Structural and functional analysis of the promiscuous AcrB and AdeB efflux pumps suggests different drug binding mechanisms
Ornik-Cha, Alina, Wilhelm, Julia, Kobylka, Jessica, Sjuts, Hanno, Vargiu, Attilio V., Malloci, Giuliano, Reitz, Julian, Seybert, Anja, Frangakis, Achilleas S., Pos, Klaas M.
Published in Nature communications (25.11.2021)
Published in Nature communications (25.11.2021)
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Perturbed structural dynamics underlie inhibition and altered efflux of the multidrug resistance pump AcrB
Reading, Eamonn, Ahdash, Zainab, Fais, Chiara, Ricci, Vito, Wang-Kan, Xuan, Grimsey, Elizabeth, Stone, Jack, Malloci, Giuliano, Lau, Andy M., Findlay, Heather, Konijnenberg, Albert, Booth, Paula J., Ruggerone, Paolo, Vargiu, Attilio V., Piddock, Laura J. V., Politis, Argyris
Published in Nature communications (04.11.2020)
Published in Nature communications (04.11.2020)
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Journal Article
Binding and Transport of Carboxylated Drugs by the Multidrug Transporter AcrB
Tam, Heng-Keat, Malviya, Viveka N., Foong, Wuen-Ee, Herrmann, Andrea, Malloci, Giuliano, Ruggerone, Paolo, Vargiu, Attilio V., Pos, Klaas M.
Published in Journal of molecular biology (14.02.2020)
Published in Journal of molecular biology (14.02.2020)
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Water-mediated interactions enable smooth substrate transport in a bacterial efflux pump
Vargiu, Attilio Vittorio, Ramaswamy, Venkata Krishnan, Malvacio, Ivana, Malloci, Giuliano, Kleinekathöfer, Ulrich, Ruggerone, Paolo
Published in Biochimica et biophysica acta. General subjects (01.04.2018)
Published in Biochimica et biophysica acta. General subjects (01.04.2018)
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Force Fields, Quantum-Mechanical- and Molecular-Dynamics-Based Descriptors of Radiometal-Chelator Complexes
Öztürk, Işılay, Gervasoni, Silvia, Guccione, Camilla, Bosin, Andrea, Vargiu, Attilio Vittorio, Ruggerone, Paolo, Malloci, Giuliano
Published in Molecules (Basel, Switzerland) (17.09.2024)
Published in Molecules (Basel, Switzerland) (17.09.2024)
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Molecular simulations of SSTR2 dynamics and interaction with ligands
Gervasoni, Silvia, Guccione, Camilla, Fanti, Viviana, Bosin, Andrea, Cappellini, Giancarlo, Golosio, Bruno, Ruggerone, Paolo, Malloci, Giuliano
Published in Scientific reports (23.03.2023)
Published in Scientific reports (23.03.2023)
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The complex of ferric-enterobactin with its transporter from Pseudomonas aeruginosa suggests a two-site model
Moynié, Lucile, Milenkovic, Stefan, Mislin, Gaëtan L. A., Gasser, Véronique, Malloci, Giuliano, Baco, Etienne, McCaughan, Rory P., Page, Malcolm G. P., Schalk, Isabelle J., Ceccarelli, Matteo, Naismith, James H.
Published in Nature communications (14.08.2019)
Published in Nature communications (14.08.2019)
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Journal Article
Chlorpromazine and Amitriptyline Are Substrates and Inhibitors of the AcrB Multidrug Efflux Pump
Grimsey, Elizabeth M, Fais, Chiara, Marshall, Robert L, Ricci, Vito, Ciusa, Maria Laura, Stone, Jack W, Ivens, Alasdair, Malloci, Giuliano, Ruggerone, Paolo, Vargiu, Attilio V, Piddock, Laura J V
Published in mBio (02.06.2020)
Published in mBio (02.06.2020)
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Pyridylpiperazine-based allosteric inhibitors of RND-type multidrug efflux pumps
Plé, Coline, Tam, Heng-Keat, Vieira Da Cruz, Anais, Compagne, Nina, Jiménez-Castellanos, Juan-Carlos, Müller, Reinke T., Pradel, Elizabeth, Foong, Wuen Ee, Malloci, Giuliano, Ballée, Alexia, Kirchner, Moritz A., Moshfegh, Parisa, Herledan, Adrien, Herrmann, Andrea, Deprez, Benoit, Willand, Nicolas, Vargiu, Attilio Vittorio, Pos, Klaas M., Flipo, Marion, Hartkoorn, Ruben C.
Published in Nature communications (10.01.2022)
Published in Nature communications (10.01.2022)
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Journal Article
Molecular Interactions of Carbapenem Antibiotics with the Multidrug Efflux Transporter AcrB of Escherichia coli
Atzori, Alessio, Malloci, Giuliano, Cardamone, Francesca, Bosin, Andrea, Vargiu, Attilio Vittorio, Ruggerone, Paolo
Published in International journal of molecular sciences (29.01.2020)
Published in International journal of molecular sciences (29.01.2020)
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Journal Article
A New Critical Conformational Determinant of Multidrug Efflux by an MFS Transporter
Zomot, Elia, Yardeni, Eliane Hadas, Vargiu, Attilio Vittorio, Tam, Heng-Keat, Malloci, Giuliano, Ramaswamy, Venkata Krishnan, Perach, Michal, Ruggerone, Paolo, Pos, Klaas Martinus, Bibi, Eitan
Published in Journal of molecular biology (27.04.2018)
Published in Journal of molecular biology (27.04.2018)
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Identification and characterization of carbapenem binding sites within the RND-transporter AcrB
Atzori, Alessio, Malviya, Viveka N., Malloci, Giuliano, Dreier, Jürg, Pos, Klaas M., Vargiu, Attilio V., Ruggerone, Paolo
Published in Biochimica et biophysica acta. Biomembranes (01.01.2019)
Published in Biochimica et biophysica acta. Biomembranes (01.01.2019)
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Journal Article
Common recognition topology of mex transporters of Pseudomonas aeruginosa revealed by molecular modelling
Catte, Andrea, K. Ramaswamy, Venkata, Vargiu, Attilio Vittorio, Malloci, Giuliano, Bosin, Andrea, Ruggerone, Paolo
Published in Frontiers in pharmacology (11.11.2022)
Published in Frontiers in pharmacology (11.11.2022)
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