Complex I inhibitor of oxidative phosphorylation in advanced solid tumors and acute myeloid leukemia: phase I trials
Yap, Timothy A, Daver, Naval, Mahendra, Mikhila, Zhang, Jixiang, Kamiya-Matsuoka, Carlos, Meric-Bernstam, Funda, Kantarjian, Hagop M, Ravandi, Farhad, Collins, Meghan E, Francesco, Maria Emilia Di, Dumbrava, Ecaterina E, Fu, Siqing, Gao, Sisi, Gay, Jason P, Gera, Sonal, Han, Jing, Hong, David S, Jabbour, Elias J, Ju, Zhenlin, Karp, Daniel D, Lodi, Alessia, Molina, Jennifer R, Baran, Natalia, Naing, Aung, Ohanian, Maro, Pant, Shubham, Pemmaraju, Naveen, Bose, Prithviraj, Piha-Paul, Sarina A, Rodon, Jordi, Salguero, Carolina, Sasaki, Koji, Singh, Anand K, Subbiah, Vivek, Tsimberidou, Apostolia M, Xu, Quanyun A, Yilmaz, Musa, Zhang, Qi, Li, Yuan, Bristow, Christopher A, Bhattacharjee, Meenakshi B, Tiziani, Stefano, Heffernan, Timothy P, Vellano, Christopher P, Jones, Philip, Heijnen, Cobi J, Kavelaars, Annemieke, Marszalek, Joseph R, Konopleva, Marina
Published in Nature medicine (01.01.2023)
Published in Nature medicine (01.01.2023)
Get full text
Journal Article
Abstract 2338: The GLS1 inhibitor IPN60090 enhances antitumor immune response through metabolic reprogramming of T cells and impacts on the tumor microenvironment
Suzuki, Erika, Molina, Jennifer, Spencer, Nakia D., Bristow, Christopher A., Harris, Angela L., Feng, Ningping, Mahendra, Mikhila, Gera, Sonal, Soth, Michael J., Le, Kang, Yap, Timothy A., Draetta, Giulio, Jones, Philip, Heffernan, Timothy P., Kovacs, Jeffrey J.
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Get full text
Journal Article
Abstract 317: Vecabrutinib inhibits C481 mutated Bruton's tyrosine kinase and its downstream signaling in vitro
Aslan, Burcu, Mahendra, Mikhila, Peoples, Michael D, Marszalek, Joe R., Vellano, Christopher P, Zheng, Xiaofeng, Wang, Jing, Taverna, Pietro, Gandhi, Varsha
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Get full text
Journal Article
Combined KRASG12C and SOS1 inhibition enhances and extends the anti-tumor response in KRASG12C-driven cancers by addressing intrinsic and acquired resistance
Thatikonda, Venu, Lu, Hengyu, Jurado, Sabine, Kostyrko, Kaja, Bristow, Christopher A, Bosch, Karin, Feng, Ningping, Gao, Sisi, Gerlach, Daniel, Gerlach, Michael, Lieb, Simone, Jeschko, Astrid, Machado, Annette A, Marszalek, Ethan D, Mikhila Mahendra, Jaeger, Philipp A, Sorokin, Alexey, Strauss, Sandra, Trapani, Francesca, Kopetz, Scott, Vellano, Christopher P, Petronczki, Mark, Kraut, Norbert, Heffernan, Timothy P, Marszalek, Joseph R, Pearson, Mark, Waizenegger, Irene, Hofmann, Marco H
Published in bioRxiv (23.01.2023)
Published in bioRxiv (23.01.2023)
Get full text
Paper
Abstract 985: BI 905711 selectively induces apoptosis and anti-tumor response in TRAILR2/CDH17- expressing pancreatic cancer models
Han, Jing, Machado, Annette A., Mahendra, Mikhila, Daniele, Joseph R., Bristow, Christopher A., Huang, Justin Kwang-Lay, Carugo, Alessandro, Mullinax, Robert A., Bivona, Benjamin J., Feng, Ningping, Gandhi, Poojabahen, Schweifer, Norbert, Chetta, Paolo Maria, Garcia-Martinez, Juan Manuel, Hilberg, Frank, Vellano, Christopher P., Heffernan, Timothy P., Marszalek, Joseph R.
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Get full text
Journal Article
Abstract 3277: IACS-9779, a development candidate that inhibits 2,3-dioxygenase (IDO) activity by blocking heme incorporation into IDO apoenzyme
Mseeh, Faika, Hamilton, Matthew M., Marszalek, Joseph R., Rogers, Norma E., Parker, Connor A., Yu, Simon S., Liu, Zhen, Reyna, Naphtali J., McAfoos, Timothy, Virgin-Downey, Brett W., Leonard, Paul G., Cross, Jason B., Feng, Ningping, Harris, Angela L., Zuniga, Andy M., Mikule, Keith, Tremblay, Martin, Jiang, Yongying, Mahendra, Mikhila, Pang, Jihai, Wu, Qi, Xu, Quanyun, Heffernan, Timothy P., Jones, Philip, Lewis, Richard T.
