789 Intratumoral plasmid IL-12 expands CD8+ T cells and induces a clinically validated CXCR3 signature in triple-negative breast cancer
Crosby, Erika, Nagata, Hiroshi, Telli, Melinda, Acharya, Chaitanya, Wapnir, Irene, Zablotsky, Kaitlin, Browning, Erica, Hermiz, Reneta, Svenson, Lauren, Bannavong, Donna, Malloy, Kellie, Canton, David, Twitty, Christopher, Osada, Takuya, Lyerly, Herbert
Published in Journal for immunotherapy of cancer (01.11.2020)
Published in Journal for immunotherapy of cancer (01.11.2020)
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Journal Article
Intratumoral Plasmid IL12 Expands CD8 + T Cells and Induces a CXCR3 Gene Signature in Triple-negative Breast Tumors that Sensitizes Patients to Anti-PD-1 Therapy
Telli, Melinda L, Nagata, Hiroshi, Wapnir, Irene, Acharya, Chaitanya R, Zablotsky, Kaitlin, Fox, Bernard A, Bifulco, Carlo B, Jensen, Shawn M, Ballesteros-Merino, Carmen, Le, Mai Hope, Pierce, Robert H, Browning, Erica, Hermiz, Reneta, Svenson, Lauren, Bannavong, Donna, Jaffe, Kim, Sell, Jendy, Foerter, Kellie Malloy, Canton, David A, Twitty, Christopher G, Osada, Takuya, Lyerly, H Kim, Crosby, Erika J
Published in Clinical cancer research (01.05.2021)
Published in Clinical cancer research (01.05.2021)
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Abstract P3-09-04: Phase 2, open-label study of intratumoral tavokinogene telseplasmid (tavo) plus electroporation in combination with intravenous pembrolizumab therapy in patients with inoperable locally advanced or metastatic triple-negative breast cancer (mTNBC) (KEYNOTE- 890/OMS-I141)
Telli, Melinda L., Wapnir, Irene, Devitt, Bianca, Cuff, Katharine, Soliman, Hatem, Vinayak, Shaveta, Canton, David A., Twitty, Christopher, Foerter, Kellie Malloy, Joshi, Rohit
Published in Cancer research (Chicago, Ill.) (15.02.2020)
Published in Cancer research (Chicago, Ill.) (15.02.2020)
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Abstract PS17-22: Intratumoral delivery of tavokinogene telseplasmid (plasmid IL-12) and electroporation induces an immune signature that predicts successful combination in patients
Crosby, Erika J, Nagata, Hiroshi, Telli, Melinda L, Acharya, Chaitanya R, Wapnir, Irene, Zablotsky, Kaitlin, Browning, Erica, Hermiz, Reneta, Svenson, Lauren, Bannavong, Donna, Malloy, Kellie, Canton, David A, Twitty, Chris G, Osada, Takuya, Lyerly, Herbert Kim
Published in Cancer research (Chicago, Ill.) (15.02.2021)
Published in Cancer research (Chicago, Ill.) (15.02.2021)
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Abstract LB-390: Intratumoral electroporation of plasmid-encoded IL-12 and membrane-bound anti-CD3 increases tumor immunogenicity and augments the function of T cell subsets
Han, Mia, Mukhopadhyay, Anandaroop, Nguyen, Bianca, Lee, Jack Y., Browning, Erica, Salazar, Jon, Hermiz, Reneta, Svenson, Lauren, Baker, Chris, O'Connor, Daniel, Malloy, Kellie, Canton, David A., Twitty, Christopher G.
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
Intratumoral plasmid IL-12 expands CD8+ T cells and induces a CXCR3 gene signature in triple-negative breast tumors that sensitizes patients to anti-PD-1 therapy
Telli, Melinda L., Nagata, Hiroshi, Wapnir, Irene, Acharya, Chaitanya R., Zablotsky, Kaitlin, Fox, Bernard A., Bifulco, Carlo B., Jensen, Shawn M., Ballesteros-Merino, Carmen, Le, Mai Hope, Pierce, Robert H., Browning, Erica, Hermiz, Reneta, Svenson, Lauren, Bannavong, Donna, Jaffe, Kim, Sell, Jendy, Foerter, Kellie Malloy, Canton, David A., Twitty, Christopher G., Osada, Takuya, Lyerly, H. Kim, Crosby, Erika J.
Published in Clinical cancer research (16.02.2021)
Published in Clinical cancer research (16.02.2021)
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480 Preliminary evaluation of a novel coronavirus vaccine (CORVax) using electroporation of plasmid DNA encoding a stabilized prefusion SARS-CoV-2 spike protein alone or with transfection of plasmid IL-12
Jensen, Shawn, Twitty, Christopher, Paustian, Christopher, Laws, Madelein, McDonnell, Glenna, Wegmann, Keith, Moudgil, Tarsem, Afentoulis, Michael, Han, Mia, Kellie Malloy Foerter, Canton, David, Lee, Jack, Nguyen, Bianca, Rodriguez, John, Jaffe, Kim, Piening, Brian, Bifulco, Carlo, Daniel O’Connor, Urba, Walter, Leidner, Rom, Hilton, Traci, Hong-Ming, Hu, Fox, Bernard
Published in Journal for immunotherapy of cancer (01.11.2020)
Published in Journal for immunotherapy of cancer (01.11.2020)
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799 Durable responses and immune activation with intratumoral electroporation of pIL-12 plus pembrolizumab in actively progressing anti-PD-1 refractory advanced melanoma: KEYNOTE 695 interim data
Fernandez-Penas, Pablo, Carlino, Matteo, Tsai, Katy, Atkinson, Victoria, Shaheen, Monaster, Sajeve, Thomas, Mihalcioiu, Catalin, Tom Van Hagen, Roberts-Thomson, Rachel, Haydon, Andrew, Mant, Andrew, Butler, Marcus, Daniels, Gregory, Buchbinder, Elizabeth, Hyngstrom, John, Moller, Mecker, Puzanov, Igor, Cowey, C Lance, Whitman, Eric, Ballesteros-Merino, Carmen, Jensen, Shawn, Fox, Bernard, Schmidt, Emmett, Krepler, Clemens, Diede, Scott, Browning, Erica, Hermiz, Reneta, Svenson, Lauren, Salazar, Jon, Lee, Jack, Baker, Christopher, Bannavong, Donna, Sell, Jendy, Kellie Malloy Foerter, Canton, David, Aung, Sandra, Twitty, Christopher, Algazi, Alain, Daud, Adil
Published in Journal for immunotherapy of cancer (01.11.2020)
Published in Journal for immunotherapy of cancer (01.11.2020)
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Journal Article