Replacing the phthalimide core in thalidomide with benzotriazole
Krasavin, Mikhail, Bubyrev, Andrey, Kazantsev, Alexander, Heim, Christopher, Maiwald, Samuel, Zhukovsky, Daniil, Dar'in, Dmitry, Hartmann, Marcus D., Bunev, Alexander
Published in Journal of enzyme inhibition and medicinal chemistry (01.12.2022)
Published in Journal of enzyme inhibition and medicinal chemistry (01.12.2022)
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Journal Article
Synthesis of novel glutarimide ligands for the E3 ligase substrate receptor Cereblon (CRBN): Investigation of their binding mode and antiproliferative effects against myeloma cell lines
Krasavin, Mikhail, Adamchik, Maria, Bubyrev, Andrey, Heim, Christopher, Maiwald, Samuel, Zhukovsky, Daniil, Zhmurov, Petr, Bunev, Alexander, Hartmann, Marcus D.
Published in European journal of medicinal chemistry (15.01.2023)
Published in European journal of medicinal chemistry (15.01.2023)
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Journal Article
Mechanism of millisecond Lys48-linked poly-ubiquitin chain formation by cullin-RING ligases
Liwocha, Joanna, Li, Jerry, Purser, Nicholas, Rattanasopa, Chutima, Maiwald, Samuel, Krist, David T, Scott, Daniel C, Steigenberger, Barbara, Prabu, J Rajan, Schulman, Brenda A, Kleiger, Gary
Published in Nature structural & molecular biology (01.02.2024)
Published in Nature structural & molecular biology (01.02.2024)
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Journal Article
Synthesis of novel glutarimide derivatives via the Ugi multicomponent reaction: affinity towards the E3 ubiquitin ligase substrate receptor Cereblon
Barkhatova, Darina, Zhukovsky, Daniil, Heim, Christopher, Maiwald, Samuel, Hartmann, Marcus D., Krasavin, Mikhail
Published in Mendeleev communications (01.11.2022)
Published in Mendeleev communications (01.11.2022)
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Journal Article
On the correlation of cereblon binding, fluorination and antiangiogenic properties of immunomodulatory drugs
Heim, Christopher, Maiwald, Samuel, Steinebach, Christian, Collins, Matthew K., Strope, Jonathan, Chau, Cindy H., Figg, William D., Gütschow, Michael, Hartmann, Marcus D.
Published in Biochemical and biophysical research communications (01.01.2021)
Published in Biochemical and biophysical research communications (01.01.2021)
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Journal Article
Leveraging Ligand Affinity and Properties: Discovery of Novel Benzamide-Type Cereblon Binders for the Design of PROTACs
Steinebach, Christian, Bricelj, Aleša, Murgai, Arunima, Sosič, Izidor, Bischof, Luca, Ng, Yuen Lam Dora, Heim, Christopher, Maiwald, Samuel, Proj, Matic, Voget, Rabea, Feller, Felix, Košmrlj, Janez, Sapozhnikova, Valeriia, Schmidt, Annika, Zuleeg, Maximilian Rudolf, Lemnitzer, Patricia, Mertins, Philipp, Hansen, Finn K., Gütschow, Michael, Krönke, Jan, Hartmann, Marcus D.
Published in Journal of medicinal chemistry (09.11.2023)
Published in Journal of medicinal chemistry (09.11.2023)
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Journal Article
Accessing three-branched high-affinity cereblon ligands for molecular glue and protein degrader design
Kuchta, Robert, Heim, Christopher, Herrmann, Alexander, Maiwald, Samuel, Ng, Yuen Lam Dora, Sosi, Izidor, Keuler, Tim, Krnke, Jan, Gütschow, Michael, Hartmann, Marcus D, Steinebach, Christian
Published in RSC chemical biology (08.03.2023)
Published in RSC chemical biology (08.03.2023)
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Journal Article
Replacing the phthalimide core in thalidomide with benzotriazole
Krasavin, Mikhail, Bubyrev, Andrey, Kazantsev, Alexander, Heim, Christopher, Maiwald, Samuel, Zhukovsky, Daniil, Dar'in, Dmitry, Hartmann, Marcus D., Bunev, Alexander
Published in Journal of Enzyme Inhibition and Medicinal Chemistry (31.12.2022)
Published in Journal of Enzyme Inhibition and Medicinal Chemistry (31.12.2022)
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