VISTA checkpoint inhibition by pH-selective antibody SNS-101 with optimized safety and pharmacokinetic profiles enhances PD-1 response
Thisted, Thomas, Smith, F Donelson, Mukherjee, Arnab, Kleschenko, Yuliya, Feng, Feng, Jiang, Zhi-Gang, Eitas, Timothy, Malhotra, Kanam, Biesova, Zuzana, Onumajuru, Adejumoke, Finley, Faith, Cifuentes, Anokhi, Zhang, Guolin, Martin, Gaëlle H, Takeuchi, Yoshiko, Thiam, Kader, Schreiber, Robert D, van der Horst, Edward H
Published in Nature communications (04.04.2024)
Published in Nature communications (04.04.2024)
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Journal Article
Aspartate β-Hydroxylase (ASPH) Expression in Acute Myeloid Leukemia: A Potential Novel Therapeutic Target
Holtzman, Noa G, Lebowitz, Michael S, Koka, Rima, Baer, Maria R, Malhotra, Kanam, Shahlaee, Amir, Ghanbari, Hossein A, Bentzen, Søren M, Emadi, Ashkan
Published in Frontiers in oncology (22.12.2021)
Published in Frontiers in oncology (22.12.2021)
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Journal Article
228 Antagonistic pH-selective VISTA antibody SNS-101 potentiates anti-PD-1/PD-L1-induced anti-tumor immunity
Thisted, Thomas, Mukherjee, Arnab, Malhotra, Kanam, Biesova, Zuzana, Kleschenko, Yuliya, Jiang, Zhi-Gang, Cifuentes, Anokhi, Boland, Nadthakarn, Nielson, Nels, Horst, Edward van der
Published in Journal for immunotherapy of cancer (01.11.2021)
Published in Journal for immunotherapy of cancer (01.11.2021)
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Journal Article
Abstract 2306: CAR-T cell therapies targeting aspartyl β-hydroxylase (ASPH)
Thisted, Thomas, Malhotra, Kanam, Lebowitz, Michael S., Ghanbari, Hossein
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
SNS-101, a highly selective monoclonal antibody against the active form of VISTA, demonstrates significantly reduced cytokine release
van der Horst, Edward, Jiang, Zhi-Gang, Malhotra, Kanam, Mukherjee, Arnab, Biesova, Zuzana, Cifuentes, Anokhi, Thisted, Thomas, Pierce, Robert Hamilton, Martin, Gaëlle, Thiam, Kader
Published in Journal of clinical oncology (01.06.2022)
Published in Journal of clinical oncology (01.06.2022)
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Journal Article
Abstract 1454: Long-term immunogenicity results from a first-in-human study evaluating the anti-ASPH cancer vaccine, SNS-301
Lebowitz, Michael S., Dai, Hong, Malhotra, Kanam, Csiki, Ildiko, Fuller, Steven, Ghanbari, Hossein A.
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
Aspartate Beta-Hydroxylase (ASPH) As a Novel Therapeutic Target in Acute Myeloid Leukemia
Holtzman, Noa G., Lebowitz, Michael S., Koka, Rima, Baer, Maria R., Malhotra, Kanam, Fuller, Steven A., Shahlaee, Amir, Ghanbari, Hossein A., Bentzen, Soren M., Emadi, Ashkan
Published in Blood (29.11.2018)
Published in Blood (29.11.2018)
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Journal Article
Abstract B106: Antibody-drug conjugates targeted at human aspartyl (asparaginyl) β-hydroxylase
Malhotra, Kanam, Walker, Susan, Fang, Chen, Birthare, Karamveer, Lebowitz, Michael S., Fuller, Steven, Sesay, Muctarr, Ghanbari, Hossein A.
Published in Molecular cancer therapeutics (01.01.2018)
Published in Molecular cancer therapeutics (01.01.2018)
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Journal Article
Abstract 4645: Identification of conditionally active antibodies that selectively block CD39 activity in the acidic tumor microenvironment
Bai, Aiping, Renahan, Elise, Malhotra, Kanam, Thisted, Thomas, Smith, F. Donelson, Pierce, Robert H, van der Horst, Edward H
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Journal Article
Abstract 5294: Conditionally active CD28xVISTA bispecific antibodies induce myeloid-driven tumor-specific T-cell co-stimulation for improved cancer immunotherapy
Thisted, Thomas, Jiang, Zhi-Gang, Biesova, Zuzana, Onumajuru, Adejumoke, Kleschenko, Yuliya, Malhotra, Kanam, Saxena, Vikas, Mukherjee, Arnab, Smith, F. Donelson, van der Horst, Edward H.
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Journal Article
Abstract 2650: Radioimmunotherapy for acute myeloid leukemia targeting human aspartyl (asparaginyl) β-hydroxylase
Lebowitz, Michael S., Revskaya, Ekaterina, Malhotra, Kanam, Shahlaee, Amir, Fuller, Steven, Baer, Maria R., Holtzman, Noa G., Emadi, Ashkan, Dadachova, Ekaterina, Ghanbari, Hossein A.
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
485 Functional characterization of the inhibitory activity and identification of novel T-cell receptors for the tumor-associated macrophage receptor VSIG4
Eitas, Tim, van der Horst, Edward, Finley, Faith, Thisted, Thomas, Malhotra, Kanam, Mukherjee, Arnab, Biesova, Zuzana, Cifuentes, Anokhi, Marder, Sandra, Helbling, Paul, Pierce, Robert
Published in Journal for immunotherapy of cancer (01.11.2022)
Published in Journal for immunotherapy of cancer (01.11.2022)
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Journal Article