Translating HIV Sequences into Quantitative Fitness Landscapes Predicts Viral Vulnerabilities for Rational Immunogen Design
Ferguson, Andrew L., Mann, Jaclyn K., Omarjee, Saleha, Ndung’u, Thumbi, Walker, Bruce D., Chakraborty, Arup K.
Published in Immunity (Cambridge, Mass.) (21.03.2013)
Published in Immunity (Cambridge, Mass.) (21.03.2013)
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Journal Article
The fitness landscape of HIV-1 gag: advanced modeling approaches and validation of model predictions by in vitro testing
Mann, Jaclyn K, Barton, John P, Ferguson, Andrew L, Omarjee, Saleha, Walker, Bruce D, Chakraborty, Arup, Ndung'u, Thumbi
Published in PLoS computational biology (01.08.2014)
Published in PLoS computational biology (01.08.2014)
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Journal Article
Differing natural killer cell, T cell and antibody profiles in antiretroviral-naive HIV-1 viraemic controllers with and without protective HLA alleles
Moyano, Ana, Ndlovu, Bongiwe, Mbele, Msizi, Naidoo, Kewreshini, Khan, Nasreen, Mann, Jaclyn K, Ndung'u, Thumbi
Published in PloS one (02.06.2023)
Published in PloS one (02.06.2023)
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Journal Article
Association between the cytokine storm, immune cell dynamics, and viral replicative capacity in hyperacute HIV infection
Muema, Daniel M, Akilimali, Ngomu A, Ndumnego, Okechukwu C, Rasehlo, Sipho S, Durgiah, Raveshni, Ojwach, Doty B A, Ismail, Nasreen, Dong, Mary, Moodley, Amber, Dong, Krista L, Ndhlovu, Zaza M, Mabuka, Jenniffer M, Walker, Bruce D, Mann, Jaclyn K, Ndung'u, Thumbi
Published in BMC medicine (25.03.2020)
Published in BMC medicine (25.03.2020)
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Journal Article
HIV-1 subtype C Nef-mediated SERINC5 down-regulation significantly contributes to overall Nef activity
Naicker, Delon, Sonela, Nelson, Jin, Steven W, Mulaudzi, Takalani, Ojwach, Doty, Reddy, Tarylee, Brockman, Mark A, Brumme, Zabrina L, Ndung'u, Thumbi, Mann, Jaclyn K
Published in Retrovirology (31.03.2023)
Published in Retrovirology (31.03.2023)
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Journal Article
Variation in HIV-1 Nef function within and among viral subtypes reveals genetically separable antagonism of SERINC3 and SERINC5
Jin, Steven W, Mwimanzi, Francis M, Mann, Jaclyn K, Bwana, Mwebesa Bosco, Lee, Guinevere Q, Brumme, Chanson J, Hunt, Peter W, Martin, Jeff N, Bangsberg, David R, Ndung'u, Thumbi, Brumme, Zabrina L, Brockman, Mark A
Published in PLoS pathogens (14.09.2020)
Published in PLoS pathogens (14.09.2020)
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Journal Article
Nef-mediated inhibition of NFAT following TCR stimulation differs between HIV-1 subtypes
Naidoo, Lisa, Mzobe, Zinhle, Jin, Steven W., Rajkoomar, Erasha, Reddy, Tarylee, Brockman, Mark A., Brumme, Zabrina L., Ndung’u, Thumbi, Mann, Jaclyn K.
Published in Virology (New York, N.Y.) (01.05.2019)
Published in Virology (New York, N.Y.) (01.05.2019)
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Journal Article
Subtype-specific differences in Gag-protease replication capacity of HIV-1 isolates from East and West Africa
Farinre, Omotayo, Gounder, Kamini, Reddy, Tarylee, Tongo, Marcel, Hare, Jonathan, Chaplin, Beth, Gilmour, Jill, Kanki, Phyllis, Mann, Jaclyn K, Ndung'u, Thumbi
Published in Retrovirology (05.05.2021)
Published in Retrovirology (05.05.2021)
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Journal Article
Ability of HIV-1 Nef to downregulate CD4 and HLA class I differs among viral subtypes
Mann, Jaclyn K, Byakwaga, Helen, Kuang, Xiaomei T, Le, Anh Q, Brumme, Chanson J, Mwimanzi, Philip, Omarjee, Saleha, Martin, Eric, Lee, Guinevere Q, Baraki, Bemuluyigza, Danroth, Ryan, McCloskey, Rosemary, Muzoora, Conrad, Bangsberg, David R, Hunt, Peter W, Goulder, Philip J R, Walker, Bruce D, Harrigan, P Richard, Martin, Jeff N, Ndung'u, Thumbi, Brockman, Mark A, Brumme, Zabrina L
Published in Retrovirology (16.09.2013)
Published in Retrovirology (16.09.2013)
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Journal Article
High frequency of transmitted HIV-1 Gag HLA class I-driven immune escape variants but minimal immune selection over the first year of clade C infection
Gounder, Kamini, Padayachi, Nagavelli, Mann, Jaclyn K, Radebe, Mopo, Mokgoro, Mammekwa, van der Stok, Mary, Mkhize, Lungile, Mncube, Zenele, Jaggernath, Manjeetha, Reddy, Tarylee, Walker, Bruce D, Ndung'u, Thumbi
Published in PloS one (17.03.2015)
Published in PloS one (17.03.2015)
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Journal Article
Attenuated HIV-1 Nef But Not Vpu Function in a Cohort of Rwandan Long-Term Survivors
Umviligihozo, Gisele, Mann, Jaclyn K., Jin, Steven W., Mwimanzi, Francis M., Hsieh, Hua-Shiuan A., Sudderuddin, Hanwei, Lee, Guinevere Q., Byakwaga, Helen, Muzoora, Conrad, Hunt, Peter W., Martin, Jeff N., Haberer, Jessica E., Karita, Etienne, Allen, Susan, Hunter, Eric, Brumme, Zabrina L., Brockman, Mark A.
