Discovery of a Janus Kinase Inhibitor Bearing a Highly Three-Dimensional Spiro Scaffold: JTE-052 (Delgocitinib) as a New Dermatological Agent to Treat Inflammatory Skin Disorders
Noji, Satoru, Hara, Yoshinori, Miura, Tomoya, Yamanaka, Hiroshi, Maeda, Katsuya, Hori, Akimi, Yamamoto, Hiroshi, Obika, Shingo, Inoue, Masafumi, Hase, Yasunori, Orita, Takuya, Doi, Satoki, Adachi, Tsuyoshi, Tanimoto, Atsuo, Oki, Chika, Kimoto, Yukari, Ogawa, Yoshihiro, Negoro, Tamotsu, Hashimoto, Hiromasa, Shiozaki, Makoto
Published in Journal of medicinal chemistry (09.07.2020)
Published in Journal of medicinal chemistry (09.07.2020)
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Structure–activity relationship study, target identification, and pharmacological characterization of a small molecular IL-12/23 inhibitor, APY0201
Hayakawa, Nobuhiko, Noguchi, Masatsugu, Takeshita, Sen, Eviryanti, Agung, Seki, Yukie, Nishio, Hikaru, Yokoyama, Ryohei, Noguchi, Misato, Shuto, Manami, Shima, Yoichiro, Kuribayashi, Kanna, Kageyama, Shunsuke, Eda, Hiroyuki, Suzuki, Manabu, Hatta, Tomohisa, Iemura, Shun-ichiro, Natsume, Tohru, Tanabe, Itsuya, Nakagawa, Ryusuke, Shiozaki, Makoto, Sakurai, Kuniya, Shoji, Masataka, Andou, Ayatoshi, Yamamoto, Takashi
Published in Bioorganic & medicinal chemistry (01.06.2014)
Published in Bioorganic & medicinal chemistry (01.06.2014)
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Discovery of (1S,2R,3R)-2,3-Dimethyl-2-phenyl-1-sulfamidocyclopropanecarboxylates: Novel and Highly Selective Aggrecanase Inhibitors
Shiozaki, Makoto, Maeda, Katsuya, Miura, Tomoya, Kotoku, Masayuki, Yamasaki, Takayuki, Matsuda, Isamu, Aoki, Kenta, Yasue, Katsutaka, Imai, Hiroto, Ubukata, Minoru, Suma, Akira, Yokota, Masahiro, Hotta, Takahiro, Tanaka, Masahiro, Hase, Yasunori, Haas, Julia, Fryer, Andrew M, Laird, Ellen R, Littmann, Nicole M, Andrews, Steven W, Josey, John A, Mimura, Takayuki, Shinozaki, Yuichi, Yoshiuchi, Hiromi, Inaba, Takashi
Published in Journal of medicinal chemistry (28.04.2011)
Published in Journal of medicinal chemistry (28.04.2011)
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Tu1864 A Novel Orally Active Phosphatidylinositol 3-Phosphate 5-Kinase (Pikfyve) Inhibitor Ameliorates Mouse Colitis by Inhibition of IL-12 and IL-23 Production From Macrophages
Andou, Ayatoshi, Yamamoto, Takashi, Agung, Eviryanti, Seki, Yukie, Nishio, Hikaru, Shuto, Manami, Noguchi, Misato, Shima, Yoichiro, Takeshita, Sen, Yokoyama, Ryohei, Hayakawa, Nobuhiko, Noguchi, Masatsugu, Kageyama, Shunsuke, Eda, Hiroyuki, Shiozaki, Makoto, Tanabe, Itsuya, Nakagawa, Ryusuke, Sakurai, Kuniya, Masataka, Shoji
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2012)
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2012)
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Novel N-substituted 2-phenyl-1-sulfonylamino-cyclopropane carboxylates as selective ADAMTS-5 (Aggrecanase-2) inhibitors
SHIOZAKI, Makoto, MAEDA, Katsuya, MIMURA, Takayuki, SHINOZAKI, Yuichi, YOSHIUCHI, Hiromi, INABA, Takashi, MIURA, Tomoya, OGOSHI, Yosuke, HAAS, Julia, FRYER, Andrew M, LAIRD, Ellen R, LITTMANN, Nicole M, ANDREWS, Steven W, JOSEY, John A
Published in Bioorganic & medicinal chemistry letters (15.03.2009)
Published in Bioorganic & medicinal chemistry letters (15.03.2009)
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CS3B-2-4 Target identification of novel orally active anti-inflammatory compound: Phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) inhibitor
