5-Heteroatom substituted pyrazoles as canine COX-2 inhibitors. Part 1: Structure–activity relationship studies of 5-alkylamino pyrazoles and discovery of a potent, selective, and orally active analog
Sakya, Subas M., Lundy DeMello, Kristin M., Minich, Martha L., Rast, Bryson, Shavnya, Andrei, Rafka, Robert J., Koss, David A., Cheng, Hengmiao, Li, Jin, Jaynes, Burton H., Ziegler, Carl B., Mann, Donald W., Petras, Carol F., Seibel, Scott B., Silvia, Annette M., George, David M., Lund, Lisa A., Denis, Suzanne St, Hickman, Anne, Haven, Michelle L., Lynch, Michael P.
Published in Bioorganic & medicinal chemistry letters (15.01.2006)
Published in Bioorganic & medicinal chemistry letters (15.01.2006)
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Journal Article
5-Heteroatom substituted pyrazoles as canine COX-2 inhibitors. Part III: Molecular modeling studies on binding contribution of 1-(5-methylsulfonyl)pyrid-2-yl and 4-nitrile
Sakya, Subas M., Hou, Xinjun, Minich, Martha L., Rast, Bryson, Shavnya, Andrei, DeMello, Kristin M.L., Cheng, Hengmiao, Li, Jin, Jaynes, Burton H., Mann, Donald W., Petras, Carol F., Seibel, Scott B., Haven, Michelle L.
Published in Bioorganic & medicinal chemistry letters (15.02.2007)
Published in Bioorganic & medicinal chemistry letters (15.02.2007)
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Journal Article
Comparative structure–activity relationship studies of 1-(5-methylsulfonylpyrid-2-yl)-5-alkyl and (hetero)aryl triazoles and pyrazoles in canine COX inhibition
Sakya, Subas M., Shavnya, Andrei, Cheng, Hengmiao, Li, Chao, Rast, Bryson, Li, Jin, Koss, David A., Jaynes, Burton H., Mann, Donald W., Petras, Carol F., Seibel, Scott B., Haven, Michelle L., Lynch, Michael P.
Published in Bioorganic & medicinal chemistry (01.02.2008)
Published in Bioorganic & medicinal chemistry (01.02.2008)
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Journal Article
Synthesis and SAR of heteroaryl-phenyl-substituted pyrazole derivatives as highly selective and potent canine COX-2 inhibitors
Cheng, Hengmiao, Lundy DeMello, Kristin M., Li, Jin, Sakya, Subas M., Ando, Kazuo, Kawamura, K., Kato, Tomoki, Rafka, Robert J., Jaynes, Burton H., Ziegler, Carl B., Stevens, Rod, Lund, Lisa A., Mann, Donald W., Kilroy, Carolyn, Haven, Michelle L., Nimz, Erik L., Dutra, Jason K., Li, Chao, Minich, Martha L., Kolosko, Nicole L., Petras, Carol, Silvia, Annette M., Seibel, Scott B.
Published in Bioorganic & medicinal chemistry letters (15.04.2006)
Published in Bioorganic & medicinal chemistry letters (15.04.2006)
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Journal Article
5-Heteroatom-substituted pyrazoles as canine COX-2 inhibitors: Part 2. Structure–activity relationship studies of 5-alkylethers and 5-thioethers
Sakya, Subas M., Cheng, Hengmiao, Lundy DeMello, Kristin M., Shavnya, Andrei, Minich, Martha L., Rast, Bryson, Dutra, Jason, Li, Chao, Rafka, Robert J., Koss, David A., Li, Jin, Jaynes, Burton H., Ziegler, Carl B., Mann, Donald W., Petras, Carol F., Seibel, Scott B., Silvia, Annette M., George, David M., Hickman, Anne, Haven, Michelle L., Lynch, Michael P.
