A Comparison of the Expression and Metabolizing Activities of Phase I and II Enzymes in Freshly Isolated Human Lung Parenchymal Cells and Cryopreserved Human Hepatocytes
SOMERS, G. I, LINDSAY, N, LOWDON, B. M, JONES, A. E, FREATHY, C, HO, S, WOODROOFFE, A. J. M, BAYLISS, M. K, MANCHEE, G. R
Published in Drug metabolism and disposition (01.10.2007)
Published in Drug metabolism and disposition (01.10.2007)
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Disposition of salmeterol xinafoate in laboratory animals and humans
Manchee, G R, Barrow, A, Kulkarni, S, Palmer, E, Oxford, J, Colthup, P V, Maconochie, J G, Tarbit, M H
Published in Drug metabolism and disposition (01.11.1993)
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Published in Drug metabolism and disposition (01.11.1993)
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The aliphatic oxidation of salmeterol to alpha-hydroxysalmeterol in human liver microsomes is catalyzed by CYP3A
Manchee, G R, Eddershaw, P J, Ranshaw, L E, Herriott, D, Park, G R, Bayliss, M K, Tarbit, M H
Published in Drug metabolism and disposition (01.05.1996)
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Published in Drug metabolism and disposition (01.05.1996)
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Microbial biotransformation of the angiotensin II antagonist GR117289 by Streptomyces rimosus to identify a mammalian metabolite
Cannell, R J, Knaggs, A R, Dawson, M J, Manchee, G R, Eddershaw, P J, Waterhouse, I, Sutherland, D R, Bowers, G D, Sidebottom, P J
Published in Drug metabolism and disposition (01.07.1995)
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Published in Drug metabolism and disposition (01.07.1995)
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X-ray crystal structure of human dopamine sulfotransferase, SULT1A3. Molecular modeling and quantitative structure-activity relationship analysis demonstrate a molecular basis for sulfotransferase substrate specificity
Dajani, R, Cleasby, A, Neu, M, Wonacott, A J, Jhoti, H, Hood, A M, Modi, S, Hersey, A, Taskinen, J, Cooke, R M, Manchee, G R, Coughtrie, M W
Published in The Journal of biological chemistry (31.12.1999)
Published in The Journal of biological chemistry (31.12.1999)
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GR94839, a κ‐opioid agonist with limited access to the central nervous system, has antinociceptive activity
Rogers, H., Birch, P.J., Harrison, S.M., Palmer, E., Manchee, G.R., Judd, D.B., Naylor, A., Scopes, D.I.C., Hayes, A.G.
Published in British journal of pharmacology (01.08.1992)
Published in British journal of pharmacology (01.08.1992)
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Absorption and disposition of ranitidine hydrochloride in rat and dog
Eddershaw, P J, Chadwick, A P, Higton, D M, Fenwick, S H, Linacre, P, Jenner, W N, Bell, J A, Manchee, G R
Published in Xenobiotica (01.09.1996)
Published in Xenobiotica (01.09.1996)
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Purification and Characterization of a Canine Liver Phenol Sulfotransferase
ODDY, E. A, MANCHEE, G. R, FREEMAN, N. M, WARD, M. A, COUGHTRIE, M. W. H
Published in Drug metabolism and disposition (01.10.1997)
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Published in Drug metabolism and disposition (01.10.1997)
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Fully automated assay for the determination of GR117289X in human plasma using mixed mode solid-phase extraction and high-performance liquid chromatography with ultraviolet detection
Murkitt, G S, Trafankowska, E Z, Dunne, M, Manchee, G R
Published in Journal of pharmaceutical and biomedical analysis (01.09.1994)
Published in Journal of pharmaceutical and biomedical analysis (01.09.1994)
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Thermospray liquid chromatography-mass spectrometry for the characterisation of sulphate ester conjugates
Bowers, G D, Higton, D M, Manchee, G R, Oxford, J, Saynor, D A
Published in Journal of chromatography (21.08.1991)
Published in Journal of chromatography (21.08.1991)
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Characterization of glucuronic acid conjugates of a novel angiotensin receptor antagonist
Bowers, G D, Eddershaw, P J, Hughes, S Y, Manchee, G R, Oxford, J
Published in Rapid communications in mass spectrometry (01.02.1994)
Published in Rapid communications in mass spectrometry (01.02.1994)
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Journal Article
Design and synthesis of orally active pyrrolidin-2-one-based factor Xa inhibitors
Watson, Nigel S., Brown, David, Campbell, Matthew, Chan, Chuen, Chaudry, Laiq, Convery, Máire A., Fenwick, Rebecca, Hamblin, J. Nicole, Haslam, Claudine, Kelly, Henry A., King, N. Paul, Kurtis, Cynthia L., Leach, Andrew R., Manchee, Gary R., Mason, Andrew M., Mitchell, Charlotte, Patel, Champa, Patel, Vipulkumar K., Senger, Stefan, Shah, Gita P., Weston, Helen E., Whitworth, Caroline, Young, Robert J.