Ayatoshi Andou, Takashi Yamamoto, Eviryanti Agung, Yukie Seki, Hikaru Nishio, Sen Takeshita, Nobuhiko Hayakawa, Masatsugu Noguchi, Ryohei Yokoyama, Manami Shuto, Misato Noguchi, Yoichiro Shima, Tohru Natsume, Shunsuke Kageyama, Hiroyuki Eda, Makoto Shiozaki, Masataka Shoji
Published in Journal of Pharmacological Sciences (15.03.2013)
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Published in Journal of Pharmacological Sciences (15.03.2013)
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Nuamcharoen, Praewpanit, Kobayashi, Takaomi, Potiyaraj, Pranut, Shiozaki, Makoto
Published in Polymer international (01.08.2020)
Published in Polymer international (01.08.2020)
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Activin A: A Commitment Factor in Erythroid Differentiation
Shiozaki, Makoto, Kosaka, Masaaki, Eto, Yuzuru
Published in Biochemical and biophysical research communications (26.01.1998)
Published in Biochemical and biophysical research communications (26.01.1998)
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Pharmacological properties of JTE-052: a novel potent JAK inhibitor that suppresses various inflammatory responses in vitro and in vivo
Tanimoto, Atsuo, Ogawa, Yoshihiro, Oki, Chika, Kimoto, Yukari, Nozawa, Keisuke, Amano, Wataru, Noji, Satoru, Shiozaki, Makoto, Matsuo, Akira, Shinozaki, Yuichi, Matsushita, Mutsuyoshi
Published in Inflammation research (01.01.2015)
Published in Inflammation research (01.01.2015)
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Journal Article
Discovery of Second Generation RORγ Inhibitors Composed of an Azole Scaffold
Kotoku, Masayuki, Maeba, Takaki, Fujioka, Shingo, Yokota, Masahiro, Seki, Noriyoshi, Ito, Keisuke, Suwa, Yoshihiro, Ikenogami, Taku, Hirata, Kazuyuki, Hase, Yasunori, Katsuda, Yoshiaki, Miyagawa, Naoki, Arita, Kojo, Asahina, Kota, Noguchi, Masato, Nomura, Akihiro, Doi, Satoki, Adachi, Tsuyoshi, Crowe, Paul, Tao, Haiyan, Thacher, Scott, Hashimoto, Hiromasa, Suzuki, Takayoshi, Shiozaki, Makoto
Published in Journal of medicinal chemistry (14.03.2019)
Published in Journal of medicinal chemistry (14.03.2019)
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Journal Article
Discovery and SAR of JTE-151: A Novel RORγ Inhibitor for Clinical Development
Maeba, Takaki, Hirata, Kazuyuki, Kotoku, Masayuki, Seki, Noriyoshi, Maeda, Katsuya, Hirashima, Shintaro, Yamanaka, Hiroshi, Sakai, Takayuki, Obika, Shingo, Hori, Akimi, Hara, Yoshinori, Noji, Satoru, Suwa, Yoshihiro, Yokota, Masahiro, Fujioka, Shingo, Yamaguchi, Takayuki, Katsuda, Yoshiaki, Hata, Takahiro, Miyagawa, Naoki, Arita, Kojo, Nomura, Yukihiro, Taniguchi, Toshio, Asahina, Kota, Aratsu, Yusuke, Naka, Yuichi, Adachi, Tsuyoshi, Nomura, Akihiro, Akai, Shota, Oshida, Shin-ichi, Pai, Sudhakar, Crowe, Paul, Bradley, Erin, Steensma, Ruo, Tao, Haiyan, Fenn, Morgan, Babine, Robert, Li, Xiaolin, Thacher, Scott, Soeta, Takahiro, Ukaji, Yutaka, Shiozaki, Makoto
Published in Journal of medicinal chemistry (25.01.2024)
Published in Journal of medicinal chemistry (25.01.2024)
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Ternary crystal structure of human RORγ ligand-binding-domain, an inhibitor and corepressor peptide provides a new insight into corepressor interaction
Noguchi, Masato, Nomura, Akihiro, Doi, Satoki, Yamaguchi, Keishi, Hirata, Kazuyuki, Shiozaki, Makoto, Maeda, Katsuya, Hirashima, Shintaro, Kotoku, Masayuki, Yamaguchi, Takayuki, Katsuda, Yoshiaki, Crowe, Paul, Tao, Haiyan, Thacher, Scott, Adachi, Tsuyoshi
Published in Scientific reports (26.11.2018)
Published in Scientific reports (26.11.2018)
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Journal Article
