Neuroprotection Against MPP + -Induced Cytotoxicity Through the Activation of PI3-K/Akt/GSK3β/MEF2D Signaling Pathway by Rhynchophylline, the Major Tetracyclic Oxindole Alkaloid Isolated From Uncaria rhynchophylla
Hu, Shengquan, Mak, Shinghung, Zuo, Xialin, Li, Haitao, Wang, Yuqiang, Han, Yifan
Published in Frontiers in pharmacology (19.07.2018)
Published in Frontiers in pharmacology (19.07.2018)
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Journal Article
A Novel Tetramethylpyrazine Derivative Prophylactically Protects against Glutamate-Induced Excitotoxicity in Primary Neurons through the Blockage of N -Methyl-D-aspartate Receptor
Hu, Shengquan, Hu, Huihui, Mak, Shinghung, Cui, Guozhen, Lee, Mingyuen, Shan, Luchen, Wang, Yuqiang, Lin, Huangquan, Zhang, Zaijun, Han, Yifan
Published in Frontiers in pharmacology (12.02.2018)
Published in Frontiers in pharmacology (12.02.2018)
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Journal Article
Assessment of Neuronal Viability Using Fluorescein Diacetate-Propidium Iodide Double Staining in Cerebellar Granule Neuron Culture
Jiajia, Lin, Shinghung, Mak, Jiacheng, Zheng, Jialing, Wang, Dilin, Xu, Shengquan, Hu, Zaijun, Zhang, Qinwen, Wang, Yifan, Han, Wei, Cui
Published in Journal of visualized experiments (10.05.2017)
Published in Journal of visualized experiments (10.05.2017)
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Journal Article
Interacting with α7 nAChR is a new mechanism for AChE to enhance the inflammatory response in macrophages
Liu, Etta Y.L., Xia, Yingjie, Kong, Xiangpeng, Guo, Maggie S.S., Yu, Anna X.D., Zheng, Brody Z.Y., Mak, Shinghung, Xu, Miranda L., Tsim, Karl W.K.
Published in Acta pharmaceutica Sinica. B (01.10.2020)
Published in Acta pharmaceutica Sinica. B (01.10.2020)
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Journal Article
Tacrine(10)-Hupyridone Prevents Post-operative Cognitive Dysfunction via the Activation of BDNF Pathway and the Inhibition of AChE in Aged Mice
Chen, Huixin, Wu, Xiang, Gu, Xinmei, Zhou, Yiying, Ye, Luying, Zhang, Ke, Pan, Hanbo, Wang, Jialing, Wei, Hua, Zhu, Binbin, Naman, C Benjamin, Mak, Shinghung, Carlier, Paul R, Cui, Wei, Han, Yifan
Published in Frontiers in cellular neuroscience (07.11.2018)
Published in Frontiers in cellular neuroscience (07.11.2018)
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Journal Article
Unexpected neuronal protection of SU5416 against 1-Methyl-4-phenylpyridinium ion-induced toxicity via inhibiting neuronal nitric oxide synthase
Cui, Wei, Zhang, Zaijun, Li, Wenming, Mak, Shinghung, Hu, Shengquan, Zhang, Huan, Yuan, Shuai, Rong, Jianhui, Choi, Tony Chunglit, Lee, Simon M Y, Han, Yifan
Published in PloS one (25.09.2012)
Published in PloS one (25.09.2012)
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Journal Article
Potent Protection Against MPP+-Induced Neurotoxicity via Activating Transcription Factor MEF2D by a Novel Derivative of Naturally Occurring Danshensu/Tetramethylpyrazine
Hu, Shengquan, Wang, Liang, Mak, Shinghung, Zhang, Zaijun, Xu, Daping, Li, Haitao, Li, Yide, Hu, Yuanjia, Lee, Simon Ming Yuen, Wang, Yuqiang, Han, Yifan
Published in Neuromolecular medicine (01.12.2016)
Published in Neuromolecular medicine (01.12.2016)
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Journal Article
Tacrine(2)–ferulic acid, a novel multifunctional dimer, attenuates 6-hydroxydopamine-induced apoptosis in PC12 cells by activating Akt pathway
Zhang, Huan, Mak, Shinghung, Cui, Wei, Li, Wenming, Han, Renwen, Hu, Shengquan, Ye, Minzhong, Pi, Rongbiao, Han, Yifan
Published in Neurochemistry international (01.12.2011)
Published in Neurochemistry international (01.12.2011)
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Journal Article
Bis(12)-hupyridone, a novel acetylcholinesterase inhibitor, protects against glutamate-induced neuronal excitotoxicity via activating α7 nicotinic acetylcholine receptor/phosphoinositide 3-kinase/Akt cascade
Cui, Wei, Hu, Shengquan, Chan, Hugh H.N., Luo, Jialie, Li, Wenming, Mak, Shinghung, Choi, Tony Chunglit, Rong, Jianhui, Carlier, Paul R., Han, Yifan
Published in Chemico-biological interactions (25.03.2013)
Published in Chemico-biological interactions (25.03.2013)
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Journal Article
Promising multifunctional anti-Alzheimer's dimer bis(7)-Cognitin acting as an activator of protein kinase C regulates activities of α-secretase and BACE-1 concurrently
Fu, Hongjun, Dou, Juan, Li, Wenming, Cui, Wei, Mak, Shinghung, Hu, Qiansheng, Luo, Jialie, Lam, Colin S.C., Pang, Yuanping, Youdim, Moussa B.H., Han, Yifan
