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Published in Journal of medicinal chemistry (31.05.2007)
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Discovery of (3S,3aR)-2-(3-Chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-benzo[g]indazole-7-carboxylic Acid (PF-3882845), an Orally Efficacious Mineralocorticoid Receptor (MR) Antagonist for Hypertension and Nephropathy
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Published in Journal of medicinal chemistry (26.08.2010)
Published in Journal of medicinal chemistry (26.08.2010)
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Use of protease substrate specificity screening in the rational design of selective protease inhibitors with unnatural amino acids: Application to HGFA, matriptase, and hepsin
Mahoney, Matthew W., Helander, Jonathan, Kooner, Anoopjit S., Norman, Mariah, Damalanka, Vishnu C., De Bona, Paolo, Kasperkiewicz, Paulina, Rut, Wioletta, Poreba, Marcin, Kashipathy, Maithri M., Battaile, Kevin P., Lovell, Scott, O'Donoghue, Anthony J., Craik, Charles S., Drag, Marcin, Janetka, James W.
Published in Protein science (01.08.2024)
Published in Protein science (01.08.2024)
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Macrocyclic Inhibitors of HGF-Activating Serine Proteases Overcome Resistance to Receptor Tyrosine Kinase Inhibitors and Block Lung Cancer Progression
Damalanka, Vishnu C, Voss, Jorine J. L. P, Mahoney, Matthew W, Primeau, Tina, Li, Shunqiang, Klampfer, Lidija, Janetka, James W
Published in Journal of medicinal chemistry (23.12.2021)
Published in Journal of medicinal chemistry (23.12.2021)
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Novel tetrahydro-β-carboline-1-carboxylic acids as inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2)
Trujillo, John I., Meyers, Marvin J., Anderson, David R., Hegde, Shridhar, Mahoney, Matthew W., Vernier, William F., Buchler, Ingrid P., Wu, Kun K., Yang, Syaluan, Hartmann, Susan J., Reitz, David B.
Published in Bioorganic & medicinal chemistry letters (15.08.2007)
Published in Bioorganic & medicinal chemistry letters (15.08.2007)
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Benzothiophene inhibitors of MK2. Part 2: Improvements in kinase selectivity and cell potency
Anderson, David R., Meyers, Marvin J., Kurumbail, Ravi G., Caspers, Nicole, Poda, Gennadiy I., Long, Scott A., Pierce, Betsy S., Mahoney, Matthew W., Mourey, Robert J., Parikh, Mihir D.
Published in Bioorganic & medicinal chemistry letters (15.08.2009)
Published in Bioorganic & medicinal chemistry letters (15.08.2009)
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Benzothiophene inhibitors of MK2. Part 1: Structure–activity relationships, assessments of selectivity and cellular potency
Anderson, David R., Meyers, Marvin J., Kurumbail, Ravi G., Caspers, Nicole, Poda, Gennadiy I., Long, Scott A., Pierce, Betsy S., Mahoney, Matthew W., Mourey, Robert J.
Published in Bioorganic & medicinal chemistry letters (15.08.2009)
Published in Bioorganic & medicinal chemistry letters (15.08.2009)
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Design, synthesis, and biological evaluation of pyrazinones containing novel P1 needles as inhibitors of TF/VIIa
Trujillo, John I., Huang, Horng-Chih, Neumann, William L., Mahoney, Matthew W., Long, Scott, Huang, Wei, Garland, Danny J., Kusturin, Carrie, Abbas, Zaheer, South, Michael S., Reitz, David B.
Published in Bioorganic & medicinal chemistry letters (15.08.2007)
Published in Bioorganic & medicinal chemistry letters (15.08.2007)
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Discovery of (3 S ,3a R )-2-(3-Chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2 H -benzo[ g ]indazole-7-carboxylic Acid (PF-3882845), an Orally Efficacious Mineralocorticoid Receptor (MR) Antagonist for Hypertension and Nephropathy
Meyers, Marvin J., Arhancet, Graciela B., Hockerman, Susan L., Chen, Xiangyang, Long, Scott A., Mahoney, Matthew W., Rico, Joseph R., Garland, Danny J., Blinn, James. R., Collins, Joe T., Yang, Shengtian, Huang, Horng-Chih, McGee, Kevin F., Wendling, Jay M., Dietz, Jessica D., Payne, Maria A., Homer, Bruce L., Heron, Marcia I., Reitz, David B., Hu, Xiao
Published in Journal of medicinal chemistry (26.08.2010)
Published in Journal of medicinal chemistry (26.08.2010)
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Synthesis of Potent Leukotriene A4 Hydrolase Inhibitors. Identification of 3-[Methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic Acid