Published in Frontiers in virology (online) (01.06.2022)
Published in Frontiers in virology (online) (01.06.2022)
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Journal Article
No evidence for selection of HIV-1 with enhanced gag-protease or Nef function among breakthrough infections in the CAPRISA 004 tenofovir microbicide trial
Chopera, Denis R, Mann, Jaclyn K, Mwimanzi, Philip, Omarjee, Saleha, Kuang, Xiaomei T, Ndabambi, Nonkululeko, Goodier, Sarah, Martin, Eric, Naranbhai, Vivek, Karim, Salim Abdool, Karim, Quarraisha Abdool, Brumme, Zabrina L, Ndung'u, Thumbi, Williamson, Carolyn, Brockman, Mark A
Published in PloS one (28.08.2013)
Published in PloS one (28.08.2013)
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Journal Article
Intersubtype Differences in the Effect of a Rare p24 Gag Mutation on HIV-1 Replicative Fitness
CHOPERA, Denis R, COTTON, Laura A, MARTIN, Eric, MIURA, Toshiyuki, PEREYRA, Florencia, WALKER, Bruce D, GRAY, Clive M, MARTIN, Darren P, NDUNG'U, Thumbi, BROCKMAN, Mark A, ABDOOL KARIM, Salim, BRUMME, Zabrina L, ZAWAIRA, Alexander, WILLIAMSON, Carolyn, MANN, Jaclyn K, NGANDU, Nobubelo K, NTALE, Roman, CARLSON, Jonathan M, MLISANA, Koleka, WOODMAN, Zenda, DE ASSIS ROSA, Debra
Published in Journal of Virology (01.12.2012)
Published in Journal of Virology (01.12.2012)
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Journal Article
Generation and characterization of infectious molecular clones of transmitted/founder HIV-1 subtype C viruses
Luthuli, Bonisile, Gounder, Kamini, Deymier, Martin J., Dong, Krista L., Balazs, Alejandro B., Mann, Jaclyn K., Ndung'u, Thumbi
Published in Virology (New York, N.Y.) (01.06.2023)
Published in Virology (New York, N.Y.) (01.06.2023)
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Journal Article
Editorial: Characterization of HIV-1 variants: implications for HIV-1 prevention, treatment and cure
Jaclyn K. Mann, Marcel Tongo, Takamasa Ueno, Takamasa Ueno
Published in Frontiers in virology (online) (16.08.2024)
Published in Frontiers in virology (online) (16.08.2024)
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Journal Article
Vulnerable targets in HIV-1 Pol for attenuation-based vaccine design
Ojwach, Doty B.A., Madlala, Paradise, Gordon, Michelle, Ndung'u, Thumbi, Mann, Jaclyn K.
Published in Virology (New York, N.Y.) (01.02.2021)
Published in Virology (New York, N.Y.) (01.02.2021)
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Journal Article
Subtle Longitudinal Alterations in Env Sequence Potentiate Differences in Sensitivity to Broadly Neutralizing Antibodies following Acute HIV-1 Subtype C Infection
Mandizvo, Tawanda, Gumede, Nombali, Ndlovu, Bongiwe, Ndlovu, Siphiwe, Mann, Jaclyn K, Chopera, Denis R, Singh, Lanish, Dong, Krista L, Walker, Bruce D, Ndhlovu, Zaza M, Lavine, Christy L, Seaman, Michael S, Gounder, Kamini, Ndung'u, Thumbi
Published in Journal of virology (21.12.2022)
Published in Journal of virology (21.12.2022)
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Journal Article