Published in European journal of pharmacology (25.11.2009)
Published in European journal of pharmacology (25.11.2009)
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Journal Article
Cinnamic Acid Derivatives: Recent Discoveries and Development Strategies for Alzheimer's Disease
Liu, Yuan, Zhang, Zhixian, Zhu, Zeyu, Yang, Yang, Peng, Weijia, Chen, Qiuhe, Mak, Shinghung, Tism, Karl Wahkeung, Pi, Rongbiao
Published in Mini reviews in medicinal chemistry (30.08.2024)
Published in Mini reviews in medicinal chemistry (30.08.2024)
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Journal Article
Promising tacrine/huperzine A‐based dimeric acetylcholinesterase inhibitors for neurodegenerative disorders: From relieving symptoms to modifying diseases through multitarget
Mak, Shinghung, Li, Wenming, Fu, Hongjun, Luo, Jialie, Cui, Wei, Hu, Shengquan, Pang, Yuanping, Carlier, Paul R., Tsim, Karl Wahkeung, Pi, Rongbiao, Han, Yifan
Published in Journal of neurochemistry (01.09.2021)
Published in Journal of neurochemistry (01.09.2021)
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Journal Article
Multifunctional memantine nitrate significantly protects against glutamate-induced excitotoxicity via inhibiting calcium influx and attenuating PI3K/Akt/GSK3beta pathway
Liu, Zheng, Qiu, Xiaoling, Mak, Shinghung, Guo, Baojian, Hu, Shengquan, Wang, Jiajun, Luo, Fangcheng, Xu, Daping, Sun, Yewei, Zhang, Gaoxiao, Cui, Guozhen, Wang, Yuqiang, Zhang, Zaijun, Han, Yifan
Published in Chemico-biological interactions (01.07.2020)
Published in Chemico-biological interactions (01.07.2020)
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Journal Article
Regulation of acetylcholinesterase during the lipopolysaccharide-induced inflammatory responses in microglial cells
Xia, Yingjie, Wu, Qiyun, Mak, Shinghung, Liu, Etta Y L, Zheng, Brody Z Y, Dong, Tina T X, Pi, Rongbiao, Tsim, Karl W K
Published in The FASEB journal (01.03.2022)
Published in The FASEB journal (01.03.2022)
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Journal Article
Significant combination of Aβ aggregation inhibitory and neuroprotective properties in silico, in vitro and in vivo by bis(propyl)-cognitin, a multifunctional anti-Alzheimer’s agent
Hu, Shengquan, Xian, Yanfang, Fan, Yubo, Mak, Shinghung, Wang, Jiajun, Tang, Jing, Pang, Yuanping, Pi, Rongbiao, Tsim, Karl Wahkeung, Liu, Fufeng, Lin, Zhixiu, Han, Yifan
Published in European journal of pharmacology (05.06.2020)
Published in European journal of pharmacology (05.06.2020)
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Journal Article
Correction to “Pharmacological Characterizations of anti-Dementia Memantine Nitrate via Neuroprotection and Vasodilation in Vitro and in Vivo”
Mak, Shinghung, Liu, Zheng, Wu, Liangmiao, Guo, Baojian, Luo, Fangcheng, Liu, Ziyan, Hu, Shengquan, Wang, Jiajun, Cui, Guozhen, Sun, Yewei, Wang, Yuqiang, Zhang, Gaoxiao, Han, Yifan, Zhang, Zaijun
Published in ACS chemical neuroscience (15.05.2024)
Published in ACS chemical neuroscience (15.05.2024)
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Journal Article
The dual‐functional memantine nitrate MN‐08 alleviates cerebral vasospasm and brain injury in experimental subarachnoid haemorrhage models
Luo, Fangcheng, Wu, Liangmiao, Zhang, Zhixiang, Zhu, Zeyu, Liu, Zheng, Guo, Baojian, Li, Ning, Ju, Jun, Zhou, Qiang, Li, Shupeng, Yang, Xifei, Mak, Shinghung, Han, Yifan, Sun, Yewei, Wang, Yuqiang, Zhang, Gaoxiao, Zhang, Zaijun
Published in British journal of pharmacology (01.09.2019)
Published in British journal of pharmacology (01.09.2019)
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Journal Article
Bis(propyl)-cognitin protects against glutamate-induced neuro-excitotoxicity via concurrent regulation of NO, MAPK/ERK and PI3-K/Akt/GSK3β pathways
Hu, Shengquan, Cui, Wei, Mak, Shinghung, Tang, Jing, Choi, Chunglit, Pang, Yuanping, Han, Yifan
Published in Neurochemistry international (01.03.2013)
Published in Neurochemistry international (01.03.2013)
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Journal Article
Discovery of a novel small molecule PT109 with multi-targeted effects against Alzheimer's disease in vitro and in vivo
Chen, Qiuhe, Tu, Yalin, Mak, Shinghung, Chen, Jingkao, Lu, Junfeng, Chen, Chen, Yang, Xiaohong, Wang, Shengnan, Wen, Shijun, Ma, Shanshan, Li, Mingtao, Han, Yifan, Wah-Keung Tsim, Karl, Pi, Rongbiao
Published in European journal of pharmacology (15.09.2020)
Published in European journal of pharmacology (15.09.2020)
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