mannar, Dhiraj, Saville, James W., Zhu, Xing, Srivastava, Shanti S., Berezuk, Alison M., Zhou, Steven, Tuttle, Katharine S., Kim, Andrew, Li, Wei, Dimitrov, Dimiter S., Subramaniam, Sriram
Published in Cell reports (Cambridge) (21.12.2021)
Published in Cell reports (Cambridge) (21.12.2021)
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Journal Article
High Potency of a Bivalent Human V H Domain in SARS-CoV-2 Animal Models
Li, Wei, Schäfer, Alexandra, Kulkarni, Swarali S, Liu, Xianglei, Martinez, David R, Chen, Chuan, Sun, Zehua, Leist, Sarah R, Drelich, Aleksandra, Zhang, Liyong, Ura, Marcin L, Berezuk, Alison, Chittori, Sagar, Leopold, Karoline, Mannar, Dhiraj, Srivastava, Shanti S, Zhu, Xing, Peterson, Eric C, Tseng, Chien-Te, Mellors, John W, Falzarano, Darryl, Subramaniam, Sriram, Baric, Ralph S, Dimitrov, Dimiter S
Published in Cell (15.10.2020)
Published in Cell (15.10.2020)
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Structure, activity and inhibition of human TMPRSS2, a protease implicated in SARS-CoV-2 activation
Fraser, Bryan J, Beldar, Serap, Seitova, Almagul, Hutchinson, Ashley, Mannar, Dhiraj, Li, Yanjun, Kwon, Daniel, Tan, Ruiyan, Wilson, Ryan P, Leopold, Karoline, Subramaniam, Sriram, Halabelian, Levon, Arrowsmith, Cheryl H, Benard, Francois
Published in bioRxiv (24.06.2021)
Published in bioRxiv (24.06.2021)
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SARS-CoV-2 Variants Omicron BA.4/5 and XBB.1.5 Significantly Escape T Cell Recognition in Solid-organ Transplant Recipients Vaccinated Against the Ancestral Strain
Halvorson, Torin, Ivison, Sabine, Huang, Qing, Ladua, Gale, Yotis, Demitra M, Mannar, Dhiraj, Subramaniam, Sriram, Ferreira, Victor H, Kumar, Deepali, Belga, Sara, Levings, Megan K
Published in Transplantation (01.04.2024)
Published in Transplantation (01.04.2024)
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Potent and broad neutralization of SARS-CoV-2 variants of concern (VOCs) including omicron sub-lineages BA.1 and BA.2 by biparatopic human VH domains
Chen, Chuan, Saville, James W., Marti, Michelle M., Schäfer, Alexandra, Cheng, Mary Hongying, Mannar, Dhiraj, Zhu, Xing, Berezuk, Alison M., Banerjee, Anupam, Sobolewski, Michele D., Kim, Andrew, Treat, Benjamin R., Da Silva Castanha, Priscila Mayrelle, Enick, Nathan, McCormick, Kevin D., Liu, Xianglei, Adams, Cynthia, Hines, Margaret Grace, Sun, Zehua, Chen, Weizao, Jacobs, Jana L., Barratt-Boyes, Simon M., Mellors, John W., Baric, Ralph S., Bahar, Ivet, Dimitrov, Dimiter S., Subramaniam, Sriram, Martinez, David R., Li, Wei
Published in iScience (19.08.2022)
Published in iScience (19.08.2022)
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Potent Neutralization of Omicron and other SARS-CoV-2 Variants of Concern by Biparatopic Human VH Domains
Chen, Chuan, Saville, James W, Marti, Michelle M, Schäfer, Alexandra, Cheng, Mary Hongying, Mannar, Dhiraj, Zhu, Xing, Berezuk, Alison M, Banerjee, Anupam, Sobolewski, Michele D, Kim, Andrew, Treat, Benjamin R, Da Silva Castanha, Priscila Mayrelle, Enick, Nathan, McCormick, Kevin D, Liu, Xianglei, Adams, Cynthia, Hines, Margaret Grace, Sun, Zehua, Chen, Weizao, Jacobs, Jana L, Barratt-Boyes, Simon M, Mellors, John W, Baric, Ralph S, Bahar, Ivet, Dimitrov, Dimiter S, Subramaniam, Sriram, Martinez, David R, Li, Wei
Published in bioRxiv (24.02.2022)
Published in bioRxiv (24.02.2022)
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