Shared genetic effects on chromatin and gene expression indicate a role for enhancer priming in immune response
Alasoo, Kaur, Rodrigues, Julia, Mukhopadhyay, Subhankar, Knights, Andrew J., Mann, Alice L., Kundu, Kousik, Hale, Christine, Dougan, Gordon, Gaffney, Daniel J.
Published in Nature genetics (01.03.2018)
Published in Nature genetics (01.03.2018)
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Genetic perturbation of PU.1 binding and chromatin looping at neutrophil enhancers associates with autoimmune disease
Watt, Stephen, Vasquez, Louella, Walter, Klaudia, Mann, Alice L., Kundu, Kousik, Chen, Lu, Sims, Ying, Ecker, Simone, Burden, Frances, Farrow, Samantha, Farr, Ben, Iotchkova, Valentina, Elding, Heather, Mead, Daniel, Tardaguila, Manuel, Ponstingl, Hannes, Richardson, David, Datta, Avik, Flicek, Paul, Clarke, Laura, Downes, Kate, Pastinen, Tomi, Fraser, Peter, Frontini, Mattia, Javierre, Biola-Maria, Spivakov, Mikhail, Soranzo, Nicole
Published in Nature communications (16.04.2021)
Published in Nature communications (16.04.2021)
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Genetic associations at regulatory phenotypes improve fine-mapping of causal variants for 12 immune-mediated diseases
Kundu, Kousik, Tardaguila, Manuel, Mann, Alice L., Watt, Stephen, Ponstingl, Hannes, Vasquez, Louella, Von Schiller, Dominique, Morrell, Nicholas W., Stegle, Oliver, Pastinen, Tomi, Sawcer, Stephen J., Anderson, Carl A., Walter, Klaudia, Soranzo, Nicole
Published in Nature genetics (01.03.2022)
Published in Nature genetics (01.03.2022)
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Journal Article
Genome-wide analysis of differential transcriptional and epigenetic variability across human immune cell types
Ecker, Simone, Chen, Lu, Pancaldi, Vera, Bagger, Frederik O, Fernández, José María, Carrillo de Santa Pau, Enrique, Juan, David, Mann, Alice L, Watt, Stephen, Casale, Francesco Paolo, Sidiropoulos, Nikos, Rapin, Nicolas, Merkel, Angelika, Stunnenberg, Hendrik G, Stegle, Oliver, Frontini, Mattia, Downes, Kate, Pastinen, Tomi, Kuijpers, Taco W, Rico, Daniel, Valencia, Alfonso, Beck, Stephan, Soranzo, Nicole, Paul, Dirk S
Published in Genome Biology (26.01.2017)
Published in Genome Biology (26.01.2017)
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The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease
Astle, William J., Elding, Heather, Jiang, Tao, Allen, Dave, Ruklisa, Dace, Mann, Alice L., Mead, Daniel, Bouman, Heleen, Riveros-Mckay, Fernando, Kostadima, Myrto A., Lambourne, John J., Sivapalaratnam, Suthesh, Downes, Kate, Kundu, Kousik, Bomba, Lorenzo, Berentsen, Kim, Bradley, John R., Daugherty, Louise C., Delaneau, Olivier, Freson, Kathleen, Garner, Stephen F., Grassi, Luigi, Guerrero, Jose, Haimel, Matthias, Janssen-Megens, Eva M., Kaan, Anita, Kamat, Mihir, Kim, Bowon, Mandoli, Amit, Marchini, Jonathan, Martens, Joost H.A., Meacham, Stuart, Megy, Karyn, O’Connell, Jared, Petersen, Romina, Sharifi, Nilofar, Sheard, Simon M., Staley, James R., Tuna, Salih, van der Ent, Martijn, Walter, Klaudia, Wang, Shuang-Yin, Wheeler, Eleanor, Wilder, Steven P., Iotchkova, Valentina, Moore, Carmel, Sambrook, Jennifer, Stunnenberg, Hendrik G., Di Angelantonio, Emanuele, Kaptoge, Stephen, Kuijpers, Taco W., Carrillo-de-Santa-Pau, Enrique, Juan, David, Rico, Daniel, Valencia, Alfonso, Chen, Lu, Ge, Bing, Vasquez, Louella, Kwan, Tony, Garrido-Martín, Diego, Watt, Stephen, Yang, Ying, Guigo, Roderic, Beck, Stephan, Paul, Dirk S., Pastinen, Tomi, Bujold, David, Bourque, Guillaume, Frontini, Mattia, Danesh, John, Roberts, David J., Ouwehand, Willem H., Butterworth, Adam S., Soranzo, Nicole
