Alterations of the gut microbiota with antibiotics protects dopamine neuron loss and improve motor deficits in a pharmacological rodent model of Parkinson's disease
Koutzoumis, Dimitri N., Vergara, Macarena, Pino, Jose, Buddendorff, Julia, Khoshbouei, Habibeh, Mandel, Ronald J., Torres, Gonzalo E.
Published in Experimental neurology (01.03.2020)
Published in Experimental neurology (01.03.2020)
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Journal Article
A comprehensive study of a 29-capsid AAV library in a non-human primate central nervous system
Kondratov, Oleksandr, Kondratova, Liudmyla, Mandel, Ronald J., Coleman, Kirsten, Savage, Michael A., Gray-Edwards, Heather L., Ness, Timothy J., Rodriguez-Lebron, Edgar, Bell, Robert D., Rabinowitz, Joseph, Gamlin, Paul D., Zolotukhin, Sergei
Published in Molecular therapy (01.09.2021)
Published in Molecular therapy (01.09.2021)
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Journal Article
phosphorylation state of Ser-129 in human α-synuclein determines neurodegeneration in a rat model of Parkinson disease
Gorbatyuk, Oleg S, Li, Shoudong, Sullivan, Layla F, Chen, Weijun, Kondrikova, Galina, Manfredsson, Fredric P, Mandel, Ronald J, Muzyczka, Nicholas
Published in Proceedings of the National Academy of Sciences - PNAS (15.01.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (15.01.2008)
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Journal Article
The Future of GDNF in Parkinson's Disease
Manfredsson, Fredric P, Polinski, Nicole K, Subramanian, Thyagarajan, Boulis, Nicholas, Wakeman, Dustin R, Mandel, Ronald J
Published in Frontiers in aging neuroscience (07.12.2020)
Published in Frontiers in aging neuroscience (07.12.2020)
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Journal Article
Correction: Site-specific modifications to AAV8 capsid yields enhanced brain transduction in the neonatal MPS IIIB mouse
Gilkes, Janine A., Judkins, Benjamin L., Herrera, Brontie N., Mandel, Ronald J., Boye, Sanford L., Boye, Shannon E., Srivastava, Arun, Heldermon, Coy D.
Published in Gene therapy (01.09.2023)
Published in Gene therapy (01.09.2023)
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Journal Article
In Vivo RNAi-Mediated α-Synuclein Silencing Induces Nigrostriatal Degeneration
Gorbatyuk, Oleg S, Li, Shoudong, Nash, Kevin, Gorbatyuk, Marina, Lewin, Alfred S, Sullivan, Layla F, Mandel, Ronald J, Chen, Weijun, Meyers, Craig, Manfredsson, Fredric P, Muzyczka, Nicholas
Published in Molecular therapy (01.08.2010)
Published in Molecular therapy (01.08.2010)
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Journal Article
Site-specific modifications to AAV8 capsid yields enhanced brain transduction in the neonatal MPS IIIB mouse
Gilkes, Janine A., Judkins, Benjamin L., Herrera, Brontie N., Mandel, Ronald J., Boye, Sanford L., Boye, Shannon E., Srivastava, Arun, Heldermon, Coy D.