Published in Bioorganic & medicinal chemistry letters (15.07.2006)
Published in Bioorganic & medicinal chemistry letters (15.07.2006)
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beta sub(2)-Agonist abuse in food producing animals: use of in vitro liver preparations to assess biotransformation and potential target residues for surveillance
Sauer, MJ, Dave, M, Lakes, B G, Manchee, G R, Howells, L C, Coldham, NG
Published in Xenobiotica (01.05.1999)
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Published in Xenobiotica (01.05.1999)
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β 2 -Agonist abuse in food producing animals: use of in vitro liver preparations to assess biotransformation and potential target residues for surveillance
SAUER, M. J., DAVE, M., LAKE, B. G., MANCHEE, G. R., HOWELLS, L. C., COLDHAM, N. G.
Published in Xenobiotica (01.01.1999)
Published in Xenobiotica (01.01.1999)
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Bromobenzofuran-based non-peptide antagonists of angiotensin II: GR13950, a potent antihypertensive agent with high oral bioavailability
JUDD, D. B, DOWLE, M. D, STUART, P. G, PATON, J. M. S, HUBBARD, T, HILDITCH, A, DREW, G. M, ROBERTSON, M. J, CLARK, K. L, TRAVERS, A, HUNT, A. E. A, POLLEY, J, MIDDLEMISS, D, EDDERSHAW, P. J, BAYLISS, M. K, MANCHEE, G. R, DONNELLY, M. D, WALKER, D. G, RICHARDS, S. A, SCOPES, D. I. C, ROSS, B. C, JACK, T. I, PASS, M, TRANSUILINI, E, HOBSON, J. E, PANCHAL, T. A
Published in Journal of medicinal chemistry (1994)
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Published in Journal of medicinal chemistry (1994)
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Benzofuran based angiotensin II antagonists related to GR117289: Part III; GR138950, a triflamide with high oral bioavailability
Dowle, M.D., Judd, D.B., Middlemiss, D., Scopes, D.I.C., Ross, B.C., Pass, M., Tranquillini, E., Jack, T.I., Hobson, J.E., Panchal, T.A., Stuart, P.G., Drew, G.M., Robertson, M.J., Hilditch, A., Clark, K.L., Travers, A., Hunt, A.A.E., Manchee, G.R., Walker, D.G., Eddershaw, P.J., Donnelly, M., Bayliss, M.K.
Published in Bioorganic & medicinal chemistry letters (1993)
Published in Bioorganic & medicinal chemistry letters (1993)
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Journal Article
Benzofuran based angiotensi II antagonists related to GR117289: Part II; amino acid amides
Middlemiss, D., Watson, S.P., Ross, B.C., Dowle, M.D., Scopes, D.I.C., Montana, J.G., Hirst, G.C., Panchal, T.A., Paton, J.M.S., Hubbard, T., Stuart, G., Drew, G.M., Hilditch, A., Travers, A., Robertson, M.J., Hunt, A.A.E., Palmer, E., Manchee, G.R.
Published in Bioorganic & medicinal chemistry letters (1993)
Published in Bioorganic & medicinal chemistry letters (1993)
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