Co-optimization of therapeutic antibody affinity and specificity using machine learning models that generalize to novel mutational space
Makowski, Emily K, Kinnunen, Patrick C, Huang, Jie, Wu, Lina, Smith, Matthew D, Wang, Tiexin, Desai, Alec A, Streu, Craig N, Zhang, Yulei, Zupancic, Jennifer M, Schardt, John S, Linderman, Jennifer J, Tessier, Peter M
Published in Nature communications (01.07.2022)
Published in Nature communications (01.07.2022)
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Journal Article
Improving antibody drug development using bionanotechnology
Makowski, Emily K, Schardt, John S, Tessier, Peter M
Published in Current opinion in biotechnology (01.04.2022)
Published in Current opinion in biotechnology (01.04.2022)
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Journal Article
Antibodies with Weakly Basic Isoelectric Points Minimize Trade-offs between Formulation and Physiological Colloidal Properties
Gupta, Priyanka, Makowski, Emily K, Kumar, Sandeep, Zhang, Yulei, Scheer, Justin M, Tessier, Peter M
Published in Molecular pharmaceutics (07.03.2022)
Published in Molecular pharmaceutics (07.03.2022)
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Journal Article
Ultradilute Measurements of Self-Association for the Identification of Antibodies with Favorable High-Concentration Solution Properties
Starr, Charles G, Makowski, Emily K, Wu, Lina, Berg, Brendan, Kingsbury, Jonathan S, Gokarn, Yatin R, Tessier, Peter M
Published in Molecular pharmaceutics (05.07.2021)
Published in Molecular pharmaceutics (05.07.2021)
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Journal Article
Directed evolution of potent neutralizing nanobodies against SARS-CoV-2 using CDR-swapping mutagenesis
Zupancic, Jennifer M., Desai, Alec A., Schardt, John S., Pornnoppadol, Ghasidit, Makowski, Emily K., Smith, Matthew D., Kennedy, Andrew A., Garcia de Mattos Barbosa, Mayara, Cascalho, Marilia, Lanigan, Thomas M., Tai, Andrew W., Tessier, Peter M.
Published in Cell chemical biology (16.09.2021)
Published in Cell chemical biology (16.09.2021)
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Journal Article
Reduction of monoclonal antibody viscosity using interpretable machine learning
Makowski, Emily K, Chen, Hsin-Ting, Wang, Tiexin, Wu, Lina, Huang, Jie, Mock, Marissa, Underhill, Patrick, Pelegri-O'Day, Emma, Maglalang, Erick, Winters, Dwight, Tessier, Peter M
Published in mAbs (2024)
Published in mAbs (2024)
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Journal Article
Reduction of Glut1 in the Neural Retina But Not the RPE Alleviates Polyol Accumulation and Normalizes Early Characteristics of Diabetic Retinopathy
Holoman, Nicholas C, Aiello, Jacob J, Trobenter, Timothy D, Tarchick, Matthew J, Kozlowski, Michael R, Makowski, Emily R, De Vivo, Darryl C, Singh, Charandeep, Sears, Jonathan E, Samuels, Ivy S
Published in The Journal of neuroscience (07.04.2021)
Published in The Journal of neuroscience (07.04.2021)
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Journal Article
Discovery and characterization of high-affinity, potent SARS-CoV-2 neutralizing antibodies via single B cell screening
Schardt, John S, Pornnoppadol, Ghasidit, Desai, Alec A, Park, Kyung Soo, Zupancic, Jennifer M, Makowski, Emily K, Smith, Matthew D, Chen, Hongwei, Garcia de Mattos Barbosa, Mayara, Cascalho, Marilia, Lanigan, Thomas M, Moon, James J, Tessier, Peter M
Published in Scientific reports (20.10.2021)
Published in Scientific reports (20.10.2021)
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Journal Article
An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence
Lee, Chang-Han, Kang, Tae Hyun, Godon, Ophélie, Watanabe, Makiko, Delidakis, George, Gillis, Caitlin M, Sterlin, Delphine, Hardy, David, Cogné, Michel, Macdonald, Lynn E, Murphy, Andrew J, Tu, Naxin, Lee, Jiwon, McDaniel, Jonathan R, Makowski, Emily, Tessier, Peter M, Meyer, Aaron S, Bruhns, Pierre, Georgiou, George
Published in Nature communications (06.11.2019)
Published in Nature communications (06.11.2019)
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Journal Article
Rational affinity maturation of anti-amyloid antibodies with high conformational and sequence specificity
Desai, Alec A., Smith, Matthew D., Zhang, Yulei, Makowski, Emily K., Gerson, Julia E., Ionescu, Edward, Starr, Charles G., Zupancic, Jennifer M., Moore, Shannon J., Sutter, Alexandra B., Ivanova, Magdalena I., Murphy, Geoffrey G., Paulson, Henry L., Tessier, Peter M.