Published in Gene therapy (01.08.2021)
Published in Gene therapy (01.08.2021)
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Journal Article
Long-term consequences of human alpha-synuclein overexpression in the primate ventral midbrain
Eslamboli, Andisheh, Romero-Ramos, Marina, Burger, Corinna, Bjorklund, Tomas, Muzyczka, Nicholas, Mandel, Ronald J., Baker, Harry, Ridley, Rosalind M., Kirik, Deniz
Published in Brain (London, England : 1878) (01.03.2007)
Published in Brain (London, England : 1878) (01.03.2007)
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Journal Article
Immune responses to adenovirus and adeno-associated vectors used for gene therapy of brain diseases: the role of immunological synapses in understanding the cell biology of neuroimmune interactions
Lowenstein, Pedro R, Mandel, Ronald J, Xiong, Wei-Dong, Kroeger, Kurt, Castro, Maria G
Published in Current gene therapy (01.10.2007)
Published in Current gene therapy (01.10.2007)
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Journal Article
Intrastriatal rAAV-mediated delivery of anti-huntingtin shRNAs induces partial reversal of disease progression in R6/1 Huntington's disease transgenic mice
Rodriguez-Lebron, Edgardo, Denovan-Wright, Eileen M, Nash, Kevin, Lewin, Alfred S, Mandel, Ronald J
Published in Molecular therapy (01.10.2005)
Published in Molecular therapy (01.10.2005)
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Journal Article
Recombinant AAV Viral Vectors Pseudotyped with Viral Capsids from Serotypes 1, 2, and 5 Display Differential Efficiency and Cell Tropism after Delivery to Different Regions of the Central Nervous System
Burger, Corinna, Gorbatyuk, Oleg S, Velardo, Margaret J, Peden, Carmen S, Williams, Philip, Zolotukhin, Sergei, Reier, Paul J, Mandel, Ronald J, Muzyczka, Nicholas
Published in Molecular therapy (01.08.2004)
Published in Molecular therapy (01.08.2004)
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Journal Article
Nigrostriatal α-Synucleinopathy Induced by Viral Vector-Mediated Overexpression of Human α-Synuclein: A New Primate Model of Parkinson's Disease
Kirik, Deniz, Annett, Lucy E., Burger, Corinna, Muzyczka, Nicholas, Mandel, Ronald J., Björklund, Anders
Published in Proceedings of the National Academy of Sciences - PNAS (04.03.2003)
Published in Proceedings of the National Academy of Sciences - PNAS (04.03.2003)
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Journal Article
AAV9: a potential blood-brain barrier buster
Manfredsson, Fredric P, Rising, Aaron C, Mandel, Ronald J
Published in Molecular therapy (01.03.2009)
Published in Molecular therapy (01.03.2009)
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Journal Article
Differential Transduction Following Basal Ganglia Administration of Distinct Pseudotyped AAV Capsid Serotypes in Nonhuman Primates
Dodiya, Hemraj B, Bjorklund, Tomas, Stansell III, James, Mandel, Ronald J, Kirik, Deniz, Kordower, Jeffrey H
Published in Molecular therapy (01.03.2010)
Published in Molecular therapy (01.03.2010)
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Journal Article
Novel oligodendroglial alpha synuclein viral vector models of multiple system atrophy: studies in rodents and nonhuman primates
Mandel, Ronald J, Marmion, David J, Kirik, Deniz, Chu, Yaping, Heindel, Clifford, McCown, Thomas, Gray, Steven J, Kordower, Jeffrey H
Published in Acta neuropathologica communications (16.06.2017)
Published in Acta neuropathologica communications (16.06.2017)
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Journal Article
Circulating Anti-Wild-Type Adeno-Associated Virus Type 2 (AAV2) Antibodies Inhibit Recombinant AAV2 (rAAV2)-Mediated, but Not rAAV5-Mediated, Gene Transfer in the Brain
PEDEN, Carmen S, BURGER, Corinna, MUZYCZKA, Nicholas, MANDEL, Ronald J
Published in Journal of Virology (01.06.2004)
Published in Journal of Virology (01.06.2004)
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Journal Article
Parkinson-Like Neurodegeneration Induced by Targeted Overexpression of alpha -Synuclein in the Nigrostriatal System
Kirik, Deniz, Rosenblad, Carl, Burger, Corinna, Lundberg, Cecilia, Johansen, Teit E, Muzyczka, Nicholas, Mandel, Ronald J, Bjorklund, Anders
Published in The Journal of neuroscience (01.04.2002)
Published in The Journal of neuroscience (01.04.2002)
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Journal Article
Continuous Low-Level Glial Cell Line-Derived Neurotrophic Factor Delivery Using Recombinant Adeno-Associated Viral Vectors Provides Neuroprotection and Induces Behavioral Recovery in a Primate Model of Parkinson's Disease
Eslamboli, Andisheh, Georgievska, Biljana, Ridley, Rosalind M, Baker, Harry F, Muzyczka, Nicholas, Burger, Corinna, Mandel, Ronald J, Annett, Lucy, Kirik, Deniz
Published in The Journal of neuroscience (26.01.2005)
Published in The Journal of neuroscience (26.01.2005)
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Journal Article