Published in Cell (17.11.2016)
Published in Cell (17.11.2016)
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Journal Article
Genetic Drivers of Epigenetic and Transcriptional Variation in Human Immune Cells
Chen, Lu, Ge, Bing, Casale, Francesco Paolo, Vasquez, Louella, Kwan, Tony, Garrido-Martín, Diego, Watt, Stephen, Yan, Ying, Kundu, Kousik, Ecker, Simone, Datta, Avik, Richardson, David, Burden, Frances, Mead, Daniel, Mann, Alice L., Fernandez, Jose Maria, Rowlston, Sophia, Wilder, Steven P., Farrow, Samantha, Shao, Xiaojian, Lambourne, John J., Redensek, Adriana, Albers, Cornelis A., Amstislavskiy, Vyacheslav, Ashford, Sofie, Berentsen, Kim, Bomba, Lorenzo, Bourque, Guillaume, Bujold, David, Busche, Stephan, Caron, Maxime, Chen, Shu-Huang, Cheung, Warren, Delaneau, Oliver, Dermitzakis, Emmanouil T., Elding, Heather, Colgiu, Irina, Bagger, Frederik O., Flicek, Paul, Habibi, Ehsan, Iotchkova, Valentina, Janssen-Megens, Eva, Kim, Bowon, Lehrach, Hans, Lowy, Ernesto, Mandoli, Amit, Matarese, Filomena, Maurano, Matthew T., Morris, John A., Pancaldi, Vera, Pourfarzad, Farzin, Rehnstrom, Karola, Rendon, Augusto, Risch, Thomas, Sharifi, Nilofar, Simon, Marie-Michelle, Sultan, Marc, Valencia, Alfonso, Walter, Klaudia, Wang, Shuang-Yin, Frontini, Mattia, Antonarakis, Stylianos E., Clarke, Laura, Yaspo, Marie-Laure, Beck, Stephan, Guigo, Roderic, Rico, Daniel, Martens, Joost H.A., Ouwehand, Willem H., Kuijpers, Taco W., Paul, Dirk S., Stunnenberg, Hendrik G., Stegle, Oliver, Downes, Kate, Pastinen, Tomi, Soranzo, Nicole
Published in Cell (17.11.2016)
Published in Cell (17.11.2016)
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Journal Article
Genetic associations at regulatory phenotypes improve fine-mapping of causal variants for twelve immune-mediated diseases
Kundu, Kousik, Mann, Alice L, Tardaguila, Manuel, Watt, Stephen, Ponstingl, Hannes, Vasquez, Louella, Morrell, Nicholas W, Stegle, Oliver, Pastinen, Tomi, Sawcer, Stephen J, Anderson, Carl A, Walter, Klaudia, Soranzo, Nicole
Published in bioRxiv (15.01.2020)
Published in bioRxiv (15.01.2020)
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Shared genetic effects on chromatin and gene expression reveal widespread enhancer priming in immune response
Kaur Alasoo, Rodrigues, Julia, Mukhopadhyay, Subhankar, Knights, Andrew J, Mann, Alice L, Kundu, Kousik, Consortium, Hipsci, Hale, Christine, Dougan, Gordon, Gaffney, Daniel J
Published in bioRxiv (18.05.2017)
Published in bioRxiv (18.05.2017)
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Variation in PU.1 binding and chromatin looping at neutrophil enhancers influences autoimmune disease susceptibility
Watt, Stephen, Vasquez, Louella, Walter, Klaudia, Mann, Alice L, Kundu, Kousik, Chen, Lu, Yan, Ying, Ecker, Simone, Burden, Frances, Farrow, Samantha, Farr, Ben, Iotchkova, Valentina, Elding, Heather, Mead, Daniel, Tardaguila, Manuel, Ponstingl, Hannes, Richardson, David, Datta, Avik, Flicek, Paul, Clarke, Laura, Downes, Kate, Pastinen, Tomi, Fraser, Peter, Frontini, Mattia, Javierre, Biola M, Spivakov, Mikhail, Soranzo, Nicole
Published in bioRxiv (29.04.2019)
Published in bioRxiv (29.04.2019)
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