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Get full text
Journal Article
Phase I trial of IACS-010759 (IACS), a potent, selective inhibitor of complex I of the mitochondrial electron transport chain, in patients (pts) with advanced solid tumors
Yap, Timothy A, Rodon Ahnert, Jordi, Piha-Paul, Sarina Anne, Fu, Siqing, Janku, Filip, Karp, Daniel D., Naing, Aung, Ileana Dumbrava, Ecaterina Elena, Pant, Shubham, Subbiah, Vivek, Tsimberidou, Apostolia Maria, Hong, David S., Rose, Kelsey Meagan, Xu, Quanyun, Vellano, Christopher P., Mahendra, Mikhila, Jones, Philip, Di Francesco, Maria Emilia, Marszalek, Joseph R., Meric-Bernstam, Funda
Published in Journal of clinical oncology (20.05.2019)
Published in Journal of clinical oncology (20.05.2019)
Get full text
Journal Article
Abstract LB-124: Promoting an anti-tumor immune environment with a novel, exquisitely selective CSF1R inhibitor
Suzuki, Erika, Kovacs, Jeffrey J., Spencer, Nakia D., Sonal, Sonal, Feng, Ningping, Harris, Angela L., Mullinax, Robert A., Zuniga, Andy M., Johnson, Sarah B., Mahendra, Mikhila, Khor, Tin Oo, Mseeh, Faika, Liu, Zhen, Burke, Jason P., Mikule, Keith, Tremblay, Martin, Heffernan, Timothy P., Jones, Philip, Czako, Barbara, Marszalek, Joseph R.
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Get full text
Journal Article
Abstract LB-071: Discovery of an imidazopyridine series of potent human IDO1 inhibitors with robust target engagement in a preclinical tumor model
Petrocchi, Alessia, Reyna, Naphtali J., Mseeh, Faika, Parker, Connor A., Yu, Simon, Xu, Quanyun, Feng, Ningping, Leonard, Paul, Rogers, Norma, Cross, Jason B., Harris, Angela L., Jiang, Yongying, Khor, Tin Oo, Mahendra, Mikhila G., Pang, Jihai, Wu, Qi, Zuniga, Andy M., McAfoos, Timothy, Hamilton, Matthew M., Marszalek, Joe R., Mikule, Keith, Vancutsem, Paul, Wilcoxen, Keith, Tremblay, Martin, Jones, Philip, Lewis, Richard T.
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Get full text
Journal Article
Abstract 4017: TAS2940 inhibits intracranial tumor growth and prolongs survival in HER2-aberrant and EGFR-amplified patient-derived xenograft models
Han, Jing, Mahendra, Mikhila, Gandhi, Poojabahen, Daniele, Joseph R., Carrillo, Caroline C., Bivona, Benjamin J., Feng, Ningping, Heymach, John V., Meric-Bernstam, Funda, Oguchi, Kei, Mizuarai, Shinji, Heffernan, Timothy P., Vellano, Christopher P., Marszalek, Joseph R.
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Get full text
Journal Article
Abstract 2856: Targeting OXPHOS with IACS-010759 to eliminate standard of care resistant tumor cells
Marszalek, Joseph R., Seth, Sahil, Corti, Denise, Zhang, Qi, Echeverria, Gloria V., Han, Lina, Sun, Yuting, Molina, Jennifer, Gera, Sonal, Chang, Edward, Khor, Tin O., Mahendra, Mikhila, Feng, Ningping, Gay, Jason P., McAfoos, Timothy, Giuliani, Virginia, Shi, Xi, Jeter-Jones, Sabrina, Loponte, Sarah, Li, Chieh-Yuan, Bristow, Christopher A., Francesco, Maria Emilia Di, Piwnica-Worms, Helen, Konopleva, Marina, Carugo, Alessandro, Viale, Andrea, Jones, Philip, Heffernan, Timothy P., Draetta, Giulio F.
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Get full text
Journal Article
Development and characterization of prototypes for in vitro and in vivo mouse models of ibrutinib-resistant CLL
Aslan, Burcu, Kismali, Gorkem, Chen, Lisa S., Iles, LaKesla R., Mahendra, Mikhila, Peoples, Michael, Gagea, Mihai, Fowlkes, Natalie W., Zheng, Xiaofeng, Wang, Jing, Vellano, Christopher P., Marszalek, Joseph R., Bertilaccio, Maria Teresa Sabrina, Gandhi, Varsha
Published in Blood advances (24.08.2021)
Published in Blood advances (24.08.2021)
Get full text
Journal Article
Combined KRAS G12C and SOS1 inhibition enhances and extends the anti-tumor response in KRAS G12C -driven cancers by addressing intrinsic and acquired resistance
Thatikonda, Venu, Lu, Hengyu, Jurado, Sabine, Kostyrko, Kaja, Bristow, Christopher A, Bosch, Karin, Feng, Ningping, Gao, Sisi, Gerlach, Daniel, Gmachl, Michael, Lieb, Simone, Jeschko, Astrid, Machado, Annette A, Marszalek, Ethan D, Mahendra, Mikhila, Jaeger, Philipp A, Sorokin, Alexey, Strauss, Sandra, Trapani, Francesca, Kopetz, Scott, Vellano, Christopher P, Petronczki, Mark, Kraut, Norbert, Heffernan, Timothy P, Marszalek, Joseph R, Pearson, Mark, Waizenegger, Irene, Hofmann, Marco H
Published in bioRxiv : the preprint server for biology (23.01.2023)
Published in bioRxiv : the preprint server for biology (23.01.2023)
Get more information
Journal Article