Penning, Thomas D, Russell, Mark A, Chen, Barbara B, Chen, Helen Y, Liang, Chi-Dean, Mahoney, Matthew W, Malecha, James W, Miyashiro, Julie M, Yu, Stella S, Askonas, Leslie J, Gierse, James K, Harding, Elizabeth I, Highkin, Maureen K, Kachur, James F, Kim, Suzanne H, Villani-Price, Doreen, Pyla, E. Yvonne, Ghoreishi-Haack, Nayereh S, Smith, Walter G
Published in Journal of medicinal chemistry (01.08.2002)
Published in Journal of medicinal chemistry (01.08.2002)
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Discovery of Potent, Nonsystemic Apical Sodium-Codependent Bile Acid Transporter Inhibitors (Part 1)
Tremont, Samuel J, Lee, Len F, Huang, Horng-Chih, Keller, Bradley T, Banerjee, Shyamal C, Both, Scott R, Carpenter, Andrew J, Wang, Ching-Cheng, Garland, Danny J, Huang, Wei, Jones, Claude, Koeller, Kevin J, Kolodziej, Steve A, Li, James, Manning, Robert E, Mahoney, Matthew W, Miller, Raymond E, Mischke, Deborah A, Rath, Nigam P, Fletcher, Theresa, Reinhard, Emily J, Tollefson, Michael B, Vernier, William F, Wagner, Grace M, Rapp, Steve R, Beaudry, Judy, Glenn, Kevin, Regina, Karen, Schuh, Joe R, Smith, Mark E, Trivedi, Jay S, Reitz, David B
Published in Journal of medicinal chemistry (08.09.2005)
Published in Journal of medicinal chemistry (08.09.2005)
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Corrigendum to “Novel tetrahydro-β-carboline-1-carboxylic acids as inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2)” [Bioorg. Med. Chem. Lett. 17 (2007) 4657–4663]
Trujillo, John I., Meyers, Marvin J., Anderson, David R., Hegde, Shridhar, Mahoney, Matthew W., Vernier, William F., Buchler, Ingrid P., Wu, Kun K., Yang, Syaulan, Hartmann, Susan J., Reitz, David B.
Published in Bioorganic & medicinal chemistry letters (15.04.2009)
Published in Bioorganic & medicinal chemistry letters (15.04.2009)
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Journal Article
Discovery of Potent, Nonsystemic Apical Sodium-Codependent Bile Acid Transporter Inhibitors (Part 2)
Huang, Horng-Chih, Tremont, Samuel J, Lee, Len F, Keller, Bradley T, Carpenter, Andrew J, Wang, Ching-Cheng, Banerjee, Shyamal C, Both, Scott R, Fletcher, Theresa, Garland, Danny J, Huang, Wei, Jones, Claude, Koeller, Kevin J, Kolodziej, Steve A, Li, James, Manning, Robert E, Mahoney, Matthew W, Miller, Raymond E, Mischke, Deborah A, Rath, Nigam P, Reinhard, Emily J, Tollefson, Michael B, Vernier, William F, Wagner, Grace M, Rapp, Steve R, Beaudry, Judy, Glenn, Kevin, Regina, Karen, Schuh, Joe R, Smith, Mark E, Trivedi, Jay S, Reitz, David B
Published in Journal of medicinal chemistry (08.09.2005)
Published in Journal of medicinal chemistry (08.09.2005)
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Synthesis of potent leukotriene A(4) hydrolase inhibitors. identification of 3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid
Penning, TD, Russell, MA, Chen, BB, Chen, HY, Liang, CD, Mahoney, MW, Malecha, JW, Miyashiro, JM, Yu, SS, Askonas, LJ, Gierse, JK, Harding, EI, Highkin, MK, Kachur, JF, Kim, SH, Villani-Price, D, Pyla, EY, Ghoreishi-Haack, NS, Smith, WG
Published in Journal of medicinal chemistry (01.08.2002)
Published in Journal of medicinal chemistry (01.08.2002)
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Synthesis of Potent Leukotriene A 4 Hydrolase Inhibitors. Identification of 3-[Methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic Acid
Penning, Thomas D., Russell, Mark A., Chen, Barbara B., Chen, Helen Y., Liang, Chi-Dean, Mahoney, Matthew W., Malecha, James W., Miyashiro, Julie M., Yu, Stella S., Askonas, Leslie J., Gierse, James K., Harding, Elizabeth I., Highkin, Maureen K., Kachur, James F., Kim, Suzanne H., Villani-Price, Doreen, Pyla, E. Yvonne, Ghoreishi-Haack, Nayereh S., Smith, Walter G.
Published in Journal of medicinal chemistry (01.08.2002)
Published in Journal of medicinal chemistry (01.08.2002)
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SUBSTITUTED 1,2-DIHYDROQUINOLINES WITH LOW CONTAMINANT LEVELS AND PROCESSES FOR PREPARING
Long Scott A, Stefanescu Andrei D, Wang Xiaojun, Arhancet Graciela B, Schultz Jason W, Mahoney Matthew W
Year of Publication 19.10.2017
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Year of Publication 19.10.2017
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PYRAZOLINE COMPOUNDS
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Year of Publication 09.02.2012
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Year of Publication 09.02.2012
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PYRAZOLINE COMPOUNDS
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Year of Publication 04.11.2010
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Year of Publication 04.11.2010
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