Published in Bioorganic & medicinal chemistry letters (01.03.2006)
Published in Bioorganic & medicinal chemistry letters (01.03.2006)
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Journal Article
Discovery of a potent, selective and orally active canine COX-2 inhibitor, 2-(3-difluoromethyl-5-phenyl-pyrazol-1-yl)-5-methanesulfonyl-pyridine
Li, Jin, DeMello, Kristin M.Lundy, Cheng, Henry, Sakya, Subas M., Bronk, Brian S., Rafka, Robert J., Jaynes, Burton H., Ziegler, Carl B., Kilroy, Carolyn, Mann, Donald W., Nimz, Eric L., Lynch, Michael P., Haven, Michelle L., Kolosko, Nicole L., Minich, Martha L., Li, Chao, Dutra, Jason K., Rast, Bryson, Crosson, Rhonda M., Morton, Barry J., Kirk, Glen W., Callaghan, Kathleen M., Koss, David A., Shavnya, Andrei, Lund, Lisa A., Seibel, Scott B., Petras, Carol F., Silvia, Annette
Published in Bioorganic & medicinal chemistry letters (05.01.2004)
Published in Bioorganic & medicinal chemistry letters (05.01.2004)
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Journal Article
In vitro and in vivo profile of 2-(3-di-fluoromethyl-5-phenylpyrazol-1-yl)-5-methanesulfonylpyridine, a potent, selective, and orally active canine COX-2 inhibitor
Li, Jin, Lynch, Michael P., DeMello, Kristin Lundy, Sakya, Subas M., Cheng, Hengmiao, Rafka, Robert J., Bronk, Brian S., Jaynes, Burton H., Kilroy, Carolyn, Mann, Donald W., Haven, Michelle L., Kolosko, Nicole L., Petras, Carol, Seibel, Scott B., Lund, Lisa A.
Published in Bioorganic & medicinal chemistry (01.03.2005)
Published in Bioorganic & medicinal chemistry (01.03.2005)
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Journal Article
DERIVADOS DE 2-AMINOBENZAZEPINA E SUA UTILIZACAO PARA O TRATAMENTO DA IMUNOSSUPRESSAO
SCOTT J. HECKER, CHRISTOPHER B. COOPER, DONALD W. MANN, JOSEPH PETER LYSSIKATOS
Year of Publication 30.08.2002
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Year of Publication 30.08.2002
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2-Aminobenzazepin-Derivate und ihre Verwendung für die Behandlung von Immunosuppression
LYSSIKATOS, JOSEPH P, COOPER, CHRISTOPHER B, HECKER, SCOTT J, MANN, DONALD W
Year of Publication 22.08.2002
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Year of Publication 22.08.2002
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2-aminobenzazepinderivater og deres anvendelse til behandling af immunosuppression
LYSSIKATOS, JOSEPH P, COOPER, CHRISTOPHER B, HECKER, SCOTT J, MANN, DONALD W
Year of Publication 22.07.2002
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Year of Publication 22.07.2002
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2-AMINOBENZAZEPIN-DERIVATE UND IHRE VERWENDUNG FÜR DIE BEHANDLUNG VON IMMUNOSUPPRESSION
LYSSIKATOS, JOSEPH P, COOPER, CHRISTOPHER B, HECKER, SCOTT J, MANN, DONALD W
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Year of Publication 15.05.2002
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2-Aminobenzazepine derivatives and their use for the treatment of immunosuppression
LYSSIKATOS, JOSEPH P, COOPER, CHRISTOPHER B, HECKER, SCOTT J, MANN, DONALD W
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Year of Publication 17.04.2002
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2-AMINOBENZAZAPINE DERIVATIVES
LYSSIKATOS, JOSEPH P, COOPER, CHRISTOPHER B, HECKER, SCOTT J, MANN, DONALD W
Year of Publication 11.12.2001
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Year of Publication 11.12.2001
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2-Aminobenzazapine derivatives
LYSSIKATOS; JOSEPH P, COOPER; CHRISTOPHER B, MANN; DONALD W, HECKER; SCOTT J
Year of Publication 28.03.2000
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Year of Publication 28.03.2000
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2-AMINOBENZAZEPINE DERIVATIVE
COOPER CHRISTOPHER B, HECKER SCOTT J, MANN DONALD W, LYSSIKATOS JOSEPH P
Year of Publication 07.04.1998
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Year of Publication 07.04.1998
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2-Aminobenzazepine derivatives and their use for the treatment of immunosuppression
LYSSIKATOS, JOSEPH P, COOPER, CHRISTOPHER B, HECKER, SCOTT J, MANN, DONALD W
Year of Publication 25.02.1998
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Year of Publication 25.02.1998
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2-AMINOBENZAZAPINE DERIVATIVES
LYSSIKATOS, JOSEPH P, COOPER, CHRISTOPHER B, HECKER, SCOTT J, MANN, DONALD W
Year of Publication 16.02.1998
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Year of Publication 16.02.1998
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