A novel RyR1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke
Yamazawa, Toshiko, Kobayashi, Takuya, Kurebayashi, Nagomi, Konishi, Masato, Noguchi, Satoru, Inoue, Takayoshi, Inoue, Yukiko U., Nishino, Ichizo, Mori, Shuichi, Iinuma, Hiroto, Manaka, Noriaki, Kagechika, Hiroyuki, Uryash, Arkady, Adams, Jose, Lopez, Jose R., Liu, Xiaochen, Diggle, Christine, Allen, Paul D., Kakizawa, Sho, Ikeda, Keigo, Lin, Bangzhong, Ikemi, Yui, Nunomura, Kazuto, Nakagawa, Shinsaku, Sakurai, Takashi, Murayama, Takashi
Published in Nature communications (13.07.2021)
Published in Nature communications (13.07.2021)
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Journal Article
Structural development of a type-1 ryanodine receptor (RyR1) Ca2+-release channel inhibitor guided by endoplasmic reticulum Ca2+ assay
Mori, Shuichi, Iinuma, Hiroto, Manaka, Noriaki, Ishigami-Yuasa, Mari, Murayama, Takashi, Nishijima, Yoshiaki, Sakurai, Akiko, Arai, Ryota, Kurebayashi, Nagomi, Sakurai, Takashi, Kagechika, Hiroyuki
Published in European journal of medicinal chemistry (01.10.2019)
Published in European journal of medicinal chemistry (01.10.2019)
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Journal Article
A novel RyR1 inhibitor prevents and rescues sudden death in a mouse model of malignant hyperthermia and heat stroke
Yamazawa, Toshiko, Kobayashi, Takuya, Kurebayashi, Nagomi, Konishi, Masato, Noguchi, Satoru, Inoue, Takayoshi, Inoue, Yukiko U, Nishino, Ichizo, Mori, Shuichi, Iinuma, Hiroto, Manaka, Noriaki, Kagechika, Hiroyuki, Uryas, Arkady, Adams, Jose, Lopez, Jose R, Liu, Xiaochen, Diggle, Christine, Allen, Paul D, Kakizawa, Sho, Ikeda, Keigo, Lin, Bangzhong, Ikemi, Yui, Nunomura, Kazuto, Nakagawa, Shinsaku, Sakurai, Takashi, Murayama, Takashi
Published in bioRxiv (06.02.2021)
Published in bioRxiv (06.02.2021)
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Paper
Structure Development of Oxolinic Acid, a Novel Inhibitor of Type 1 Ryanodine Receptor (RyR1) Ca2+ Release Channel
Nishijima, Yoshiaki, Murayama, Takashi, Mori, Shuichi, Iinuma, Hiroto, Manaka, Noriaki, Kurebayashi, Nagomi, Ishigami-Yuasa, Mari, Kagechika, Hiroyuki, Sakurai, Takashi
Published in Biophysical journal (15.02.2019)
Published in Biophysical journal (15.02.2019)
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Journal Article
Structural development of a type-1 ryanodine receptor (RyR1) Ca 2+ -release channel inhibitor guided by endoplasmic reticulum Ca 2+ assay
Mori, Shuichi, Iinuma, Hiroto, Manaka, Noriaki, Ishigami-Yuasa, Mari, Murayama, Takashi, Nishijima, Yoshiaki, Sakurai, Akiko, Arai, Ryota, Kurebayashi, Nagomi, Sakurai, Takashi, Kagechika, Hiroyuki
Published in European journal of medicinal chemistry (29.06.2019)
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Published in European journal of medicinal chemistry (29.06.2019)
Journal Article
新規1型リアノジン受容体阻害薬オキソリン酸の構造展開
村山, 尚, 西島, 由朗, 森, 修一, 飯沼, 大翔, 間中, 紀暁, 呉林, なごみ, 湯浅(石上), 磨里, 影近, 弘之, 櫻井, 隆
Published in 日本薬理学会年会要旨集 (2019)
Published in 日本薬理学会年会要旨集 (2019)
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Journal Article
Structure development of oxolinic acid, a novel inhibitor of type 1 ryanodine receptor
Murayama, Takashi, Nishijima, Yoshiaki, Mori, Shuichi, Iinuma, Hiroto, Manaka, Noriaki, Kurebayashi, Nagomi, Ishigami-Yuasa, Mari, Kagechika, Hiroyuki, Sakurai, Takashi
Published in Proceedings for Annual Meeting of The Japanese Pharmacological Society (2019)
Published in Proceedings for Annual Meeting of The Japanese Pharmacological Society (2019)
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Journal Article