T-cell activation by transitory neo-antigens derived from distinct microbial pathways
Corbett, Alexandra J., Eckle, Sidonia B. G., Birkinshaw, Richard W., Liu, Ligong, Patel, Onisha, Mahony, Jennifer, Chen, Zhenjun, Reantragoon, Rangsima, Meehan, Bronwyn, Cao, Hanwei, Williamson, Nicholas A., Strugnell, Richard A., Van Sinderen, Douwe, Mak, Jeffrey Y. W., Fairlie, David P., Kjer-Nielsen, Lars, Rossjohn, Jamie, McCluskey, James
Published in Nature (London) (15.05.2014)
Published in Nature (London) (15.05.2014)
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Journal Article
Natural Products with Anti-Bredt and Bridgehead Double Bonds
Mak, Jeffrey Y. W., Pouwer, Rebecca H., Williams, Craig M.
Published in Angewandte Chemie International Edition (08.12.2014)
Published in Angewandte Chemie International Edition (08.12.2014)
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Journal Article
MAIT Cells Promote Tumor Initiation, Growth, and Metastases via Tumor MR1
Yan, Juming, Allen, Stacey, McDonald, Elizabeth, Das, Indrajit, Mak, Jeffrey Y W, Liu, Ligong, Fairlie, David P, Meehan, Bronwyn S, Chen, Zhenjun, Corbett, Alexandra J, Varelias, Antiopi, Smyth, Mark J, Teng, Michele W L
Published in Cancer discovery (01.01.2020)
Published in Cancer discovery (01.01.2020)
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Journal Article
Recipient mucosal-associated invariant T cells control GVHD within the colon
Varelias, Antiopi, Bunting, Mark D, Ormerod, Kate L, Koyama, Motoko, Olver, Stuart D, Straube, Jasmin, Kuns, Rachel D, Robb, Renee J, Henden, Andrea S, Cooper, Leanne, Lachner, Nancy, Gartlan, Kate H, Lantz, Olivier, Kjer-Nielsen, Lars, Mak, Jeffrey Yw, Fairlie, David P, Clouston, Andrew D, McCluskey, James, Rossjohn, Jamie, Lane, Steven W, Hugenholtz, Philip, Hill, Geoffrey R
Published in The Journal of clinical investigation (01.05.2018)
Published in The Journal of clinical investigation (01.05.2018)
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Journal Article
Computer Modelling and Synthesis of Deoxy and Monohydroxy Analogues of a Ribitylaminouracil Bacterial Metabolite that Potently Activates Human T Cells
Ler, Geraldine J. M., Xu, Weijun, Mak, Jeffrey Y. W., Liu, Ligong, Bernhardt, Paul V., Fairlie, David P.
Published in Chemistry : a European journal (05.12.2019)
Published in Chemistry : a European journal (05.12.2019)
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Journal Article
MR1-Restricted T Cells with MAIT-like Characteristics Are Functionally Conserved in the Pteropid Bat Pteropus alecto
Leeansyah, Edwin, Hey, Ying Ying, Sia, Wan Rong, Ng, Justin Han Jia, Gulam, Muhammad Yaaseen, Boulouis, Caroline, Zhu, Feng, Ahn, Matae, Mak, Jeffrey Y.W., Fairlie, David P., Kwa, Andrea Lay Hoon, Sandberg, Johan K., Wang, Lin-Fa
Published in iScience (18.12.2020)
Published in iScience (18.12.2020)
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Journal Article
Chemical Modulators of Mucosal Associated Invariant T Cells
Mak, Jeffrey Y. W, Liu, Ligong, Fairlie, David P
Published in Accounts of chemical research (07.09.2021)
Published in Accounts of chemical research (07.09.2021)
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Journal Article
Histone deacetylase 7: a signalling hub controlling development, inflammation, metabolism and disease
Wang, Yizhuo, Abrol, Rishika, Mak, Jeffrey Y. W., Das Gupta, Kaustav, Ramnath, Divya, Karunakaran, Denuja, Fairlie, David P., Sweet, Matthew J.
Published in The FEBS journal (01.06.2023)
Published in The FEBS journal (01.06.2023)
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Journal Article
Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells
Keller, Andrew N, Eckle, Sidonia B G, Xu, Weijun, Liu, Ligong, Hughes, Victoria A, Mak, Jeffrey Y W, Meehan, Bronwyn S, Pediongco, Troi, Birkinshaw, Richard W, Chen, Zhenjun, Wang, Huimeng, D'Souza, Criselle, Kjer-Nielsen, Lars, Gherardin, Nicholas A, Godfrey, Dale I, Kostenko, Lyudmila, Corbett, Alexandra J, Purcell, Anthony W, Fairlie, David P, McCluskey, James, Rossjohn, Jamie
Published in Nature immunology (01.04.2017)
Published in Nature immunology (01.04.2017)
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Journal Article
Tuning Electrostatic and Hydrophobic Surfaces of Aromatic Rings to Enhance Membrane Association and Cell Uptake of Peptides
Araujo, Aline D., Hoang, Huy N., Lim, Junxian, Mak, Jeffrey Y. W., Fairlie, David P.