Published in The Journal of biological chemistry (01.01.2021)
Published in The Journal of biological chemistry (01.01.2021)
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Journal Article
Computational optimization of antibody humanness and stability by systematic energy-based ranking
Tennenhouse, Ariel, Khmelnitsky, Lev, Khalaila, Razi, Yeshaya, Noa, Noronha, Ashish, Lindzen, Moshit, Makowski, Emily K, Zaretsky, Ira, Sirkis, Yael Fridmann, Galon-Wolfenson, Yael, Tessier, Peter M, Abramson, Jakub, Yarden, Yosef, Fass, Deborah, Fleishman, Sarel J
Published in Nature biomedical engineering (01.01.2024)
Published in Nature biomedical engineering (01.01.2024)
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Journal Article
Endogenous insulin signaling in the RPE contributes to the maintenance of rod photoreceptor function in diabetes
Tarchick, Matthew J., Cutler, Alecia H., Trobenter, Timothy D., Kozlowski, Michael R., Makowski, Emily R., Holoman, Nicholas, Shao, Jianning, Shen, Bailey, Anand-Apte, Bela, Samuels, Ivy S.
Published in Experimental eye research (01.03.2019)
Published in Experimental eye research (01.03.2019)
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Journal Article
Quantitative flow cytometric selection of tau conformational nanobodies specific for pathological aggregates
Zupancic, Jennifer M., Smith, Matthew D., Trzeciakiewicz, Hanna, Skinner, Mary E., Ferris, Sean P., Makowski, Emily K., Lucas, Michael J., McArthur, Nikki, Kane, Ravi S., Paulson, Henry L., Tessier, Peter M.
Published in Frontiers in immunology (09.08.2023)
Published in Frontiers in immunology (09.08.2023)
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Journal Article
Reduction of therapeutic antibody self-association using yeast-display selections and machine learning
Makowski, Emily K, Chen, Hongwei, Lambert, Matthew, Bennett, Eric M, Eschmann, Nicole S, Zhang, Yulei, Zupancic, Jennifer M, Desai, Alec A, Smith, Matthew D, Lou, Wenjia, Fernando, Amendra, Tully, Timothy, Gallo, Christopher J, Lin, Laura, Tessier, Peter M
Published in mAbs (2022)
Published in mAbs (2022)
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Journal Article
Directed evolution of conformation‐specific antibodies for sensitive detection of polypeptide aggregates in therapeutic drug formulations
Lou, Wenjia, Stimple, Samuel D., Desai, Alec A., Makowski, Emily K., Kalyoncu, Sibel, Mogensen, Jesper E., Spang, Lotte T., Asgreen, Désirée J., Staby, Arne, Duus, Karen, Amstrup, Jan, Zhang, Yulei, Tessier, Peter M.
Published in Biotechnology and bioengineering (01.02.2021)
Published in Biotechnology and bioengineering (01.02.2021)
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