Discovery of Selective Transforming Growth Factor β Type II Receptor Inhibitors as Antifibrosis Agents
Miwa, Shohei, Yokota, Masahiro, Ueyama, Yoshifumi, Maeda, Katsuya, Ogoshi, Yosuke, Seki, Noriyoshi, Ogawa, Naoki, Nishihata, Jun, Nomura, Akihiro, Adachi, Tsuyoshi, Kitao, Yuki, Nozawa, Keisuke, Ishikawa, Tomohiro, Ukaji, Yutaka, Shiozaki, Makoto
Published in ACS medicinal chemistry letters (13.05.2021)
Published in ACS medicinal chemistry letters (13.05.2021)
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Journal Article
SAR Exploration Guided by LE and Fsp(3): Discovery of a Selective and Orally Efficacious ROR gamma Inhibitor
Hirata, Kazuyuki, Kotoku, Masayuki, Seki, Noriyoshi, Maeba, Takaki, Maeda, Katsuya, Hirashima, Shintaro, Sakai, Takayuki, Obika, Shingo, Hori, Akimi, Hase, Yasunori, Yamaguchi, Takayuki, Katsuda, Yoshiaki, Hata, Takahiro, Miyagawa, Naoki, Arita, Kojo, Nomura, Yukihiro, Asahina, Kota, Aratsu, Yusuke, Kamada, Masafumi, Adachi, Tsuyoshi, Noguchi, Masato, Doi, Satoki, Crowe, Paul, Bradley, Erin, Steensma, Ruo, Tao, Haiyan, Fenn, Morgan, Babine, Robert, Li, Xiaolin, Thacher, Scott, Hashimoto, Hiromasa, Shiozaki, Makoto
Published in ACS medicinal chemistry letters (14.01.2016)
Published in ACS medicinal chemistry letters (14.01.2016)
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Journal Article
Ternary complex of human ROR[gamma] ligand-binding domain, inverse agonist and SMRT peptide shows a unique mechanism of corepressor recruitment
Noguchi, Masato, Nomura, Akihiro, Murase, Ken, Doi, Satoki, Yamaguchi, Keishi, Hirata, Kazuyuki, Shiozaki, Makoto, Hirashima, Shintaro, Kotoku, Masayuki, Yamaguchi, Takayuki, Katsuda, Yoshiaki, Steensma, Ruo, Li, Xioalin, Tao, Haiyan, Tse, Bruno, Fenn, Morgan, Babine, Robert, Bradley, Erin, Crowe, Paul, Thacher, Scott, Adachi, Tsuyoshi, Kamada, Masafumi
Published in Genes to cells : devoted to molecular & cellular mechanisms (01.06.2017)
Published in Genes to cells : devoted to molecular & cellular mechanisms (01.06.2017)
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Journal Article
Ternary complex of human RORγ ligand‐binding domain, inverse agonist and SMRT peptide shows a unique mechanism of corepressor recruitment
Noguchi, Masato, Nomura, Akihiro, Murase, Ken, Doi, Satoki, Yamaguchi, Keishi, Hirata, Kazuyuki, Shiozaki, Makoto, Hirashima, Shintaro, Kotoku, Masayuki, Yamaguchi, Takayuki, Katsuda, Yoshiaki, Steensma, Ruo, Li, Xioalin, Tao, Haiyan, Tse, Bruno, Fenn, Morgan, Babine, Robert, Bradley, Erin, Crowe, Paul, Thacher, Scott, Adachi, Tsuyoshi, Kamada, Masafumi
Published in Genes to cells : devoted to molecular & cellular mechanisms (01.06.2017)
Published in Genes to cells : devoted to molecular & cellular mechanisms (01.06.2017)
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Journal Article
Concise SAR Exploration Based on the “Head-to-Tail” Approach: Discovery of PI4KIIIα Inhibitors Bearing Diverse Scaffolds
Noji, Satoru, Seki, Noriyoshi, Maeba, Takaki, Sakai, Takayuki, Watanabe, Eiichi, Maeda, Katsuya, Fukushima, Kyoko, Noguchi, Toru, Ogawa, Kazuya, Toyonaga, Yukiyo, Negoro, Tamotsu, Kawasaki, Hisashi, Shiozaki, Makoto
Published in ACS medicinal chemistry letters (13.10.2016)
Published in ACS medicinal chemistry letters (13.10.2016)
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Journal Article
Preparation and enzymic activity of poly[(N-acylimino)ethylene]-modified catalase
Miyamoto, Masatoshi, Naka, Kensuke, Shiozaki, Makoto, Chujo, Yoshiki, Saegusa, Takeo
Published in Macromolecules (01.06.1990)
Published in Macromolecules (01.06.1990)
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