Published in Angewandte Chemie International Edition (18.07.2022)
Published in Angewandte Chemie International Edition (18.07.2022)
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Journal Article
Stabilizing short-lived Schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant T cells
Mak, Jeffrey Y. W., Xu, Weijun, Reid, Robert C., Corbett, Alexandra J., Meehan, Bronwyn S., Wang, Huimeng, Chen, Zhenjun, Rossjohn, Jamie, McCluskey, James, Liu, Ligong, Fairlie, David P.
Published in Nature communications (08.03.2017)
Published in Nature communications (08.03.2017)
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Journal Article
Recognition of Vitamin B Precursors and Byproducts by Mucosal Associated Invariant T Cells
Eckle, Sidonia B.G., Corbett, Alexandra J., Keller, Andrew N., Chen, Zhenjun, Godfrey, Dale I., Liu, Ligong, Mak, Jeffrey Y.W., Fairlie, David P., Rossjohn, Jamie, McCluskey, James
Published in The Journal of biological chemistry (18.12.2015)
Published in The Journal of biological chemistry (18.12.2015)
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Journal Article
MAIT cells protect against pulmonary Legionella longbeachae infection
Wang, Huimeng, D’Souza, Criselle, Lim, Xin Yi, Kostenko, Lyudmila, Pediongco, Troi J., Eckle, Sidonia B. G., Meehan, Bronwyn S., Shi, Mai, Wang, Nancy, Li, Shihan, Liu, Ligong, Mak, Jeffrey Y. W., Fairlie, David P., Iwakura, Yoichiro, Gunnersen, Jennifer M., Stent, Andrew W., Godfrey, Dale I., Rossjohn, Jamie, Westall, Glen P., Kjer-Nielsen, Lars, Strugnell, Richard A., McCluskey, James, Corbett, Alexandra J., Hinks, Timothy S. C., Chen, Zhenjun
Published in Nature communications (22.08.2018)
Published in Nature communications (22.08.2018)
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Journal Article
Mouse mucosal-associated invariant T cell receptor recognition of MR1 presenting the vitamin B metabolite, 5-(2-oxopropylideneamino)-6-d-ribitylaminouracil
Ciacchi, Lisa, Mak, Jeffrey Y.W., Le, Jeremy P., Fairlie, David P., McCluskey, James, Corbett, Alexandra J., Rossjohn, Jamie, Awad, Wael
Published in The Journal of biological chemistry (01.05.2024)
Published in The Journal of biological chemistry (01.05.2024)
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Journal Article
Endoplasmic reticulum chaperones stabilize ligand-receptive MR1 molecules for efficient presentation of metabolite antigens
McWilliam, Hamish E. G., Mak, Jeffrey Y. W., Awad, Wael, Zorkau, Matthew, Cruz-Gomez, Sebastian, Lim, Hui Jing, Yan, Yuting, Wormald, Sam, Dagley, Laura F., Eckle, Sidonia B. G., Corbett, Alexandra J., Liu, Haiyin, Li, Shihan, Reddiex, Scott J. J., Mintern, Justine D., Liu, Ligong, McCluskey, James, Rossjohn, Jamie, Fairlie, David P., Villadangos, Jose A.
Published in Proceedings of the National Academy of Sciences - PNAS (06.10.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (06.10.2020)
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Journal Article
MAIT Cells Upregulate α4β7 in Response to Acute Simian Immunodeficiency Virus/Simian HIV Infection but Are Resistant to Peripheral Depletion in Pigtail Macaques
Juno, Jennifer A, Wragg, Kathleen M, Amarasena, Thakshila, Meehan, Bronwyn S, Mak, Jeffrey Y W, Liu, Ligong, Fairlie, David P, McCluskey, James, Eckle, Sidonia B G, Kent, Stephen J
Published in The Journal of immunology (1950) (01.04.2019)
Published in The Journal of immunology (1950) (01.04.2019)
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Journal Article
HDAC7 Inhibition by Phenacetyl and Phenylbenzoyl Hydroxamates
Mak, Jeffrey Y. W, Wu, Kai-Chen, Gupta, Praveer K, Barbero, Sheila, McLaughlin, Maddison G, Lucke, Andrew J, Tng, Jiahui, Lim, Junxian, Loh, Zhixuan, Sweet, Matthew J, Reid, Robert C, Liu, Ligong, Fairlie, David P
Published in Journal of medicinal chemistry (25.02.2021)
Published in Journal of medicinal chemistry (25.02.2021)
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Journal Article
The molecular basis underpinning the potency and specificity of MAIT cell antigens
Awad, Wael, Ler, Geraldine J. M., Xu, Weijun, Keller, Andrew N., Mak, Jeffrey Y. W., Lim, Xin Yi, Liu, Ligong, Eckle, Sidonia B. G., Le Nours, Jérôme, McCluskey, James, Corbett, Alexandra J., Fairlie, David P., Rossjohn, Jamie
Published in Nature immunology (01.04.2020)
Published in Nature immunology (01.04.2020)
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Journal Article